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Biography:
Sidney M. Hecht is the director for the Center for BioEnergetics in the Biodesign Institute at Arizona State University. He researches diseases caused by defects in the body's energy production processes. Energy production is similar mechanistically to other molecular processes that he has studied extensively. He played a key role in the development of Hycamtin, a drug used to treat ovarian and lung cancer, as well as the study of the mechanism of the anti-tumor agent bleomycin.
In a career spanning more than three decades, Professor Hecht has held both academic and industrial research positions. He joins ASU from the University of Virginia, where he was a professor of both chemistry and biology. From 1981 to 1987, he concurrently held leadership positions in research and development for Smith Kline and French Laboratories. Prior to his 28 years at the University of Virginia, he was a faculty member at MIT. Hecht is the co-founder of Edison Pharmaceuticals, a pharmaceutical company focusing on inherited mitochondrial disorders. He earned a B.A. in chemistry from the University of Rochester and a Ph.D. in chemistry with emphasis in biochemistry from the University of Illinois.
Fax:
480/965-0038
Education:
- Ph.D. Chemistry (minor Biochemistry), University of Illinois 1970
- B.A. Chemistry, University of Rochester 1966
Research Interests:
Energy production is similar mechanistically to other molecular processes that are studied extensively. Hecht played a key role in the development of Hycamtin, a drug used to treat ovarian and lung cancer, as well as the study of the mechanism of the anti-tumor agent bleomycin. In a career spanning more than three decades, Hecht has held both academic and industrial research positions. He joins ASU from the University of Virginia, where he was a professor of both chemistry and biology. From 1981 to 1987, he concurrently held leadership positions in research and development for Smith Kline and French Laboratories. Prior to his 28 years at the University of Virginia, he was a faculty member at MIT. Hecht is the co-founder of Edison Pharmaceuticals, a pharmaceutical company focusing on inherited mitochondrial disorders. He earned a BA in chemistry from the University of Rochester and a PhD in chemistry with emphasis in biochemistry from the University of Illinois.
Publications:
D. P. Brust, D. S. Tarbell and S. M. Hecht, Studies of Cyclizations of an O-(a-Methylallyl)phenol and the Corresponding Methyl Ether Induced by Electrophilic Reagents, Proc. Natl. Acad. Sci. USA, 53, 233-236 (1965).
D. P. Brust, D. S. Tarbell, S. M. Hecht, E. C. Hayward and L. D. Colebrook, Preparation of cis- and trans-2,3-Dimethyl-2,3-dihydrobenzofurans and Related Compounds. Cyclization Involving Oxonium Ions, J. Org. Chem., 31, 2192-2201 (1966).
N. J. Leonard and S. M. Hecht, 6-(-3-Methylbut-3-enylamino)purine: A Highly Active Cytokinin, J. C. S. Chem. Commun., 973 (1967).
S. M. Hecht, J. P. Helgeson and T. Fujii, N-(3-Methyl-2-butenyl)adenine, "Synthetic Procedures in Nucleic Acid Chemistry", John Wiley-Interscience Publishers, New York, 1968, p. 8-10.
N. J. Leonard, S. M. Hecht, F. Skoog and R. Y. Schmitz, Cytokinins: Synthesis of 6-(3-Methyl-3-butenylamino)-9- b-D-ribofuranosylpurine (3iPA), and the Effect of Side-Chain Unsaturation on the Biological Activity of Isopentylaminopurines and their Ribosides, Proc. Natl. Acad. Sci. USA, 59, 15-21 (1968).
W. J. Burrows, D. J. Armstrong, F. Skoog, S. M. Hecht, J. T. A. Boyle, N. J. Leonard and J. Occolowitz, Cytokinin from Soluble RNA of Escherichia coli: 6-(3-Methyl-2-butenylamino)-2-methylthio-9-b-D -ribosuranosylpurine, Science, 161, 691-693 (1968).
N. J. Leonard, S. M. Hecht, F. Skoog and R. Y. Schmitz, Cytokinins: Synthesis and Biological Activity of Related Derivatives of 2iP, 3iP, and their Ribosides, Israel J. Chem., 6, 539-550 (1968).
N. J. Leonard, S. M. Hecht, F. Skoog and R. Y. Schmitz, Cytokinins: Synthesis, Mass Spectra and Biological Activity of Compounds Related to Zeatin, Proc. Natl. Acad. Sci. USA, 63, 175-182 (1969).
S. M. Hecht, A. S. Gupta and N. J. Leonard, Mass Spectra of Nucleoside Components of tRNA, Anal. Biochem., 30, 249-270 (1969).
S. M. Hecht, A. S. Gupta and N. J. Leonard, Position of Uridine Thiation: The Identification of Minor Nucleosides from Transfer RNA by Mass Spectrometry, Biochem. Biophys. Acta, 182, 444-448 (1969).
W. J. Burrows, D. J. Armstrong, F. Skoog, S. M. Hecht, J. T. A. Boyle, N. J. Leonard and J. Occolowitz, The Isolation and Identification of Two Cytokinins from Escherichia coli Transfer Ribonucleic Acids, Biochemistry, 8, 3071-3076 (1969).
S. M. Hecht, N. J. Leonard, J. Occolowitz, W. J. Burrows, D. J. Armstrong, F. Skoog, R. M. Bock, I. Gillam and B. M. Tener, Cytokinins: Isolation and Identification of 6-(3-Methyl-2-butenylamino)- 9-b-D-ribofuranosylpurine (2iPA) from Yeast Cysteine tRNA, Biochem. Biophys. Res. Commun., 35, 205-209 (1969).
S. M. Hecht, N. J. Leonard, W. J. Burrows, D. J. Armstrong, F. Skoog and J. Occolowitz, Cytokinin from the Transfer RNA of Wheat Germ: 6-(4-Hydroxy-3-methyl-2-butenylamino)-2-methylthio-9-b-D-ribofuranosylpurine, Science, 166, 1272-1274 (1969).
S. M. Hecht, N. J. Leonard, R. Y. Schmitz and F. Skoog, Cytokinins: Synthesis and Growth-Promoting Activity of 2-Substituted Compounds in the N6-Isopentenyladenine and Zeatin Series, Phytochemistry, 9, 1173-1180 (1970).
D. J. Armstrong, P. K. Evans, W. J. Burrows, F. Skoog, J. F. Petit, J. Dahl, T. Steward, J. L. Strominger, N. J. Leonard, S. M. Hecht and J. Occolowitz, Cytokinins: Activity and Identification in Staphylococcus epidermidis Transfer RNA, J. Biol. Chem., 245, 2922-2926 (1970).
S. M. Hecht, N. J. Leonard, R. Y. Schmitz and F. Skoog, Cytokinins: Influence of Side Chain Planarity of N6-Substituted Adenines and Adenosines on Cell Division and Growth, Phytochemistry, 9, 1907-1913 (1970).
W. J. Burrows, D. J. Armstrong, M. Kaminek, F. Skoog, R. M. Bock, S. M. Hecht, L. G. Dammann, N. J. Leonard and J. Occolowitz, The Isolation and Identification of Cytokinins from the Transfer Ribonucleic Acids of Wheat Germ, Biochemistry, 9, 1867-1872 (1970).
S. M. Hecht, Mass Spectrometric Identification of Some Prenylaminopurines, Biochim. Biophys. Acta, 213, 269-272 (1970).
S. M. Hecht, R. M. Bock, N. J. Leonard, R. Y. Schmitz and F. Skoog, Cytokinin Activity in tRNAPhe, Biochem. Biophys. Res. Commun., 41, 435-440 (1970).
S. M. Hecht, A. S. Gupta and N. J. Leonard, Mass Spectra of Ribonucleoside Components of tRNA. II., Anal. Biochem., 38, 230-251 (1970).
R. Y. Schmitz, F. Skoog, S. M. Hecht and N. J. Leonard, Cytokinins: Synthesis and Biological Activity of Zeatin Esters and Related Compounds, Phytochemistry, 10, 275-280 (1971).
S. M. Hecht, L. H. Kirkegaard and R. M. Bock, Chemical Modifications of tRNA Species. Desulfurization with Raney Nickel, Proc. Natl. Acad. Sci. USA, 68, 48-51 (1971).
M. Sundaralingam., C. D. Stout and S. M. Hecht, The Structure of Bis(4-aminoimidazole-5-carboxamidoxime)copper(II) perchlorate, a Degradation Product of Adenine N1-oxide, J.C. S. Chem. Commun., 240-241 (1971).
S. M. Hecht, R. M. Bock, R. Y. Schmitz, F. Skoog, N. J. Leonard and J. Occolowitz, Question of the Function of the Ribosyl Moiety in the Promotion of Callus Growth by Exogenously Added Cytokinins, Biochemistry, 10, 4224-4228 (1971).
S. M. Hecht, The Mass Spectra of Some Heterocycles Related to N6-(D2-Isopentenyl)adenosine, Anal. Biochem., 44, 262-275 (1971).
S. M. Hecht and R. M. Bock, Chemical Modifications of Transfer RNA Species. Metal Ion Binding to Monoperphthalate-Treated tRNA, Biochem. Biophys. Res. Commun., 45, 416-420 (1971).
S. M. Hecht and R. M. Bock, R. Y. Schmitz, F. Skoog and N. J. Leonard, Cytokinins: Development of a Potent Antagonist, Proc. Natl. Acad. Sci. USA, 68, 2608-2610 (1971).
S. M. Hecht and J. J. McDonald, The Mass Spectra of Some N6-acyladenines and 6-Substituted Ureidopurines, Anal. Biochem., 47, 157-173 (1972).
R. Y. Schmitz, F. Skoog, S. M. Hecht, R. M. Bock and N. J. Leonard, Comparison of Cytokinin Activities of Naturally Occurring Ribonucleosides and Corresponding Bases, Phytochemistry, 11, 1603-1610 (1972).
S. M. Hecht and J. W. Kozarich, A Convenient Method for the Production of Diazomethane-d2, Tetrahedron Lett., 1501-1502 (1972).
R. Y. Schmitz, F. Skoog, S. M. Hecht and N. J. Leonard, Comparison of Zeatin Indoleacetate with Zeatin and Indoleacetic Acid in the Tobacco Bioassay, Plant Physiol., 50, 114-116 (1972).
S. M. Hecht and M. Sundaralingam, Stereochemistry of Nucleic Acids and Their Constituents. XXVII. The Crystal and Molecular Structure of a 1:1 Adduct of Ethanol and 3'-Deoxy-3'-(dihydroxyphosphinylmethyl)adenosine, an Analog of 3'-AMP, J. Am. Chem. Soc., 94, 4314-4319 (1972).
F. J. Schmidt, R. M. Bock and S. M. Hecht, Chemical Modifications of Transfer RNA Species. Heavy Atom Derivatization of Aminoacyl tRNA, Biochem. Biophys. Res. Commun., 48, 451-456 (1972).
R. C. Gallo, S. M. Hecht, J. Whang-Peng and S. O'Hopp, N6-(D2-isopentenyl)adenosine. The Regulatory Effect of a Cytokinin and Modified Nucleoside from tRNA on Human Lymphocytes, Biochem. Biophys. Acta, 28, 488-500 (1972).
S. M. Hecht and J. W. Kozarich, The Base-Induced Decomposition of N-Nitroso-N-methylurea, Tetrahedron Lett., 5147-5150 (1972).
F. Skoog, R. Y. Schmitz, R. M. Bock and S. M. Hecht, Cytokinin Antagonists: Synthesis and Physiological Effects of 7-Substituted-3-methylpyrazolo[4,3-d]-pyrimidines, Phytochemistry, 12, 25-37 (1973).
S. M. Hecht and J. W. Kozarich, Diazomethane: Its in situ Generation and Utilization in Selective Methylations, Tetrahedron Lett., 1397-1400 (1973).
S. M. Hecht and J. W. Kozarich, Mechanism of the Base-Induced Decomposition of N-nitroso-N-methylurea, J. Org. Chem., 38, 1821-1824 (1973).
S. M. Hecht and J. W. Kozarich, Demethylation of 7-Methylguanosine with Lithium 2-Methylpropane-2-thiolate, J. C. S. Chem. Commun., 387-388 (1973).
S. M. Hecht, S. D. Hawrelak, J. W. Kozarich, F. J. Schmidt and R. M. Bock, Chemical Modifications of Transfer RNA Species. Synthesis of tRNA's Terminating in 2'- and 3'-O-Methyladenosine, Biochem. Biophys. Res. Commun., 52, 1341-1347 (1973).
S. M. Hecht and D. Werner, A Concise Synthesis of Substituted Pyrazolo[3,4-d]pyrimidines, J.C.S. Perkin Trans. 1, 1903-1906 (1973).
J. W. Kozarich, A. C. Chinault and S. M. Hecht, Ribonucleoside Phosphates via Phosphorimidazolidate Intermediates. The Synthesis of Pseudo-ATP, Biochemistry, 12, 4458-4463 (1973).
S. M. Hecht and J. W. Kozarich, A Chemical Synthesis of g-32P-Adenosine 5'-triphosphate, Biochem. Biophys. Acta, 331, 307-309 (1973).
J. P. Helgeson, G. T. Haberlach and S. M. Hecht, On the Inhibition of Tobacco Callus and Suspension Culture by Pyrazolo[4,3-d]pyrimidine Analogs of Cytokinins, Proc. 8th Intern. Conf. on Plant Growth Subst., Tokyo, 1973, pp. 485-493.
S. M. Hecht, J. W. Kozarich and F. J. Schmidt, Isomeric Phenylalanyl-tRNA's. Position of the Aminoacyl Moiety During Protein Biosynthesis, Proc. Natl. Acad. Sci. USA, 71, 4317-4321 (1974).
S. M. Hecht, R. D. Faulkner and S. D. Hawrelak, Competitive Inhibition of Beef Heart Cyclic AMP Phosphodiesterase by Cytokinins and Related Compounds, Proc. Natl. Acad. Sci. USA, 71, 4670-4674 (1974).
S. M. Hecht and S. D. Hawrelak, Interaction of Glycyl-L-phenylalanine with E. coli Phenylalanyl-tRNA Synthetase, Biochemistry, 13, 4967-4975 (1974).
S. M. Hecht and S. D. Hawrelak, Hydrolysis of Ribonucleoside 3'-Diphosphates by Rye Grass 3'-Nucleotidase, Biochemistry, 14, 974-981 (1975).
J. W. Kozarich, A. C. Chinault and S. M. Hecht, Ribonucleoside 3'-Di and Triphosphates. Synthesis of Guanosine Tetraphosphate (ppGpp), Biochemistry, 14, 981-988 (1975).
S. M. Hecht, D. Werner, D. D. Traficante, M. Sundaralingam, P. Prusiner, T. Ito and T. Sakurai. Structure Determination of the N-Methyl Isomers of 5-Amino-3,4-Dicyanopyrazole and Certain Related Pyrazolo[3,4-d]pyrimidines, J. Org. Chem., 40, 1815-1822 (1975).
S. M. Hecht, R. B. Frye, D. Werner, S. D. Hawrelak, F. Skoog and R. Y. Schmitz, On the "Activation" of Cytokinins, J. Biol. Chem., 250, 7343-7351 (1975).
F. Skoog, R. Y. Schmitz, S. M. Hecht and R. B. Frye, Anticytokinin Activity of Substituted Pyrrolo[2,3-d]pyrimidines, Proc. Natl. Acad. Sci. USA, 72, 3508-3512 (1975).
S. M. Hecht and A. C. Chinault, Position of Aminoacylation of Individual E. coli and Yeast tRNA's, Proc. Natl. Acad. Sci. USA, 73, 405-409 (1976).
S. M. Hecht, R. B. Frye, D. Werner, T. Fukui and S. D. Hawrelak, Synthesis and Biological Activity of Pyrazolo[3,4-d]pyrimidine Nucleosides and Nucleotides Related to Tubercidin, Toyocamycin and Sangivamycin, Biochemistry, 15, 1005-1015 (1976).
S. M. Hecht, B. L. Adams and J. W. Kozarich, Chemical Transformations of 7,9-Disubstituted Purines and Related Heterocycles. Selective Reduction of Imines and Immonium Salts, J. Org. Chem., 41, 2303-2311 (1976).
S. M. Hecht, K. H. Tan, A. C. Chinault and P. Arcari, Isomeric Aminoacyl-tRNA's are Both Bound by Elongation Factor Tu, Proc. Natl. Acad. Sci. USA, 74, 437-441 (1977).
A. C. Chinault, J. W. Kozarich, S. M. Hecht, F. J. Schmidt and R. M. Bock, Preparation of E. coli tRNA's Terminating in Modified Nucleosides Using CTP(ATP): tRNA Nucleotidyltransferase and Polynucleotide Phosphorylase, Biochemistry, 16, 756-765 (1977).
A. C. Chinault, K. H. Tan, S. M. Hassur and S. M. Hecht, Initial Position of Aminoacylation of Individual Escherichia coli, Yeast and Calf Liver Transfer RNA's, Biochemistry, 16, 766-776 (1977).
S. M. Hecht, Participation of Isomeric tRNA's in the Partial Reactions of Protein Biosynthesis, Tetrahedron, 33, 1671-1696 (1977).
S. M. Hecht, Utilization of Isomeric Aminoacyl-tRNA's in Peptide Bond Formation, Accts. Chem. Res., 10, 239-245 (1977).
S. M. Hecht, P. Arcari and B. L. Adams, Isoenergetic Hydride Transfer. A Phase-Transition Mediated, Reversible tRNA Modification, J. Am. Chem. Soc., 99, 3890-3892 (1977).
D. A. McGowan, U. Jordis, D. K. Minster and S. M. Hecht, A Biomimetic Synthesis of the Bithiazole Moiety of Bleomycin, J. Am. Chem. Soc., 99, 8078-8079 (1977).
S. M. Hecht, Cytokinin Antagonists: Regulation of the Growth of Plant and Animal Cells, in "BioOrganic Chemistry", Vol. IV, E. E. van Tamelen, Ed., Academic Press, New York, 1978, p. 179-206.
B. L. Adams, M. Morgan, S. Muthukrishnan, S. M. Hecht and A. J. Shatkin, The Effect of "Cap" Analogs on Reovirus mRNA Binding to Wheat Germ Ribosomes. Evidence for Enhancement of Ribosomal Binding via a Preferred Cap Conformation, J. Biol. Chem., 253, 2589-2595 (1978).
D. K. Minster, U. Jordis, D. L. Evans and S. M. Hecht, Thiazoles from Cysteinyl Peptides, J. Org. Chem., 43, 1624-1626 (1978).
S. M. Hecht, B. L. Alford, Y. Kuroda and S. Kitano, "Chemical Aminoacylation" of tRNA's, J. Biol. Chem., 253, 4517-4520 (1978).
B. Alford and S. M. Hecht, 2' versus 3'-OH Specificity in tRNA Aminoacylation. Further Support for the "Secondary Cognition" Proposal, J. Biol. Chem., 253, 4844-4850 (1978).
D. K. Minster and S. M. Hecht, Synthesis of L-Gulose from D-Glucose via Aldose Interchange, J. Org. Chem., 43, 3987-3988 (1978).
P. Arcari and S. M. Hecht, Isoenergetic Hydride Transfer. A Reversible tRNA Modification with Concomitant Alteration of Biochemical Properties, J. Biol. Chem., 253, 8278-8284 (1978).
B. Alford, A. C. Chinault, S. O. Jolly and S. M. Hecht, Preparation of tRNA's Terminating in 2' and 3'-Deoxyadenosine, Methods Enzymol., 59G, 121-134 (1979).
S. M. Hecht, 2'-Versus 3'-OH Specificity in tRNA Aminoacylation, in "Transfer RNA: Structure, Properties and Recognition", J. Abelson, P. Schimmel and D. Soll, Eds., Cold Spring Harbor Laboratory, N. Y., 1979, p. 345-360.
D. L. Evans, D. K. Minster, U. Jordis, S. M. Hecht, A. L. Mazzu and A. I. Meyers, Nickel Peroxide Dehydrogenation of O, S and N-Containing Heterocycles, J. Org. Chem., 44, 497-501 (1979).
S. M. Hecht, Symposium Summary, in "Bleomycin: Chemical, Biochemical and Biological Aspects", S. M. Hecht, Ed., Springer-Verlag, New York, 1979, pp. 1-23.
S. M. Hecht, D. Burlett, Y. Mushika, Y. Kuroda and M. D. Levin, Studies on the Total Synthesis of Bleomycin, in "Bleomycin: Chemical, Biochemical and Biological Aspects", S. M. Hecht, Ed., Springer-Verlag, New York, 1979, pp. 48-62.
S. M. Hecht, K. M. Rupprecht and P. M. Jacobs, Synthesis of L-erythro-b-Hydroxyhistidine from D-Glucosamine, J. Am. Chem. Soc., 101, 3982-3983 (1979).
B. L. Alford, J. M. Pezzuto, K. H. Tan and S. M. Hecht, Both Positional Isomers of Aminoacyl-tRNA's are Bound by Elongation Factor Tu, J. Biol. Chem., 254, 6894-6903 (1979).
N. J. Oppenheimer, L. O. Rodriguez and S. M. Hecht, Proton Nuclear Magnetic Resonance Study of the Structure of Bleomycin and the Zinc-Bleomycin Complex, Biochemistry, 18, 3439-3445 (1979).
B. L. Alford and S. M. Hecht, Transfer RNA Control of the Activation of Isomeric tRNATrp's, J. Biol. Chem., 254, 6873-6875 (1979).
N. Sonenberg, K. M. Rupprecht., S. M. Hecht and A. J. Shatkin, Eukaryotic mRNA Cap Binding Protein: Purification by Affinity Chromatography on Sepharose-Coupled m7GDP, Proc. Natl. Acad. Sci. USA, 76, 4345-4349 (1979).
S. M. Hecht, Anticytokinins as Probes of Cytokinin Utilization, in "Plant Growth Substances", N. B. Mandava, Ed., ACS Symposium Series 111, Washington, 1979, pp. 79-98.
N. J. Oppenheimer, L. O. Rodriguez and S. M. Hecht, Structural Studies of "Active Complex” of Bleomycin: An Assignment of the Ligands to the Ferrous Ion in a Ferrous-Bleomycin-Carbon Monoxide Complex, Proc. Natl. Acad. Sci. USA, 76, 5616-5620 (1979).
M. D. Levin, K. Subrahamanian, H. Katz, M. B. Smith, D. J. Burlett and S. M. Hecht, Bleomycin: Synthesis and Structural Verification of the Tripeptide S and Tetrapeptide S Moieties, J. Am. Chem. Soc., 102, 1452-1453 (1980).
J. M. Pezzuto and S. M. Hecht, Amino Acid Substitutions in Protein Biosynthesis. Poly A-Directed Polyphenylalanine Synthesis, J. Biol. Chem., 255, 865-869 (1980).
S. M. Hecht, Nucleoside Phosphates as Probes of the Mechanism of Protein Biosynthesis, in "Phosphorous Chemistry Directed Towards Biology", W. J. Stec, Ed., Pergamon Press, Oxford, 1980, pp. 219-231.
J. M. Pezzuto, P. P. Lau, Y. Luh, P. D. Moore, G. N. Wogan and S. M. Hecht, There is a Correlation Between the DNA Affinity and Mutagenicity of Several 3-Amino-1-methyl-5H-pyrido[4,3-b]indoles, Proc. Natl. Acad. Sci. USA, 77, 1427-1431 (1980).
N. Sonenberg, H. Trachsel, S. Hecht and A. J. Shatkin, Differential Stimulation of Capped mRNA Translation in vitro by Cap Binding Protein, Nature, 285, 331-333 (1980).
N. J. Oppenheimer, L. O. Rodriguez and S. M. Hecht, Metal Binding to Modified Bleomycins. Zinc and Ferrous Complexes with an Acetylated Bleomycin, Biochemistry, 19, 4096-4103 (1980).
H. Arai, W. K. Hagmann, H. Suguna and S. M. Hecht, Synthesis of the Pyrimidine Moieties of Bleomycin and Epibleomycin, J. Am. Chem. Soc., 102, 6631-6633 (1980).
A. Dell, H. R. Morris, S. M. Hecht and M. D. Levin, Characterization of Guanidino-Containing Antibiotics: Field Desorption Mass Spectrometry of Bleomycin B2 and Phleomycins D1 and E, Biochem. Biophys. Res. Commun., 97, 987-994 (1980).
S. M. Hecht, Probing the Cytokinin Receptor Sites, in "Plant Growth Substances 1979", F. Skoog, Ed., Springer-Verlag, Berlin, 1980, pp. 144-158.
J. M. Pezzuto, P. D. Moore and S. M. Hecht, Metabolic Activation of 1-Methyl-3-amino-5H-pyrido[4,3-b]indole and Several Structurally Related Mutagens, Biochemistry, 20, 298-305 (1981).
N. J. Oppenheimer, C. Chang, L. O. Rodriguez and S. M. Hecht, Copper(I)•Bleomycin. A Structurally Unique Redox-active Complex, J. Biol. Chem., 256, 1514-1517 (1981).
T. Ohgi and S. M. Hecht, (2S,3S,4R)-4-Amino-3-hydroxy-2-methylvalerate: Synthesis of an Amino Acid Constituent of Bleomycin from L-Rhamnose, J. Org. Chem., 46, 1232-1234 (1981).
W. K. Hagmann, F. Z. Basha, M. Hashimoto, R. B. Frye, S. Kojo and S. M. Hecht, Chemistry of 2-Substituted Pyrimidines. Studies Directed toward the Synthesis of the Pyrimidine Moiety of Bleomycin, J. Org. Chem., 46, 1413-1423 (1981).
K. M. Rupprecht, N. Sonenberg, A. J. Shatkin and S. M. Hecht, Design and Preparation of Affinity Resins for the Purification of Eukaryotic mRNA Cap Binding Protein, Biochemistry, 20, 6570-6577 (1981).
V. Pozsgay, T. Ohgi and S. M. Hecht, Synthesis of the Carbohydrate Moiety of Bleomycin, J. Org. Chem., 46, 3761-3763 (1981).
A. Dell, H. R. Morris, M. D. Levin and S. M. Hecht, Field Desorption and Fast Atom Bombardment Mass Spectrometry of Bleomycins and Their Derivatives, Biochem. Biophys. Res. Commun., 102, 730-738 (1981).
K. Nishikawa, B. L. Adams and S. M. Hecht, Chemical Excision of Apurinic Acids from RNA. A Structurally Modified Yeast tRNAPhe, J. Am. Chem. Soc., 104, 326-328 (1982).
L. O. Rodriguez and S. M. Hecht, Iron(II)-Bleomycin. Biochemical and Spectral Properties in the Presence of Radical Scavengers, Biochem. Biophys. Res. Commun., 104, 1470-1476 (1982).
N. J. Oppenheimer, C. Chang, L.-H. Chang, G. Ehrenfeld, L. O. Rodriguez and S. M. Hecht, Deglyco-bleomycin. Degradation of DNA and Formation of a Structurally Unique Fe(II)•CO Complex, J. Biol. Chem., 257, 1606-1609 (1982).
J. Kross, W. D. Henner, W. A. Haseltine, L. Rodriguez, M. D. Levin and S. M. Hecht, Structural Basis for the DNA Affinity of Bleomycins, Biochemistry, 21, 3711-3721 (1982).
J. Kross, W. D. Henner, S. M. Hecht and W. A. Haseltine, Specificity of Deoxyribonucleic Acid Cleavage by Bleomycin, Phleomycin and Tallysomycin, Biochemistry, 21, 4310-4318 (1982).
N. Murugesan, G. M. Ehrenfeld and S. M. Hecht, Oxygen Transfer from Bleomycin-Metal Complexes, J. Biol. Chem., 257, 8600-8603 (1982).
Y. Aoyagi, H. Suguna, N. Murugesan, G. M. Ehrenfeld, L.-H. Chang, T. Ohgi, M. S. Shekhani, M. P. Kirkup and S. M. Hecht, Deglycobleomycin: Total Synthesis and Oxygen Transfer Properties of an Active Bleomycin Analog, J. Am. Chem. Soc., 104, 5237-5239 (1982).
Y. Aoyagi, K. Katano, H. Suguna, J. Primeau, L.-H. Chang and S. M. Hecht, Total Synthesis of Bleomycin, J. Am. Chem. Soc., 104, 5537-5538 (1982).
K. Nishikawa and S. M. Hecht, A Structurally Modified Yeast tRNAPhe with Six Nucleotides in the Anticodon Loop Lacks Significant Phenylalanine Acceptance, J. Biol. Chem., 257, 10536-10539 (1982).
J. R. Pellon, A. J. Sinskey, S. M. Hecht and R. F. Gomez, Kinetics of the Bleomycin A2 Damage in vivo to the Folded Chromosome of Escherichia coli, Chem.-Biol. Interactions, 43, 245-251 (1983).
T. G. Heckler, Y. Zama, T. Naka and S. M. Hecht, Dipeptide Formation with Misacylated tRNAPhe's, J. Biol. Chem., 258, 4492-4495 (1983).
H. Sasamori, K. S. Reddy, M. P. Kirkup, J. Shabanowitz, D. G. Lynn, S. M. Hecht, K. A. Woode, R. F. Bryan, J. Campbell, W. S. Lynn, E. Egert and G. Sheldrick, New Cytotoxic Principles from Datisca glomerata, JCS Perkin Trans. 1, 1333-1347 (1983).
W. D. Henner, L. O. Rodriguez, S. M. Hecht and W. A. Haseltine, g Ray Induced Deoxyribonucleic Acid Strand Breaks: 3'-Glycolate Termini, J. Biol. Chem., 258, 711-713 (1983).
T. A. Francis, G. M. Ehrenfeld, M. R. Gregory and S. M. Hecht, Transfer RNA Pyrophosphorolysis with CTP(ATP): tRNA Nucleotidyltransferase. A Direct Route to tRNA's Modified at the 3'-Terminus, J. Biol. Chem., 258, 4279-4284 (1983).
G. M. Ehrenfeld, T. A. Francis, and S. M. Hecht, Loss of Positional Specificity in the Aminoacylation of E. coli tRNAGly, J. Biol. Chem., 258, 11745-11750 (1983).
S. D. Fang, D. E. Berry, D. G. Lynn, S. M. Hecht, J. Campbell and W. S. Lynn, The Chemistry of Toxic Principles from Maytenus nemerosa, Phytochemistry, 23, 631-633 (1984).
T. G. Heckler, L.-H. Chang, Y. Zama, T. Naka and S. M. Hecht, Preparation of 2'-(3')-O-Acyl-pCpA Derivatives as Substrates for T4 RNA Ligase-Mediated "Chemical Aminoacylation", Tetrahedron, 40, 87-94 (1984).
T. G. Heckler, L.-H. Chang, Y. Zama, T. Naka, M. S. Chorghade and S. M. Hecht, T4 RNA Ligase Mediated Preparation of Novel "Chemically Misacylated" tRNAPhe's, Biochemistry, 23, 1468-1473 (1984).
G. M. Ehrenfeld, N. Murugesan and S. M. Hecht, Activation of Oxygen and Mediation of DNA Degradation by Manganese-Bleomycin, Inorg. Chem., 23, 1496-1498 (1984).
K. S. Reddy, M. S. Shekhani, D. E. Berry, D. G. Lynn and S. M. Hecht, Afromontoside. A New Cytotoxic Principle from Dracaena afromontana. J.C.S. Perkins Trans., 1, 987-992 (1984).
R. E. Kilkuskie, T. L. Macdonald and S. M. Hecht, Bleomycin May be Activated for DNA Cleavage by NADPH-Cytochrome P-450 Reductase, Biochemistry, 23, 6165-6171 (1984).
X. Fang, C. H. Phoebe, Jr., J. M. Pezzuto, H. H. S. Fong, N. R. Farnesworth, B. Yellin and S. M. Hecht, Plant Anticancer Agents XXXIV. Cucurbitacins from Elaeocarpus dolichostylus, J. Nat. Prod., 47, 988-993 (1984).
N. Murugesan and S. M. Hecht, Bleomycin as an Oxene Transferase. Catalytic Oxygen Transfer to Olefins, J. Am. Chem. Soc., 107, 493-500 (1985).
G. M. Ehrenfeld, L. O. Rodriguez, S. M. Hecht, C. Chang, V. J. Basus and N. J. Oppenheimer, Copper(I)-Bleomycin: Structurally Unique Complex that Mediates Oxidative DNA Strand Scission, Biochemistry, 24, 81-92 (1985).
R. E. Kilkuskie, H. Suguna, B. Yellin, N. Murugesan and S. M. Hecht, Oxygen Transfer by Bleomycin Analogs Dysfunctional in DNA Cleavage, J. Am. Chem. Soc., 107, 260-261 (1985).
D. E. Berry, L.-H. Chang and S. M. Hecht, DNA Damage and Growth Inhibition in Cultured Human Cells by Bleomycin Congeners, Biochemistry, 24, 3207-3214 (1985).
D. E. Berry, R. E. Kilkuskie and S. M. Hecht, DNA Damage Induced by Bleomycin in the Presence of Dibucaine is not Predictive of Cell Growth Inhibition, Biochemistry, 24, 3214-3219 (1985).
H. Sugiyama, C. Xu, N. Murugesan and S. M. Hecht, Structure of the Alkali-Labile Product Formed During Fe(II)•Bleomycin-Mediated DNA Strand Scission, J. Am. Chem. Soc., 107, 4104-4105 (1985).
C. Che, X. Fang, C. H. Phoebe, Jr., A. D. Kinghorn, N. R. Farnesworth, B. Yellin and S. M. Hecht, High Field 1H-NMR Spectral Analysis of Some Cucurbitacins, J. Nat. Prod., 48, 429-434 (1985).
R. P. Hertzberg, M. J. Caranfa and S. M. Hecht, DNA Methylation Diminishes Bleomycin-Mediated DNA Strand Scission, Biochemistry, 24, 5285-5289 (1985).
N. Murugesan, C. Xu, G. M. Ehrenfeld, H. Sugiyama, R. E. Kilkuskie, L. O. Rodriguez, L.-H. Chang and S. M. Hecht, Analysis of Products Formed During Bleomycin-Mediated DNA Degradation, Biochemistry, 24, 5735-5744 (1985).
Y.-H. Hsiang, R. Hertzberg, S. M. Hecht and L. F. Liu, Camptothecin Induces Protein-Linked DNA Breaks via Mammalian DNA Topoisomerase I, J. Biol. Chem., 260, 14873-14878 (1985).
H. Sugiyama, R. E. Kilkuskie, S. M. Hecht, G. A. van der Marel and J. H. van Boom, An Efficient, Site-Specific DNA Target for Bleomycin, J. Am. Chem. Soc., 107, 7765-7767 (1985).
K. Katano, P.-I. Chang, A. Millar, V. Pozsgay, D. K. Minster, T. Ohgi and S. M. Hecht, Synthesis of the Carbohydrate Moiety of Bleomycin. 1,3,4,6-Tetra-O-Substituted-L-Gulose Derivatives, J. Org. Chem., 50, 5807-5815 (1985).
H. Sugiyama, G. M. Ehrenfeld, J. B. Shipley, R. E. Kilkuskie, L.-H. Chang and S. M. Hecht, DNA Strand Scission by Bleomycin Group Antibiotics, J. Nat. Prod., 48, 869-877 (1985).
A. Millar, K. H. Kim, D. K. Minster, T. Ohgi and S. M. Hecht, Synthesis of the Carbohydrate Moiety of Bleomycin. 2,3,4,6-Tetra-O-Substituted-D-Mannose Derivatives, J. Org. Chem., 51, 189-196 (1986).
R. P. Hertzberg, S. M. Hecht, V. L. Reynolds, I. J. Molineux and L. H. Hurley, DNA Sequence Specificity of the Pyrrolo[1,4]benzodiazepine Antitumor Antibiotics. Methidiumpropyl-EDTA-Iron(II) Footprinting Analysis of DNA Binding Sites for Anthramycin and Related Drugs, Biochemistry, 25, 1249-1258 (1986).
H. Sugiyama, R. E. Kilkuskie, L.-H. Chang, L.-T. Ma, S. M. Hecht, G. A. van der Marel and J. H. van Boom, DNA Strand Scission by Bleomycin: Catalytic Cleavage and Strand Selectivity, J. Am. Chem. Soc., 108, 3852-3854 (1986).
K. Katano, A. Millar, V. Pozsgay, J. L. Primeau and S. M. Hecht, Synthesis of the Disaccharide Moiety of Bleomycin. 2-O-(3-O-Carbamoyl-a-D-mannopyranosyl)-L-gulopyranose Derivatives, J. Org. Chem., 51, 2927-2932 (1986).
S. M. Hecht, DNA Strand Scission by Activated Bleomycin Group Antibiotics, Fed. Proc., 45, 2784-2791 (1986).
J. R. Roesser, M. S. Chorghade and S. M. Hecht, Ribosome-Catalyzed Formation of an Abnormal Peptide Analog, Biochemistry, 25, 6361-6365 (1986).
D. C. Heimbrook, R. L. Mulholland and S. M. Hecht, Multiple Pathways in the Oxidation of cis-Stilbene by Fe•Bleomycin, J. Am. Chem. Soc., 108, 7839-7840 (1986).
S. M. Hecht, The Chemistry of Activated Bleomycin, Acc. Chem. Res., 19, 383-391 (1986).
G. M. Ehrenfeld, J. B. Shipley, D. C. Heimbrook, H. Sugiyama, E. C. Long, J. H. van Boom, G. A. van der Marel, N. J. Oppenheimer and S. M. Hecht, Copper Dependent Cleavage of DNA by Bleomycin, Biochemistry, 26, 931-942 (1987).
R. C. Payne, B. P. Nichols and S. M. Hecht, Escherichia coli Tryptophan Synthase: Synthesis of Catalytically Competent a Subunit in a Cell Free System Containing Preacylated tRNA's, Biochemistry, 26, 3197-3205 (1987).
D. C. Heimbrook, S. A. Carr, M. A. Mentzer, E. C. Long and S. M. Hecht, On the Mechanism of Oxygenation of cis-Stilbene by Fe•Bleomycin, Inorg. Chem., 26, 3835-3836 (1987).
H. Sugiyama, C. Xu, N. Murugesan, S. M. Hecht, G. A. van der Marel and J. H. van Boom, Chemistry of the Alkali-Labile Lesion Formed from Iron(II) Bleomycin and d(CGCTTTAAAGCG), Biochemistry, 27, 58-67 (1988).
L. A. Chrisey, G. H. Shahidi Bonjar and S. M. Hecht, DNA Strand Scission by
(-)Epicatechin and Procyanidin B2, J. Am. Chem. Soc., 110, 644-646 (1988).
J. B. Shipley and S. M. Hecht, Bleomycin Congeners Exhibiting Altered DNA Cleavage Specificity, Chem. Res. Toxicol., 1, 25-27 (1988).
B. Gold, V. Dange, M. A. Moore, A. Eastman, G. A. van der Marel, J. H. van Boom and S. M. Hecht, Alteration of Bleomycin Cleavage Specificity in a Platinated DNA Oligomer of Defined Structure, J. Am. Chem. Soc., 110, 2347-2349 (1988).
M. J. Levy and S. M. Hecht, Cu(II) Facilitates Bleomycin-Mediated Unwinding of Plasmid DNA, Biochemistry, 27, 2647-2650 (1988).
R. P. Hertzberg, M. J. Caranfa and S. M. Hecht, Degradation of Structurally Modified DNA's by Bleomycin Group Antibiotics, Biochemistry, 27, 3164-3174 (1988).
J. D. Leber, J. R. E. Hoover, K. G. Holden, R. K. Johnson and S. M. Hecht, A Revised Structure for Sibiromycin, J. Am. Chem. Soc., 110, 2992-2993 (1988).
R. T. Scannell, J. R. Barr, V. S. Murty, K. S. Reddy and S. M. Hecht, DNA Strand Scission by Naturally Occurring 5-Alkylresorcinols, J. Am. Chem. Soc., 110, 3650-3651 (1988).
S. M. Hecht, DNA Strand Scission by Activated Bleomycin Group Antibiotics, in "Anticarcinogenesis and Radiation Protection", P. A. Cerutti, O. F. Nygaard and M. G. Simic, Eds., Plenum Press, New York, 1988, p. 437-440.
J. R. Barr, V. S. Murty, K. Yamaguchi, S. Singh, D. H. Smith and S. M. Hecht, 5-Alkylresorcinols from Hakea Amplexicaulis that Cleave DNA, Chem. Res. Toxicol., 1, 204-207 (1988).
A. Jäger, M. J. Levy and S. M. Hecht, Oligodeoxynucleotide N-Alkylphosphoramidates: Synthesis and Binding to Polynucleotides, Biochemistry, 27, 7237-7246 (1988).
T. G. Heckler, J. R. Roesser, C. Xu, P.-I. Chang and S. M. Hecht, Ribosomal Binding and Dipeptide Formation by Misacylated tRNAPhe's, Biochemistry, 27, 7254-7262 (1988).
E. C. Long and S. M. Hecht, Direct Comparison of Oxygen Transfer by Iron Bleomycin and Zinc Bleomycin, Tetrahedron Lett., 29, 6413-6416 (1988).
S. M. Hecht, Natural Products that Cleave DNA, Pure Appl. Chem., 61, 577-580 (1989).
S. M. Sebti, J. C. DeLeon, L.-T. Ma, S. M. Hecht and J. S. Lazo, Substrate Specificity of Bleomycin Hydrolase, Biochem. Pharmacol., 38, 141-147 (1989).
I. Saito, T. Morii, H. Sugiyama, T. Matsuura, C. F. Meares, and S. M. Hecht, Photo-induced DNA Strand Scission by Cobalt Bleomycin Green Complex, J. Am. Chem. Soc., 111, 2307-2308 (1989).
R. B. Van Atta, E. C. Long, S. M. Hecht, G.A. van der Marel, and J. H. van Boom, Electrochemical Activation of Oxygenated Fe•Bleomycin, J. Am. Chem. Soc., 111, 2722-2724 (1989).
R.P. Hertzberg, M. J. Caranfa, and S. M. Hecht, On the Mechanism of Topoisomerase I Inhibition by Camptothecin: Evidence for Binding to an Enzyme-DNA Complex, Biochemistry, 28, 4629-4638 (1989).
J. R. Roesser, C. Xu, R. C. Payne, C. K. Surratt and S. M. Hecht, Preparation of Misacylated Aminoacyl-tRNAPhe's Useful as Probes of the Ribosomal Acceptor Site, Biochemistry, 28, 5185-5195 (1989).
C. K. Surratt, B. J. Carter, and S. M. Hecht, Processing of a Synthetic tRNA Precursor Model by E. coli RNase P and M1 RNA in "UCLA Symposium on the "Molecular Biology of RNA", Volume 94, T. Cech, Ed., A. R. Liss, Inc., 1989, pp 79-88.
S. M. Hecht, Bleomycin: Studies on the Mechanism of Action of an Antitumor Antibiotic, in "Molecular Aspects of Human Diseases", J. W. Gorrod, O. Albano, and S. Papa, Eds., Ellis Horwood, Ltd., 1989, pp 24-32.
S. M. Hecht, The Chemistry of Activated Bleomycin, in "The Chemistry of Antitumor Agents", D. E. V. Wilman, Ed., Blackie and Son Limited, Glasgow, 1990, pp 395-402.
B. J. Carter, V. S. Murty, K. S. Reddy, S.-N. Wang, and S. M. Hecht, A Role for the Metal Binding Domain of Bleomycin in Determining the DNA Sequence Selectivity of Fe-Bleomycin, J. Biol. Chem., 265, 4193-4196 (1990).
A. Natrajan, S. M. Hecht, G. A. van der Marel and J. H. van Boom, A Study of O2 vs H2O2-Supported Activation of Fe•Bleomycin, J. Am. Chem. Soc., 112, 3997-4002 (1990).
B. J. Carter, B. S. Vold and S. M. Hecht, Control of the Position of RNase P-Mediated Transfer RNA Precursor Processing, J. Biol. Chem., 265, 7100-7103 (1990).
J. R. Barr, R. B. Van Atta, A. Natrajan, S. M. Hecht, G. A. van der Marel and J. H. van Boom, Fe(II)•BLM-Mediated Reduction of O2 to H2O: An 17O-NMR Study, J. Am. Chem. Soc., 112, 4058-4060 (1990).
V. Dange, R. B. Van Atta and S. M. Hecht, A Mn2+-Dependent Ribozyme, Science, 248, 585-588 (1990).
A. Natrajan, S. M. Hecht, G. A. van der Marel and J. H. van Boom, Activation of Fe(II)•BLM by 10-Hydroperoxy-8, 12-octadecadienoic Acid, J. Am. Chem. Soc., 112, 4532-4538 (1990).
R. B. Van Atta, J. Bernadou, B. Meunier, and S. M. Hecht, On the Chemical Nature of DNA and RNA Modification by a Hemin Model System, Biochemistry, 29, 4783-4789 (1990).
B. K. Carté, C. DeBrosse, D. Eggleston, M. Hemling, M. Mentzer, B. Poehland, N. Troupe, J. W. Westley and S. M. Hecht, Isolation and Characterization of a Presumed Biosynthetic Precursor of Camptothecin from Extracts of Camptotheca Acuminata, Tetrahedron, 46, 2747-2760 (1990).
E. C. Long, S. M. Hecht, G. A. van der Marel and J. H. van Boom, Interaction of Bleomycin with a Methylated DNA Oligonucleotide, J. Am. Chem. Soc., 112, 5272-5276 (1990).
S. M. Hecht, E. C. Long, R. B. Van Atta, E. de Vroom and B. J. Carter, On the Mechanism of Bleomycin Activation and Polynucleotide Strand Scission, in "Molecular Mechanisms in BioOrganic Processes", C. Beasdale and B. T. Golding, Eds., Royal Society of Chemistry, 1990, pp 100-114.
B. J. Carter, E. de Vroom, E. C. Long, G. A. van der Marel, J. H. van Boom and S. M. Hecht, Site-Specific Cleavage of RNA by Fe(II)•Bleomycin, Proc. Natl. Acad. Sci. USA, 87, 9373-9377 (1990).
R. P. Hertzberg, R. W. Busby, M. J. Caranfa, K. G. Holden, R. K. Johnson, S. M. Hecht and W. D. Kingsbury, Irreversible Trapping of the DNA - Topoisomerase I Covalent Complex. Affinity Labeling of the Camptothecin Binding Site, J. Biol. Chem., 265, 19287-19295 (1990).
Y. Aoyagi, M. S. Chorghade, A. A. Padmapriya, H. Suguna, and S. M. Hecht, Synthesis of Pyrimidoblamic Acid and Epipyrimidoblamic Acid, J. Org. Chem., 55, 6291-6298 (1990).
C. K. Surratt, Z. Lesnikowski, A. L. Schifman, F. J. Schmidt, and S. M. Hecht, Construction and Processing of Transfer RNA Precursor Models, J. Biol. Chem., 265 22506-22512 (1990).
C. K. Surratt, B. J. Carter, R. C. Payne and S. M. Hecht, Metal Ion and Substrate Structure Dependence of the Processing of tRNA Precursors by RNase P and M1 RNA, J. Biol. Chem., 265 22513-22519 (1990).
W. D. Kingsbury, J. C. Boehm, D. R. Jakas, K. G. Holden, S. M. Hecht, G. Gallagher, M. J. Caranfa, F. L. McCabe, L. F. Faucette, R. K. Johnson and R. P. Hertzberg, Synthesis of Water-Soluble Aminoalkylcamptothecin Analogues: Inhibition of Topoisomerase I and Antitumor Activity, J. Med. Chem., 34, 98-107 (1991).
B. J. Carter, K. S. Reddy and S. M. Hecht, Polynucleotide Recognition and Strand Scission by Fe•Bleomycin, Tetrahedron, 47, 2463-2474 (1991).
D. E. Berry, J. A. Chan, L. MacKenzie and S. M. Hecht, 9-Octadecynoic Acid: A Novel DNA Binding Agent, Chem. Res. Toxicol., 4, 195-198 (1991).
B. J. Carter, C. E. Holmes, R. B. Van Atta, V. Dange and S. M. Hecht, Metal-Catalyzed Polynucleotide Strand Scission, Nucleosides & Nucleotides, 10, 215-227 (1991).
R. P. Hertzberg, M. J. Caranfa, W. D. Kingsbury, B. Smith, R. K. Johnson and S. M. Hecht, The Biochemistry of Camptothecin-Topoisomerase I Interaction, in "DNA Topoisomerases in Cancer", M. Potmesil and K.W. Kohn Eds., Oxford University Press, New York, 1991, pp 103-120.
K. Nagai, B. J. Carter, J. Xu and S. M. Hecht, DNA Cleavage by Oxygen Radicals Produced in the Absence of Metal Ions or Light, J. Am. Chem. Soc., 113, 5099-5100 (1991).
A. Natrajan and S. M. Hecht, Production of 2-Octenyl Radicals from the Fe(III)•Bleomycin-Mediated Fragmentation of 10-Hydroperoxy-8,12-octadecadienoic Acid, J. Org. Chem., 56, 5239-5241 (1991).
K. Nagai and S. M. Hecht, Site-Specific DNA Cleavage by Antisense Oligonucleotides Covalently Linked to Phenazine Di-N-oxide, J. Biol. Chem., 266, 23994-24002 (1991).
D. E. Berry, L. MacKenzie, E. A. Shultis, J. A. Chan and S. M. Hecht, Naturally Occurring Inhibitors of Topoisomerase I-Mediated DNA Relaxation, J. Org. Chem., 57, 420-422 (1992).
S. M. Hecht, D. E. Berry, L. J. MacKenzie, R. W. Busby and C. A. Nasuti, A Strategy for Identifying Novel, Mechanistically Unique Inhibitors of Topoisomerase I, J. Nat. Prod., 55, 401-413 (1992).
N. Hamamichi, A. Natrajan and S. M. Hecht, On the Role of Individual Bleomycin Thiazoles in Oxygen Activation and DNA Cleavage, J. Am. Chem. Soc., 114, 6278-6291 (1992).
E. Resto, A. Iida, M. D. Van Cleve and S. M. Hecht, Amplification of Protein Expression in a Cell Free System, Nucleic Acids Res., 20, 5979-5983 (1992).
S. M. Hecht, Probing the Synthetic Capabilities of a Center of Biochemical Catalysis, Acc. Chem. Res., 25, 545-552 (1992).
R. Van Atta and S. M. Hecht, A Ribozyme Model: Site-Specific Cleavage of an RNA Substrate by Mn2+, Adv. Inorg. Biochem., 9, 1-40 (1993).
M. L. Sznaidman, C. Crasto and S. M. Hecht, A New Method for the Synthesis of Nitriles from Amides Under Non-Acidic Conditions, Tetrahedron Lett., 34, 1581-1584 (1993).
C. E. Holmes, B. J. Carter and S. M. Hecht, Characterization of Fe(II)•Bleomycin-Mediated RNA Strand Scission, Biochemistry, 32, 4293-4307 (1993).
R. J. Duff, E. de Vroom, A. Geluk, S. M. Hecht, G. A. van der Marel and J. H. van Boom, Evidence for C-1’ H Abstraction from Modified Oligonucleotides by Fe•Bleomycin, J. Am. Chem. Soc., 115, 3350-3351 (1993).
S.-D. Fang, L.-K. Wang and S. M. Hecht, Inhibitors of DNA Topoisomerase I Isolated from the Roots of Zanthoxylum nitidum, J. Org. Chem., 58, 5025-5027 (1993).
L.-K. Wang, R. K. Johnson and S. M. Hecht, Inhibition of Topoisomerase I-Mediated DNA Cleavage by Nitidine and Fagaronine, Chem. Res. Toxicol, 6, 813-818 (1993).
C. E. Holmes and S. M. Hecht, Fe•Bleomycin Cleaves a Transfer RNA Precursor and its “Transfer DNA” Analog at the Same Major Site, J. Biol. Chem., 268, 25909-25913 (1993).
J. C. Quada, Jr., M. J. Levy and S. M. Hecht, Highly Efficient DNA Strand Scission by Photoactivated Chlorobithiazoles, J. Am. Chem. Soc., 115, 12171-12172 (1993).
N. Hamamichi and S. M. Hecht, Determination of the Absolute Configuration of the Thiazolinylthiazole Moiety of Phleomycin, J. Am. Chem. Soc., 115, 12605-12606 (1993).
A. Natrajan and S. M. Hecht, Bleomycins: Mechanism of Polynucleotide Recognition and Oxidative Degradation, in "Molecular Aspects of Anticancer Drug-DNA Interactions", Vol. 2, S. Neidle and M. J. Waring, Eds., Macmillan Press, London, 1994, pp 197-242.
S. A. Kane, A. Natrajan and S. M. Hecht, On the Role of the Bithiazole Moiety in Sequence Selective DNA Cleavage by Fe•Bleomycin, J. Biol. Chem., 269, 10899-10904 (1994).
M. Overhand and S. M. Hecht, A Concise Synthesis of the Antifungal Agent (+)-Preussin, J. Org. Chem., 59, 4721-4722 (1994).
M. A. Morgan and S. M. Hecht, Iron(II)Bleomycin-Mediated Degradation of a DNA-RNA Heteroduplex, Biochemistry, 33, 10286-10293 (1994).
S. M. Hecht, D. E. Berry, L. J. MacKenzie, E. A. Shultis, and J. A. Chan, A Strategy for Identifying Novel Inhibitors of DNA Topoisomerase I, in “Anticancer Drug Discovery and Development; Natural Products and New Molecular Models”, F. Valeriote, T. H. Corbett, and L. H. Baker, Eds., Kluwer, Boston, 1994, pp 85-94.
S. M. Hecht, RNA Degradation by Bleomycin, a Naturally Occurring Bioconjugate, Bioconjugate Chem., 5, 513-526 (1994).
R. A. Manderville, J. F. Ellena and S. M. Hecht, Solution Structure of a Zn(II)•Bleomycin A5-d(CGCTAGCG)2 Complex, J. Am. Chem. Soc., 116, 10851-10852 (1994).
S. A. Kane and S. M. Hecht, Polynucleotide Recognition and Degradation by Bleomycin, Prog. Nucleic Acid Res. Mol. Biol., 49, 313-352 (1994).
S. A. Kazakov and S. M. Hecht, Metal-Nucleic Acid Interactions, in "Encyclopedia of Inorganic Chemistry", R. B. King, Ed., John Wiley, London, 1994, pp 2697-2720.
S. M. Hecht, Bleomycin Group Antitumor Agents, in "Cancer Chemotherapeutic Agents", W. O. Foye, Ed., American Chemical Society, Washington, DC, 1995, pp 369-388.
K. A. Henningfeld and S. M. Hecht, Topoisomerase I-Mediated Illegitimate Recombination with Duplex DNA Substrates Containing Branches, Nicks and Gaps, Biochemistry, 34, 6120-6129 (1995).
M. L. Sznaidman, S. C. Johnson, C. Crasto and S. M. Hecht, Carbohydrate Cyclic Ketene Acetals, J. Org. Chem., 60, 3942-3943 (1995).
R. A. Manderville, J. F. Ellena and S. M. Hecht, Interaction of Zn(II)•Bleomycin with d(CGCTAGCG)2. A Binding Model Based on NMR Experiments and Restrained Molecular Dynamics Calculations, J. Am. Chem. Soc., 117, 7891-7903 (1995).
S. A. Kane, H. Sasaki and S. M. Hecht, Guanosine-Specific DNA Damage by a Co(II)•Bithiazole Complex, J. Am. Chem. Soc., 117, 9107-9118 (1995).
M. V. Keck and S. M. Hecht, Sequence-Specific Hydrolysis of Yeast tRNAPhe Mediated by Metal Free Bleomycin, Biochemistry, 34, 12029-12037 (1995).
M. A. Morgan, S. A. Kazakov and S. M. Hecht, Phosphoryl Migration During the Chemical Synthesis of RNA, Nucleic Acids Res., 23, 3949-3953 (1995).
W. Lytollis, R. T. Scannell, H. An, V. S. Murty, K. S. Reddy, J. R. Barr and S. M. Hecht, 5-Alkylresorcinols from Hakea trifurcata that Cleave DNA, J. Am. Chem. Soc., 117, 12683-12690 (1995).
U. S. Singh, R. T. Scannell, H. An, B. J. Carter and S. M. Hecht, DNA Cleavage by Di- and Trihydroxyalkylbenzenes. Characterization of the Roles of O2, Cu(II) and Alkali, J. Am. Chem. Soc., 117, 12691-12699 (1995).
S. A. Kane, S. M. Hecht, J.-S. Sun, T. Garestier and C. Hélène, Specific Cleavage of a DNA Triple Helix by FeII•Bleomycin, Biochemistry, 34, 16715-16724 (1995).
L.-K. Wang, B. D. Rogers and S. M. Hecht, Inhibition of Topoisomerase I Function by Coralyne and 5,6-Dihydrocoralyne, Chem. Res. Toxicol., 9, 75-83 (1996).
S. M. Hecht, Polynucleotide Cleavage and the Expression of Antitumor Activity by Bleomycin, NATO ASI Ser., Ser. C, 479, 77-89 (1996).
S. V. Mamaev, A. L. Laikhter, T. Arslan and S. M. Hecht, Firefly Luciferase: Alteration of the Color of Emitted Light Resulting from Substitutions at Position 286, J. Am. Chem. Soc., 118, 7243-7244 (1996).
C. E. Holmes, A. T. Abraham, S. M. Hecht, C. Florentz and R. Giegé, Fe•Bleomycin as a Probe of RNA Conformation, Nucleic Acids Res., 24, 3399-3406 (1996).
K. A. Henningfeld, T. Arslan and S. M. Hecht, Alteration of DNA Primary Structure by DNA Topoisomerase I. Isolation of the Covalent Topoisomerase I - DNA Binary Complex in Enzymatically Competent Form, J. Am. Chem. Soc., 118, 11701-11714 (1996).
E. P. Locke and S. M. Hecht, Enantiospecific Total Synthesis of (+) and (-)-Avarone and Avarol, J. Chem. Soc., Chem. Commun., 2717-2718 (1996).
M. Lodder, S. Golovine and S. M. Hecht, A Chemical Deprotection Strategy for the Elaboration of Misacylated Transfer RNA’s, J. Org. Chem., 62, 778-779 (1997).
C. E. Holmes, R. J. Duff, G. A. van der Marel, J. van Boom and S. M. Hecht, On the Chemistry of RNA Degradation by Fe(II)•BLM, Bioorg. Med. Chem., 5, 1235-1248 (1997).
V. A. Karginov, S. V. Mamaev, H. An, M. D. Van Cleve, S. M. Hecht, G. A. Komatsoulis and J. N. Abelson, Probing the Role of an Active Site Aspartic Acid in Dihydrofolate Reductase, J. Am. Chem. Soc., 119, 8166-8176 (1997).
V. A. Karginov, S. V. Mamaev and S. M. Hecht, In Vitro Suppression as a Tool for the Investigation of Translation Initiation, Nucleic Acids Res., 25, 3912-3916 (1997).
T. Arslan, S. V. Mamaev, N. V. Mamaeva and S. M. Hecht, Structurally Modified Firefly Luciferase. Effects of Amino Acid Substitution at Position 286, J. Am. Chem. Soc., 119, 10877-10887 (1997).
S. M. Hecht, RNA as a Therapeutic Target for Bleomycin, in “The Many Faces of RNA”, D. S. Eggleston, C. D. Prescott and N. D. Pearson, Eds., Academic Press Ltd., London, 1998, pp 3-17.
M. Lodder, S. Golovine, A. L. Laikhter, V. A. Karginov and S. M. Hecht, Misacylated Transfer RNAs Having a Chemically Removable Protecting Group, J. Org. Chem., 63, 794-803 (1998).
K. E. Loeb, J. M. Zaleski, C. D. Hess, S. M. Hecht and E. I. Solomon, Spectroscopic Investigation of the Metal Ligation and Reactivity of the Ferrous Active Sites of Bleomycin and Bleomycin Derivatives, J. Am. Chem. Soc., 120, 1249-1259 (1998).
T. Arslan, A. T. Abraham and S. M. Hecht, Structurally Altered Substrates for DNA Topoisomerase I. Effects of Inclusion of a Single 3’-Deoxynucleotide within the Scissile Strand, Nucleosides & Nucleotides, 17, 515-530 (1998).
X.-Y. Wang, K. A. Henningfeld and S. M. Hecht, DNA Topoisomerase I-Mediated Formation of Structurally Modified DNA Duplexes. Effects of Metal Ions and Topoisomerase I Inhibitors, Biochemistry, 37, 2691-2700 (1998).
J. A. Killian, M. D.Van Cleve, Y. F. Shayo and S. M. Hecht, Ribosome-Mediated Incorporation of Hydrazinophenylalanine into Modified Peptide and Protein Analogues, J. Am. Chem. Soc., 120, 3032-3042 (1998).
S. C. Johnson, C. Crasto and S. M. Hecht, Facial Selectivity in the Cycloaddition of Heterodienes to Carbohydrate Cyclic Ketene Acetals. A Novel Synthesis of Disaccharide Derivatives, J. Chem. Soc., Chem. Commun., 1019-1020 (1998).
T. Arslan, A. T. Abraham and S. M. Hecht, DNA Duplexes Containing 3’-Deoxynucleotides as Substrates for DNA Topoisomerase I Cleavage and Ligation, J. Biol. Chem., 273, 12383-12390 (1998).
J. C. Quada, Jr., G. F. Zuber and S. M. Hecht, Interaction of Bleomycin with DNA, Pure Appl. Chem., 70, 307-311 (1998).
X.-Y. Wang, L.-K. Wang, W. D. Kingsbury, R. K. Johnson and S. M. Hecht, Differential Effects of Camptothecin Derivatives on Topoisomerase I-Mediated DNA Structure Modification, Biochemistry, 37, 9399-9408 (1998).
S. J. Sucheck, J. F. Ellena and S. M. Hecht, Characterization of Zn(II)•Deglycobleomycin A2 and Interaction with d(CGCTAGCG)2. Direct Evidence for Minor Groove Binding of the Bithiazole Moiety, J. Am. Chem. Soc., 120, 7450-7460 (1998).
G. Zuber, J. C. Quada, Jr. and S. M. Hecht, Sequence Selective Cleavage of a DNA Octanucleotide by Chlorinated Bithiazoles and Bleomycins, J. Am. Chem. Soc., 120, 9368-9369 (1998).
S. M. Hecht, B. Wang, S. V. Mamaev, T. Arslan, G. F. Short, III, M. Lodder and S. Golovine, Misacylated tRNAs: A Source of Structurally Modified Peptides and Proteins, Nucleic Acids Res., Symp. Ser., 39, 15-16 (1998).
K. Katano, H. An, Y. Aoyagi, M. Overhand, S. J. Sucheck, W. C. Stevens, Jr., C. D. Hess, X. Zhou and S. M. Hecht, Total Synthesis of Bleomycin Group Antibiotics. Total Syntheses of Bleomycin Demethyl A2, Bleomycin A2 and Decarbamoyl Bleomycin Demethyl A2, J. Am. Chem. Soc., 120, 11285-11296 (1998).
X.-Y. Wang, G. F. Short, III, W.D. Kingsbury, R. K. Johnson and S. M. Hecht, Effects of Camptothecin Analogues on DNA Transformations Mediated by Calf Thymus and Human DNA Topoisomerases I, Chem. Res. Toxicol., 11, 1352-1360 (1998).
J. Chen, Y.-H. Zhang, L.-K. Wang, S. J. Sucheck, A. M. Snow and S. M. Hecht, Inhibitors of DNA Polymerase b from Schoepfia Californica, J. C. S. Chem. Commun., 2769-2770 (1998).
G. F. Short, III, M. Lodder, A. L. Laikhter, T. Arslan and S. M. Hecht, Caged HIV-1 Protease: Dimerization is Independent of the Ionization State of the Active Site Aspartates, J. Am. Chem. Soc., 121, 478-479 (1999).
A. T. Abraham, X. Zhou and S. M. Hecht, DNA Cleavage by Fe(II)•Bleomycin Conjugated to a Solid Support, J. Am. Chem. Soc., 121, 1982-1983 (1999).
X.-Y. Wang, X. Zhou and S. M. Hecht, Role of the 20-Hydroxyl Group in Camptothecin Binding by the Topoisomerase I-DNA Binary Complex, Biochemistry, 38, 4374-4381 (1999).
J.-Z. Deng, S. R. Starck and S. M. Hecht, Bis-5-Alkylresorcinols from Panopsis rubescens that Inhibit DNA Polymerase b, J. Nat. Prod., 62, 477-480 (1999).
J.-Z. Deng, D.-A. Sun, S. R. Starck, S. M. Hecht, R. L. Cerny and J. R. Engen Chrysochlamic Acid, A New Diterpenoid Substituted Quinol from Chrysochlamys Ulei that Inhibits DNA Polymerase b, J. Chem. Soc., Perkin Trans. 1, 1147-1149 (1999).
G. F. Short, III, S. Y. Golovine and S. M. Hecht, Effects of Release Factor 1 on In Vitro Protein Translation and the Elaboration of Proteins Containing Unnatural Amino Acids, Biochemistry, 38, 8808-8819 (1999).
D.-A. Sun, J.-Z. Deng, S. R. Starck and S. M. Hecht, Mispyric Acid, a New Monocyclic Triterpenoid with a Novel Skeleton from Mischocarpus Pyriformis that Inhibits DNA Polymerase b, J. Am. Chem. Soc., 121, 6120-6124 (1999).
J.-Z. Deng, S. R. Starck, S. M. Hecht, C. F. Ijames and M. Hemling, Harbinatic Acid, a Novel and Potent DNA Polymerase b Inhibitor from Hardwickia Binata, J. Nat. Prod., 62, 1000-1002 (1999).
A. V. Karginov, M. Lodder and S. M. Hecht, Facile Characterization of Translation Initiation via Nonsense Codon Suppression, Nucleic Acids Res., 27, 3283-3290 (1999).
D.-A. Sun, S. R. Starck, E. P. Locke and S. M. Hecht, DNA Polymerase b Inhibitors from Sandoricum Koetjape, J. Nat. Prod., 62, 1110-1113 (1999).
M. Aso, M. Kondo, H. Suemune and S. M. Hecht, Chemistry of the Bleomycin Induced Alkali-Labile Lesion, J. Am. Chem. Soc., 121, 9023-9033 (1999).
J.-Z. Deng, S. R. Starck and S. M. Hecht, DNA Polymerase b Inhibitors from Baecka Gunniana, J. Nat. Prod., 62, 1624-1626 (1999).
J. Ma, S. R. Starck and S. M. Hecht, DNA Polymerase b Inhibitors from Tetracera Boiviniana, J. Nat. Prod., 62, 1660-1663 (1999).
J.-Z. Deng, S. R. Starck and S. M. Hecht, Pentacyclic Triterpenoids from Freziera sp. that Inhibit DNA Polymerase b, BioOrg. Med. Chem., 8, 247-250 (2000).
S. M. Hecht, Bleomycin: New Perspectives on the Mechanism of Action, J. Nat. Prod., 63, 158-168 (2000).
S. R. Starck, J.-Z. Deng and S. M . Hecht, Naturally Occurring Alkylresorcinols that Mediate DNA Damage and Inhibit its Repair, Biochemistry, 39, 2413-2419 (2000).
B.-N. Zhou, R. K. Johnson, M. R. Mattern, X.-Y. Wang, S. M. Hecht, H. T. Beck, A. Ortiz and D. G. I. Kingston, Isolation and Biochemical Characterization of a New Topoisomerase I Inhibitor from Ocotea Leucoxylum, J. Nat. Prod., 63, 217-221 (2000).
M. Lodder, C. F. Crasto, A. L. Laikhter, H. An, T. Arslan, V. A. Karginov, G. F. Short, III and S. M. Hecht, Synthesis of Aspartic Acid Derivatives Useful for the Preparation of Misacylated Transfer RNAs, Can. J. Chem., 78, 884-891 (2000).
B. Wang, M. Lodder, J. Zhou, T. T. Baird, Jr., K. C. Brown, C. S. Craik and S. M. Hecht, Chemically Mediated Site-Specific Cleavage of Proteins, J. Am. Chem. Soc., 122, 7402-7403 (2000).
G. F. Short, III, A. L. Laikhter, M. Lodder, Y. F. Shayo, T. Arslan and S. M. Hecht, Probing the S1/S1’ Substrate Binding Pocket Geometry of HIV-1 Protease with Modified Aspartic Acid Analogues, Biochemistry, 39, 8768-8781 (2000).
J.-Z. Deng, D. J. Newman and S. M. Hecht, Use of COMPARE Analysis to Discover Functional Analogues of Bleomycin, J. Nat. Prod., 63, 1269-1272 (2000).
B.-N. Zhou, J. M. Hoch, R. K. Johnson, M. R. Mattern, W.-K. Eng, J. Ma, S. M. Hecht, D. J. Newman and D. G. I. Kingston, Use of COMPARE Analysis to Discover New Natural Product Drugs: Isolation of Camptothecin and 9-Methoxycamptothecin from a New Source, J. Nat. Prod., 63, 1273-1276 (2000).
C. J. Leitheiser, M. J. Rishel, X. Wu and S. M. Hecht, Solid Phase Synthesis of Bleomycin Group Antibiotics. Elaboration of Deglycobleomycin A5, Org. Lett., 2, 3397-3399 (2000).
J.-Z. Deng, S. R. Starck, D. A. Sun, M. Sabat and S. M. Hecht, A New 7,8-Euphadien-type Triterpenoid from Brackenridgea nitida and Bleasdalea bleasdalei that Inhibits DNA Polymerase b, J. Nat. Prod., 63, 1356-1360 (2000).
M. Lodder, B. Wang and S. M. Hecht, N-Substituted 2-Amino-4-pentenoic Acids for Amino Acid Protection and Resolution, Tetrahedron, 56, 9421-9429 (2000).
T. T. Baird, Jr., B. Wang, M. Lodder, S. M. Hecht and C. S. Craik, Generation of Active Trypsin by Chemical Cleavage, Tetrahedron, 56, 9477-9485 (2000).
S. M. Hecht, Camptothecin as Probes of the Microenvironments of Topoisomerase I-DNA Complexes, in “The Camptothecins”, J. G. Liehr, B. C. Giovanella, C. F. Verschraegen, Eds., New York Academy of Sciences, 2000, pp 76-91.
N. E. Fahmi, S. Golovine, B. Wang and S. M. Hecht, Studies Toward the Site Specific Incorporation of Sugars into Proteins: Synthesis of Glycosylated Aminoacyl-tRNAs, Carbohydr. Res., 330, 149-164 (2001).
A. K. Choudhury, Z.-F. Tao and S. M. Hecht, Synthesis and DNA Cleavage Activity of a Novel Bleomycin A5 Glycoconjugate, Org. Lett., 3,1291-1294 (2001).
A. T. Abraham, X. Zhou and S. M. Hecht, Metallobleomycin-Mediated Cleavage of DNA Not Involving a Threading Intercalation Mechanism, J. Am. Chem. Soc., 123, 5167-5175 (2001).
S. Hashimoto, B. Wang and S. M. Hecht, Kinetics of DNA Cleavage by Fe(II)•Bleomycins, J. Am. Chem. Soc., 123, 7437-7438 (2001).
B. O. Krogh, C. D. Claeboe, S. M. Hecht, and S. Shuman, Effect of 2’-5’ Phosphodiesters on DNA Transesterification by Vaccinia Topoisomerase, J. Biol. Chem., 276, 20907-20912 (2001).
M. L. Sznaidman and S. M. Hecht, Studies on the Total Synthesis of Tallysomycin. Synthesis of the Threonylbithiazole Moiety Containing a Structurally Unique Glycosylcarbinolamide, Org. Lett., 3, 2811-2814 (2001).
M. J. Rishel and S. M. Hecht, Analogues of Bleomycin: Synthesis of Conformationally Rigid Methylvalerates, Org. Lett., 3, 2867-2869 (2001).
J. C. Quada, Jr., D. Boturyn and S. M. Hecht, Photoactivated DNA Cleavage by Compounds Structurally Related to the Bithiazole Moiety of Bleomycin, Bioorg. Med. Chem., 9, 2303-2314 (2001).
M. V. Keck, R. A. Manderville and S. M. Hecht, Chemical and Structural Characterization of the Interaction of Bleomycin A2 with d(CGCGAATTCGCG)2. A Double-Strand Cleavage Accessible Without Structural Reorganization, J. Am. Chem. Soc., 123, 8690-8700 (2001).
A. T. Abraham, D. L. Brautigan, S. M. Hecht and A. Periasamy, Localization of Bleomycin in a Single Living Cell Using Three-Photon Excitation Microscopy, Proc. SPIE, 4262, 347-353 (2001).
C. J. Thomas, M. M. McCormick, C. Vialas, Z.-F. Tao, C. J. Leitheiser, M. J. Rishel, X. Wu and S. M. Hecht, Alteration of the Selectivity of DNA Cleavage by a Deglycobleomycin Analogue Containing a Trithiazole Moiety, J. Am. Chem. Soc., 124, 3875-3884 (2002).
B. Wang, K. C. Brown, M. Lodder, C. S. Craik and S. M. Hecht, Chemically Mediated Site-Specific Proteolysis. Alteration of Protein-Protein Interaction, Biochemistry, 41, 2805-2813 (2002).
K. L. Smith, Z.-F. Tao, S. Hashimoto, C. J. Leitheiser, X. Wu and S. M. Hecht, Deglycobleomycin: Solid-Phase Synthesis and DNA Cleavage by the Resin-Bound Ligand, Org. Lett., 4, 1079-1082 (2002).
P. B. Arimondo, A. Boutorine, B. Baldeyrou, C. Bailly, M. Kuwahara, S. M. Hecht, J.-S. Sun, T. Garestier and C. Hélène, Design and Optimization of Conjugates of Camptothecin Derivatives of Triple Helix-Forming Oligonucleotides for Sequence-Specific DNA Cleavage by Topoisomerase I, J. Biol. Chem., 277, 3132-3140 (2002).
Z.-F. Tao, C. J. Leitheiser, K. L. Smith, S. Hashimoto and S. M. Hecht, Solid Phase Synthesis of Deglycobleomycins: A C-Terminal Tetraamine Linker that Permits Direct Evaluation of Resin-Bound Bleomycins, Bioconjugate Chem., 13, 426-434 (2002).
Y. Zou, N. E. Fahmi, C.Vialas, G. M. Miller and S. M. Hecht, Total Synthesis of Deamido Bleomycin A2, the Major Catabolite of the Antitumor Agent Bleomycin, J. Am. Chem. Soc., 124, 9476-9488 (2002).
R. D. Anderson, J. Zhou and S. M. Hecht, Fluorescence Resonance Energy Transfer Between Unnatural Amino Acids in a Structurally Modified Dihydrofolate Reductase, J. Am. Chem. Soc., 124, 9674-9675 (2002).
B. M. Eisenhauer and S. M. Hecht, Site-Specific Incorporation of (Aminooxy)acetic Acid into Proteins, Biochemistry, 41, 11472-11478 (2002).
C. J. Thomas, A. O., Chizhov, C. J. Leitheiser, M. J. Rishel, K. Konishi, Z.-F. Tao and S. M. Hecht, Solid Phase Synthesis of Bleomycin A5 and Three Monosaccharide Analogues. Exploring the Role of the Carbohydrate Moiety in RNA Cleavage, J. Am. Chem. Soc., 124, 12926-12927 (2002).
J.-Z. Deng, R. Marshall, S. H. Jones, R. K. Johnson and S. M. Hecht, DNA Damaging Agents from Crypteronia Paniculata, J. Nat. Prod., 65, 1930-1932 (2002).
S. M. Hecht, RNA Targeting by Bleomycin, in “DNA and RNA Binders: From Small Molecules to Drugs,” M. Demeunynck, C. Bailly and W. D. Wilson, Eds., Vol. 1, Wiley-VCH, 2003, pp 41-57.
A. T. Abraham, J.-J. Lin, D. L. Newton, S. Rybak and S. M. Hecht, RNA Cleavage and Inhibition of Protein Synthesis by Bleomycin, Chemistry & Biology, 10, 45-52 (2003).
Y.-M. Xu, J.-Z. Deng, J. Ma, S.-N. Chen, R. Marshall, S. H. Jones, R. K. Johnson and S. M. Hecht, DNA Damaging Activity of Ellagic Acid Derivatives, BioOrg. Med. Chem., 11, 1593-1596 (2003).
L. M. Dedkova, N. E. Fahmi, S. Y. Golovine and S. M. Hecht, Efficient D-Amino Acid Incorporation into Protein by Modified Ribosomes, J. Am. Chem. Soc., 125, 6616-6617 (2003).
C. J. Leitheiser, K. L. Smith, M. J. Rishel, S. Hashimoto, K. Konishi, C. J. Thomas, C. Li, M. M. McCormick and S. M. Hecht, Solid Phase Synthesis of Bleomycin Group Antibiotics. Construction of a 108-Member Deglycobleomycin Library, J. Am. Chem. Soc., 125, 8218-8227 (2003).
L. Tian, C. D. Claeboe, S. M. Hecht and S. Shuman, Guarding the Genome: Electrostatic Repulsion of Water by DNA Suppresses a Potent Nuclease Activity of Topoisomerase IB, Mol. Cell, 12, 199-208 (2003).
M. J. Rishel, C. J. Thomas, Z.-F. Tao, C. Vialas, C. J. Leitheiser and S. M. Hecht, Conformationally Constrained Analogues of Bleomycin A5, J. Am. Chem. Soc., 125, 10194-10205 (2003).
C. D. Claeboe, R. Gao and S. M. Hecht, 3’-Modified Oligonucleotides by Reverse DNA Synthesis, Nucleic Acids Res., 31, 5685-5691 (2003).
A. Cagir, S. H. Jones, R. Gao, B. M. Eisenhauer and S. M. Hecht, Luotonin A. A Naturally Occurring Human DNA Topoisomerase I Poison, J. Am. Chem. Soc., 125, 13628-13629 (2003).
A. Cagir, Z.-F. Tao, S. J. Sucheck and S. M. Hecht, Solid Phase Synthesis and Biochemical Evaluation of Conformationally Constrained Analogues of Deglycobleomycin A5, BioOrg. Med. Chem., 11, 5179-5187 (2003).
V. S. P. Chaturvedula, Z. Gao, S. M. Hecht, S. H. Jones and D. G. I. Kingston, A New Acylated Oleanane Triterpenoid from Couepia polyandra that Inhibits the Lyase Activity of DNA Polymerase b, J. Nat. Prod., 66, 1463-1465 (2003).
C. J. Leitheiser and S. M. Hecht, Solid Phase Synthesis of Deglycobleomycin and Bleomycin, Curr. Opin. Drug Discovery Dev., 6, 827-837 (2003).
S. M. Hecht, Inhibitors of the Lyase Activity of DNA Polymerase b, Pharmaceut. Biol., 41, 68-77 (2003).
N. J. Rahier, B. M. Eisenhauer, R. Gao, S. H. Jones and S. M. Hecht, Water Soluble Camptothecin Derivatives that are Intrinsic Topoisomerase I Poisons, Org. Lett., 6, 321-324 (2004).
L. Tian, C. D. Claeboe, S. M. Hecht and S. Shuman, Remote Phosphate Contacts Trigger Assembly of the Active Site of DNA Topoisomerase IB, Structure, 12, 31-40 (2004).
C. J. Thomas, N. J. Rahier and S. M. Hecht, Camptothecin: Current Perspectives, BioOrg. Med. Chem., 12, 1585-1604 (2004).
A. Cagir, S. H. Jones, B. M. Eisenhauer, R. Gao and S. M. Hecht, Synthesis and Biological Properties of E-ring Modified Luotonin A Derivatives, BioOrg. Med. Chem. Lett., 14, 2051-2054 (2004).
J. Ma and S. M. Hecht, Javaniside, A Novel DNA Cleavage Agent from Alangium javanicum Having an Unusual Oxindole Skeleton, J. Chem. Soc., Chem. Commun., 1190-1191 (2004).
R. Gao, C. D. Claeboe, B. M. Eisenhauer and S. M. Hecht, Identification of Specific Phosphate Oxygens Important for DNA Cleavage by Human Topoisomerase I, Biochemistry, 43, 6167-6181 (2004).
V. S. P. Chaturvedula, Z. Gao, S. H. Jones, S. M. Hecht and D. G. I. Kingston, A New Ursane Triterpene from Monochaetum vulanicum that Inhibits DNA Polymerase b Lyase, J. Nat. Prod., 67, 899-901 (2004).
J. Ma, S. H. Jones and S. M. Hecht, Phenolic Acid Amides. A New Type of DNA Strand Scission Agent from Piper caninum, BioOrg. Med. Chem., 12, 3885-3889 (2004).
S.-S. Li, Z. Gao, X. Feng, S. H. Jones and S. M. Hecht, Plant Sterols as Selective DNA Polymerase b Lyase Inhibitors and Potentiators of Bleomycin Cytotoxiciy, BioOrg. Med. Chem., 12, 4253-4258 (2004).
J. Ma, S. H. Jones, R. Marshall, R. K. Johnson and S. M. Hecht, A DNA Damaging Oxoaporphine Alkaloid from Piper caninum, J. Nat. Prod., 67, 1162-1164 (2004).
H.-Y. Hu, J. K. Horton, M. R. Gryk, R. Prasad, J. M. Naron, D.-A. Sun, S. M. Hecht, S. H. Wilson and G. P. Mullen, Identification of Small Molecule Synthetic Inhibitors of DNA Polymerase b by NMR Chemical Shift Mapping, J. Biol. Chem., 279, 39736-39744 (2004).
S.-S. Li, Z. Gao, X. Feng and S. M. Hecht, Biscoumarin Derivatives from Edgeworthia gardneri that Inhibit the Lyase Activity of DNA Polymerase b, J. Nat. Prod., 67, 1608-1610 (2004).
J. Ma, S. H. Jones and S. M. Hecht, A Coumarin from Mallotus resinous that Mediates DNA Cleavage, J. Nat. Prod., 67, 1614-1616 (2004).
V. S. P. Chaturvedula, Z. Gao, S. J. Thomas, S. M. Hecht and D. G. I. Kingston, New Norditerpenoids and a Diterpenoid from a Sponge that Inhibit the Lyase Activity of DNA Polymerase b, Tetrahedron, 60, 9991-9995 (2004).
A. Cagir, B. M. Eisenhauer, R. Gao, S. J. Thomas and S. M. Hecht, Synthesis and Topoisomerase I Inhibitory Properties of Luotonin Analogues, BioOrg. Med. Chem., 12, 6287-6299 (2004).
S. Cao, Z. Gao, S. J. Thomas, S. M. Hecht, J. Lazo and D. G. I. Kingston, Marine Sesquiterpenoids that Inhibit the Lyase Activity of DNA Polymerase b, J. Nat. Prod., 67, 1716-1718 (2004).
V. S. P. Chaturvedula, B.-N. Zhou, Z. Gao, S. J. Thomas, S. M. Hecht and D. G. I. Kingston, New Lupane Triterpenoids from Solidago Canadensis that Inhibit the Lyase Activity of DNA Polymerase b, Bioorg. Med. Chem., 12, 6271-6275 (2004).
V. S. P. Chaturvedula, S. M. Hecht, Z. Gao, S. H. Jones and D. G. I. Kingston, New Neolignans that Inhibit DNA Polymerase b Lyase, J. Nat. Prod., 67, 964-967 (2004).
X. Feng, Z. Gao, S.-S.Li, S. H. Jones and S. M. Hecht, DNA Polymerase b Lyase Inhibitors from Maytenus putterlickoides, J. Nat. Prod., 67, 1744-1747 (2004).
G. J. Klarmann, B. M. Eisenhauer, Y. Zhang, K. Sitaraman, D. K., Chatterjee, S. M. Hecht and S. F. J. LeGrice, Site- and Subunit-Specific Incorporation of Unnatural Amino Acids Into HIV-1 Reverse Transcriptase, Prot. Expr. Purif., 38, 37-44 (2004).
Y.-M. Xu, R. K. Johnson and S. M. Hecht, Polybrominated Diphenyl Ethers from a Sponge of the Dysidea Genus that Inhibit Tie2 Kinase, BioOrg. Med. Chem., 13, 657-659 (2005).
J. Ma, S. H. Jones, R. Marshall, X. Wu and S. M. Hecht, DNA Topoisomerase I Inhibitors from Rinorea Anguifera, Bioorg Med. Chem. Lett., 15, 813-816 (2005).
J. Ma, S. H. Jones and S. M. Hecht, A Dihydroflavonol Glucoside from Commiphora africana that Mediates DNA Strand Scission, J. Nat. Prod., 68, 115-117 (2005).
K. Cheng, N. J. Rahier, B. M. Eisenhauer, R. Gao, S. J. Thomas and S. M. Hecht, 14-Azacamptothecin: A Potent Water-Soluble Topoisomerase I Poison, J. Am. Chem. Soc., 127, 838-839 (2005).
N. J. Rahier, R. Gao, B. M. Eisenhauer, S. H. Jones and S. M. Hecht, On the Role of E-Ring Oxygen Atoms in the Binding of Camptothecin to the Topoisomerase I-DNA Covalent Binary Complex, BioOrg. Med. Chem., 13, 1381-1386 (2005).
J. A. Smith, Y. Xu, S. M. Hecht and D. Lannigan, A p90 Rsk-Specific Inhibitor, SL0101, Inhibits Transformed Cell Proliferation, Cancer Res., 65, 1027-1034 (2005).
S. M. Hecht, Inhibitors of Topoisomerase I Function, in “Camptothecins in Cancer Chemotherapy”, V. R. Adams and T. G. Burke, Eds., Humana Press, 2005, pp. 39-59, Totowa, New Jersey.
R. Gao, Y. Zhang, A. K. Choudhury, L. M. Dedkova and S. M. Hecht, Analogues of Vaccinia Virus DNA Topoisomerase I Modified at the Active Site Tyrosine, J. Am. Chem. Soc., 127, 3321-3331 (2005).
P. B. Arimondo, G. S. Laco, C. J. Thomas, L. Halby, D. Pez, P. Schmitt, A. Boutorine, T. Garestier, Y. Pommier, S. M. Hecht, J.-S. Sun and C. Bailly, Activation of Camptothecin Derivatives by Conjugation to Triple-Helix-Forming Oligonucleotides, Biochemistry, 44, 4171-4180 (2005).
N. J. Rahier, K. Cheng, R. Gao, B. M. Eisenhauer and S. M. Hecht, Synthesis of 14-Azacamptothecin, A Water Soluble Topoisomerase I Poison, Org. Lett., 7, 835-837 (2005).
D. J. Maloney and S. M. Hecht, Synthesis of a Potent and Selective Inhibitor of p90 Rsk, Org. Lett., 7, 1097-1099 (2005).
D. J. Maloney, J.-Z. Deng, S. R. Starck, Z. Gao and S. M Hecht, (+)-Myristinin A, A Naturally Occurring DNA Polymerase b Inhibitor and Potent DNA Damaging Agent, J. Am. Chem. Soc., 127, 4140-4141 (2005).
J.-Z. Deng, D. J. Newman and S. M. Hecht, Umbelactonyl Cinnamate Derivatives from Crypteronia paniculata that Mediate DNA Strand Scission, J. Nat. Prod., 68, 465-467 (2005).
N. J. Rahier, C. J. Thomas and S. M. Hecht, Camptothecin and its Analogues, in "Antitumor Agents from Natural Sources," G. M. Cragg, D. G. I. Kingston and D. J. Newman, Eds., CRC Press, 2005, pp 5-21, Boca Raton.
S. M. Hecht, Bleomycin Group Antitumor Agents, in "Antitumor Agents from Natural Sources," G. M. Cragg, D. G. I. Kingston and D. J. Newman, Eds., CRC Press, 2005, pp 357-381, Boca Raton.
S. M. Hecht, Camptothecin: Roles of the D and E Rings in Binding to the Topoisomerase I-DNA Covalent Binary Complex, Current Medicinal Chemistry-Anticancer Agents, 5, 353-362 (2005).
L. Tian, C. D. Claeboe, S. M. Hecht and S. Shuman, DNA Electrostatics Dictate the Requirement for a Catalytic Arginine in Topoisomerase IB, Structure, 13, 513-520 (2005).
M. Lodder, B. Wang and S. M. Hecht, The N-Pentenoyl Protecting Group for Aminoacyl-tRNAs, Methods, 36, 245-251 (2005).
V. C. Pham, J. Ma, S. J. Thomas and S. M. Hecht, Alkaloids from Alangium javanicum and Alangium grisolleoides that Mediate DNA Strand Scission, J. Nat. Prod., 68, 1147-1152 (2005).
I. Nakanishi, C. Nishizawa, K. Ohkubo, K. Takeshita, K. T. Suzuki, T. Ozawa, S. M. Hecht, M. Tanno, S. Sueyoshi, N. Miyata, H. Okuda, S. Fukuzumi, N. Ikota and K. Fukuhara, Hydroxyl Radical Generation via Photoreduction of a Simple Pyridine N-oxide by an NADH Analogue, Org. Biomol. Chem., 4, 626-629 (2005).
D. J. Maloney and S. M. Hecht, A Stereocontrolled Synthesis of δ-trans-Tocotrienoloic Acid Using an Acid-Catalyzed Cyclodehydration Reaction, Org. Lett., 7, 4297-4300 (2005).
S. A. Kazakov and S. M. Hecht, Nucleic Acid-Metal Ion Interactions, in “Encyclopedia of Inorganic Chemistry”, 2nd Edition, R. Scott, Ed., John Wiley, London, 2005.
J.-Z. Deng, S. R. Starck, S. Li and S.M. Hecht, Myristinins A and D from Knema elegans that Inhibit DNA Polymerase b and Cleave DNA, J. Nat. Prod., 68, 1625-1628 (2005).
V. A. Karginov, A. Yohannes, T. M. Robinson, N. E. Fahmi, K. Alibek and S. M. Hecht, b-Cyclodextrin Derivatives that Inhibit Anthrax Lethal Toxin, Bioorg. Med. Chem., 14, 33-40 (2006).
P. B. Arimondo, C. J. Thomas, K. Oussedik, B. Baldeyrou, C. Mahieu, L. Halby, D. Guianvarc'h, A. Lanisiaux, S. M. Hecht, C. Bailly and C. Giovannangeli, Exploring the Cellular Activity of Camptothecin-Triple-Helix-Forming Oligonucleotide Conjugates, Mol. Cell. Biol., 26, 324-333 (2006).
J. A. Clement, M. Li., S. M. Hecht and D. G. I. Kingston, Bioactive Isomalabaricane Triterpenoids from Rhabdastrella globostellata that Stabilize the Binding of DNA Polymerase b to DNA, J. Nat. Prod., 69, 373-376 (2006).
D. J. Maloney, S. Chen and S. M. Hecht, Stereoselective Synthesis of the Atropisomers of Myristinin B/C, Org. Lett., 8, 1925-1927 (2006).
Y.-M. Xu, J. A. Smith, D. A. Lannigan and S. M. Hecht, Three Acetylated Flavonol Glycosides from Forsteronia refracta that Specifically Inhibit p90 RSK, BioOrg. Med. Chem., 14, 3974-3977 (2006).
J. A. Smith, D. J. Maloney, D. E. Clark, Y. Xu, S. M. Hecht and D. A. Lannigan, Influence of Rhamnose Substituents on the Potency of SL0101, an Inhibitor of the Ser/Thr Kinase, RSK, BioOrg. Med. Chem., 14, 6034-6042 (2006).
B. Wang, J. Zhou, M. Lodder and S. M. Hecht, Tandemly Activated Transfer RNAs Participate in Protein Synthesis, J. Biol. Chem., 281, 13865-13868 (2006).
R. Gao, Y. Zhang, L. Dedkova, A. K. Choudhury, N. J. Rahier and S. M. Hecht, Effects of Modification of the Active Site Tyrosine of Human DNA Topoisomerase I, Biochemistry, 45, 8402-8410 (2006).
T. L. Nguyen, R. Gussio, J. A. Smith, D. A. Lannigan, S. M. Hecht, D. A. Scudiero, R. H. Shoemaker and D. W. Zaharevitz, Homology Model of RSK2 N-Terminal Kinase Domain, Structure-Based Identification of Novel RSK2 Inhibitors, and Preliminary Common Pharmacophore, Bioorg. Med. Chem., 14, 6097-6105 (2006).
M. A. Elban, W. Sun, B. M. Eisenhauer, R. Gao and S. M. Hecht, Synthesis and Biological Evaluation of 10,11-Methylenedioxy-14-azacamptothecin, Org. Lett., 8, 3513-3516 (2006).
V. A. Karginov, E. M. Nestorovich, A. Yohannes, T. M. Robinson, N. E. Fahmi, F. Schmidtmann, S. M. Hecht and S. M. Bezrukov, Search for Cyclodextrin-Based Inhibitors of Anthrax Toxins: Synthesis: Structural Features, and Relative Activities, Antimicrob. Agents Chemother., 50, 3740-3753 (2006).
L. M. Dedkova, N. E. Fahmi, S. Y. Golovine and S. M. Hecht, Construction of Modified Ribosomes for Incorporation of D-Amino Acids into Proteins, Biochemistry, 45, 15541-15551 (2006).
Z.-F. Tao, K. Konishi, G. Keith, and S. M. Hecht, An Efficient Mammalian Transfer RNA Target for Bleomycin, J. Am. Chem. Soc., 128, 14806-14807 (2006).
N. E. Fahmi, L. Dedkova, B. Wang, S. Golovine and S. M. Hecht, Site Specific Incorporation of Glycosylated Serine and Tyrosine Derivatives into Proteins, J. Am. Chem. Soc., 129, 3586-3597 (2007).
G. J. Klarmann, B. M. Eisenhauer, Y. Zhang, M. Gotte, J. Pata, D. K. Chatterjee, S. M. Hecht and S. F. J. Le Grice, Substituting the "Steric Gate" of HIV-1 Reverse Transcriptase with Unnatural Amino Acids Can Increase Catalytic Efficiency, Biochemistry, 46, 2118-2126 (2007).
A. K. Choudhury, S. Y. Golovine, L. Dedkova, A. L. Laikhter and S. M. Hecht, Analogues of Firefly Luciferase Containing Modified Arginine Residues, Biochemistry, 46, 4066-4076 (2007).
M. Duca, D. J. Maloney, M. Lodder, B. Wang and S. M. Hecht, Synthesis of Bisaminoacylated pdCpAs and Tandemly Activated Transfer RNAs, Bioorg. Med. Chem., 15, 4629-4642 (2007).
J. A. Smith, D. J. Maloney, S. M. Hecht and D. A. Lannigan, Structural Basis for the Activity of the RSK-Specific Inhibitor, SL0101, Bioorg. Med. Chem., 15, 5018-5034 (2007).
V. A. Karginov, E. M. Nestorovich, F. Schmidtmann, T. M. Robinson, A. Yohannes, N. E. Fahmi, S. M. Bezrukov and S. M. Hecht, Inhibition of S. aureus α-Hemolysin and B. anthracis Lethal Toxin by β-Cyclodextrin Derivatives, Bioorg. Med. Chem., 15, 5424-5431 (2007).
M. A. Elban, M. Li, J. C. Chapuis, and S. M. Hecht, Synthesis and Biological Evaluation of Cepharadiones A and B and Structural Analogues, Bioorg. Med. Chem., 15, 6119-6125 (2007).
D. J. Maloney, N. Ghanem, J. Zhou and S. M. Hecht, Positional Assignment of Differentially Bisaminoacylated pdCpAs, Org. Biomol. Chem., 5, 3135-3138 (2007).
Q. Ma, Z. Xu, B. R. Schroeder, W. Sun, F. Wei, S. Hashimoto, K. Konishi, C. J. Leitheiser and S. M. Hecht, Biochemical Evaluation of a 108-Member Deglycobleomycin Library: Viability of a Selection Strategy for Identifying Bleomycin Analogues with Novel Properties, J. Am. Chem. Soc., 129, 12439-12452 (2007).
M. Duca, S. Chen and S. M. Hecht, Activation of Transfer RNAs with One and Two Amino Acids, Methods, 44, 87-99 (2008).
M. A. Elban and S. M. Hecht, Total Synthesis of the Topopyrones–A New Class of Topoisomerase I Poisons, J. Org. Chem., 73, 785-793 (2008).
Z. Gao, D. J. Maloney, L. M. Dedkova and S. M. Hecht, Inhibitors of DNA Polymerase b: Activity and Mechanism, Bioorg. Med. Chem., 16, 4331-4340 (2008).
L. Yakovleva, S. Chen, S. M. Hecht and S. Shuman, Chemical and Traditional Mutagenesis of Vaccinia DNA Topoisomerase Provide Insights to Cleavage Site Recognition and Transesterification Chemistry, J. Biol. Chem., 283, 16093-16103 (2008).
Y. Akiyama, Q. Ma, E. Edgar, A. Laikhter and S. M. Hecht, A Novel DNA Hairpin Substrate for Bleomycin, Org. Lett., 10, 2127-2130 (2008).
M. Duca, S. Chen and S. M. Hecht, Modeling the Reactive Properties of Tandemly Activated tRNAs, Org. Biomol. Chem., 6, 3292-3299 (2008).
Y. Akiyama, Q. Ma, E. Edgar, A. Laikhter and S. M. Hecht, Identification of Strong DNA Binding Motifs for Bleomycin, J. Am. Chem. Soc., 130, 9650-9651 (2008).
S. Chen and S. M. Hecht, Synthesis of pdCpAs and Transfer RNAs Activated with Derivatives of Aspartic Acid and Cysteine, Bioorg. Med. Chem., 16, 9023-9031 (2008).
Q. A. Khan, M. A. Elban and S. M. Hecht, The Topopyrones Poison Human DNA Topoisomerases I and II, J. Am. Chem. Soc., 130, 12888-12889 (2008).
S. M. Hecht, Synthesis of Modified Proteins Using Misacylated tRNAs, in "Protein Engineering", U. L. RajBhandary and C. Koehrer, Eds., Springer, 2008, pp 251-266.
J.-C. Chapuis, O. Khdour, X. Cai, J. Lu and S. M. Hecht, Synthesis and Characterization of Δlac-Acetogenins that Potently Inhibit Mitochondrial Complex I, Bioorg. Med. Chem., 17, 2204-2209 (2009).
Q. Ma, Y. Akiyama, Z. Xu, K. Konishi and S. M. Hecht, Identification and Cleavage Site Analysis of DNA Sequences Bound Strongly by Bleomycin, J. Am. Chem. Soc., 131, 2013-2022 (2009).
J.-C. Chapuis, R. M. Schmaltz, K. S. Tsosie, M. Belohlavek and S. M. Hecht, Carbohydrate Dependent Targeting of Tumor Cells by a Bleomycin-Microbubble Conjugate, J. Am. Chem. Soc., 131, 2438-2439 (2009).
Q. A. Khan, J. Lu and S. M. Hecht, Calothrixins: a New Class of Human DNA Topoisomerase I Poisons, J. Nat Prod., 72, 438-442 (2009).
S. M. Hecht, Nucleic Acids: Expanding the Structural and Functional Horizons, J. Am. Chem. Soc., 131, 3791-3793 (2009).
S. Kendrick, Y. Akiyama, S. M. Hecht and L. H. Hurley, i-Motif in the bcl-2 P1 Promoter Forms an Unexpectedly Stable Structure with a Unique 8:5:7 Loop Folding Pattern, J. Am. Chem. Soc., 131, 17667-17676 (2009).
S. J. Leiris, O. M. Khdour, Z. J. Segerman, K. S. Tsosie, J.-C.Chapuis and S. M. Hecht, Synthesis and Evaluation of Verticipyrone Analogues as Mitochondrial Complex I Inhibitors, Bioorg. Med. Chem., 18, 3481-3493 (2010).
J. S. Armstrong, O. Khdour and S. M. Hecht, Does Oxidative Stress Contribute to the Pathology of Friedreich’s Ataxia? A Radical Question, FASEB J., 24, 2152-2163 (2010).
D. Y. Duveau, P. M. Arce, R. A. Schoenfeld, N. Raghav, G. A. Cortopassi and S. M. Hecht, Synthesis and Characterization of MitoQ and Idebenone Analogues as Mediators of Oxygen Consumption in Mitochondria, Bioorg. Med. Chem., 18, 6429-6441 (2010).
J. Lu, O. M. Khdour, J. S. Armstrong and S. M. Hecht, Design, Synthesis and Evaluation of an a-Tocopherol Analogue as a Mitochondrial Antioxidant, Bioorg. Med. Chem., 18, 7628-7638 (2010).
R. A. Giroux and S. M. Hecht, Characterization of Bleomycin Cleavage Sites in Strongly Bound Hairpin DNAs, J. Am. Chem. Soc., 132, 16987-16996 (2010).
J. Lu, X. Cai and S. M. Hecht, Concise Synthesis of Bicyclic Pyridinol Antioxidants, Org. Lett., 12, 5189-5191 (2010).
N. J. Rahier, C. J. Thomas and S. M. Hecht, Camptothecin and its Analogues, in "Antitumor Agents from Natural Sources," G. M. Cragg, D. G. I. Kingston and D. J. Newman, Eds., CRC Press, 2nd edition, 2011, pp 5-25, Boca Raton.
S. M. Hecht, Bleomycin Group Antitumor Agents, in "Antitumor Agents from Natural Sources," G. M. Cragg, D. G. I. Kingston and D. J. Newman, Eds., CRC Press, 2nd edition, 2011, pp 451-478, Boca Raton.
O. M. Khdour, J. Lu and S. M Hecht, An Acetate Prodrug of a Pyridinol-Based Vitamin E Analogue, Pharm. Res., 28, 2896-2909 (2011).
X. Cai, P. A. Zaleski, A. Cagir and Sidney M. Hecht, Deglycobleomycin A6 analogues modified in the methylvalerate moiety, Bioorg. Med. Chem., 19, 3831-3844 (2011).
P. M. Arce, O. M. Khdour, R. Goldschmidt, J. S. Armstrong and S. M. Hecht, A Strategy for Suppressing Redox Stress Within Mitochondria, ACS Med. Chem. Lett., 2, 608-613 (2011).
M. Duca, C. Trindle and S. M. Hecht, Structural Basis for the Exceptional Stability of Bisaminoacylated Nucleotides and Transfer RNAs, J. Am. Chem. Soc., 133, 11368-11377 (2011).
R. C. Nangreave, L. M. Dedkova, S. Chen and S. M. Hecht, A New Strategy for the Synthesis of Bisaminoacylated tRNAs, Org. Lett., 13, 4906–4909 (2011).
S. Chen, Y. Zhang and S. M. Hecht, p-Thiophenylalanine-Induced DNA Cleavage and Religation Activity of a Modified Vaccinia Topoisomerase IB, Biochemistry, 50, 9340-9351 (2011).
H. Rosso, V. Richard, M. DePaolis, V. C. Collin, S. Dey, S. M. Hecht, C. Prandi and J. Maddaluno, One-pot Regio- and Stereoselective Diversity-oriented Synthesis of a’-Methoxy-g-pyrones from a’, a’-Dimethoxy-g-pyrone, J. Org. Chem., 76, 9429-9437 (2011).
L. M. Dedkova, N. E. Fahmi, R. Paul, M. del Rosario, L. Zhang, S. Chen, G. Feder and S. M. Hecht, β-Puromycin Selection of Modified Ribosomes for in vitro Incorporation of β-Amino Acids, Biochemistry, 51, 401-415 (2012).
S. Chen, N. E. Fahmi, R. C. Nangreave, Y. Mehellou and S. M. Hecht, Synthesis of pdCpAs and Transfer RNAs Activated with Thiothreonine and Derivatives, Bioorg. Med Chem., 20, 2679-2689 (2012).
X. Cai, O. M. Khdour, J. Jaruvangsanti and S. M. Hecht, Simplified a-Tocopherol Analogues as Potent Mitochondrial Antioxidants: Synthesis and Biological Evaluation, Bioorg. Med. Chem., 20, 3584-3595 (2012).
P. A. Zaleski, R. Maini, S. J. Leiris, M. A. Elban and S. M. Hecht, Synthesis and Biological Activities of
Topopyrones, J. Nat. Prod., 75, 577-585 (2012).
P. M. Arce, R. Goldschmidt, O. M. Khdour, M. M. Madathil, J. Jaruvangsanti, S. Dey, D. M. Fash, J. S. Armstrong and S. M. Hecht, Analysis of the Structural and Mechanistic Factors in Antioxidants that Preserve Mitochondrial Function and Confer Cytoprotection, Bioorg. Med. Chem., 20, 5188-5201 (2012).
T. C. Bozeman, R. Nanjunda, C. Tang, Y. Liu, Z. J. Segerman, P. A. Zaleski, W. D. Wilson and S. M. Hecht, Dynamics of Bleomycin Interaction with a Strongly Bound Hairpin DNA Substrate, and Implications for Cleavage of the Bound DNA, J. Am. Chem. Soc., 134, 17842-17845 (2012).
S. Chen, L. Wang, N. E. Fahmi, S. J. Benkovic and S. M. Hecht, Two Pyrenylalanines in Dihydrofolate Reductase
Form an Excimer Enabling the Study of Protein Dynamics, J. Am. Chem. Soc., 134, 18883-18885 (2012).
M. M. Madathil, O. M. Khdour, J. Jaruvangsanti and S. M. Hecht, Synthesis and Biological Activities of N-(3-carboxypropyl)-5-amino-2-hydroxy-3-tridecyl-1,4-benzoquinone and Analogues, J. Nat. Prod., 75, 2209-2215 (2012).
R. Goldschmidt, P. M. Arce, O. M. Khdour, V. C. Collin, S. Dey, J. Jaruvangsanti, D. M. Fash and S. M. Hecht, Effects of Cytoprotective Antioxidants on Lymphocytes from Representative Mitochondrial Neurodegenerative Diseases, Bioorg. Med. Chem., 21, 969-978 (2013).
R. M. Mrozowski, R. Vemula, B. Wu, Q. Zhang, B. R. Schroeder, M. K. Hilinski, D. E. Clark, S. M. Hecht, G. A. O’Doherty, and D. A. Lannigan, Improving the Affinity of SL0101 for RSK Using Structure-Based Design, ACS Med. Chem. Lett., 4, 175-179 (2013).
R. Maini, D. Nguyen, S. Chen, L. M. Dedkova, S. Roy Chowdhury, R. Alcala-Torano and S. M. Hecht, Incorporation of b-Amino Acids into Dihydrofolate Reductase by Ribosomes Having Modifications in the Peptidyltransferase Center, Bioorg. Med Chem., 21, 1088-1096 (2013).
D. M. Fash, O. M. Khdour, S. J. Sahdeo, R. Goldschmidt, J. Jaruvangsanti, S. Dey, P. M. Arce, V. C. Collin, G. A. Cortopassi and S. M. Hecht, Effects of Alkyl Side Chain Modification of Coenzyme Q10 on Mitochondrial Respiratory Chain Function and Cytoprotection, Bioorg. Med. Chem., 21, 2346-2354 (2013).
Z. Yu, R. M. Schmaltz, T. C. Bozeman, R. Paul, M. J. Rishel, K. S. Tsosie and S. M. Hecht, Selective Tumor Cell Targeting by the Disaccharide Moiety of Bleomycin, J. Am. Chem. Soc, 135, 2883-2886 (2013).
O. M. Khdour, P. M. Arce, B. Roy and S. M. Hecht, An Optimized Pyrimidinol Multifunctional Radical Quencher, ACS Med. Chem. Lett.,4, 724-729 (2013).
Z. J. Segerman, B. Roy and S. M. Hecht, Characterization of Bleomycin-Mediated Cleavage of a Hairpin DNA Library, Biochemistry, 52, 5315-5327 (2013).
M. M. Madathil, O. M. Khdour, J. Jaruvangsanti and S. M. Hecht, A Structurally Simplified Analogue of Geldanamycin Exhibits Neuroprotective Activity, ACS Med. Chem. Lett., 4, 953-957 (2013).
S. Chen, N. E. Fahmi, L. Wang, C. Bhattacharya, S. J. Benkovic and S. M. Hecht, Detection of DHFR Conformational Change by FRET Using Two Fluorescent Amino Acids, J. Am Chem. Soc., 135, 12924-12927 (2013).
S. Chen, N. E. Fahmi, C. Bhattacharya, L. Wang, Y. Jin, S. J. Benkovic and S. M. Hecht, Fluorescent Biphenyl Derivatives of Phenylalanine Suitable for Protein Modification, Biochemistry, 52, 8580-8589 (2013).
P. Talukder, S. Chen, P. M. Arce and S. M. Hecht, Efficient Asymmetric Synthesis of Tryptophan Analogues Having Useful Photophysical Properties, Org. Lett., 16, 556-559 (2014).
S. Kendrick, H.-J. Kang, M. P. Alam, M. M. Madathil, P. Agrawal, V. Gokhale, D. Yang, S. M. Hecht and L. H. Hurley, The Dynamic Character of the BCL-2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds that Bind Selectively to the Alternative DNA Species, J. Am. Chem. Soc., 136, 4161-4171 (2014).
H.-J. Kang, S. Kendrick, S. M. Hecht and L. H. Hurley, The Transcriptional Complex Between the BCL2 i-Motif and
hnRNP LL is a Molecular Switch for Control of Gene Expression that can be Modulated by Small Molecules, J. Am.
Chem. Soc., 136, 4172-4183 (2014).
B. Roy and S. M. Hecht, Hairpin DNA Sequences Bound Strongly by Bleomycin Exhibit Enhanced Double-Strand
Cleavage, J. Am Chem. Soc., 136, 4382-4393 (2014).
C. Bhattacharya, Z. Yu, M. J. Rishel and S. M. Hecht, The Carbamoylmannose Moiety of
Bleomycin Mediates Selective Tumor Cell Targeting, Biochemistry, 53, 3264-3266
(2014).
M. P. Alam, O. M. Khdour, P. M. Arce, B. Roy, W. G. Johnson, Y. Chen, S. Dey and S. M. Hecht, Cytoprotective Pyridinol Antioxidants as Potential Therapeutic Agents for Neurodegenerative and Mitochondrial Diseases, Bioorg. Med. Chem., 22, 4935-4947 (2014).
P. Talukder, S. Chen, C. T. Liu, E. A. Baldwin, S. J. Benkovic and S. M. Hecht, Tryptophan-based Fluorophores for Studying Protein Conformational Changes, Bioorg. Med. Chem., 22, 5924-5934 (2014).
B. Roy, C. Tang, M. P. Alam and S. M. Hecht, DNA Methylation Reduces Binding and Cleavage by Bleomycin, Biochemistry, 53, 6103-6112 (2014).
B. R. Schroeder, M. I. Ghare, C. Bhattacharya, R. Paul, Z. Yu, P. A. Zaleski, T. C. Bozeman, M. J. Rishel and S. M. Hecht, The Disaccharide Moiety of Bleomycin Facilitates Uptake by Cancer Cells, J. Am. Chem. Soc., 136, 13641-13656 (2014).
C. Tang, A. Paul, M. P. Alam, B. Roy, W. D. Wilson and S. M. Hecht, A Short DNA Sequence Confers Strong Bleomycin Binding to Hairpin DNAs, J. Am. Chem. Soc., 136, 13715-13726 (2014).
M. M. Madathil, C. Bhattacharya, Z. Yu, R. Paul, M. J. Rishel and S. M. Hecht, Modified Bleomycin Disaccharides Exhibiting Improved Tumor Cell Targeting, Biochemistry, 53, 6800-6810 (2014).
X. Yu, P. Talukder, C. Bhattacharya, N. E. Fahmi, J. A. Lines, L. M. Dedkova, J. LaBaer, S. M. Hecht and S. Chen, Probing the CD4 Binding Pocket of HIV-1 gp120 Glycoprotein Using Unnatural Phenylalanine Analogues, Bioorg. Med. Chem. Lett., 24, 5699-5703 (2014).
J. A. Bernatchez, R. Paul, E. P. Tchesnokov, M. Ngure, G. L. Beilhartz, A. M. Berghuis, R. Lavoie, L. Li, A. Auger, R. A. Melnyk, J. A. Grobler, M. D. Miller, D. J. Hazuda, S. M. Hecht and M. Götte, Derivatives of Mesoxalic Acid Block Translocation of HIV-1 Reverse Transcriptase, J. Biol. Chem., 290, 1474-1484 (2015).
Z. Wang, P. Talukder, S. M. Hecht and S. Chen, Fluorescent CD4 Probe for Potential HIV-1 gp120 Protein Detection, Bioorg. Med. Chem. Lett. 25, 1182-1185 (2015).
D. Mastroeni, O. M. Khdour, P. M. Arce, S. M. Hecht and P. D. Coleman, Novel Antioxidants Protect Mitochondria from the Effects of Oligomeric Amyloid Beta and Contribute to the Maintenance of Epigenome Function, ACS Chem. Neurosci., 6, 588-598 (2015).
Z. Yu, R. Paul, C. Bhattacharya, T. C. Bozeman, M. J. Rishel, and S. M. Hecht, Structural Features Facilitating Tumor Cell Targeting and Internalization by Bleomycin and its Disaccharide, Biochemistry, 54, 3100-3109 (2015).
R. Maini, S. Roy Chowdhury, L. M. Dedkova, B. Roy, S. M. Daskalova, R. Paul, S. Chen and S. M. Hecht, Protein Synthesis with Ribosomes Selected for the Incorporation of b-Amino Acids, Biochemistry, 54, 3694-3706 (2015).
Y. V. Gerasimova, P. Yakovchuk, L. M. Dedkova, S. M. Hecht and D. M. Kolpashchikov, Expedited Quantification of Mutant ribosomal RNA by Binary Deoxyribosome (BiDz) Sensors, RNA, 21, 1834-1843 (2015).
R. Maini, L. M. Dedkova, R. Paul, M. M. Madathil, S. Roy Chowdhury, S. Chen and S. M. Hecht, Ribosome-Mediated Incorporation of Dipeptides and Dipeptide Analogues into Proteins in Vitro, J. Am. Chem. Soc., 137, 11206-11209 (2015).
S. Roy Chowdhury, R. Maini, L. M. Dedkova and S. M. Hecht, Synthesis of Fluorescent Dipeptidomimetics and their Ribosomal Incorporation into Green Fluorescent Protein, Bioorg. Med. Chem. Lett., 25, 4715-4718 (2015).
P. Talukder, S. Chen, B. Roy, P. Yakovchuk, M. M. Spiering, M. P. Alam, M. M.
Madathil, C. Bhattacharya, S. J. Benkovic and S. M. Hecht, Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA–Protein Interaction, Biochemistry, 54, 7457-7469 (2015).
S. Roy Chowdhury, P. S. Chauhan, L. M. Dedkova, X. Bai, S. Chen. P. Talukder and S. M. Hecht, Synthesis and Evaluation of a Library of Fluorescent Dipeptidomimetic Analogues as Substrates for Modified Bacterial Ribosomes, Biochemistry, 55, 2427-2440 (2016).
A. Chevalier, Y. Zhang, O. M. Khdour and S. M Hecht, Selective Functionalization of Antimycin A Through an N-Transacylation Reaction, Org. Lett., 18, 2395-2398 (2016).
P. Talukder, L. M. Dedkova, A. D. Ellington, P. Yakovchuk, J. Lim, E. V. Anslyn and S. M. Hecht, Synthesis of Alanyl Nucleobase Amino Acids and Their Incorporation into Proteins, Bioorg. Med. Chem., 24, 4177-4187 (2016).
B. Roy, P. Talukder, H.-J. Kang, S. S. Tsuen, M. P. Alam, L. H. Hurley and S. M. Hecht, Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA, J. Am. Chem. Soc., 138, 10950-10962 (2016).
A. Chevalier, M. P. Alam, O. M. Khdour, M. Schmierer, P. M. Arce and S. M. Hecht, Optimization of Pyrimidinol Antioxidants as Mitochondrial Protective Agents: ATP Production and Metabolic Stability, Bioorg. Med. Chem., 24, 5206-5220 (2016).
A. Chevalier, Y. Zhang, O. M. Khdour, J. B. Kaye and S. M. Hecht, Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting, J. Am. Chem. Soc., 138, 12009-12012 (2016).
D. Mastroeni, O. M. Khdour, E. Delvaux, J. Nolz, G. Olsen, N. Berchtold, C. Cotman, S. M. Hecht, and P. D. Coleman, Nuclear, but Not Mitochondrial Encoded Oxidative Phosphorylation Genes are Altered in Aging, Mild Cognitive Impairment, and Alzheimer’s Disease, Alzheimer’s & Dementia, 13, 510-519 (2017).
Y. Zhang, S. Jiang, D. Zhang, X. Bai, S. M. Hecht and S. Chen, DNA-Affibody Nanoparticles for Inhibiting Breast Cancer Cells Overexpressing HER2, Chem. Commun., 53, 573-576 (2017).
A. Chevalier, O. M. Khdour, M. Schmierer, I. Bandyopadhyay and S. M. Hecht, Influence of Substituent Heteroatoms on the Cytoprotective Properties of Pyrimidinol Antioxidants, Bioorg. Med. Chem., 25, 1703-1716 (2017).
S. M. Daskalova, C. Bhattacharya, L. M. Dedkova and S. M. Hecht, Probing the Flexibility of the Catalytic Nucleophile in the Lyase Catalytic Pocket of Human DNA Polymerase b with Unnatural Lysine Analogues, Biochemistry, 56, 500-513 (2017).
X. Bai, P. Talukder, S. M. Daskalova, B. Roy, S. Chen, Z. Li, L. M. Dedkova and S. M. Hecht, Enhanced Binding Affinity for an i-Motif DNA Substrate Exhibited by a Protein Containing Nucleobase Amino Acids, J. Am. Chem. Soc., 139, 4611-4614 (2017).
V. Arutla, J. Leal, X. Liu, S. Sokalingam, M. Raleigh, A. Adaralegbe, L. Liu, P. R. Pentel, S. M. Hecht and Y. Chang, Prescreening of Nicotine Hapten Linkers In Vitro to Select Hapten-conjugate Vaccine Candidates for Pharmacokinetics Evaluation In Vivo, ACS Comb. Sci., 19, 286-298 (2017).
Y. Zhang, A. Chevalier, O. M. Khdour, L. Morales Soto and S. M. Hecht, Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A, Planta Medica,, 83, 1377-1383 (2017).
S. Roy Chowdhury, O. M. Khdour, I. Bandyopadhyay and S. M. Hecht, Methylene Violet Analogues as Potential Therapeutic Agents for Neurodegenerative and Mitochondrial Diseases, Bioorg. Med. Chem., 25, 5537-5547 (2017).
S. Chen, R. Maini, X. Bai, R. C. Nangreave, L. M. Dedkova and S. M. Hecht, Incorporation of Phosphorylated Tyrosine into Proteins: In Vitro Translation and Study of Phosphorylated IkB-α and its Interaction with NF-kB, J. Am. Chem. Soc., 139, 14098-14108 (2017).
D. Mastroeni, J. Nolz, O. M. Khdour, S. Sekar, E. Delvaux, W. S. Liang, S. M. Hecht, and P. D. Coleman, Oligomeric Amyloid Beta Preferentially Targets Neuronal and Not Glial Mitochondrial Encoded mRNAs, Alzheimer’s & Dementia, 14, 775-786 (2018).
M. Gao, D. Daniel, H. Zou, S. Jiang, S. Lin, C. Huang, S. M. Hecht and S. Chen, Rapid Detection of a Dengue Virus RNA Sequence with Single Molecule Sensitivity Using Tandem Toehold-Mediated Displacement Reactions, Chem. Commun., 54, 968-971 (2018).
S. M. Daskalova, X. Bai and S. M. Hecht, Study of the Lyase Activity of Human DNA Polymerase b Using Analogues of the Intermediate Schiff Base Complex, Biochemistry, 57, 2711-2722 (2018).
O. M. Khdour, I. Bandyopadhyay, S. Roy Chowdhury, N. P. Visavadiya and S. M. Hecht, Lipophilic Methylene Blue Analogues Enhance Mitochondrial Function and Increase Frataxin Levels in a Cellular Model of Friedreich’s Ataxia, Bioorg. Med. Chem., 26, 3359-3369 (2018).
I. Bandyopadhyay, S. Roy Chowdhury, N. Visavadiya, S. M. Hecht and O. M. Khdour, Chemical Synthesis of Lipophilic Methylene Blue Analogues Which Increase Mitochondrial Biogenesis and Frataxin Levels, Data Brief, 20, 1105-1114 (2018).
O. M. Khdour, I. Bandyopadhyay, N. Visavadiya, S. Roy Chowdhury and S. M. Hecht, Phenothiazine Antioxidants Increase Mitochondrial Biogenesis and Frataxin Levels in Friedreich’s Ataxia Cells, MedChemComm, 9, 1491-1501 (2018).
S. Chen, X. Ji, M. Gao, L. M. Dedkova, and S. M. Hecht, In Cellulo Synthesis of Proteins Containing a Fluorescent Oxazole Amino Acid, J. Am. Chem. Soc., 141, 5597-5601 (2019).
L. M. Dedkova and S. M. Hecht, Expanding the Scope of Protein Synthesis Using Modified Bacterial Ribosomes, J. Am. Chem. Soc., 141, 6430-6447 (2019).
X. Ji, O. M. Khdour and S. M. Hecht, Multifunctional Radical Quenchers for the Treatment of Mitochondrial Disorders, Future Med. Chem., 11, 1605-1624 (2019).
M. Gao, J. J. Waggoner, S. M. Hecht and S. Chen, Selective Detection of Dengue Virus Serotypes Using Tandem Toehold-mediated Displacement Reactions, ACS Infect. Dis., 5, 1907-1914 (2019).
C. Zhang, S. Chen, X. Bai, L. M. Dedkova and S. M. Hecht, Alteration of Transcriptional Regulator Rob In Vivo: Enhancement of Promoter DNA Binding and Antibiotic Resistance in the Presence of Nucleobase Amino Acids, Biochemistry, 59, 1217-1220 (2020).
C. Zhang, S. Chen, L. M. Dedkova and S. M. Hecht, Effects of Nucleobase Amino Acids on the Binding of Rob to its Promoter DNA: Differential Alteration of DNA Affinity and Phenotype, Biochemistry, 59, 2111-2119 (2020).
S. M. Daskalova, B. M. Eisenhauer, M. Gao, X. Feng, X. Ji, Q. Cheng, N. E. Fahmi, S. Chen and S. M. Hecht, An Assay for DNA Polymerase b Lyase Inhibitors that Engage the Catalytic Nucleophile for Binding, Bioorg. Med. Chem., 28, 115642 (2020).
J. Liu, I. Bandyopadhyay, L. Zheng, O. M. Khdour and S. M. Hecht, Antiferroptic Activity of Phenothiazine Analogues: a Novel Therapeutic Strategy for Oxidative Stress Related Disease, ACS Med. Chem. Lett., 11, 2165-2173 (2020).
C. Zhang, X. Bai, L. M. Dedkova and S. M. Hecht, Protein Synthesis with Conformationally Constrained Cyclic Dipeptides, Bioorg. Med. Chem., 28, 115780 (2020).
C.-K. Hui, A. Tomilov, C. Garcia, X.-S. Jiang, D. M. Fash, O. M. Khdour, C. Rosso, G. Filippini, M. Prato, J. Graham, S. Hecht, P. Havel and G. Cortopassi, Novel Idebenone Analogs Block Shc's Access to Insulin Receptor to Improve Insulin Sensitivity, Biomed. Pharmacother., 132, 110823 (2020).
C. Zhang, P. Talukder, L. M. Dedkova and S. M. Hecht, Facilitated Synthesis of Proteins Containing Modified Dipeptides, Bioorg. Med. Chem., 41, 116210 (2021).
S. Chen, X. Ji, L. M. Dedkova and S. M. Hecht, Site-Selective Incorporation of Phosphorylated Tyrosine Into the p50 Subunit of NF-kB and Activation of its Downstream Gene CD40, Chem. Commun., 57, 12651-12654 (2021).
Research Activity:
- Petuskey,William T*, Bimonte-Nelson,Heather, Coon,David Wayne, Gonzalez,Graciela H, Hecht,Sidney Michael, Sierks,Michael Richard, Smith,Brian, Petuskey,William T*, Bimonte-Nelson,Heather, Coon,David Wayne, Gonzalez,Graciela H, Hecht,Sidney Michael, Sierks,Michael Richard, Smith,Brian, Wang,Yalin. FY14: Arizona Alzheimer's Disease Consortium. AADC(12/22/2014 - 6/30/2014).
- Hecht,Sidney Michael*, Dedkova,Larisa. Selection of Modified Ribosomes Using Novel Puromycins. HHS-NIH-NIBIB(9/13/2013 - 8/31/2016).
- Chang,Yung*, Hecht,Sidney Michael, Kumar,Sudhir, Yan,Hao. Rational design and targeted selection of effective DNA-scaffolded nicotine vaccines (Chang). HHS-NIH-NIDA(4/15/2013 - 2/29/2016).
- Hecht,Sidney Michael*. Mulltifunctional Radical Quenchers for the Treatment of Mitochondrial Disorders Evaluation in Cellular Disease Models. UMDF(9/17/2012 - 10/31/2013).
- Hecht,Sidney Michael*. Multifunctional Radical Quenchers for the Treatment of Mitochondrial Disorders Exploration of the MRQ B Series. UMDF(9/17/2012 - 12/31/2013).
- Hecht,Sidney Michael*. Advanced Generation Multifunctional Radical Quenchers. FARA(8/1/2012 - 10/30/2013).
- Hecht,Sidney Michael*. Misacylated Suppressor tRNA Transcripts. SAIC(10/1/2011 - 1/16/2014).
- Chang,Yung*, Hecht,Sidney Michael, Yan,Hao. TURNABLE NICOTINE DNA-NANOVACCINES. HHS-NIH-NIDA(4/1/2011 - 3/31/2014).
- Hecht,Sidney Michael*. Therapeutic Strategies for rescuing mitochondrial function in Alzhemier's disease. Banner(1/1/2011 - 6/30/2012).
- Hecht,Sidney Michael*. Multifunctional Radical Quenchers for the Treatment of Friedreich's Ataxia. FARA(6/5/2010 - 12/31/2011).
- Hecht,Sidney Michael*. Dynamic Properties that Enhance Enzyme Function. HHS-NIH-NIGMS(4/1/2010 - 3/31/2015).
- Hecht,Sidney Michael*. Molecular Recognition by Bleomycin. HHS-NIH-NCI(1/18/2010 - 12/31/2015).
- Hecht,Sidney Michael*. Bleomycin-induced Pulmonary Toxicity: Origins and Mechanisms of Pro-fibrotic Activities in the Lung. MAYO CLINIC SCOTTSDALE(1/1/2009 - 12/31/2009).
- Hecht,Sidney Michael*. Inhibitors of p90Rsk. HHS-NIH-NCI(8/6/2008 - 1/31/2010).
- Hecht,Sidney Michael*. Analysis and Restoration of Mitochondrial Function. FARA(5/15/2008 - 8/31/2009).
| Summer 2022 | |
|---|---|
| Course Number | Course Title |
| BIO 495 | Undergraduate Research |
| Spring 2022 | |
|---|---|
| Course Number | Course Title |
| CHM 598 | Special Topics |
| BCH 598 | Special Topics |
| Fall 2021 | |
|---|---|
| Course Number | Course Title |
| MBB 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
| Summer 2021 | |
|---|---|
| Course Number | Course Title |
| BIO 495 | Undergraduate Research |
| Fall 2020 | |
|---|---|
| Course Number | Course Title |
| MBB 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
| NAN 598 | Special Topics |
| CHM 598 | Special Topics |
| BCH 598 | Special Topics |
| Summer 2020 | |
|---|---|
| Course Number | Course Title |
| BIO 495 | Undergraduate Research |
| Fall 2019 | |
|---|---|
| Course Number | Course Title |
| MBB 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
| NAN 598 | Special Topics |
| CHM 598 | Special Topics |
| BCH 598 | Special Topics |
| Summer 2019 | |
|---|---|
| Course Number | Course Title |
| BIO 495 | Undergraduate Research |
| Fall 2018 | |
|---|---|
| Course Number | Course Title |
| MBB 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
| BCH 598 | Special Topics |
| CHM 598 | Special Topics |
| Summer 2018 | |
|---|---|
| Course Number | Course Title |
| BIO 495 | Undergraduate Research |
| Fall 2017 | |
|---|---|
| Course Number | Course Title |
| MBB 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
| NAN 598 | Special Topics |
| CHM 598 | Special Topics |
| BCH 598 | Special Topics |
Presentations:
- Sidney Hecht. Invited Participant. A-T Childrens Proj Wkshp on Mitochondria/Metabolic Signaling in Ataxia-Telangiectasia, Tarrytown, NY (Dec 2014).
- Sidney Hecht. Invited Lecturer. GlaxoSmithKline Mitochondrial Science Day, Collegeville, Pennsylvania (Sep 2014).
- Sidney Hecht. Lecturer. Scripps Florida: External Seminar Series, Jupiter, Florida (Sep 2014).
- Sidney Hecht. Plenary Lecturer. Fusion Conference on Natural Products: A Celebration and Resurrection with Reverse Pharma., Chicago (Jul 2014).
- Sidney Hecht. Invited Lecturer. Mitochondrial Medicine 2014, United Mitochondrial Disease Foundation, Pittsburgh, Pennsylvania (Jun 2014).
- Sidney Hecht. Invited Lecturer. Isis Pharmaceuticals, Carlsbad, California (May 2014).
- Sidney Hecht. Invited Lecturer. 247th National ACS Meeting, Symposium on Frontiers of Nucleic Acid Chemistry, Dallas, Texas (Mar 2014).
- Sidney Hecht. Invited Lecturer. York University (Chemistry Department), Toronto, Canada (Mar 2014).
- Sidney Hecht. Invited Lecturer. Ohio State University: University Molecular Life Sciences Seminar Series, Columbus, Ohio (Feb 2014).
- Sidney Hecht. Invited Lecturer. Arizona State University (Department of Chemistry and Biochemistry), Tempe, Arizona (Feb 2014).
- Sidney Hecht. Invited Lecturer. University of Colorado Cancer Center Symposium Series, Denver, Colorado (Dec 2013).
- Sidney Hecht. Invited Lecturer. AARS 2013 9th International Symposium on Aminoacyl-tRNA Synthetases, Hakone, Japan (Oct 2013).
- Sidney Hecht. Invited Lecturer. Evelyn F. McKnight Brain Institute Symposium/University of Arizona, Tucson, Arizona (Oct 2013).
- Sidney Hecht. Invited Lecturer. Jacques Monod Conference on DNA Methylation and Demethylation, Roscoff, France (Sep 2013).
- Sidney Hecht. Invited Lecturer. Lanzhou University/College of Chemistry and Chemical Engineering, China (Jul 2013).
- Sidney Hecht. Invited Lecturer. The 9th SINO-US Chemistry Professors Conference/Sichuan University, China (Jul 2013).
- Sidney Hecht. Invited Lecturer. Wuhan University/College of Chemistry and Molecular Sciences, China (Jul 2013).
- Sidney Hecht. Invited Lecturer. Peking University/School of Pharmaceutical Sciences, China (Jul 2013).
- Sidney Hecht. Plenary Lecturer. 2012 IOCD International Conference on Functional Molecules in Nature, Nanjing, China (Nov 2012).
- Sidney Hecht. Invited Lecturer. Shanghai Institute of Materia Medica (Oct 2012).
- Sidney Hecht. Invited Lecturer. American Chemical Society Symposium, Shanghai Institute of Organic Chemistry (Sep 2012).
- Sidney Hecht. Invited Lecturer. Joint Chinese Chem. Soc.-American Chem. Soc. Symposium, Annual Meeting of Chin. Chem. Soc., Sichuan (Aug 2012).
- Sidney Hecht. Invited Lecturer. Translational Medicine in Arizona. Networks, Partnerships and Initiatives, Flagstaff, Arizona (Jun 2012).
- Sidney Hecht. Invited Lecturer. 2012 Arizona Alzheimer’s Consortium Annual Scientific Conference, Barrow Neurological Institute (May 2012).
- Sidney Hecht. Invited Lecturer. Université de Rouen (Chemistry Department) (Apr 2012).
- Sidney Hecht. Invited Lecturer. Workshop on Mitochondria, Metabolism and Cancer, Tempe, Arizona (Mar 2012).
- Sidney Hecht. Invited Lecturer. 2012 Arizona Alzheimer’s Disease Consortium Retreat, Tuba City, Arizona (Feb 2012).
- Sidney Hecht. Invited Lecturer. Peking University (School of Pharmaceutical Sciences (Nov 2011).
- Sidney Hecht. Invited Lecturer. Wuhan University (College of Chemistry and Molecular Sciences) (Nov 2011).
- Sidney Hecht. Invited Lecturer. 1st International Conference on Chemical and Structural Biology of Nucleic Acids and Proteins (Sep 2011).
- Sidney Hecht. Invited Lecturer. Pierre Fabre (Centre de Recherche et de Développement) (Aug 2011).
- Sidney Hecht. Invited Lecturer. Institut de Biologie Moléculaire et Cellulaire du CNRS, Université de Strasbourg (Jun 2011).
- Sidney Hecht. Invited Lecturer. Institut de Science et d'Ingénierie Supramoléculaire, Université de Strasbourg (Jun 2011).
- Sidney Hecht. Invited Lecturer. Friedreich’s Ataxia Research Alliance (Board of Directors) (Apr 2011).
- Sidney Hecht. Invited Lecturer. Academia Sinica, Taipei (Institute of Chemistry) (Mar 2011).
- Sidney Hecht. Invited Lecturer. Academia Sinica, Taipei (Genomics Research Institute) (Mar 2011).
- Sidney Hecht. Invited Lecturer. National Taiwan University (Chemistry Department) (Mar 2011).
- Sidney Hecht. Invited Lecturer. Banner Sun Health Research Institute (May 2010).
- Sidney Hecht. Invited Lecturer. 240 National ACS Meeting, Symposium on Recognition of DNA: Recent Advances, Boston (Apr 2010).
- Sidney Hecht. Invited Lecturer. Penwest Pharmaceuticals (Mar 2010).
- Sidney Hecht. Invited Lecturer. AIM 2010 (Third Ataxia Investigator's Meeting), Chicago (Feb 2010).
- Sidney Hecht. Invited Lecturer. General Electric Global Research (Jan 2010).
- Sidney Hecht. Invited Lecturer. University of Missouri (Chemistry Department) (Jul 2009).
- Sidney Hecht. Invited Lecturer. University of Missouri (Biochemistry Department) (Jun 2009).
- Sidney Hecht. Chemical Biology in the 21st Century, University of Buffalo, Buffalo, NY. Invited Lecturer (May 2009).
- Sidney Hecht. Friedreich’s Ataxia Research Alliance Therapeutics Symposium, Philadelphia. Invited Lecturer (Apr 2009).
- Sidney Hecht. Invited Lecturer. Institut de Chimie des Substances Naturelle, Gif-sur-Yvette (Mar 2009).
- Sidney Hecht. Sidney M. Hecht Lectureship. University of Virginia (Feb 2009).
- Sidney Hecht. Invited Lecturer. Isis Pharmaceuticals (Jan 2009).
Service:
- FARA/NCATS Biomarker Meeting, Participant (2014 - Present)
- NIH Synthetic and Biological Chemistry B Study Section, Ad hoc Member (2014 - Present)
- Biodesign Industrial Liaison Team, Chair (2011 - Present)
- Biodesign Industrial Liaison Team, Chair (2011 - Present)
- Biodesign Industrial Liaison Team, Chair (2011 - Present)
- Biodesign Industrial Liaison Team, Chair (2011 - Present)
- Chemistry Department Interdepartmental Relations Commmittee, Committee Member (2010 - Present)
- Chemistry Department Interdepartmental Relations Commmittee, Committee Member (2010 - Present)
- Chemistry Department Interdepartmental Relations Commmittee, Committee Member (2010 - Present)
- Chemistry Department Interdepartmental Relations Commmittee, Committee Member (2010 - Present)
- Chemistry Department Interdepartmental Relations Commmittee, Committee Member (2010 - Present)
- Chemistry Department Faculty Search Committee, Committee Member (2009 - Present)
- Chemistry Department Faculty Search Committee, Committee Member (2009 - Present)
- Chemistry Department Faculty Search Committee, Committee Member (2009 - Present)
- Chemistry Department Faculty Search Committee, Committee Member (2009 - Present)
- Chemistry Department Faculty Search Committee, Committee Member (2009 - Present)
- Chemistry Department Graduate Programs Committee, Committee Member (2009 - Present)
- Chemistry Department Graduate Programs Committee, Committee Member (2009 - Present)
- Chemistry Department Graduate Programs Committee, Committee Member (2009 - Present)
- Chemistry Department Graduate Programs Committee, Committee Member (2009 - Present)
- Chemistry Department Graduate Programs Committee, Committee Member (2009 - Present)
- Chemistry Department Graduate Programs Committee, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for High Resolution Mass Spectrometry, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for High Resolution Mass Spectrometry, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for High Resolution Mass Spectrometry, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for High Resolution Mass Spectrometry, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for Magnetic Resonance Research Center, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for Magnetic Resonance Research Center, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for Magnetic Resonance Research Center, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for Magnetic Resonance Research Center, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for Magnetic Resonance Research Center, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for Magnetic Resonance Research Center, Committee Member (2009 - Present)
- Oncology Research/Anticancer Drug Design, Editorial Advisory Board (2002 - Present)
- Oncology Research/Anticancer Drug Design, Editorial Advisory Board (2002 - Present)
- Oncology Research/Anticancer Drug Design, Editorial Advisory Board (2002 - Present)
- Oncology Research/Anticancer Drug Design, Editorial Advisory Board (2002 - Present)
- Oncology Research/Anticancer Drug Design, Editorial Advisory Board (2002 - Present)
- Oncology Research/Anticancer Drug Design, Editorial Advisory Board (2002 - Present)
- Molecular Cancer Therapeutics, Editorial Advisory Board (2001 - Present)
- Molecular Cancer Therapeutics, Editorial Advisory Board (2001 - Present)
- Molecular Cancer Therapeutics, Editorial Advisory Board (2001 - Present)
- Molecular Cancer Therapeutics, Editorial Advisory Board (2001 - Present)
- Molecular Cancer Therapeutics, Editorial Advisory Board (2001 - Present)
- Molecular Cancer Therapeutics, Editorial Advisory Board (2001 - Present)
- Current Medicinal Chemistry-Anticancer Agents, Editorial Advisory Board (2000 - Present)
- Current Medicinal Chemistry-Anticancer Agents, Editorial Advisory Board (2000 - Present)
- Current Medicinal Chemistry-Anticancer Agents, Editorial Advisory Board (2000 - Present)
- Current Medicinal Chemistry-Anticancer Agents, Editorial Advisory Board (2000 - Present)
- Current Medicinal Chemistry-Anticancer Agents, Editorial Advisory Board (2000 - Present)
- Current Medicinal Chemistry-Anticancer Agents, Editorial Advisory Board (2000 - Present)
- Journal of the American Chemical Society, Associate Editor (1992 - Present)
- Journal of the American Chemical Society, Associate Editor (1992 - Present)
- Journal of the American Chemical Society, Associate Editor (1992 - Present)
- Journal of the American Chemical Society, Associate Editor (1992 - Present)
- Journal of the American Chemical Society, Associate Editor (1992 - Present)
- Journal of the American Chemical Society, Associate Editor (1992 - Present)
Expertise Areas: