Nataly Podolnikova

Research Assistant Professor, School of Life Sciences

ISTB-1, office 422 550 E. Orange St Tempe, AZ 85287
Mail code: 4501

Campus: Tempe
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Education

1994-1998 B.S. in Biological Sciences, National University of “Kyiv-Mohyla Academy”, Kyiv, Ukraine

1998-2000 M.S. in Biological Sciences, National University of “Kyiv-Mohyla Academy”, Kyiv, Ukraine

2000-2004 Ph.D. in Biochemistry, the National Academy of Sciences, Kyiv, Ukraine

Curriculum Vitae

Publications

Podolnikova NP, Lishko VK, Roberson R, Koh Z, Derkach, Richardson D, Sheller M, and Ugarova TP. Platelet factor 4 (PF4) improves survival in a murine model of antibiotic-susceptible and methicillin-resistant Staphylococcus aureus peritonitis. Frontiers in Cellular and Infection Microbiology, 2023; 13.
Podolnikova NP, Key S, Wang X. and Ugarova TP. The CIS association of CD47 with integrin Mac-1 regulates macrophage responses by stabilizing the extended integrin conformation. J Biol Chem. 2023 Apr; 294(4):103024
Balabiyev A, Podolnikova NP, Kilbourne JA, Baluch DP, Lowry D, Zare A, Ros R, Flick MJ, and Ugarova TP. Fibrin polymer on the surface of biomaterial implants drives the foreign body reaction. Biomaterials. 2021 Oct;277:121087
Feng W, Nguyen H, Shen D, Deng H, Jiang Z, Podolnikova NP, Ugarova TP, and Wang X. Structural characterization of the interaction between the aMI-domain of the integrin Mac-1 (aMb2) and the cytokine pleiotrophin. Biochemistry 2021 Jan 26;60(3):182-193
Balabiyev A, Podolnikova NP, Mursalimov A, Lowry D, Newbern J, Roberson R and. Ugarova TP. Transition of podosomes into the zipper-like structures in macrophage-derived multinucleated giant cells. Mol Biol Cell. 2020 Jun 24:mbcE19120707.
Cui K, Podolnikova NP, Bailey W, Szmuc E, Podrez EA., Byzova TV, Yakubenko VP. Inhibition of integrin αDβ2-mediated macrophage adhesion to end product of docosahexaenoic acid (DHA) oxidation prevents macrophage accumulation during inflammation. J Biol Chem. 2019 Sep 27;294(39):14370-14382
Faust JJ, Balabiyev A, Heddleston JM, Podolnikova NP, Baluch DP, Chew TL, Ugarova TP. An actin-based protrusion originating from a podosome-enriched region initiates macrophage fusion. Mol Biol Cell 2019 Aug 1;30(17):2254-226
Podolnikova NP, Hlavackova M, Wu Y, Yakubenko VP, Faust J, Balabiyev A, Wang X, Ugarova TP. Interaction between the integrin Mac-1 and signal regulatory protein α (SIRPα) mediates fusion in heterologous cells. J Biol Chem. 2019 May 10;294(19):7833-7849
Cui K, Ardell CL, Podolnikova NP, Yakubenko VP, Distinct migratory properties of M1, M2, and resident macrophages are regulated by αDβ2 and αMβ2 integrin-mediated adhesion. Front Immunol. 2018 Nov 15;9:2650
Lishko VK, Yakubenko VP, Ugarova TP, Podolnikova NP*. Leukocyte integrin Mac-1 (CD11b/CD18, αMβ2, CR3) acts as a functional receptor for platelet factor 4. J. Biol. Chem. 2018 May 4; 293(18):6869-6882.
Shen D, Podolnikova NP, Yakubenko VP, Ardell CL, Balabiyev A, Ugarova TP, Wang X. Pleiotrophin, a multifunctional cytokine and growth factor, induces leukocyte responses through the integrin MAC-1. J Biol Chem. 2017 Sep 292, 18848-18861.
Podolnikova NP, Kushchayeva YS, Wu Y, Faust J, Ugarova TP. The Role of Integrins αMβ2 (Mac-1, CD11b/CD18) and αDβ2 (CD11d/CD18) in Macrophage Fusion. Am J Pathol. 2016 Aug;186(8):2105-16.
Lishko VK, Moreno B, Podolnikova NP, Ugarova TP. Identification of Human Cathelicidin Peptide LL-37 as a Ligand for Macrophage Integrin αMβ2 (Mac-1, CD11b/CD18) that Promotes Phagocytosis by Opsonizing Bacteria. Res Rep Biochem. 2016 Jul 7;2016(6):39-55.
Tsen SD, Kibler K, Jacobs B, Fay JC, Podolnikova NP, Ugarova TP, Achilefu S, Tsen KT. Selective photonic disinfection of cell culture using a visible ultrashort pulsed laser. IEEE J Sel Top Quantum Electron. 2016 May-Jun;22(3).
Podolnikova NP, Brothwell JA, Ugarova TP. The opioid peptide dynorphin A induces leukocyte responses via integrin Mac-1 (αMβ2, CD11b/CD18). Mol Pain. 2015 Jun 3;11:33.
Podolnikova NP, Podolnikov AV, Haas TA, Lishko VK, Ugarova TP. Ligand Recognition Specificity of Leukocyte Integrin αMβ2 (Mac-1, CD11b/CD18) and Its Functional Consequences. Biochemistry. 2015 Feb 17;54(6):1408-20..
Gorbatyuk V, Nguyen K, Podolnikova NP, Deshmukh L, Lin X, Ugarova TP, Vinogradova O. Skelemin association with αIIbβ3 integrin: a structural model. Biochemistry. 2014 Nov 4;53(43):6766-75.
Podolnikova NP, Yakovlev S, Yakubenko VP, Wang X, Gorkun OV, Ugarova TP. The interaction of integrin αIIbβ3 with fibrin occurs through multiple binding sites in the αIIb β-propeller domain. J Biol Chem. 2014 Jan 24;289(4):2371-83.
Yermolenko IS, Gorkun OV, Fuhrmann A, Podolnikova NP, Lishko VK, Oshkadyerov SP, Lord ST, Ros R, Ugarova TP. The assembly of nonadhesive fibrinogen matrices depends on the αC regions of the fibrinogen molecule. J Biol Chem. 2012 Dec 7;287(50):41979-90.
Podolnikova NP, Yermolenko IS, Fuhrmann A, Lishko VK, Magonov S, Bowen B, Enderlein J, Podolnikov AV, Ros R, Ugarova TP. Control of integrin αIIbβ3 outside-in signaling and platelet adhesion by sensing the physical properties of fibrin(ogen) substrates. Biochemistry. 2010 Jan 12;49(1):68-77.
Podolnikova NP, O'Toole TE, Haas TA, Lam SC, Fox JE, Ugarova TP. Adhesion-induced unclasping of cytoplasmic tails of integrin αIIbβ3. Biochemistry. 2009 Jan 27;48(3):617-29.
Podolnikova NP, Gorkun OV, Loreth RM, Yee VC, Lord ST, Ugarova TP. A cluster of basic amino acid residues in the g370-381 sequence of fibrinogen comprises a binding site for platelet integrin αIIbβ3 (glycoprotein IIb/IIIa). Biochemistry, 2005, 44(51):16920-16930.
Lishko VK, Podolnikova NP, Yakubenko VP, Yakovlev S, Medved L, Yadav SP, Ugarova TP. Multiple binding sites in fibrinogen for integrin αMβ2 (Mac-1). J Biol Chem. 2004 Oct 22;279(43):44897-906.
Ugarova TP, Lishko VK, Podolnikova NP, Okumura N, Merkulov SM, Yakubenko VP, Yee VC, Lord ST, Haas TA. Sequence gamma 377-395(P2), but not gamma 190-202(P1), is the binding site for the αM I-domain of integrin αMβ2 in the gamma C-domain of fibrinogen. Biochemistry. 2003 Aug 12;42(31):9365-73.
Podolnikova NP, Yakubenko VP, Volkov GL, Plow EF, Ugarova TP. Identification of a novel binding site for platelet integrins αIIbβ3 (GPIIbIIIa) and α5β1 in the g C-domain of fibrinogen. J Biol Chem. 2003 Aug 22;278(34):32251-8.

Research Activity

Podolnikova,Nataly*. Molecular Basis for Fibrin Binding by Platelet Integrin Alpha IIb Beta 3. AMER HEART ASSN(7/1/2008 - 6/30/2013).
Podolnikova,Nataly*. Molecular Basis for Fibrin Binding by Platelet Integrin Alpha IIb Beta 3. AMER HEART ASSN(7/1/2008 - 6/30/2012).

Expertise Areas

Cell biology

Molecular Biology

Biochemistry