From 1996 to 1998, Marco Saraniti was a faculty research associate with the Electrical Engineering Department of Arizona State University. He joined the Electrical and Computer Engineering Department of the Illinois Institute of Technology, Chicago, in 1998, where he was awarded tenure in 2004, and was promoted to the rank of full professor in June 2007. He joined the faculty of the School of Electrical, Computer and Energy Engineering of ASU in the month of August of 2007.

He is the author or co-author of more than 90 publications, four book chapters and four technical reports. His current research focuses mainly on computational electronics applied to the simulation of semiconductor devices and biological structures. His recent scientific work covers the following fields: the development of Monte Carlo and cellular automaton techniques for 2-D and 3-D simulation of semiconductor devices, simulation and engineering of semiconductor devices, and the development of numerical methods for the modeling and simulation of membrane proteins.