Douglas Lake is a tumor immunologist who has been at ASU since 2006. Previously, he was at the University of Arizona Cancer Center where he studied anti-tumor T cells and tumor-associated peptides as immunotherapy targets.
Currently, he is investigating an enzyme called QSOX1 that is over-expressed in multiple tumor types. Lake was the first to show that this enzyme is important in tumor cell growth, invasion and metastasis. His laboratory is developing chemical and biological inhibitors of QSOX1 with strong therapeutic potential.
His laboratory also studies Valley Fever (Coccidioidomycosis). A pressing clinical need is that Valley Fever lacks an accurate and sensitive diagnostic test while patients are acutely symptomatic. Because the current test relies on an immune respone, which is often delayed in this disease, patients can go for as long as three months without a diagnosis. As a result, many patients are inappropriately treated. Lake is developing a test that detects bits and pieces of the fungus in urine in infected patients.
Lake's research team also studies chimeric antigen receptor T cells (CAR T cells). This technology re-directs the immune system toward defined markers on tumors and unleashes T cells as the most potent killers against tumors. The vision for CAR T therapies is to re-activate patients' immune systems against their tumors, such that they will have lifelong immunity against their tumor and any mutant tumors that might arise.
In addition, Lake teaches immunology and microbiology at the undergraduate level and advance cell biology at the graduate level.
Spring 2021 | |
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Course Number | Course Title |
MIC 493 | Honors Thesis |
BIO 493 | Honors Thesis |
MBB 493 | Honors Thesis |
MIC 495 | Undergraduate Research |
BIO 495 | Undergraduate Research |
MBB 495 | Undergraduate Research |
MCB 556 | Adv Molecular/Cell Biol II |
BDE 792 | Research |
BDE 799 | Dissertation |
Fall 2020 | |
---|---|
Course Number | Course Title |
MIC 421 | Experimental Immunology |
MIC 492 | Honors Directed Study |
MBB 492 | Honors Directed Study |
BIO 492 | Honors Directed Study |
Summer 2020 | |
---|---|
Course Number | Course Title |
BDE 792 | Research |
Spring 2020 | |
---|---|
Course Number | Course Title |
MIC 493 | Honors Thesis |
BIO 493 | Honors Thesis |
MBB 493 | Honors Thesis |
MIC 495 | Undergraduate Research |
BIO 495 | Undergraduate Research |
MBB 495 | Undergraduate Research |
MCB 556 | Adv Molecular/Cell Biol II |
BDE 792 | Research |
BDE 799 | Dissertation |
Fall 2019 | |
---|---|
Course Number | Course Title |
MIC 421 | Experimental Immunology |
MBB 492 | Honors Directed Study |
MIC 492 | Honors Directed Study |
MIC 493 | Honors Thesis |
Spring 2019 | |
---|---|
Course Number | Course Title |
MIC 492 | Honors Directed Study |
MIC 493 | Honors Thesis |
MBB 493 | Honors Thesis |
BIO 493 | Honors Thesis |
BIO 495 | Undergraduate Research |
MIC 495 | Undergraduate Research |
MBB 495 | Undergraduate Research |
MCB 556 | Adv Molecular/Cell Biol II |
BDE 792 | Research |
BDE 799 | Dissertation |
Fall 2018 | |
---|---|
Course Number | Course Title |
MIC 421 | Experimental Immunology |
MIC 492 | Honors Directed Study |
MBB 492 | Honors Directed Study |
Spring 2018 | |
---|---|
Course Number | Course Title |
MIC 220 | Biology of Microorganisms |
MIC 493 | Honors Thesis |
BIO 493 | Honors Thesis |
MBB 493 | Honors Thesis |
MIC 495 | Undergraduate Research |
MBB 495 | Undergraduate Research |
BIO 495 | Undergraduate Research |
MCB 556 | Adv Molecular/Cell Biol II |
Fall 2017 | |
---|---|
Course Number | Course Title |
MIC 421 | Experimental Immunology |
MIC 492 | Honors Directed Study |
MBB 492 | Honors Directed Study |
Summer 2017 | |
---|---|
Course Number | Course Title |
MIC 495 | Undergraduate Research |
Spring 2017 | |
---|---|
Course Number | Course Title |
MIC 220 | Biology of Microorganisms |
MBB 493 | Honors Thesis |
BIO 493 | Honors Thesis |
MIC 495 | Undergraduate Research |
MBB 495 | Undergraduate Research |
BIO 495 | Undergraduate Research |
MCB 556 | Adv Molecular/Cell Biol II |
Fall 2016 | |
---|---|
Course Number | Course Title |
MIC 421 | Experimental Immunology |
MBB 492 | Honors Directed Study |
MIC 492 | Honors Directed Study |
MCB 591 | Seminar |
Summer 2016 | |
---|---|
Course Number | Course Title |
MIC 495 | Undergraduate Research |