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Christos Katsanos

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Associate Professor
Faculty, TEMPE Campus, Mailcode 4501
Biography

Christos Katsanos is a physiologist who studies metabolic responses in obese individuals. He and his research team focus on two aspects of human metabolism — muscle protein metabolism and dietary fat metabolism.

They study metabolic responses by tracing alternative forms (isotopes) of certain molecules as they move through the body. By using isotope-specific techniques, they can compare metabolic responses in normal-weight individuals to those of obese individuals to understand what metabolic abnormalities are implicated in obesity.

The team is also working to understand how insulin resistance, which is a common observation in obesity, may contribute to metabolic abnormalities that are specific to the skeletal muscle. Katsanos and his collaborators study these issues from a more patient-oriented approach by investigating how nutrient metabolism can be improved through diet and exercise.

Education

PhD, 2001, Florida State University

Publications
  • Puga GM, Meyer C, Mandarino LJ, Katsanos CS. "Increased plasma availability of L-arginine in the postprandial period decreases the postprandial lipemia in older adults". Nutrition 29(1):81-88, 2013.
  • Puga GM, Meyer C, Mandarino LJ, Katsanos CS. "Postprandial spillover of dietary lipid into plasma is increased with moderate amounts of ingested fat and is inversely related to adiposity in healthy older men". J Nutr 142(10):1806-1811, 2012.
  • Everman S, Yi Z, Langlais P, Mandarino LJ, Luo M, Roberts C,Katsanos CS. "Reproducibility of an HPLC-ESI-MS/MS method for the measurement of stable-isotope enrichment of in vivo-labeled muscle ATP synthase beta subunit". PLoS ONE 6(10):e26171. doi:10.1371/journal.pone.0026171, 2011.
  • Puga GM, Meyer C, Everman S, Mandarino LJ, Katsanos CS. "Postprandial lipemia in the elderly involves increased incorporation of ingested lipid in plasma free fatty acids and small (Sf 20-400) triglyceride-rich lipoproteins". Am J Physiol Endocrinol Metab 301(2):E356-E361, 2011.
  • Katsanos CS, Mandarino LJ. "Protein metabolism in human obesity: a shift in focus from whole-body to skeletal muscle". Obesity (Silver Spring) 19(3):469-475, 2011.

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  • Puga GM, Meyer C, Mandarino LJ, Katsanos CS. Increased plasma availability of L-arginine in the postprandial period decreases the postprandial lipemia in older adults. Nutrition (2013).
  • Puga GM, Meyer C, Mandarino LJ, Katsanos CS. Postprandial spillover of dietary lipid into plasma is increased with moderate amounts of ingested fat and is inversely related to adiposity in healthy older men. J Nutr (2012).
  • Everman S, Yi Z, Langlais P, Mandarino LJ, Luo M, Roberts C, Katsanos CS. Reproducibility of an HPLC-ESI-MS/MS method for the measurement of stable-isotope enrichment of in vivo-labeled muscle ATP synthase beta subunit. PLoS ONE (2011).
  • Katsanos CS, Mandarino LJ. Protein metabolism in human obesity: a shift in focus from whole-body to skeletal muscle. Obesity (Silver Spring) (2011).
  • Puga GM, Meyer C, Everman S, Mandarino LJ, Katsanos CS. Postprandial lipemia in elderly is associated with increased incorporation of ingested lipid in plasma free fatty acids and VLDL-triglycerides. Am J Physiol Endocrinol Metab (2011).
  • Katsanos CS, Aarsland A, Cree MG, Wolfe RR. Muscle protein synthesis and balance responsiveness to essential amino acids ingestion in the presence of elevated plasma free fatty acid concentrations. J Clin Endocrinol Metab (2009).
  • Christos Katsanos, D Chinkes, D Paddon-Jones, X Zhang, A Aarsland, R Wolfe. Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content. Nutr Res (2008).
  • Christos Katsanos. Prescribing exercise for the regulation of postprandial lipid metabolism: current research and recommendations. Sports Med (2006).
  • Christos Katsanos, H Kobayashi, M Sheffield-Moore, A Aarsland, R Wolfe. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab (2006).
  • Christos Katsanos, H Kobayashi, M Sheffield-Moore, A Aarsland, R Wolfe. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab (2006).
  • D Paddon-Jones, M Sheffield-Moore, Christos Katsanos, X Zhang, R Wolfe. Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. Experimental Gerontology (2006).
  • D Paddon-Jones, M Sheffield-Moore, X Zhang, Christos Katsanos, R Wolfe. Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. Exp Gerontol (2006).
  • Christos Katsanos, D Chinkes, M Sheffield-Moore, A Aarsland, H Kobayashi, R Wolfe. Method for the determination of the arteriovenous muscle protein balance during non-steady-state blood and muscle amino acid concentrations. Am J Physiol Endocrinol Metab (2005).
  • Christos Katsanos, H Kobayashi, M Sheffield-Moore, A Aarsland, R Wolfe. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr (2005).
  • Christos Katsanos, R Moffatt. Reliability of heart rate responses at given ratings of perceived exertion in cycling and walking. Res Q Exerc Sport (2005).
  • Christos Katsanos. Lipid-induced insulin resistance in the liver: role of exercise. Sports Med (2004).
  • Christos Katsanos, P Grandjean, R Moffatt. Effects of low and moderate exercise intensity on postprandial lipemia and postheparin plasma lipoprotein lipase activity in physically active men. J Appl Physiol (2004).
  • Christos Katsanos, R Moffatt. Acute effects of premeal versus postmeal exercise on postprandial hypertriglyceridemia. Clin J Sport Med (2004).
  • M Cree, B Newcomer, Christos Katsanos, M Sheffield-Moore, D Chinkes, A Aarsland, R Urban, R Wolfe. Intramuscular and liver triglycerides are increased in the elderly. J Clin Endocrinol Metab (2004).
  • H Simoes, C Campbell, M Kushnick, A Nakamura, Christos Katsanos, V Baldissera, R Moffatt. Blood glucose threshold and the metabolic responses to incremental exercise tests with and without prior lactic acidosis induction. Eur J Appl Physiol (2003).
  • Christos Katsanos, S Cheuvront, E Haymes. Energy expenditure relative to perceived exertion: stationary cycling versus treadmill walking. Res Q Exerc Sport (2001).
  • Katsanos CS, Mandarino LJ. Protein Metabolism in Human Obesity: A Shift in Focus from Whole-body to Skeletal Muscle. Obesity (0).
Research Activity
Fall 2016
Course NumberCourse Title
BIO 181General Biology I
BIO 189Life Sciences Career Paths
BIO 494Special Topics
BIO 598Special Topics
Summer 2016
Course NumberCourse Title
BIO 495Undergraduate Research
Fall 2015
Course NumberCourse Title
BIO 181General Biology I
BIO 494Special Topics
BIO 598Special Topics
Summer 2015
Course NumberCourse Title
BIO 495Undergraduate Research
Fall 2014
Course NumberCourse Title
BIO 181General Biology I
BIO 494Special Topics
BIO 598Special Topics
Summer 2014
Course NumberCourse Title
BIO 495Undergraduate Research
Spring 2014
Course NumberCourse Title
BIO 495Undergraduate Research
Fall 2013
Course NumberCourse Title
BIO 189Life Sciences Career Paths
BIO 360Animal Physiology
BIO 494Special Topics
BIO 495Undergraduate Research
BIO 598Special Topics
Summer 2013
Course NumberCourse Title
BIO 495Undergraduate Research
Spring 2013
Course NumberCourse Title
BIO 360Animal Physiology
Fall 2012
Course NumberCourse Title
BIO 494Special Topics
BIO 499Individualized Instruction
BIO 598Special Topics
Summer 2012
Course NumberCourse Title
BIO 360Animal Physiology
Presentations
  • Katsanos CS, Tran L, Mandarino LJ, DeFilippis E, Roust L. Regulation of muscle ATP synthase ß subunit expression in obesity. Obesity Week (Nov 2014).
  • Tran L, Masters HM, Katsanos CS. Hyperaminoacidemia eliminates the influence of body fat and insulin sensitivity on fractional synthesis rate and myostatin regulation in humans". Annual Experimental Biology Meeting, San Diego. Annual Experimental Biology Meeting (Apr 2014).
  • Tran L, Masters HM, Katsanos CS. L-[2,3,3,4,5,5,5,6,6,6-2H10]leucine improves accuracy of muscle protein synthesis determinations when using blood amino acid enrichment as the precursor pool. Annual Experimental Biology Meeting (Apr 2014).
  • Kras KA, Willis WT, Barker N, Czyzyk T, Katsanos CS. The enzyme Nagarse modifies parameters associated with function of mechanically-liberated mitochondria. Annual Experimental Biology Meeting (Apr 2014).
Service
  • Safety Committee, SOLS, Chair (2014 - Present)
  • University Environmental Health & Safety Policy Committee, Member (2014 - Present)
  • Safety Committee, SOLS, Chair (2013 - Present)
  • Safety Commitee, Member (2012 - Present)
  • Safety Committee, Member (2011 - Present)
  • Safety Committee, SOLS, Member (2013 - 2013)
  • Clinical Research Unit Advisory Committee, Chair (Present)