Chris Diehnelt

Biodesign Center for Innovations in Medicine

Associate Research Professor

Faculty, TEMPE Campus, Mailcode 5901

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Publications

Rabinowitz, J.A., Lainson, J.C., Johnston, S.A., Diehnelt, C.W. Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands. Chem. Comm. 54 (2018) 1417-1420.
Johnston, S.A., Domenyuk, V., Gupta, N., Tavares Batista, M., Lainson, J.C., Zhao, Z.G., Lusk, J.F., Loskutov, A., Cichacz, Z., Stafford, P., Legutki, J.B., Diehnelt, C.W. A Simple Platform for the Rapid Development of Antimicrobials. Sci. Reports. 7 (2017) 17610.
Lainson, J.C., Daly, S.M., Triplett, K., Johnston, S.A., Hall, P.R., Diehnelt, C.W. Synthetic Antibacterial Peptide Exhibits Synergy with Oxacillin against MRSA. ACS Med. Chem. Lett. 8 (2017) 853-857.
Gupta, N., Lainson, J., Belcher, P.E., Shen, L., Mason, H., Johnston, S.A., Diehnelt, C.W. Cross-Reactive Synbody Affinity Ligands Capture Diverse Noroviruses. Anal. Chem. 89 (2017) 7174-7181.
Gupta, N., Lainson, J., Domenyuk, V., Zhao, Z.G., Johnston, S.A., Diehnelt, C.W. Whole-Virus Screening to Develop Synbodies for the Influenza Virus. Bioconj. Chem. 27 (2016) 2505-2512.
Lainson, J.C., Fuenmayor, M.F., Johnston, S.A., Diehnelt, C.W. Conjugation approach to produce a Staphylococcus aureus synbody with activity in serum. Bioconj. Chem 26 (2015) 2125-2132.
Diehnelt, C.W. Peptide array based discovery of synthetic antimicrobial peptides. Front. Microbiol 4 (2013) 402.
Domenyuk, V., Loskutov, A., Johnston, S.A., Diehnelt, C.W. A Technology for Developing Synbodies with Antibacterial Activity. PLoS One 8 (2013) e54162.
Gupta, N., Belcher, P.E., Johnston, S.A., Diehnelt, C.W. Engineering synthetic ligands for Tumor Necrosis Factor – Alpha. Bioconj. Chem 22 (2011) 1473-1478.
C.W. Diehnelt, M. Shah, N. Gupta, P.E. Belcher, M.P. Greving, P. Stafford, S.A. Johnston. Discovery of High-affinity Protein Binding Ligands – Backwards. PLoS One (2010).
Greving, M.P., Belcher, P.E., Diehnelt, C.W., Emery, J., Gonzalez-Moa, M., Fu, J., Johnston, S.A., Woodbury, N.W. Creating high affinity from low affinity peptide ligands via thermodynamic additivity. PLoS One (2010).
M.P. Greving, P.E. Belcher, C.D. Cox, D. Daniel, C.W. Diehnelt, N.W. Woodbury. High-Throughput Screening in Two Dimensions: Binding Intensity and Off-Rate on a Peptide Microarray. Anal. Biochem (2010).
Chris Diehnelt, N Dugan, S Peterman, W Budde. Identification of Microcystin Toxins from a Strain of Microcystis aeruginosa by Liquid Chromatography Introduction into a Hybrid Linear Ion Trap-Fourier Transform Ion Cyclotron Resonance Mass Spectrometer. Anal. Chem (2006).
Chris Diehnelt, S Peterman, W Budde. Liquid Chromatography-Tandem Mass Spectrometry and Accurate m/z Measurements of Cyclic Peptide Cyanobacteria Toxins. Trends Anal. Chem (2005).
Chris Diehnelt, R English, M Van Stipdonk, E Schweikert. Coincidence Measurements in Mass Spectrometry. Nucl. Instr. and Meth. B (2002).
Chris Diehnelt, M Van Stipdonk, E Schweikert. Effectiveness of Atomic and Polyatomic Primary Ions for Organic Secondary Ion Mass Spectrometry. Int. J. Mass Spectrom (2001).
R English, M Van Stipdonk, Chris Diehnelt, E Schweikert. Influence of Constituent Mass on Secondary Ion Yield Enhancements from Polyatomic Ion Impacts on Aminoethanethiol Self-Assembled Monolayer Surfaces. Rapid Comm. Mass Spectrom (2001).

Research Activity

Diehnelt,Chris W*. Norovirus Synbodies for Capture of Norovirus from Berry Samples (9/16/15 – 5/31/17).
Diehnelt,Chris W*, Jacobs, Bertram. Development of Ebola virus neutralizing synbodies (7/1/15 – 7/1/16).
Diehnelt,Chris W*. New Antibiotics for Superbugs (ASUF 30005899). ASU FDN(4/5/2014 - 10/31/2015).
Diehnelt,Chris W*. Development of Synbodies for AKT, KRAS, and Pneumonia. (3/1/2012 - 12/30/2012).
Arntzen,Charles*, Diehnelt,Chris W. Building Capacity to Control Viral Foodborne Disease: A Translational Multidisciplinary Approach. NORTH CAROLINA STATE UNIV(6/1/2011 - 5/31/2014).
Johnston,Stephen Albert*, Diehnelt,Chris W, Stafford,Phillip. Therapeutics to Any Pathogen in 7 Days. DOD-DARPA(7/15/2010 - 7/14/2012).
Chaput,John C*, Diehnelt,Chris W. A High-throughput Route to Synthetic Antibodies for Array-based Cancer Detection. HHS-NIH-NCI(9/29/2008 - 8/31/2011).

Courses

Fall 2019
Course Number	Course Title
BIO 495	Undergraduate Research

Summer 2019
Course Number	Course Title
BIO 495	Undergraduate Research

Spring 2019
Course Number	Course Title
BIO 493	Honors Thesis
BIO 495	Undergraduate Research

Fall 2018
Course Number	Course Title
BIO 495	Undergraduate Research

Summer 2018
Course Number	Course Title
BIO 495	Undergraduate Research

Spring 2018
Course Number	Course Title
BIO 493	Honors Thesis

Fall 2017
Course Number	Course Title
BIO 495	Undergraduate Research

Spring 2017
Course Number	Course Title
BIO 493	Honors Thesis

Fall 2016
Course Number	Course Title
BIO 495	Undergraduate Research

Spring 2016
Course Number	Course Title
BIO 493	Honors Thesis

Fall 2015
Course Number	Course Title
BIO 492	Honors Directed Study
BIO 495	Undergraduate Research

Editorships

Reviewer: Current Medical Chemistry, PLoS One, Food Chemistry Antibiotics, Journal of Virological Methods, RSC Advances, Molecular Pharmaceutics, Analytical Chemistry, and Journal of Medicinal Chemistry.

Service

Reviewer: NIH Small Business: Non-HIV Microbial Vaccine Research ZRG1 IMM-R (12)
Reviewer: NIH PR-INBRE Research Grant Program
Reviewer: Medical Research Council Antimicrobial Target Discovery and Validation (AMR TDV)
T-100 Shared Instrument Steering Committee, Member (2008 - 2014)
Judge, Intel International Science and Engineering Fair; ASU Edson Student Entrepreneurship Contest; Arizona First Lego League State Science Tournament;
Mentor, ASU College of Technology & Entrepreneurship; ASU Student Entrepreneurship Program

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Chris Diehnelt