Jiseon Yang

Assistant Research Professor, Biodesign Center for Fundamental & Applied Microbiomics

jiseon.yang@asu.edu

BIODESIGN BLDG B340A TEMPE, AZ 85287
Mail code: 6101

Campus: Tempe
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Student Information

Graduate Student
Statistics
The College of Lib Arts & Sci

Long Bio

I specialize in the fields of bacteriology and space life science, with extensive research experience in bacterial pathogenesis, molecular genetic engineering, biofilms, space biology, vaccine development, and host-pathogen interaction. To conduct my research, I have utilized a range of human surrogate infection models, such as 3-D tissue culture models, worms, mice, and chickens, with a focus on vaccine development.

My current research interests are focused on understanding microbial interactions in mixed populations and their long-term effects on human health and the environment, both on Earth and in space. Specifically, I aim to explore how the interactions between microbial communities within complex ecosystems can contribute to their pathogenicity, persistence, and species evolution. The ultimate goal of my study is to better understand complex bacterial interactions within heterogeneous populations and their long-term impact on human health and living environments, thus contributing to enhancing the sustainability of life on Earth and in space.

I was awarded an Alfred P. Sloan Postdoctoral Fellowship, jointly funded by NASA, to study microbiome of the International Space Station. I published on genomics, bacterial pathogenesis, vaccine development, 3-D tissue engineering, microbiome, and space microbiology. I am currently participating multiple spaceflight projects and serving as a single PI for a NASA-funded project focused on investigating bacterial interspecies interactions and the long-term changes in Earth or space environment. My approach involves utilizing multi-directional comparison analysis and systemic approaches to advance our understanding of microbial interactions in complex environments. I have been the recipient of several awards and research funding, including the ASM Peggy Cotter Early Career Award and an Outstanding Teaching Award.

Education

Alfred P. Sloan Postdoctoral Fellow 2017-2019
Ph.D. Microbiology, Arizona State University 2015

Google Scholar URL

https://scholar.google.com/citations?user=__yH8X4AAAAJ&hl=en

Publications

Book Chapter

Jennifer Barrila, James W. Wilson, Anjali Soni, Jiseon Yang, C. Mark Ott, Cheryl A. Nickerson, Using Spaceflight and Spaceflight Analogue Culture for Novel Mechanistic Insight into Salmonella Pathogenesis. p 209-235. In Effect of Spaceflight and Spaceflight Analogue Culture on Human and Microbial Cells. (Eds) Cheryl A. Nickerson, Neal R. Pellis, C. Mark Ott. 2016. Springer New York. DOI. 10.1007/978-1-4939-3277-1_11
Jiseon Yang, Starla G Thornhill, Jennifer Barrila, Cheryl A Nickerson, C Mark Ott, and Robert JC McLean. Microbiology of the Built Environment in Spacecraft Used for Human Flight. In Microbiology of Atypical Environments. (Eds) Gűrtler, Volker and Trevors, Jack T. 2018. Jan. Elsevier. DOI: 10.1016/bs.mim.2018.07.002

Publications

Rosa Santomartino, Nils JH Averesch, Marufa Bhuiyan, Charles S Cockell, Jesse Colangelo, Yosephine Gumulya, Devanshu Jha, Benjamin Lehner, Ivanna Lopez, Sean McMahon, Anurup Mohanty, Sergio R Santa Maria, Camilla Urbaniak, Rik Volger, Jiseon Yang, Luis Zea. Toward Sustainable Space Exploration: A Roadmap for Harnessing the Power of Microorganisms. Nat Commun 14, 1391 (2023).
Y V Justiniano, D M Goeres, E L Sandvik, B V Kjellerup, T A Sysoeva, J S Harris, S Warnat, M McGlennen, C M Foreman, J Yang, W Li, C D Cassilly, K Lott, L E HerrNeckar. Mitigation and use of biofilms in space for the benefit of human space exploration. Biofilm. 2023. 5:100102
Franco Meléndez K, Crenshaw K, Barrila J, Yang J, Gangaraju S, Davis RR, Forsyth RJ, Ott CM, Kader R, Curtiss R 3rd, Roland K, Nickerson CA. Role of RpoS in Regulating Stationary Phase Salmonella Typhimurium Pathogenesis-Related Stress Responses under Physiological Low Fluid Shear Force Conditions. mSphere. 2022 Aug 1:e0021022. doi: 10.1128/msphere.00210-22. Epub ahead of print. PMID: 35913142.
Barrila J, Yang J, Franco Meléndez KP, Yang S, Buss K, Davis TJ, Aronow BJ, Bean HD, Davis RR, Forsyth RJ, Ott CM, Gangaraju S, Kang BY, Hanratty B, Nydam SD, Nauman EA, Kong W, Steel J and Nickerson CA (2022) Spaceflight Analogue Culture Enhances the Host-Pathogen Interaction Between Salmonella and a 3-D Biomimetic Intestinal Co-Culture Model. Front. Cell. Infect. Microbiol. 12:705647. doi: 10.3389/fcimb.2022.705647
C Mark Ott, Cheryl A Nickerson, George Poste, Roy Curtiss III, James Wilson, Robert JC McLean, Neal Pellis, David Niesel, Kent Buchanan, Jiseon Yang, Eleanor Blakely, Mark Shelhamer, Diego Bohórquez, Jared Broddrick, Phillip Stafford, Millicent E Goldschmidt, Heidi B Kaplan, Erik Antonsen, Eric Nauman, Cherie Oubre. 2021. A Vision for the Next Generation of Spaceflight Microbiology: Human Health and Habitat Sustainability. Submitted to the Decadal Survey on Biological and Physical Sciences Research in Space 2023-2032 conducted by the National Academies of Science, Engineering and Medicine.
Yo-Ann Velez Justiniano, Daria Goeres, Elizabeth Sandvik, Birthe Veno Kjellerup, Tatyana Sysoeva, Jacob Harris, Christine Foreman, Robert JC McLean, Jiseon Yang, Wenyan Li, Aubrie O’Rourke, Chelsi Cassilly, Katelynn Lott and Lauren HerrNeckar. Topical: Mitigation and Use of Biofilms in Space for the Benefit of Human Space Exploration. 2021. Submitted to the Decadal Survey on Biological and Physical Sciences Research in Space 2023-2032 conducted by the National Academies of Science
Rosa Santomartino, Nils JH Averesch, Marufa Bhuiyan, Charles S Cockell, Jesse Colangelo, Yosephine Gumulya, Devanshu Jha, Benjamin Lehner, Ivanna Lopez, Sean McMahon, Anurup Mohanty, Sergio R Santa Maria, Camilla Urbaniak, Rik Volger, Jiseon Yang. Biologically Facilitated Processes Towards Sustainable Space Exploration. 2021. Topical White Paper submitted to the Biological and Physical Sciences in Space Decadal Survey 2023-2032
Jiseon Yang†, Jennifer Barrila, C. Mark Ott, Olivia King, Rebekah Bruce, Robert JC McLean, and Cheryl A. Nickerson. 2021. Longitudinal Characterization of Multispecies Microbial Populations Recovered from Spaceflight Potable Water. npj Biofilms Microbiomes 7, 70 (2021). https://doi.org/10.1038/s41522-021-00240-5. †Corresponding author.
Jennifer Barrila, Aurélie Crabbé, Jiseon Yang, Karla Franco, Seth Nydam, Rebecca Forsyth, Richard Davis, Sandhya Gangaraju, C. Mark Ott, Carolyn Coyne, Mina Bissell, and Cheryl Nickerson, 2018. Sep 4. Modeling Host-Pathogen Interactions in the Context of Polarity and Microenvironment: 3-D Cell Culture Comes of Age. Infect Immun 86:e00282-18 doi:10.1128/IAI.00282-18
Jennifer Barrila*, Jiseon Yang*(‘co-first author), Aurélie Crabbé, Shameema F. Sarker, Yulong Liu, C. Mark Ott, Mayra A. Nelman-Gonzalez, Simon J. Clemett, Seth D. Nydam, Rebecca J. Forsyth, Richard R. Davis, Brian E. Crucian, Heather Quiriarte, Kenneth L. Roland, Karen Brenneman, Clarence Sams, Christine Loscher, Cheryl A. Nickerson, 2017.Feb 28. Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns. NPJ Microgravity 3:10 doi:10.1038/s41526-017-0011-2.
Jiseon Yang*, Jennifer Barrila*, Kenneth L. Roland, C. Mark Ott, Cheryl A. Nickerson. 2016. Jun 9. Physiological Fluid Shear Alters the Virulence Potential of Invasive Multidrug Resistant Non-typhoidal Salmonella Typhimurium D23580. NPJ Microgravity 2:16021. doi:10.1038/npjmgrav.2016.21 *Co-first author.
Jiseon Yang*, Jennifer Barrila*, Kenneth L. Roland, Jacqueline Kilbourne, C. Mark Ott, Rebecca Forsyth, and Cheryl A. Nickerson. 2015. Jun 19. Characterization of the Invasive, Multidrug Resistant Nontyphoidal Salmonella strain D23580 in a Murine Model of Infection. PLoS Negl Trop Dis 9(6): e0003839. doi:10.1371/journal.pntd.0003839
Yingqin Luo, Qingke Kong, Jiseon Yang, Arindam Mitra, Greg Golden, Soo-Young Wanda, Roderick V. Jensen, Peter B. Ernst, Roy Curtiss III. 2012. Jul 6. Comparative Genome Analysis of the High Pathogenicity Salmonella Typhimurium Strain UK-1. PLoS ONE 7: e40645. https://doi.org/10.1371/journal.pone.0040645.
María Dolores Juárez-Rodríguez, Jiseon Yang, Rebin Kader, Praveen Alamuri, Roy Curtiss III, and Josephine Clark-Curtiss. 2012 Feb 5. Live attenuated Salmonella vaccines displaying regulated delayed lysis and delayed antigen synthesis to confer protection against Mycobacterium tuberculosis. Infect Immun 80(2):815-31. doi: 10.1128/IAI.05526-11.
Qingke Kong, Jiseon Yang, Qing Liu, Praveen Alamuri, Kenneth L. Roland and Roy Curtiss III. 2011 Oct 18. Effect of deletion of genes involved in lipopolysaccharide core and O-antigen synthesis on virulence and immunogenicity of Salmonella enterica serovar Typhimurium. Infect Immun 79(10):4227-39. doi:10.1128/IAI.05398-11.
Yingqin Luo, Qingke Kong, Jiseon Yang, Greg Golden, Soo-Young Wanda, Roderick V. Jensen, Peter B. Ernst, and Roy Curtiss III. 2011 Aug 27. Complete Genome Sequence of the Universal Killer Salmonella enterica Serovar Typhimurium UK-1 (ATCC 68169). J Bacteriol 193(15): 4035-4036.
Shamaila Ashraf, Wei Kong, Shifeng Wang, Jiseon Yang, Roy Curtiss III. 2011 May 3. Protective cellular responses elicited by vaccination with inﬂuenza nucleoprotein delivered by a live recombinant attenuated Salmonella vaccine. Vaccine. 29(23): 3990-4002.
Ah Young Yoo, Jong E. Yu, Jiseon Yang, Young H. Kim, Chang-Ho Baek, Jeong-Il Oh, Ho Y. Kang. 2008. Regulation of an outer membrane protein, OmpW, expression and its biological function in Salmonella Typhimurium. Kor J Life Sci 18(11): 1606-1611

Research Activity

Understanding the evolution of microbial interactions during spaceflight. Jiseon Yang Ph.D. (PI, Arizona State University). NASA (11/01/2019-10/30/2023). $749,999
Spaceflight-Induced Changes in Microbial Virulence and the Impact to the Host Immune Response. Mark Ott, Ph.D. (PI); Cheryl A. Nickerson, Ph.D. (PI, Arizona State University). NASA (12/1/2019 - 11/30/2024). $2,100,000
Polymicrobial biofilm growth and control during spaceflight. Robert McLean Ph.D. (PI); Cheryl A. Nickerson, Ph.D. (Co-PI); Jiseon Yang (Senior Person). NASA (10/1/2016-8/31/25) $1,255,879
Biofilm Inhibition with Germicidal Light Side-Emitted from Nano-enabled Flexible Optical Fibers in Water Systems. Paul Westerhoff, Ph.D., (PI); Cheryl A. Nickerson, Ph.D., (Co-PI); Jennifer Barrila, Ph.D. (Co-PI); Francois Perreault, Ph.D. (Co-PI); Jiseon Yang (Senior Person). NSF, NASA (10/1/2022 - 9/30/2025). $380,000
Developing Predictive Model Systems of Polymicrobial Biofilm Formation and Susceptibility to Chemical Disinfectant: A longitudinal study with implications for spaceflight systems integrity and health risks. Jiseon Yang (sponsor PI), Cheryl Nickerson (internal PI). Sloan (Alfred P.) Foundation. $140,000

Honors / Awards

(Selected)

NASA, Alfred P. Sloan Foundation Award Fellowships ($140,000) 2017
ASM Peggy Cotter Early Career Award, the American Society for Microbiology. March 1, 2019.
Outstanding Teaching Associate of the Year for 2013-2014 at Arizona State University, School of Life Sciences. May 12, 2014.
Fellowship for Graduate Training Award ($2,500) 2014
University Graduate Fellowship (UGF) awards

Expertise Areas