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Jordan Yaron

Assistant Research Professor
Post Doctoral Scholars, TEMPE Campus, Mailcode 6401
Biography: 

Virus-derived Immune Modulators

Co-evolution of viruses with their natural hosts invokes an adaptation arms race, where a successful strategy for the virus relies on immune evasion, often targeting key pathways that drive immune activation. Large DNA viruses, such as members of the poxvirus family, are adept at evading the innate immune system via a suite of virulence factors. Furthermore, because viruses are limited in their genomic space, it is common for immune modulating proteins to exhibit multipotent functionality, targeting numerous pathways simultaneously. Translationally, these factors constitute a rich toolbox for developing novel immune modulators.

I work with immune modulators from Myxomavirus, a poxvirus which is pathogenic in European rabbits but not in humans or rodents. Myxomavirus has evolved a highly efficient suite of multipotent immune modulators which target a wide array of pathways involved in immune response. A number of these immune modulators have already proven effective in rodent models of disease as well as in clinical trials in humans.

Education: 
  • Postdoctoral Training in Virus-derived immune modulators
    2017-2020, The Biodesign Institute at Arizona State University
    Lab of Alexandra Lucas, MD
     
  • Postdoctoral Training in Acute Pancreatitis
    2015-2017, Mayo Clinic
    Lab of Vijay Singh, MBBS
     
  • Ph.D. Biological Design - Inflammasome biology
    2015, Arizona State University
     
  • B.S. Biological Sciences - Genetics, Cell and Developmental Biology
    2010, Arizona State University

    Summa cum laude
Research Interests: 
  • Inflammation and innate immunity
  • Programmed cell death
  • Cellular ion signaling
Publications: 

Articles. Descending chronological order.

  • Yaron JR†, Ambadapadi S†, Zhang L, Chavan RN, Tibbetts SA, Keinan S, Varsani A, Maldonado J, Tafoya AM, Bullard WL, Kilbourne J, Stern-Harbutte A, Krajmalnik-Brown R, Munk BH, Koppang EO, Lim ES, Lucas AR (2020). Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection.
    AcceptedScientific Reports (†Equal Contributions)
  • Kwiecien JM, Dabrowski W, Dabrowska-Bouta B, Sulkowski G, Oakden W, Kwiecien-Delaney CJ, Yaron JR, Zhang L, Schutz L, Marzec-Kotarska B, Stanisz GJ, Karis JP, Struzynska L, Lucas AR. Prolonged inflammation leads to ongoing damage after spinal cord injury.
    In Revision
  • Kwiecien JM†, Zhang L†, Yaron JR†, Schutz LN, Kwiecien-Delaney CJ, Awo EA, Burgin M, Dabrowski W, Lucas AR. Local Chitosan-Serpin Injection after Spinal Cord Injury Reduces Inflammatory Damage and Improves Neurologic Function.
    In Revision (†Equal Contributions)
  • Khatua B, Yaron JR, El-Kurdi B, Kostenko S, Papachristou GI, Singh VP (2020). Ringer’s lactate prevents early organ failure by providing extracellular calcium.
    Journal of Clinical Medicine. 9(1), 263
  • Zhang L†, Yaron JR†, Tafoya AM, Wallace SE, Kilbourne J, Haydel S, Rege K, McFadden G, Lucas AR (2019). A virus-derived immune modulating SERPIN accelerates wound closure with improved collagen remodeling.
    Journal of Clinical Medicine. 8(1626), 1-17 (†Equal Contributions)
         - Selected as issue cover
  • Yaron JR†, Chen H†, Ambadapadi S†, Zhang L, Tafoya AM, Munk BH, Wakefield D, Fuentes J, Marques BJ, Harripersaud K, Bartee MY, Davids J, Zheng D, Rand K, Dixon L, Moyer R, Clapp W, Lucas AR (2019). Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice.
    Journal of Inflammation. 16(1), 12 (†Equal Contributions)
  • Yaron JR†, Kwiecien JM†, Zhang L†, Ambadapadi S, Wakefield DN, Clapp WL, Dabrowski W, Burgin M, Munk BH, McFadden G, Chen H, Lucas AR (2019). Modifying the Organ Matrix Pre-Engraftment; A New Transplant Paradigm?
    Trends in Molecular Medicine. 25(7), 626-639 (†Equal Contributions)
  • Kwiecien JM, Dabrowski W, Marzec-Kotarska B, Kwiecien-Delaney CJ, Yaron JR, Zhang L, Schutz L, Lucas AR (2019). Myxoma virus derived immune modulating proteins, M-T7 and Serp-1, reduce early inflammation after spinal cord injury in the rat model.
    Folia Neuropathologica. 57(1), 41-50
  • Chen H, Bartee M, Yaron J, Liu L, Zhang L, Zheng D, Hogue I, Bullard W, Tibbetts S, Lucas A (2018). Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR−/−) That Is Blocked by Interleukin-10.
    Viruses. 10(10), 518
  • Kostenko S, Heu CC, Yaron JR, Singh G, Oliveira CD, Muller WJ, Singh VP (2018). c-Src Regulates Cargo Transit via the Golgi in Pancreatic Acinar Cells.
    Scientific Reports. 8(1), 11903
  • Chen H, Ambadapadi S, Wakefield D, Bartee MY, Yaron JR, Zhang L, Archer-Hartmann SA, Azadi P, Burgin M, Borges C, Zheng D, Ergle K, Muppala V, Morshed S, Rand K, Clapp W, Proudfoot A, Lucas A (2018). Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection.
    Scientific Reports. 8(1), 13433
  • Mahon BP, Ambadapadi S, Yaron JR, Lomelino CL, Pinard MA, Keinan S, Kurnikov I, Macaulay C, Zhang L, Reeves W, McFadden G, Tibbetts S, McKenna R, Lucas AR (2018). Crystal Structure of Serp-1, a Myxomavirus-derived Immune Modulating Serpin; Structural Design of Serpin Reactive Center Loop (RCL) Peptides with Improved Therapeutic Function.
    Biochemistry. 57(7), 1096-1107
  • Al-Ani M†, Ambadapadi S†, Yaron JR†, Zheng D, Fortunel A, Doroton-Guevara M, Liu L, Morshed S, Fricker J, Miles W, McKillop M, Lucas A (2017). Atrial Fibrillation Ablation Increases Inflammation-Chemokine Modulation Suppresses Activation of Leukocytes Isolated after Ablation.
    Cardiovascular and Hematologic Disorders: Drug Targets. 17(3), 195-204 (†Equal Contributions)
  • Lucas A, Ambadapadi S, Mahon B, Viswanathan K, Chen H, Liu L, Dai E, Munuswami-Ramanujam G, Kwiecien JM, Yaron JR, Narute PS, McKenna R, Keenan S, Brantly M, McFadden G (2017). The Serpintine Solution.
    Journal of Clinical and Experimental Cardiology. 8(1), e150
  • Yaron JR, Rao MY, Gangaraju S, Zhang L, Kong X, Su F, Tian Y, Glenn HL, Meldrum DR (2016). The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux.
    Biochemical and Biophysical Research Communications. 472(3), 545-550
  • Oliveira CD, Patel K, Mishra V, Trivedi RN, Noel P, Singh A, Yaron JR, Singh VP (2016). Characterization and Predictive Value of Near Infrared 2-Deoxyglucose Optical Imaging in Severe Acute Pancreatitis.
    PLoS ONE. 11(2), e0149073
  • Yaron JR, Gangaraju S, Rao MY, Kong X, Zhang L, Su F, Tian Y, Glenn HL, Meldrum DR (2015). K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells.
    Cell Death and Disease. 6(10), e1954
  • Kong X, Su F, Zhang L, Yaron J, Lee F, Shi Z, Tian Y, Meldrum DR (2015). A Highly Selective Mitochondria-Targeting Fluorescent K+ Sensor.
    Angewandte Chemie: International Edition. 54(41), 12053-12057
  • Yaron JR, Ziegler CP, Tran TH, Glenn HL, Meldrum DR (2014). A convenient, optimized pipeline for isolation, fluorescence microscopy and molecular analysis of live single cells.
    Biological Procedures Online. 16(9)

Published abstracts & proceedings. Descending chronological order.

  • Yaron J, Ambadapadi S, Zhang L, Tibbetts S, Keinan S, Chavan R, Varsani A, Maldonado J, Tafoya A, Bullard W, Kilbourne J, Munk B, Thomas R, Koppang E, Lim E, Lucas A (2019). Gut Microbiota Determine Severity Of Lethal Gammaherpesvirus-Induced Vasculitis And Efficacy Of Immune-Modulating Therapy In Mice. Atherosclerosis. 287, e76, 0559
  • Lucas A, Yaron J, Zhang L (2019). Modifying Mouse Herpesvirus-Induced Vasculitis and Serpin Anti-Inflammatory Treatment-Profound Effects of the Gut Microbiota. The FASEB Journal. 33(1_supplement), 461.13
  • Shah C, Moreb J, Kannampuzha J, Yaron J, Ambadapadi S, Yao J, Schultz-Cherry S, House M, Maranian P, Zhang L, Gong Y, Pepine C, Varsani A, Lucas A (2018). Identification of Viral Gene Signatures in Cancer Patients With Reduced Ejection Fraction After Chemotherapy. Circulation. 138(Suppl_1), A15398
  • Kwiecien J, Kwiecien-Delaney CJ, Yaron J, Schutz L, Wallace S, Zhang L, Dabrowski W, Lucas AR (2018). Analysis of virus-derived immune modulating protein therapeutics infused subdurally in a rat model of spinal cord injury. Journal of Neurotrauma. 35(16). A52
  • Kwiecien J, Dabrowska-Bouta D, Marzec-Kotarska B, Oakden W, Yaron J, Kwiecien-Delaney CJ, Ostrowska A, Rola R, Klapec M, Stanisz G, Struzynska L, Dabrowski W, Lucas AR (2018). Mechanisms in pathogenesis of the spinal cord injury in the rat model. Journal of Neurotrauma. 35(16), A52
  • Lucas A, Yaron JR, Ambadapadi S, Zhang L (2018). Modulation of inflammatory vasculitis (IVS) and antiinflammatory treatment by the gut microbiota-a mouse herpesvirus IVS model. Cardiology. 140, 257
  • Lucas AR, Chen H, Ambadapadi S, Yaron J, Zhang L (2018). Conditional Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial Significantly Decreases Acute Allograft Rejection. Atherosclerosis Supplements 32, 109
  • Ambadapadi S, Wakefield DN, Chen H, Bartee MY, Azadi P, Archer-Hartmann S, Yaron JR, Zheng D, Ergle KD, Zhang L, Borges CR, Croker BP, Rand KH, Esko JD, Clapp WL, Lucas A (2017). Modulating Heparan Sulfation and Disaccharide Content Significantly Blocks Early Rejection in Mouse Renal Transplants. Circulation 136(S1), A18629
  • Ambadapadi S, Yaron JR, Mahon B, Thomas RM, Jobin C, Karst SM, Tibbetts SA, Keinan S, Varsani A, Zhang L, McFadden G, Lucas A (2017). The Gut Microbiome Modulates Disease Progression and Anti-Inflammatory Treatment in Mouse Herpesvirus-Induced Vasculitis. Circulation 136(S1), A18525.
  • Lucas A, Ambadapadi S, Mahon B, Thomas RM, Jobin C, Karst S, Tibbetts S, Yaron JR, Keinan S, Varsani A, McFadden G (2017). Modified Myxomaviral Serpin Reactive Center Loop (RCL) Peptide Improves Survival and Outcomes in an Accelerated Lethal Mouse Inflammatory Vasculitic Syndrome Model. Cardiology 137(S1), 126
  • Yaron JR, Khatua B, Patel K, Oliveira CD, Singh VP (2017). The Extracellular Ca2+ Provided by Ringer’s Lactate but Not Lactate Reduces Necrosis and Improves Survival During Severe Acute Pancreatitis. Gastroenterology 152(5S1), S893 doi:10.1016/S0016-5085(17)33049-4
  • El Kurdi B, Yaron JR, Masood S, Noel P, Patel K, Khatua B, Oliveira CD, Singh VP (2017). Lipotoxicity May Result in Inflammatory Cell Death and Associated Immune Paralysis During Severe Acute Pancreatitis (SAP). Gastroenterology 152(5S1), S895. doi:10.1016/S0016-5085(17)33058-5
  • Yaron JR, Patel K, Khatua B, Oliveira CD, Singh VP (2016). Extracellular Ca2+ Contributes to the Beneficial Effects of Lactated Ringer’s During Acute Pancreatitis. Pancreas 45. Poster of Distinction
  • Yaron JR, Singh G, Patel K, Trivedi RN, Oliveira CD, Singh VP (2016). C-Src is Involved in Physiologic Zymogen Synthesis and Packaging Through the Golgi in Pancreatic Acinar Cells. Pancreas 45. Poster of Distinction
  • Oliveira CD, Patel K, Mishra V, Trivedi RN, Bradley J, Yaron JR, Singh VP (2016). Transgastric Therapeutic Pancreatic Hypothermia as a Novel Therapy for Acute Pancreatitis (AP). Pancreas 45.
  • Patel K, Khatua B, Yaron JR, Oliveira CD, Singh RJ, Papachristou GI, Yadav D, Lee K, Murad F, Singh VP (2016). Bile Acids (BA) in Human Pancreatic Necrosis (PN) Worsen Acute Pancreatitis (AP) via a Non-Micellar Interaction with Fatty Acids (FA). Pancreas 45.
  • Yaron JR, Pan J, Borkar T, Lee KB, Wang KC, Anderson CL, Glenn HL and Meldrum DR (2014). Automated Cell Counting in a High Density, Polymer-Coated, Live Single Cell Sandwich Microarray. Microsc. Microanal. 20(S3), 1438-1439
  • Yaron JR, Zhang L, Kong X, Ziegler CP, Su F, Gangaraju S, Tian Y, Glenn HL, and Meldrum DR (2014). Real-time visualization of intracellular potassium dynamics in mouse macrophages during inflammasome-associates processes. Mol. Biol. Cell 25, P635
  • Yaron J, Ziegler C, Tran T, Tian Y, Su F, Glenn HL, and Meldrum DR (2013). Single cell temporal heterogeneity in caspase-1 activation in response to NLRP3 stimuli is independent of potassium ion efflux rate. Mol. Biol. Cell 24, 1543

Book chapters.

  • Yaron, J.R., Ambadapadi, S., Zhang, L., Lucas, A., 2018. Kinetic Measurement of Serpin Inhibitory Activity by Real-time Fluorogenic Biochemical Assay. SERPINS: Methods and Protocols (Methods in Molecular Biology). SpringerNature/Humana Press, Vol. 1826. ISBN: 978-1-4939-8644-6, pp.65-71
  • Zhang, L., Yaron, J.R., Ambadapadi, S., Lucas, A., 2018. Viral Serpin Reactive Center Loop (RCL) Peptides: Design and Testing. SERPINS: Methods and Protocols (Methods in Molecular Biology). SpringerNature/Humana Press, Vol. 1826. ISBN: 978-1-4939-8644-6, pp.133-142
  • Chen, H., Ambadapadi, S., Dai, E., Liu, L., Yaron, J.R., Zhang, L., Lucas, A., 2018. Analysis of In Vivo Serpin Functions in Models of Inflammatory Vascular Disease. SERPINS: Methods and Protocols (Methods in Molecular Biology). SpringerNature/Humana Press, Vol. 1826. ISBN: 978-1-4939-8644-6, pp.157-182
  • Lucas, A., Yaron J.R., Zhang, L., Macaulay, C., McFadden, G., 2018. Serpins: Development for Therapeutic Applications. SERPINS: Methods and Protocols (Methods in Molecular Biology). SpringerNature/Humana Press, Vol. 1826. ISBN: 978-1-4939-8644-6, pp.255-265
  • Lucas, A., Yaron, J.R., Zhang, L., Ambadapadi, S., 2018. Overview of Serpins and Their Roles in Biological Systems. SERPINS: Methods and Protocols (Methods in Molecular Biology). SpringerNature/Humana Press, Vol. 1826. ISBN: 978-1-4939-8644-6, pp.1-7
  • Maldonado, J., Yaron, J.R., Zhang, L., Lucas, A., 2018. Next-Generation Sequencing Library Preparation for 16S rRNA Microbiome Analysis After Serpin Treatment. SERPINS: Methods and Protocols (Methods in Molecular Biology). SpringerNature/Humana Press, Vol. 1826. ISBN: 978-1-4939-8644-6, pp.213-221