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Qiang Chen

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Professor
Faculty, TEMPE Campus, Mailcode 5401
Professor
Faculty, TEMPE Campus, Mailcode 7501
Professor
Faculty, TEMPE Campus, Mailcode 5401
Biography

Dr. Qiang “Shawn” Chen is a molecular biologist who specializes in developing novel human therapeutics and vaccines in plants to combat infectious diseases, cancer, and biological warfare agents. His research aims to ameliorate diseases and improve human health, as well as to contribute new knowledge to the basic understanding of how gene expression and protein modification are regulated in plants.  

Dr. Chen and his team use rational design strategies to develop biologics that possess superior efficacy and safety.  Flavivirus therapeutics and vaccine development and the modulation of antibody-dependent enhancement (ADE) of viral infections are part of their research focus. His team has developed monoclonal antibody (MAb) variants in plants that have shown promise in improving brain targeting, eliminating ADE, and enhancing efficacy against West Nile, Dengue and Chikungunya virus compared to their parent MAbs.  The disease targets also include Zika virus, Ebola virus and colorectal cancer. 

In addition, Dr. Chen has expertise in QA/QC and biochemistry research under FDA’s cGMP regulations, drawn from his more than a decade of experience in the biotechnology and pharmaceutical industry directing research in both plant and mammalian cell culture systems. He is interested in mentoring students and scientists in these areas of translational research for conducting human clinical trials.  Dr. Chen is a Professor at the School of Life Sciences and a faculty member at the Center for Immunotherapy, Vaccines and Virotherapy in the Biodesign Institute of ASU.

 

Education

PH.D

University of Arizona

Publications
Research Activity
  • Chen,Qiang*. Bifunctional antibodies with targeted CNS delivery against West Nile virus. HHS-NIH-NIAID (6/1/2014 - 5/31/2017).
  • Zhang, Peiming* and Chen, Qiang*. Biochemical construction of a tripod antibody to target glycoproteins of Ebola virus for immunotherapy. Multicenter Research BDI (7/1/2015-6/30/2016).
  • Chen, Qiang* and Zhang Peiming*. Trackable molecular Trojan horse as a platform for delivery of monoclonal antibody-based biologics into the brain to treat CNS diseases. Multi-Center Research Initiatives BDI (8/1/2014-7/31/2015).
  • Chen,Qiang*. Bifunctional antibodies with targeted CNS delivery against West Nile virus. HHS-NIH-NIAID (6/1/2012 - 5/31/2014).
  • Chen,Qiang*. Alternative Delivery of Human Milk Proteins to Infants. GATES (BILL & MELINDA) FDN (11/1/2011 - 10/31/2013).
  • Arntzen,Charles, Chen,Qiang, Mason,Hugh S. SBC: Commercialization of Norovirus Vaccine Technology in an Arizona Spin-off Company. SFAz (7/1/2008 - 12/31/2009).
  • Chen,Qiang*. Plant-derived MAb therapeutics for West Nile Virus. HHS-NIH-NIAID (8/1/2007 - 7/31/2012).
  • Chen,Qiang*. Targeted Homologous Recombination in Meiotic Plant Cells. USDA (5/15/2007 - 8/31/2008).
  • Chen,Qiang*. Protein Production in Tobacco from an Amplified Inducible System. DOD 8/1/2006 - 1/31/2007).
  • Arntzen,Charles*, Chen,Qiang, Mason,Hugh S. Plant-Derived Vaccines Against Hepatitis C Cooperative Research Center. HHS-NIH-NIAID(8/1/2005 - 7/31/2012).
  • Arntzen,Charles*, Chen,Qiang, Mason,Hugh S. Development of a Vaccine for Ebola Virus in Plant System. HHS-NIH-NIAID(3/15/2005 - 2/28/2011).
  • Arntzen,Charles*, Chen,Qiang, Leket-Mor,Tsafrir Shlomo, Mason,Hugh S. Plant-Made Microbicides and Mucosal Vaccines for STIs. HHS-NIH-NIAID(9/1/2004 - 8/31/2011).
Fall 2017
Course NumberCourse Title
BIO 353Cell Biology
MBB 492Honors Directed Study
MBB 493Honors Thesis
MBB 495Undergraduate Research
MIC 495Undergraduate Research
MCB 598Special Topics
Summer 2017
Course NumberCourse Title
MIC 495Undergraduate Research
Spring 2017
Course NumberCourse Title
BIO 493Honors Thesis
MBB 493Honors Thesis
MIC 495Undergraduate Research
MBB 495Undergraduate Research
BIO 495Undergraduate Research
MBB 499Individualized Instruction
MCB 598Special Topics
Fall 2016
Course NumberCourse Title
BIO 353Cell Biology
MBB 492Honors Directed Study
MBB 493Honors Thesis
MBB 495Undergraduate Research
MIC 495Undergraduate Research
MCB 598Special Topics
Summer 2016
Course NumberCourse Title
MIC 495Undergraduate Research
Spring 2016
Course NumberCourse Title
PLB 308Plant Physiology
BIO 493Honors Thesis
MBB 493Honors Thesis
MIC 495Undergraduate Research
MBB 495Undergraduate Research
BIO 495Undergraduate Research
MCB 598Special Topics
Fall 2015
Course NumberCourse Title
BIO 189Life Sciences Career Paths
PLB 308Plant Physiology
BIO 492Honors Directed Study
MBB 492Honors Directed Study
MBB 493Honors Thesis
MBB 495Undergraduate Research
MIC 495Undergraduate Research
MCB 598Special Topics
Summer 2015
Course NumberCourse Title
MIC 495Undergraduate Research
Spring 2015
Course NumberCourse Title
BIO 181General Biology I
PLB 308Plant Physiology
BIO 493Honors Thesis
MIC 495Undergraduate Research
BIO 495Undergraduate Research
MBB 495Undergraduate Research
Fall 2014
Course NumberCourse Title
BIO 492Honors Directed Study
MBB 493Honors Thesis
MIC 495Undergraduate Research
Spring 2014
Course NumberCourse Title
ABS 311Molecular and Cellular Biology
BIO 495Undergraduate Research
MBB 495Undergraduate Research
ABS 598Special Topics
Fall 2013
Course NumberCourse Title
MBB 495Undergraduate Research
MIC 499Individualized Instruction
MBB 499Individualized Instruction
Spring 2013
Course NumberCourse Title
ABS 311Molecular and Cellular Biology
ABS 489Undergraduate Research
ABS 490Applied Biol Sciences Seminar
ABS 493Honors Thesis
MIC 495Undergraduate Research
MBB 499Individualized Instruction
ABS 499Individualized Instruction
ABS 598Special Topics
Editorships
  • International Journal of Molecular Sciences, Editorial Board Member (2015 - Present)
  • Heliyon (Elsevier), Editorial Board member (2017 - Present)
  • Scientific Advisory Board, BioStrategies, Member (2012 - Present)
Service
  • National Science Fundation (NSF), Panelist (2010 - Present)
  • National Institutes of Health (NIH), Panelist (2008 - Present)
  • Canadian Ministry of agriculture research grant peer reviewer (2006 - Present)
  • NIH Peer Review: Gene and Drug Delivery, Panelist (2015)
  • Czech Science Foundation, Grant reviewer (2015)
  • Natural Sciences and Engineering Research Council of Canada (NSERC), Grant reviewer (2015)
  • NIH Peer Review: Cell, computational and Molecular Biology : 2015/10 ZRG1 IMST-J (15), Panelist (2015)
  • BioMed Research International, Special Issue: Plant-Made Biologics, Lead Editor (2013 - 2014)
  • IJMS, Special Issue: Protein Engineering, Editor (2014-2015)