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Biography:
Sidney M. Hecht is the director for the Center for BioEnergetics in the Biodesign Institute at Arizona State University. He researches diseases caused by defects in the body's energy production processes. Energy production is similar mechanistically to other molecular processes that he has studied extensively. He played a key role in the development of Hycamtin, a drug used to treat ovarian and lung cancer, as well as the study of the mechanism of the anti-tumor agent bleomycin.
In a career spanning more than three decades, Professor Hecht has held both academic and industrial research positions. He joins ASU from the University of Virginia, where he was a professor of both chemistry and biology. From 1981 to 1987, he concurrently held leadership positions in research and development for Smith Kline and French Laboratories. Prior to his 28 years at the University of Virginia, he was a faculty member at MIT. Hecht is the co-founder of Edison Pharmaceuticals, a pharmaceutical company focusing on inherited mitochondrial disorders. He earned a B.A. in chemistry from the University of Rochester and a Ph.D. in chemistry with emphasis in biochemistry from the University of Illinois.
Education:
- Ph.D. Chemistry (minor Biochemistry), University of Illinois 1970
- B.A. Chemistry, University of Rochester 1966
Research Interests:
Energy production is similar mechanistically to other molecular processes that are studied extensively. Hecht played a key role in the development of Hycamtin, a drug used to treat ovarian and lung cancer, as well as the study of the mechanism of the anti-tumor agent bleomycin. In a career spanning more than three decades, Hecht has held both academic and industrial research positions. He joins ASU from the University of Virginia, where he was a professor of both chemistry and biology. From 1981 to 1987, he concurrently held leadership positions in research and development for Smith Kline and French Laboratories. Prior to his 28 years at the University of Virginia, he was a faculty member at MIT. Hecht is the co-founder of Edison Pharmaceuticals, a pharmaceutical company focusing on inherited mitochondrial disorders. He earned a BA in chemistry from the University of Rochester and a PhD in chemistry with emphasis in biochemistry from the University of Illinois.
Publications:
- Hui, C., Tomilov, A., Garcia, C., Jiang, X., Fash, D.M., Khdour, O.M., Rosso, C., Filippini, G., Prato, M., Graham, J., Hecht, S., Havel, P., Cortopassi, G. Novel idebenone analogs block Shc's access to insulin receptor to improve insulin sensitivity. Biomedicine & Pharmacotherapy (2020).
- Liu, J. Bandyopadhyay, I., Zheng, L., Khdour, O.M., Hecht, S.M. Antiferroptotic Activity of Phenothiazine Analogues: A Novel Therapeutic Strategy for Oxidative Stress Related Disease. ACS Medicinal Chemistry Letters (2020).
- Daskalova, SM, Eisenhauer, BM, Gao, M, Feng, X, Ji, X, Cheng, Q, Fahmi, NE, Khdour, OM, Chen, S, Hecht, SM. An assay for DNA polymerase beta lyase inhibitors that engage the catalytic nucleophile for binding. Bioorganic & Medicinal Chemistry (2020).
- Zhang, C, Chen, S, Dedkova, LM, Hecht, SM. Effects of Nucleobase Amino Acids on the Binding of Rob to Its Promoter DNA: Differential Alteration of DNA Affinity and Phenotype. Biochemistry (2020).
- Zhang, C, Chen, S, Bai, X, Dedkova, LM, Hecht, SM. Alteration of Transcriptional Regulator Rob In Vivo: Enhancement of Promoter DNA Binding and Antibiotic Resistance in the Presence of Nucleobase Amino Acids. Biochemistry (2020).
- Ji, X., Khdour, O.M., Hecht, S.M., Multifunctional radical quenchers as potential therapeutic agents for the treatment of mitochondrial dysfunction. Future Medicinal Chemistry (2019).
- Dedkova, L.M., Hecht, S.M, Expanding the Scope of Protein Synthesis Using Modified Ribosomes. Journal of the Amercian Chemical Society (2019).
- Chen, S, Ji, X, Gao, M, Dedkova, LM, Hecht, SM. In Cellulo Synthesis of Proteins Containing a Fluorescent Oxazole Amino Acid. Journal of the American Chemical Society (2019).
- Gao M, Daniel D, Zou H, Jiang S, Lin S, Huang C, Hecht SM, Chen S. Rapid detection of a dengue virus RNA sequence with single molecule sensitivity using tandem toehold-mediated displacement reactions. Chem Commun (Camb). (2018).
- Khdour, OM, Bandyopadhyay, I, Visavadiya, NP, Chowdhury, SR, Hecht, SM. Phenothiazine antioxidants increase mitochondrial biogenesis and frataxin levels in Friedreich's ataxia cells. Medchemcomm (2018).
- Khdour, OM, Bandyopadhyay, I, Chowdhury, SR, Visavadiya, NP, Hecht, SM. Lipophilic methylene blue analogues enhance mitochondrial function and increase frataxin levels in a cellular model of Friedreich's ataxia. Bioorganic & Medicinal Chemistry (2018).
- Mastroeni, D, Nolz, J, Khdour, OM, Sekar, S, Delvaux, E, Cuyugan, L, Liang, WS, Hecht, SM, Coleman, PD. Oligomeric amyloid beta preferentially targets neuronal and not glial mitochondrial-encoded mRNAs. Alzheimers & Dementia (2018).
- Daskalova, SM, Bai, X, Hecht, SM. Study of the Lyase Activity of Human DNA Polymerase beta Using Analogues of the Intermediate Schiff Base Complex. Biochemistry (2018).
- Roy Chowdhury S, Khdour OM, Bandyopadhyay I, Hecht SM. Lipophilic methylene violet analogues as modulators of mitochondrial function and dysfunction. Bioorg Med Chem. (2017).
- Chen S, Maini R, Bai X, Nangreave RC, Dedkova LM, Hecht SM. Incorporation of Phosphorylated Tyrosine into Proteins: In Vitro Translation and Study of Phosphorylated IκB-α and Its Interaction with NF-κB. J Am Chem Soc. (2017).
- Zhang Y, Chevalier A, Khdour OM, Soto LM, Hecht SM. Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A. Planta Med. (2017).
- Arutla V, Leal J, Liu X, Sokalingam S, Raleigh M, Adaralegbe A, Liu L, Pentel PR, Hecht SM, Chang Y. Prescreening of Nicotine Hapten Linkers in Vitro To Select Hapten-Conjugate Vaccine Candidates for Pharmacokinetic Evaluation in Vivo. ACS Comb Sci. (2017).
- Bai X, Talukder P, Daskalova SM, Roy B, Chen S, Li Z, Dedkova LM, Hecht SM. Enhanced Binding Affinity for an i-Motif DNA Substrate Exhibited by a Protein Containing Nucleobase Amino Acids. J Am Chem Soc. (2017).
- Chevalier A, Khdour OM, Schmierer M, Bandyopadhyay I, Hecht SM. Influence of substituent heteroatoms on the cytoprotective properties of pyrimidinol antioxidants. Bioorg Med Chem. (2017).
- Daskalova SM, Bhattacharya C, Dedkova LM, Hecht SM. Probing the Flexibility of the Catalytic Nucleophile in the Lyase Catalytic Pocket of Human DNA Polymerase β with Unnatural Lysine Analogues. Biochemistry (2017).
- Zhang Y, Jiang S, Zhang D, Bai X, Hecht SM, Chen S. DNA-affibody nanoparticles for inhibiting breast cancer cells overexpressing HER2. Chem Commun (Camb) (2017).
- Mastroeni D, Khdour OM, Delvaux E, Nolz J, Olsen G, Berchtold N, Cotman C, Hecht SM, Coleman PD. Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease. Alzheimers Dement. (2017).
- Chevalier A, Alam MP, Khdour OM, Schmierer M, Arce PM, Cripe CD, Hecht SM. Optimization of pyrimidinol antioxidants as mitochondrial protective agents: ATP production and metabolic stability. Bioorg Med Chem. (2016).
- Kendrick S, Kang HJ, Alam MP, Madathil MM, Agrawal P, Gokhale V, Yang D, Hecht SM, Hurley LH. Correction to "The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure". J Am Chem Soc. (2016).
- Chevalier A, Zhang Y, Khdour OM, Kaye JB, Hecht SM. Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting. J Am Chem Soc. (2016).
- Roy B, Talukder P, Kang HJ, Tsuen SS, Alam MP, Hurley LH, Hecht SM. Interaction of Individual Structural Domains of hnRNP LL with the BCL2 Promoter i-Motif DNA. J Am Chem Soc. (2016).
- Talukder P, Dedkova LM, Ellington AD, Yakovchuk P, Lim J, Anslyn EV, Hecht SM. Synthesis of alanyl nucleobase amino acids and their incorporation into proteins. Bioorg Med Chem. (2016).
- Chevalier A, Zhang Y, Khdour OM, Hecht SM. Selective Functionalization of Antimycin A Through an N-Transacylation Reaction. Org Lett. (2016).
- Chowdhury SR, Chauhan PS, Dedkova LM, Bai X, Chen S, Talukder P, Hecht SM. Synthesis and Evaluation of a Library of Fluorescent Dipeptidomimetic Analogues as Substrates for Modified Bacterial Ribosomes. Biochemistry (2016).
- Talukder P, Chen S, Roy B, Yakovchuk P, Spiering MM, Alam MP, Madathil MM, Bhattacharya C, Benkovic SJ, Hecht SM. Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA-Protein Interaction. Biochemistry (2015).
- Chowdhury SR, Maini R, Dedkova LM, Hecht SM. Synthesis of fluorescent dipeptidomimetics and their ribosomal incorporation into green fluorescent protein. Bioorg Med Chem Lett. (2015).
- Maini R, Dedkova LM, Paul R, Madathil MM, Chowdhury SR, Chen S, Hecht SM. Ribosome-Mediated Incorporation of Dipeptides and Dipeptide Analogues into Proteins in Vitro. J Am Chem Soc. (2015).
- Gerasimova YV, Yakovchuk P, Dedkova LM, Hecht SM, Kolpashchikov DM. Expedited quantification of mutant ribosomal RNA by binary deoxyribozyme (BiDz) sensors. RNA (2015).
- J. A. Bernatchez, R. Paul, E. P. Tchesnokov, M. Ngure, G. L. Beilhartz, A. M. Berghuis, R. Lavoie, L. Li, A. Auger, R. A. Melnyk, J. A. Grobler, M. D. Miller, D. J. Hazuda, S. M. Hecht and M. Götte, Derivatives of Mesoxalic Acid Block Translocation of HIV-1 Reverse Transcriptase, J. Biol. Chem. (2015).
- Z. Wang, P. Talukder, S. M. Hecht and S. Chen, Fluorescent CD4 Probe for Potential HIV-1 gp120 Protein Detection, Bioorg. Med. Chem. Lett. (2015).
- D. Mastroeni, O. M. Khdour, P. M. Arce, S. M. Hecht and P. D. Coleman, Novel Antioxidants Protect Mitochondria from the Effects of Oligomeric Amyloid Beta and Contribute to the Maintenance of Epigenome Function, ACS Chem. Neurosci. (2015).
- Z. Yu, R. Paul, C. Bhattacharya, T. C. Bozeman, M. J. Rishel, and S. M. Hecht, Structural Features Facilitating Tumor Cell Targeting and Internalization by Bleomycin and its Disaccharide, Biochemistry (2015).
- R. Maini, S. R. Chowdhury, L. M. Dedkova, B. Roy, S. M. Daskalova, R. Paul, S. Chen and S. M. Hecht, Protein Synthesis with Ribosomes Selected for the Incorporation of b-Amino Acids, Biochemistry (2015).
- Y. V. Gerasimova, P. Yakovchuk, L. M. Dedkova, S. M. Hecht and D. M. Kolpashchikov, Expedited Quantification of Mutant ribosomal RNA by Binary Deoxyribosome (BiDz) Sensors, RNA (2015).
- R. Maini, L. M. Dedkova, R. Paul, M. M. Madathil, S. R. Chowdhury, S. Chen, and S. M. Hecht, Ribosome-Mediated Incorporation of Dipeptides and Dipeptide Analogues into Proteins in Vitro, J. Am. Chem. Soc. (2015).
- S. R. Chowdhury, R. Maini, L. M. Dedkova and S. M. Hecht, Synthesis of Fluorescent Dipeptidomimetics and their Ribosomal Incorporation into Green Fluorescent Protein, Bioorg. Med. Chem. Lett., (2015).
- P. Talukder, S. Chen, B. Roy, P. Yakovchuk, M. M. Spiering, M. P. Alam, M. M. Madathil, C. Bhattacharya, S. J. Benkovic and S. M. Hecht, Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA–Protein Interaction, Biochemistry (2015).
- B. R. Schroeder, M. I. Ghare, C. Bhattacharya, R. Paul, Z. Yu, P. A. Zaleski, T. C. Bozeman, M. J. Rishel and S. M. Hecht. The Disaccharide Moiety of Bleomycin Facilitates Uptake by Cancer Cells. Journal of the American Chemical Society (2014).
- B. Roy and S. M. Hecht. Hairpin DNA Sequences Bound Strongly by Bleomycin Exhibit Enhanced Double-Strand Cleavage. Journal of the American Chemical Society (2014).
- B. Roy, C. Tang, M. P. Alam and S. M. Hecht. DNA Methylation Reduces Binding and Cleavage by Bleomycin. Biochemistry (2014).
- C. Bhattacharya, Z. Yu, M. J. Rishel and S. M. Hecht. The Carbamoylmannose Moiety of Bleomycin Mediates Selective Tumor Cell Targeting. Biochemistry (2014).
- C. Tang, A. Paul, M. P. Alam, B. Roy, W. D. Wilson and S. M. Hecht. A Short DNA Sequence Confers Strong Bleomycin Binding to Hairpin DNAs. Journal of the American Chemical Society (2014).
- H.-J. Kang, S. Kendrick, S. M. Hecht and L. H. Hurley. The Transcriptional Complex Between the BCL2 i-Motif and hnRNP LL is a Molecular Switch for Control of Gene Expression that can be Modulated by Small Molecules. Journal of the American Chemical Society (2014).
- M. M. Madathil, C. Bhattacharya, Z. Yu, R. Paul, M. J. Rishel and S. M. Hecht. Modified Bleomycin Disaccharides Exhibiting Improved Tumor Cell Targeting. Biochemistry (2014).
- M. P. Alam, O. M. Khdour, P. M. Arce, B. Roy, W. G. Johnson, Y. Chen, S. Dey and S. M. Hecht. Cytoprotective Pyridinol Antioxidants as Potential Therapeutic Agents for Neurodegenerative and Mitochondrial Diseases. Bioorganic Medicinal Chemistry (2014).
- P. Talukder, S. Chen, C. T. Liu, E. A. Baldwin, S. J. Benkovic and S. M. Hecht. Tryptophan-based Fluorophores for Studying Protein Conformational Changes. Bioorganic Medicinal Chemistry (2014).
- P. Talukder, S. Chen, P. M. Arce and S. M. Hecht. Efficient Asymmetric Synthesis of Tryptophan Analogues Having Useful Photophysical Properties. Organic Letters (2014).
- S. Kendrick, H.-J. Kang, M. P. Alam, M. M. Madathil, P. Agrawal, V. Gokhale, D. Yang, S. M. Hecht and L. H. Hurley. The Dynamic Character of the BCL-2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds that Bind Selectively to the Alternative DNA Species. Journal of the American Chemical Society (2014).
- X. Yu, P. Talukder, C. Bhattacharya, N. E. Fahmi, J. A. Lines, L. M. Dedkova, J. LaBaer, S. M. Hecht and S. Chen. Probing the CD4 Binding Pocket of HIV-1 gp120 Glycoprotein Using Unnatural Phenylalanine Analogues. Bioorganic Medicinal Chemistry Letters (2014).
- D. M. Fash, O. M. Khdour, S. J. Sahdeo, R. Goldschmidt, J. Jaruvangsanti, S. Dey, P. M. Arce, V. C. Collin, G. A. Cortopassi and S. M. Hecht. Effects of Alkyl Side Chain Modification of Coenzyme Q10 on Mitochondrial Respiratory Chain Function and Cytoprotection. Bioorganic Medicinal Chemistry (2013).
- M. M. Madathil, O. M. Khdour, J. Jaruvangsanti and S. M. Hecht. A Structurally Simplified Analogue of Geldanamycin Exhibits Neuroprotective Activity. ACS Medicinal Chemistry Letters (2013).
- O. M. Khdour, P. M. Arce, B. Roy and S. M. Hecht. An Optimized Pyrimidinol Multifunctional Radical Quencher. ACS Medicinal Chemistry Letters (2013).
- R. Goldschmidt, P. M. Arce, O. M. Khdour, V. C. Collin, S. Dey, J. Jaruvangsanti, D. M. Fash and S. M. Hecht. Effects of Cytoprotective Antioxidants on Lymphocytes from Representative Mitochondrial Neurodegenerative Diseases. Bioorganic Medicinal Chemistry (2013).
- R. M. Mrozowski, R. Vemula, B. Wu, Q. Zhang, B. R. Schroeder, M. K. Hilinski, D. E. Clark, S. M. Hecht, G. A. O’Doherty, and D. A. Lannigan. Improving the Affinity of SL0101 for RSK Using Structure-Based Design. ACS Medicinal Chemistry Letters (2013).
- R. Maini, D. Nguyen, S. Chen, L. M. Dedkova, S. Roy Chowdhury, R. Alcala-Torano and S. M. Hecht. Incorporation of beta-Amino Acids into Dihydrofolate Reductase by Ribosomes Having Modifications in the Peptidyltransferase Center. Bioorganic Medicinal Chemistry (2013).
- S. Chen, N. E. Fahmi, C. Bhattacharya, L. Wang, Y. Jin, S. J. Benkovic and S. M. Hecht. Fluorescent Biphenyl Derivatives of Phenylalanine Suitable for Protein Modification. Biochemistry (2013).
- S. Chen, N. E. Fahmi, L. Wang, C. Bhattacharya, S. J. Benkovic and S. M. Hecht. Detection of DHFR Conformational Change by FRET Using Two Fluorescent Amino Acids. Journal of the American Chemical Society (2013).
- Z. J. Segerman, B. Roy and S. M. Hecht. Characterization of Bleomycin-Mediated Cleavage of a Hairpin DNA Library. Biochemistry (2013).
- Z. Yu, R. M. Schmaltz, T. C. Bozeman, R. Paul, M. J. Rishel, K. S. Tsosie and S. M. Hecht. Selective Tumor Cell Targeting by the Disaccharide Moiety of Bleomycin. Journal of the American Chemical Society (2013).
- L. M. Dedkova, N. E. Fahmi, R. Paul, M. del Rosario, L. Zhang, S. Chen, G. Feder and S. M. Hecht. ß-Puromycin Selection of Modified Ribosomes for in vitro Incorporation of ß-Amino Acids. Biochemistry (2012).
- M. M. Madathil, O. M. Khdour, J. Jaruvangsanti and S. M. Hecht. Synthesis and Biological Activities of N-(3-carboxypropyl)-5-amino-2-hydroxy-3-tridecyl-1,4-benzoquinone and Analogues. Journal of Natural Products (2012).
- P. A. Zaleski, R. Maini, S. J. Leiris, M. A. Elban and S. M. Hecht. Synthesis and Biological Activities of Topopyrones. Journal of Natural Products (2012).
- P. M. Arce, R. Goldschmidt, O. M. Khdour, M. M. Madathil, J. Jaruvangsanti, S. Dey, D. M. Fash, J. S. Armstrong and S. M. Hecht. Analysis of the Structural and Mechanistic Factors in Antioxidants that Preserve Mitochondrial Function and Confer Cytoprotection. Bioorganic Medicinal Chemistry (2012).
- S. Chen, L. Wang, N. E. Fahmi, S. J. Benkovic and S. M. Hecht. Two Pyrenylalanines in Dihydrofolate Reductase Form an Excimer Enabling the Study of Protein Dynamics. Journal of the American Chemical Society (2012).
- S. Chen, N. E. Fahmi, R. C. Nangreave, Y. Mehellou and S. M. Hecht. Synthesis of pdCpAs and Transfer RNAs Activated with Thiothreonine and Derivatives. Bioorganic Medicinal Chemistry (2012).
- T. C. Bozeman, R. K. Nanjunda, C. Tang, Y. Liu, Z. J. Segerman, P. A. Zaleski, W. D. Wilson and S. M. Hecht. Dynamics of Bleomycin Interaction with a Strongly Bound Hairpin DNA Substrate, and Implications for Cleavage of the Bound DNA. Journal of the American Chemical Society (2012).
- X. Cai, O. M. Khdour, J. Jaruvangsanti and S. M. Hecht. Simplified Bicyclic Pyridinol Analogues Protect Mitochondrial Function. Bioorganic Medicinal Chemistry (2012).
- H. Rosso, V. Richard, M. DePaolis, V. C. Collin, S. Dey, S.M. Hecht, C. Prandi and J. Maddaluno. One-Pot Regio- and Stereoselective Diversity-Oriented Synthesis of a’- Methoxy-?-Pyrones from a’, a’-Dimethoxy-?-Pyrone. Journal of Organic Chemistry (2011).
- M. Duca, C. Trindle and S.M. Hecht. Structural Basis for the Exceptional Stability of Bisaminoacylated Nucleotides and Transfer RNAs. Journal of the American Chemical Society (2011).
- O.M. Khdour, J. Lu and S.M. Hecht. An Acetate Prodrug of a Pyridinol-Based Vitamin E Analogue. Pharmaceutical Research (2011).
- P.M. Arce, O.M. Khdour, R. Goldschmidt, J.S. Armstrong and S.M. Hecht. A Strategy for Suppressing Redox Stress Within Mitochondria. ACS Medicinal Chemistry Letters (2011).
- R.C. Nangreave, L.M. Dedkova, S. Chen and S.M. Hecht. A New Strategy for the Synthesis of Bisaminoacylated tRNAs. Organic Letters (2011).
- S. Chen, Y. Zhang and S.M. Hecht. p-Thiophenylalanine-Induced DNA Cleavage and Religation Activity of a Modified Vaccinia Topoisomerase IB. Biochemistry (2011).
- X. Cai, P.A. Zaleski, A. Cagir and S.M. Hecht. Deglycobleomycin A6 Analogues Modified in the Methylvalerate Moiety. Bioorganic Medicinal Chemistry (2011).
- N.J. Rahier, C.J. Thomas, S.M. Hecht. Camptothecin and its Analogues. Antitumor Agents from Natural Sources (2011).
- S.M. Hecht. Bleomycin Group Antitumor Agents. Antitumor Agents from Natural Sources (2011).
- D. Y. Duveau, P. M. Arce, R. A. Schoenfeld, N. Raghav, G. A. Cortopassi and S. M. Hecht. Synthesis and Characterization of MitoQ and Idebenone Analogues as Mediators of Oxygen Consumption in Mitochondria. Bioorganic Medicinal Chemistry (2010).
- J. Lu, O. M. Khdour, J. S. Armstrong and S. M. Hecht. Design, Synthesis and Evaluation of an Alpha-Tocopherol Analogue as a Mitochondrial Antioxidant. Bioorganic Medicinal Chemistry (2010).
- J. Lu, X. Cai and S. M. Hecht. A Concise Synthesis of Bicyclic Pyridinol Antioxidants. Organic Letters (2010).
- J. S. Armstrong, O. Khdour and S. M. Hecht. Does Oxidative Stress Contribute to the Pathology of Friedreich's Ataxia? A Radical Question. FASEB Journal (2010).
- R. A. Giroux and S. M. Hecht. Characterization of Bleomycin Cleavage Sites in Strongly Bound Hairpin DNAs. Journal of the American Chemical Society (2010).
- S. J. Leiris, O. M. Khdour, Z. J. Segerman, K. S. Tsosie, J.-C. Chapuis and S. M. Hecht. Synthesis and Evaluation of Verticipyrone Analogues as Mitochondrial Complex I Inhibitors. Bioorganic Medicinal Chemistry (2010).
- S. Kendrick, Y. Akiyama, S. M. Hecht and L. H. Hurley. The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern. Journal of the American Chemical Society (2009).
- O. M. Khdour, I. Bandyopadhyay, N. Visavadiya, S. Roy Chowdhury and S. M. Hecht. Lipophilic Phenothiazine Antioxidants Increase Mitochondrial Biogenesis and Frataxin Levels in a Cellular Model of Friedreich's Ataxia. MedChemComm (2018).
- I. Bandyopadhyay, S. Roy Chowdhury, N. Visavadiya, S. M. Hecht and O. M. Khdour. Chemical Synthesis of Lipophilic Methylene Blue Analogues Which Increase Mitochondrial Biogenesis and Frataxin Levels. Data Brief (2018).
- O. M. Khdour, I. Bandyopadhyay, S. Roy Chowdhury, N. P. Visavadiya and S. M. Hecht. Lipophilic Methylene Blue Analogues Enhance Mitochondrial Function and Increase Frataxin Levels in a Cellular Model of Friedreich’s Ataxia. Bioorganic Medicinal Chemistry (2018).
- S. M. Daskalova, X. Bai and S. M. Hecht. Study of the Lyase Activity of Human DNA Polymerase beta Using Analogues of the Intermediate Schiff Base Complex. Biochemistry (2018).
- M. Gao, D. Daniel, H. Zou, S. Jiang, S. Lin, C. Huang, S. M. Hecht and S. Chen. Rapid Detection of a Dengue Virus RNA Sequence with Single Molecule Sensitivity Using Tandem Toehold-Mediated Displacement Reactions. Chemical Communications (2018).
- D. Mastroeni, J. Nolz, O. M. Khdour, S. Sekar, E. Delvaux, W. S. Liang, S. M. Hecht, and P. D. Coleman. Oligomeric Amyloid Beta Preferentially Targets Neuronal and Not Glial Mitochondrial Encoded mRNAs. Alzheimer's & Dementia (2018).
Research Activity:
- Petuskey,William T*, Bimonte-Nelson,Heather, Coon,David Wayne, Gonzalez,Graciela H, Hecht,Sidney Michael, Sierks,Michael Richard, Smith,Brian, Petuskey,William T*, Bimonte-Nelson,Heather, Coon,David Wayne, Gonzalez,Graciela H, Hecht,Sidney Michael, Sierks,Michael Richard, Smith,Brian, Wang,Yalin. FY14: Arizona Alzheimer's Disease Consortium. AADC(12/22/2014 - 6/30/2014).
- Hecht,Sidney Michael*, Dedkova,Larisa. Selection of Modified Ribosomes Using Novel Puromycins. HHS-NIH-NIBIB(9/13/2013 - 8/31/2016).
- Chang,Yung*, Hecht,Sidney Michael, Kumar,Sudhir, Yan,Hao. Rational design and targeted selection of effective DNA-scaffolded nicotine vaccines (Chang). HHS-NIH-NIDA(4/15/2013 - 2/29/2016).
- Hecht,Sidney Michael*. Mulltifunctional Radical Quenchers for the Treatment of Mitochondrial Disorders Evaluation in Cellular Disease Models. UMDF(9/17/2012 - 10/31/2013).
- Hecht,Sidney Michael*. Multifunctional Radical Quenchers for the Treatment of Mitochondrial Disorders Exploration of the MRQ B Series. UMDF(9/17/2012 - 12/31/2013).
- Hecht,Sidney Michael*. Advanced Generation Multifunctional Radical Quenchers. FARA(8/1/2012 - 10/30/2013).
- Hecht,Sidney Michael*. Misacylated Suppressor tRNA Transcripts. SAIC(10/1/2011 - 1/16/2014).
- Chang,Yung*, Hecht,Sidney Michael, Yan,Hao. TURNABLE NICOTINE DNA-NANOVACCINES. HHS-NIH-NIDA(4/1/2011 - 3/31/2014).
- Hecht,Sidney Michael*. Therapeutic Strategies for rescuing mitochondrial function in Alzhemier's disease. Banner(1/1/2011 - 6/30/2012).
- Hecht,Sidney Michael*. Multifunctional Radical Quenchers for the Treatment of Friedreich's Ataxia. FARA(6/5/2010 - 12/31/2011).
- Hecht,Sidney Michael*. Dynamic Properties that Enhance Enzyme Function. HHS-NIH-NIGMS(4/1/2010 - 3/31/2015).
- Hecht,Sidney Michael*. Molecular Recognition by Bleomycin. HHS-NIH-NCI(1/18/2010 - 12/31/2015).
- Hecht,Sidney Michael*. Bleomycin-induced Pulmonary Toxicity: Origins and Mechanisms of Pro-fibrotic Activities in the Lung. MAYO CLINIC SCOTTSDALE(1/1/2009 - 12/31/2009).
- Hecht,Sidney Michael*. Inhibitors of p90Rsk. HHS-NIH-NCI(8/6/2008 - 1/31/2010).
- Hecht,Sidney Michael*. Analysis and Restoration of Mitochondrial Function. FARA(5/15/2008 - 8/31/2009).
| Fall 2020 | |
|---|---|
| Course Number | Course Title |
| MBB 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
| NAN 598 | Special Topics |
| CHM 598 | Special Topics |
| BCH 598 | Special Topics |
| Summer 2020 | |
|---|---|
| Course Number | Course Title |
| BIO 495 | Undergraduate Research |
| Fall 2019 | |
|---|---|
| Course Number | Course Title |
| MBB 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
| NAN 598 | Special Topics |
| CHM 598 | Special Topics |
| BCH 598 | Special Topics |
| Summer 2019 | |
|---|---|
| Course Number | Course Title |
| BIO 495 | Undergraduate Research |
| Fall 2018 | |
|---|---|
| Course Number | Course Title |
| MBB 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
| BCH 598 | Special Topics |
| CHM 598 | Special Topics |
| Summer 2018 | |
|---|---|
| Course Number | Course Title |
| BIO 495 | Undergraduate Research |
| Fall 2017 | |
|---|---|
| Course Number | Course Title |
| MBB 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
| NAN 598 | Special Topics |
| CHM 598 | Special Topics |
| BCH 598 | Special Topics |
| Summer 2017 | |
|---|---|
| Course Number | Course Title |
| BIO 495 | Undergraduate Research |
| Fall 2016 | |
|---|---|
| Course Number | Course Title |
| MBB 493 | Honors Thesis |
| BIO 495 | Undergraduate Research |
| NAN 598 | Special Topics |
| CHM 598 | Special Topics |
| BCH 598 | Special Topics |
| Summer 2016 | |
|---|---|
| Course Number | Course Title |
| BIO 495 | Undergraduate Research |
Presentations:
- Sidney Hecht. Invited Participant. A-T Childrens Proj Wkshp on Mitochondria/Metabolic Signaling in Ataxia-Telangiectasia, Tarrytown, NY (Dec 2014).
- Sidney Hecht. Invited Lecturer. GlaxoSmithKline Mitochondrial Science Day, Collegeville, Pennsylvania (Sep 2014).
- Sidney Hecht. Lecturer. Scripps Florida: External Seminar Series, Jupiter, Florida (Sep 2014).
- Sidney Hecht. Plenary Lecturer. Fusion Conference on Natural Products: A Celebration and Resurrection with Reverse Pharma., Chicago (Jul 2014).
- Sidney Hecht. Invited Lecturer. Mitochondrial Medicine 2014, United Mitochondrial Disease Foundation, Pittsburgh, Pennsylvania (Jun 2014).
- Sidney Hecht. Invited Lecturer. Isis Pharmaceuticals, Carlsbad, California (May 2014).
- Sidney Hecht. Invited Lecturer. 247th National ACS Meeting, Symposium on Frontiers of Nucleic Acid Chemistry, Dallas, Texas (Mar 2014).
- Sidney Hecht. Invited Lecturer. York University (Chemistry Department), Toronto, Canada (Mar 2014).
- Sidney Hecht. Invited Lecturer. Ohio State University: University Molecular Life Sciences Seminar Series, Columbus, Ohio (Feb 2014).
- Sidney Hecht. Invited Lecturer. Arizona State University (Department of Chemistry and Biochemistry), Tempe, Arizona (Feb 2014).
- Sidney Hecht. Invited Lecturer. University of Colorado Cancer Center Symposium Series, Denver, Colorado (Dec 2013).
- Sidney Hecht. Invited Lecturer. AARS 2013 9th International Symposium on Aminoacyl-tRNA Synthetases, Hakone, Japan (Oct 2013).
- Sidney Hecht. Invited Lecturer. Evelyn F. McKnight Brain Institute Symposium/University of Arizona, Tucson, Arizona (Oct 2013).
- Sidney Hecht. Invited Lecturer. Jacques Monod Conference on DNA Methylation and Demethylation, Roscoff, France (Sep 2013).
- Sidney Hecht. Invited Lecturer. Lanzhou University/College of Chemistry and Chemical Engineering, China (Jul 2013).
- Sidney Hecht. Invited Lecturer. The 9th SINO-US Chemistry Professors Conference/Sichuan University, China (Jul 2013).
- Sidney Hecht. Invited Lecturer. Wuhan University/College of Chemistry and Molecular Sciences, China (Jul 2013).
- Sidney Hecht. Invited Lecturer. Peking University/School of Pharmaceutical Sciences, China (Jul 2013).
- Sidney Hecht. Plenary Lecturer. 2012 IOCD International Conference on Functional Molecules in Nature, Nanjing, China (Nov 2012).
- Sidney Hecht. Invited Lecturer. Shanghai Institute of Materia Medica (Oct 2012).
- Sidney Hecht. Invited Lecturer. American Chemical Society Symposium, Shanghai Institute of Organic Chemistry (Sep 2012).
- Sidney Hecht. Invited Lecturer. Joint Chinese Chem. Soc.-American Chem. Soc. Symposium, Annual Meeting of Chin. Chem. Soc., Sichuan (Aug 2012).
- Sidney Hecht. Invited Lecturer. Translational Medicine in Arizona. Networks, Partnerships and Initiatives, Flagstaff, Arizona (Jun 2012).
- Sidney Hecht. Invited Lecturer. 2012 Arizona Alzheimer’s Consortium Annual Scientific Conference, Barrow Neurological Institute (May 2012).
- Sidney Hecht. Invited Lecturer. Université de Rouen (Chemistry Department) (Apr 2012).
- Sidney Hecht. Invited Lecturer. Workshop on Mitochondria, Metabolism and Cancer, Tempe, Arizona (Mar 2012).
- Sidney Hecht. Invited Lecturer. 2012 Arizona Alzheimer’s Disease Consortium Retreat, Tuba City, Arizona (Feb 2012).
- Sidney Hecht. Invited Lecturer. Peking University (School of Pharmaceutical Sciences (Nov 2011).
- Sidney Hecht. Invited Lecturer. Wuhan University (College of Chemistry and Molecular Sciences) (Nov 2011).
- Sidney Hecht. Invited Lecturer. 1st International Conference on Chemical and Structural Biology of Nucleic Acids and Proteins (Sep 2011).
- Sidney Hecht. Invited Lecturer. Pierre Fabre (Centre de Recherche et de Développement) (Aug 2011).
- Sidney Hecht. Invited Lecturer. Institut de Biologie Moléculaire et Cellulaire du CNRS, Université de Strasbourg (Jun 2011).
- Sidney Hecht. Invited Lecturer. Institut de Science et d'Ingénierie Supramoléculaire, Université de Strasbourg (Jun 2011).
- Sidney Hecht. Invited Lecturer. Friedreich’s Ataxia Research Alliance (Board of Directors) (Apr 2011).
- Sidney Hecht. Invited Lecturer. Academia Sinica, Taipei (Institute of Chemistry) (Mar 2011).
- Sidney Hecht. Invited Lecturer. Academia Sinica, Taipei (Genomics Research Institute) (Mar 2011).
- Sidney Hecht. Invited Lecturer. National Taiwan University (Chemistry Department) (Mar 2011).
- Sidney Hecht. Invited Lecturer. Banner Sun Health Research Institute (May 2010).
- Sidney Hecht. Invited Lecturer. 240 National ACS Meeting, Symposium on Recognition of DNA: Recent Advances, Boston (Apr 2010).
- Sidney Hecht. Invited Lecturer. Penwest Pharmaceuticals (Mar 2010).
- Sidney Hecht. Invited Lecturer. AIM 2010 (Third Ataxia Investigator's Meeting), Chicago (Feb 2010).
- Sidney Hecht. Invited Lecturer. General Electric Global Research (Jan 2010).
- Sidney Hecht. Invited Lecturer. University of Missouri (Chemistry Department) (Jul 2009).
- Sidney Hecht. Invited Lecturer. University of Missouri (Biochemistry Department) (Jun 2009).
- Sidney Hecht. Chemical Biology in the 21st Century, University of Buffalo, Buffalo, NY. Invited Lecturer (May 2009).
- Sidney Hecht. Friedreich’s Ataxia Research Alliance Therapeutics Symposium, Philadelphia. Invited Lecturer (Apr 2009).
- Sidney Hecht. Invited Lecturer. Institut de Chimie des Substances Naturelle, Gif-sur-Yvette (Mar 2009).
- Sidney Hecht. Sidney M. Hecht Lectureship. University of Virginia (Feb 2009).
- Sidney Hecht. Invited Lecturer. Isis Pharmaceuticals (Jan 2009).
Service:
- FARA/NCATS Biomarker Meeting, Participant (2014 - Present)
- NIH Synthetic and Biological Chemistry B Study Section, Ad hoc Member (2014 - Present)
- Biodesign Industrial Liaison Team, Chair (2011 - Present)
- Biodesign Industrial Liaison Team, Chair (2011 - Present)
- Biodesign Industrial Liaison Team, Chair (2011 - Present)
- Biodesign Industrial Liaison Team, Chair (2011 - Present)
- Chemistry Department Interdepartmental Relations Commmittee, Committee Member (2010 - Present)
- Chemistry Department Interdepartmental Relations Commmittee, Committee Member (2010 - Present)
- Chemistry Department Interdepartmental Relations Commmittee, Committee Member (2010 - Present)
- Chemistry Department Interdepartmental Relations Commmittee, Committee Member (2010 - Present)
- Chemistry Department Interdepartmental Relations Commmittee, Committee Member (2010 - Present)
- Chemistry Department Faculty Search Committee, Committee Member (2009 - Present)
- Chemistry Department Faculty Search Committee, Committee Member (2009 - Present)
- Chemistry Department Faculty Search Committee, Committee Member (2009 - Present)
- Chemistry Department Faculty Search Committee, Committee Member (2009 - Present)
- Chemistry Department Faculty Search Committee, Committee Member (2009 - Present)
- Chemistry Department Graduate Programs Committee, Committee Member (2009 - Present)
- Chemistry Department Graduate Programs Committee, Committee Member (2009 - Present)
- Chemistry Department Graduate Programs Committee, Committee Member (2009 - Present)
- Chemistry Department Graduate Programs Committee, Committee Member (2009 - Present)
- Chemistry Department Graduate Programs Committee, Committee Member (2009 - Present)
- Chemistry Department Graduate Programs Committee, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for High Resolution Mass Spectrometry, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for High Resolution Mass Spectrometry, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for High Resolution Mass Spectrometry, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for High Resolution Mass Spectrometry, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for Magnetic Resonance Research Center, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for Magnetic Resonance Research Center, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for Magnetic Resonance Research Center, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for Magnetic Resonance Research Center, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for Magnetic Resonance Research Center, Committee Member (2009 - Present)
- Faculty/Scientific Advisory Committee for Magnetic Resonance Research Center, Committee Member (2009 - Present)
- Oncology Research/Anticancer Drug Design, Editorial Advisory Board (2002 - Present)
- Oncology Research/Anticancer Drug Design, Editorial Advisory Board (2002 - Present)
- Oncology Research/Anticancer Drug Design, Editorial Advisory Board (2002 - Present)
- Oncology Research/Anticancer Drug Design, Editorial Advisory Board (2002 - Present)
- Oncology Research/Anticancer Drug Design, Editorial Advisory Board (2002 - Present)
- Oncology Research/Anticancer Drug Design, Editorial Advisory Board (2002 - Present)
- Molecular Cancer Therapeutics, Editorial Advisory Board (2001 - Present)
- Molecular Cancer Therapeutics, Editorial Advisory Board (2001 - Present)
- Molecular Cancer Therapeutics, Editorial Advisory Board (2001 - Present)
- Molecular Cancer Therapeutics, Editorial Advisory Board (2001 - Present)
- Molecular Cancer Therapeutics, Editorial Advisory Board (2001 - Present)
- Molecular Cancer Therapeutics, Editorial Advisory Board (2001 - Present)
- Current Medicinal Chemistry-Anticancer Agents, Editorial Advisory Board (2000 - Present)
- Current Medicinal Chemistry-Anticancer Agents, Editorial Advisory Board (2000 - Present)
- Current Medicinal Chemistry-Anticancer Agents, Editorial Advisory Board (2000 - Present)
- Current Medicinal Chemistry-Anticancer Agents, Editorial Advisory Board (2000 - Present)
- Current Medicinal Chemistry-Anticancer Agents, Editorial Advisory Board (2000 - Present)
- Current Medicinal Chemistry-Anticancer Agents, Editorial Advisory Board (2000 - Present)
- Journal of the American Chemical Society, Associate Editor (1992 - Present)
- Journal of the American Chemical Society, Associate Editor (1992 - Present)
- Journal of the American Chemical Society, Associate Editor (1992 - Present)
- Journal of the American Chemical Society, Associate Editor (1992 - Present)
- Journal of the American Chemical Society, Associate Editor (1992 - Present)
- Journal of the American Chemical Society, Associate Editor (1992 - Present)
Expertise Areas: