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Jordan Yaron

Asst Research Professor (FSC)
Faculty, TEMPE Campus, Mailcode 6106

Therapeutics for Repair

I am interested in injury and repair at all scales of life: from fundamental molecular and cellular mechanisms to systemic responses to sterile and infected injury. Understanding how the immune system and organized cell systems in a tissue respond to injury, and how this response is influenced by complex comorbidities (e.g., diabetes, advanced age), can help to identify the fundamental basis of tissue repair and direct us towards novel treatment avenues to improve healing and limit long-term complications.

  • Postdoctoral Training (2017-2020)
    Arizona State University
    The Biodesign Institute
    Immune modulation
    Advisor: Alexandra Lucas, MD

  • Postdoctoral Training (2015-2017)
    Mayo Clinic
    Department of Medicine
    Acute Pancreatitis
    Advisor: Vijay Singh, MD MBBS

  • PhD, Biological Design (2010-2015)
    Arizona State University
    School for Biological and Health Systems Engineering
    Dissertation: “Ion Flux Regulates Inflammasome Signaling”
    Chair: Deirdre Meldrum, PhD; Advisor: Honor Glenn, PhD

  • BS, Biological Sciences: Genetics, Cell and Developmental Biology (2006-2010)
    Arizona State University
    School of Life Sciences
    Summa cum laude & Honors Thesis

HeLa giant cell cytoskeleton immunofluorescence

Cyan: Nucleus; Yellow: Tubulin; Magenta: Actin
Macrophage inflammasome imaging

Inflammasome assembly in macrophages

Blue: Nucleus; Green: Active caspase-1

Potassium efflux and membrane pore opening after ATP exposure in mouse macrophages

Cyan: TO-PRO-3 membrane impermeant dye; Red: KS6 potassium sensor. Left to right: Control, 1 mM ATP, 3 mM ATP, 5 mM ATP.
Research Interests: 
  • Mechanisms of wound repair
  • Serpins (serine protease inhibitors)
  • Inflammation and innate immunity
  • Programmed cell death
  • Cellular ion signaling


  1. Zanetti IR, Burgin M, Zhang L, Yeh S, Ambadapadi S, Kilbourne J, Yaron J, Lowe KM, Daggett-Vondras J, Fonseca D, Boyd R, Wakefield D, Clapp W, Lim E, Chen H, Lucas A (2022). Virus-derived Chemokine Modulating Protein Pre-treatment Blocks Chemokine-Glycosaminoglycan Interactions and Significantly Reduces Transplant Immune Damage. PathogensAccepted.
  2. Varkoly K, Tan S, Beladi R, Fonseca D, Zanetti IR, Kraberger S, Shah C, Yaron JR, Zhang L, Juby L, Fath AR, Ambadapadi S, House M, Maranian P, Pepine C, Varsani A, Moreb J, Schutlz-Cherry S, Lucas AR (2022). RNA Virus Gene Signatures Detected in Patients with Cardiomyopathy after Chemotherapy. Frontiers in Cardiovascular Medicine. 9, 821162


  1. Ju B, Guo O, Benissan-Messan DZ, Shawver MH, Chen P, Geng B, Wei S, Yaron JR, Lucas AR, Hua Z (2021). Serp-1 Promotes Corneal Wound Healing by Facilitating Re-epithelialization and Inhibiting Fibrosis and Angiogenesis. Frontiers in Cardiovascular Medicine. 8, 649124
  2. Yaron JR, Zhang L, Guo Q, Haydel SE, Lucas AR (2021). Fibrinolytic Serine Proteases, Therapeutic Serpins and Inflammation: Fire Dancers and Firestorms. Frontiers in Cardiovascular Medicine. 8, 648947
  3. Beladi RN†, Varkoly KS†, Schutz L†, Zhang L, Yaron JR, Guo Q, Burgin M, Hogue I, Tierney W, Dabrowski W, Lucas AR (2021). Serine Proteases and Chemokines in Neurotrauma; New Targets for Immune Modulating Therapeutics in Spinal Cord Injury. Current Neuropharmacology. 19(11):1835-1854(†Equal Contributions)
  4. Guo Q, Yaron JR, Wallen III JW, Browder KF, Boyd R, Olson TL, Burgin M, Ulrich P, Aliskevich E, Schutz LN, Fromme P, Zhang L, Lucas A (2021). PEGylated Serp-1 Markedly Reduces Pristane-Induced Experimental Diffuse Alveolar Hemorrhage, Altering uPAR Distribution, and Macrophage Invasion. Frontiers in Cardiovascular Medicine. 8, 633212
  5. Khatua B, El Kurdi B, Patel K, Rood C, Noel P, Crowell M, Yaron J, Kostenko S, Guerra A, Faigel DO, Lowe M, Singh VP (2021). Adipose saturation reduces lipotoxic systemic inflammation and explains the obesity paradox. Science Advances. 7(5) eabd6449


  1. Yaron JR†, Zhang L†, Guo Q, Awo EA, Burgin M, Schutz LN, Zhang N, Kilbourne J, Daggett-Vondras J, Lowe KM, Lucas AR (2020). Recombinant Myxoma virus-derived immune modulator M-T7 accelerates cutaneous wound healing and improves tissue remodeling. Pharmaceutics. 12(11), 1003. (†Equal Contributions)
  2. Fath AR, Aglan A, Platt J, Yaron JR, Varkoly KS, Beladi R, Gorgas D, Jean JT, Dasni P, Eldaly AS, Jupy M, Lucas AR (2020). Chronological Impact of Earthquakes on Blood Pressure: A Literature Review and Retrospective Study of Hypertension in Haiti before and after the 2010 Earthquake. Frontiers in Public Health. 8, 600157
  3. Yaron JR†, Zhang L†, Guo Q, Awo EA, Burgin M, Schutz LN, Zhang N, Kilbourne J, Daggett-Vondras J, Lowe KM, Lucas AR. Recombinant Myxoma virus-derived immune modulator M-T7 accelerates cutaneous wound healing and improves tissue remodeling. Pharmaceutics. 12(11), 1003. (†Equal Contributions)
  4. Kwiecien JM, Dabrowski W, Kwiecien-Delaney BJ, Kwiecien-Delaney CJ, Siwicka-Gieroba D, Yaron JR, Zhang L, Delaney KH, Lucas AR (2020). Neuroprotective effect of subdural infusion of Serp-1 in spinal cord trauma. Biomedicines. 8(10), 372.
  5. Kwiecien JM, Dabrowski W, Yaron JR, Zhang L, Delaney KH, Lucas AR (2020). The Role of Astrogliosis in Formation of the Syrinx in Spinal Cord Injury. Current Neuropharmacology. 19(2), 972.
  6. Ghosh D, Godeshala S, Nitiyanandan R, Islam MS, Yaron JR, DiCaudo D, Kilbourne J, Rege K (2020). Copper-Eluting Fibers for Enhanced Tissue Sealing and Repair. ACS Applied Materials & Interfaces. 12(25), 27951-27960
  7. Kwiecien JM†, Zhang L†, Yaron JR†, Schutz LN, Kwiecien-Delaney CJ, Awo EA, Burgin M, Dabrowski W, Lucas AR (2020). Local Chitosan-Serpin Injection after Spinal Cord Injury Reduces Inflammatory Damage and Improves Neurologic Function. Journal of Clinical Medicine. 9(4), 1221 (†Equal Contributions)
  8. Yaron JR†, Zhang L†, Guo Q, Burgin M, Schutz L, Awo E, Wise L, Krause KL, Ildefonso CJ, Kwiecien JM, Juby M, Rahman MM, Chen H, Moyer RW, Alcami A, McFadden G, Lucas AR (2020). Deriving Immune Modulating Drugs from Viruses – A New Class of Biologics. Journal of Clinical Medicine. 9(4), 972 (†Equal Contributions)
  9. Kwiecien JM, Dabrowski W, Dabrowska-Bouta B, Sulkowski G, Oakden W, Kwiecien-Delaney CJ, Yaron JR, Zhang L, Schutz L, Marzec-Kotarska B, Stanisz GJ, Karis JP, Struzynska L, Lucas AR (2020). Prolonged inflammation leads to ongoing damage after spinal cord injury. PLoS ONE15(3), e0226584
  10. Yaron JR†, Ambadapadi S†, Zhang L, Chavan RN, Tibbetts SA, Keinan S, Varsani A, Maldonado J, Tafoya AM, Bullard WL, Kilbourne J, Stern-Harbutte A, Krajmalnik-Brown R, Munk BH, Koppang EO, Lim ES, Lucas AR (2020). Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection. Scientific Reports. 10(1), 1-13 (†Equal Contributions)
  11. Khatua B, Yaron JR, El-Kurdi B, Kostenko S, Papachristou GI, Singh VP (2020). Ringer’s lactate prevents early organ failure by providing extracellular calcium. Journal of Clinical Medicine. 9(1), 263


  1. Zhang L†, Yaron JR†, Tafoya AM, Wallace SE, Kilbourne J, Haydel S, Rege K, McFadden G, Lucas AR (2019). A virus-derived immune modulating SERPIN accelerates wound closure with improved collagen remodeling. Journal of Clinical Medicine. 8(1626), 1-17 (†Equal Contributions)
    • Selected as issue cover
  2. Yaron JR†, Chen H†, Ambadapadi S†, Zhang L, Tafoya AM, Munk BH, Wakefield D, Fuentes J, Marques BJ, Harripersaud K, Bartee MY, Davids J, Zheng D, Rand K, Dixon L, Moyer R, Clapp W, Lucas AR (2019). Serp-2, a virus-derived apoptosis and inflammasome inhibitor, attenuates liver ischemia-reperfusion injury in mice. Journal of Inflammation. 16(1), 12 (†Equal Contributions)
  3. Yaron JR†, Kwiecien JM†, Zhang L†, Ambadapadi S, Wakefield DN, Clapp WL, Dabrowski W, Burgin M, Munk BH, McFadden G, Chen H, Lucas AR (2019). Modifying the Organ Matrix Pre-Engraftment; A New Transplant Paradigm? Trends in Molecular Medicine. 25(7)626-639 (†Equal Contributions)
  4. Kwiecien JM, Dabrowski W, Marzec-Kotarska B, Kwiecien-Delaney CJ, Yaron JR, Zhang L, Schutz L, Lucas AR (2019). Myxoma virus derived immune modulating proteins, M-T7 and Serp-1, reduce early inflammation after spinal cord injury in the rat model. Folia Neuropathologica. 57(1), 41-50


  1. Chen H, Bartee M, Yaron J, Liu L, Zhang L, Zheng D, Hogue I, Bullard W, Tibbetts S, Lucas A (2018). Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR−/−) That Is Blocked by Interleukin-10. Viruses. 10(10), 518
  2. Kostenko S, Heu CC, Yaron JR, Singh G, Oliveira CD, Muller WJ, Singh VP (2018). c-Src Regulates Cargo Transit via the Golgi in Pancreatic Acinar Cells. Scientific Reports. 8(1), 11903
  3. Chen H, Ambadapadi S, Wakefield D, Bartee MY, Yaron JR, Zhang L, Archer-Hartmann SA, Azadi P, Burgin M, Borges C, Zheng D, Ergle K, Muppala V, Morshed S, Rand K, Clapp W, Proudfoot A, Lucas A (2018). Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection. Scientific Reports. 8(1), 13433
  4. Mahon BP, Ambadapadi S, Yaron JR, Lomelino CL, Pinard MA, Keinan S, Kurnikov I, Macaulay C, Zhang L, Reeves W, McFadden G, Tibbetts S, McKenna R, Lucas AR (2018). Crystal Structure of Serp-1, a Myxomavirus-derived Immune Modulating Serpin; Structural Design of Serpin Reactive Center Loop (RCL) Peptides with Improved Therapeutic Function. Biochemistry. 57(7), 1096-1107


  1. Al-Ani M†, Ambadapadi S†, Yaron JR†, Zheng D, Fortunel A, Doroton-Guevara M, Liu L, Morshed S, Fricker J, Miles W, McKillop M, Lucas A (2017). Atrial Fibrillation Ablation Increases Inflammation-Chemokine Modulation Suppresses Activation of Leukocytes Isolated after Ablation. Cardiovascular and Hematologic Disorders: Drug Targets. 17(3), 195-204 (†Equal Contributions)
  2. Lucas A, Ambadapadi S, Mahon B, Viswanathan K, Chen H, Liu L, Dai E, Munuswami-Ramanujam G, Kwiecien JM, Yaron JR, Narute PS, McKenna R, Keenan S, Brantly M, McFadden G (2017). The Serpintine Solution. Journal of Clinical and Experimental Cardiology. 8(1), e150


  1. Yaron JR, Rao MY, Gangaraju S, Zhang L, Kong X, Su F, Tian Y, Glenn HL, Meldrum DR (2016). The oxindole Syk inhibitor OXSI-2 blocks nigericin-induced inflammasome signaling and pyroptosis independent of potassium efflux. Biochemical and Biophysical Research Communications. 472(3), 545-550
  2. Oliveira CD, Patel K, Mishra V, Trivedi RN, Noel P, Singh A, Yaron JR, Singh VP (2016). Characterization and Predictive Value of Near Infrared 2-Deoxyglucose Optical Imaging in Severe Acute Pancreatitis. PLoS ONE. 11(2), e0149073


  1. Yaron JR, Gangaraju S, Rao MY, Kong X, Zhang L, Su F, Tian Y, Glenn HL, Meldrum DR (2015). K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells. Cell Death and Disease. 6(10), e1954
  2. Kong X, Su F, Zhang L, Yaron J, Lee F, Shi Z, Tian Y, Meldrum DR (2015). A Highly Selective Mitochondria-Targeting Fluorescent K+ Sensor. Angewandte Chemie: International Edition. 54(41), 12053-12057


  1. Yaron JR, Ziegler CP, Tran TH, Glenn HL, Meldrum DR (2014). A convenient, optimized pipeline for isolation, fluorescence microscopy and molecular analysis of live single cells. Biological Procedures Online. 16(9)
    Spring 2022
    Course NumberCourse Title
    NTR 590Reading and Conference
    Fall 2021
    Course NumberCourse Title
    BIO 495Undergraduate Research
    Graduate Faculties / Mentoring History: 
    • Mr. Andrew Shabilla (2010-12)
    • Ms. Colleen Ziegler (2010-12) - Honors Thesis Committee
    • Ms. Garima Khanal, PA-C (2013)
    • Dr. Mounica Rao, MD (2013-15)
    • Mr. Fred Lee (2014-15)
    • Mr. Shubham Trivedi (2015)
    • Ms. Saara Khan (2016)
    • Ms. Quinn Urbaniak-Dornstauder (2017)
    • Ms. Mercedeh Javadi (2017-19)
    • Ms. Sarah Wallace, MBA (2018)
    • Dr. Savanah McMahon, MD (2018-19)
    • Dr. Ayman Fath, MD (2019-20)
    • Ms. Enkidia Awo (2019-20)
    • Dr. Michael Juby, DO (2019-20)
    • Ms. Michelle Burgin, MS (2017-20) - Masters Thesis Committee
    • Ms. Lauren Schutz (2018-21) - Honors Thesis Committee
    • Mr. Deepanjan Ghosh (2019 - Present)
    • Dr. Roxana Beladi, DO (2020)
    • Dr. Kyle Varkoly, DO (2020)
    • Ms. Antara Sira (2020 - Present)
    • Ms. Jordan Roberts (2020 - Present)
    • Ms. May Nguyen (2020 - Present)