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Chris Diehnelt

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Biodesign Center for Innovations in Medicine
Associate Research Professor
Faculty, TEMPE Campus, Mailcode 5901
Research Website: 
https://www.researchgate.net/profile/Chris_Diehnelt
Google Scholar: 
Google Scholar Profile
Publications: 
  • Jung, J., Grant, T., Thomas, D.R., Diehnelt, C.W., Grigorieff, N., Joshua-Tor, L. High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations. Proc. Nat. Acad. Sci. U.S.A. 116 (2019) 12828-12832.
  • Ma, D., Shen, L., Wu, K., Diehnelt, C.W., Green, A. Low-cost detection of norovirus using paper-based cell-free systems and synbody-based viral enrichment. Synthetic Biology. 3 (2018) ysy018.
  • Rabinowitz, J.A., Lainson, J.C., Johnston, S.A., Diehnelt, C.W. Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands. Chem. Comm. 54 (2018) 1417-1420. 
  • Johnston, S.A., Domenyuk, V., Gupta, N., Tavares Batista, M., Lainson, J.C., Zhao, Z.G., Lusk, J.F., Loskutov, A., Cichacz, Z., Stafford, P., Legutki, J.B., Diehnelt, C.W. A Simple Platform for the Rapid Development of Antimicrobials. Sci. Reports. 7 (2017) 17610.
  • Lainson, J.C., Daly, S.M., Triplett, K., Johnston, S.A., Hall, P.R., Diehnelt, C.W. Synthetic Antibacterial Peptide Exhibits Synergy with Oxacillin against MRSA. ACS Med. Chem. Lett. 8 (2017) 853-857. 
  • Gupta, N., Lainson, J., Belcher, P.E., Shen, L., Mason, H., Johnston, S.A., Diehnelt, C.W. Cross-Reactive Synbody Affinity Ligands Capture Diverse Noroviruses. Anal. Chem. 89 (2017) 7174-7181.
  • Gupta, N., Lainson, J., Domenyuk, V., Zhao, Z.G., Johnston, S.A., Diehnelt, C.W. Whole-Virus Screening to Develop Synbodies for the Influenza Virus. Bioconj. Chem. 27 (2016) 2505-2512.
  • Lainson, J.C., Fuenmayor, M.F., Johnston, S.A., Diehnelt, C.W. Conjugation approach to produce a Staphylococcus aureus synbody with activity in serum. Bioconj. Chem 26 (2015) 2125-2132.
  • Diehnelt, C.W. Peptide array based discovery of synthetic antimicrobial peptides. Front. Microbiol 4 (2013) 402.
  • Domenyuk, V., Loskutov, A., Johnston, S.A., Diehnelt, C.W.  A Technology for Developing Synbodies with Antibacterial Activity.  PLoS One 8 (2013) e54162.
  • Gupta, N., Belcher, P.E., Johnston, S.A., Diehnelt, C.W.  Engineering synthetic ligands for Tumor Necrosis Factor – Alpha. Bioconj. Chem 22 (2011) 1473-1478.
  • C.W. Diehnelt, M. Shah, N. Gupta, P.E. Belcher, M.P. Greving, P. Stafford, S.A. Johnston. Discovery of High-affinity Protein Binding Ligands – Backwards. PLoS One (2010).
  • Greving, M.P., Belcher, P.E., Diehnelt, C.W., Emery, J., Gonzalez-Moa, M., Fu, J., Johnston, S.A., Woodbury, N.W. Creating high affinity from low affinity peptide ligands via thermodynamic additivity. PLoS One (2010).
  • M.P. Greving, P.E. Belcher, C.D. Cox, D. Daniel, C.W. Diehnelt, N.W. Woodbury. High-Throughput Screening in Two Dimensions: Binding Intensity and Off-Rate on a Peptide Microarray. Anal. Biochem (2010).
  • Chris Diehnelt, N Dugan, S Peterman, W Budde. Identification of Microcystin Toxins from a Strain of Microcystis aeruginosa by Liquid Chromatography Introduction into a Hybrid Linear Ion Trap-Fourier Transform Ion Cyclotron Resonance Mass Spectrometer. Anal. Chem (2006).
  • Chris Diehnelt, S Peterman, W Budde. Liquid Chromatography-Tandem Mass Spectrometry and Accurate m/z Measurements of Cyclic Peptide Cyanobacteria Toxins. Trends Anal. Chem (2005).
  • Chris Diehnelt, R English, M Van Stipdonk, E Schweikert. Coincidence Measurements in Mass Spectrometry. Nucl. Instr. and Meth. B (2002).
  • Chris Diehnelt, M Van Stipdonk, E Schweikert. Effectiveness of Atomic and Polyatomic Primary Ions for Organic Secondary Ion Mass Spectrometry. Int. J. Mass Spectrom (2001).
  • R English, M Van Stipdonk, Chris Diehnelt, E Schweikert. Influence of Constituent Mass on Secondary Ion Yield Enhancements from Polyatomic Ion Impacts on Aminoethanethiol Self-Assembled Monolayer Surfaces. Rapid Comm. Mass Spectrom (2001).
Research Activity: 
Spring 2020
Course NumberCourse Title
BIO 493Honors Thesis
BIO 495Undergraduate Research
Fall 2019
Course NumberCourse Title
BIO 495Undergraduate Research
Summer 2019
Course NumberCourse Title
BIO 495Undergraduate Research
Spring 2019
Course NumberCourse Title
BIO 493Honors Thesis
BIO 495Undergraduate Research
Fall 2018
Course NumberCourse Title
BIO 495Undergraduate Research
Summer 2018
Course NumberCourse Title
BIO 495Undergraduate Research
Spring 2018
Course NumberCourse Title
BIO 493Honors Thesis
Fall 2017
Course NumberCourse Title
BIO 495Undergraduate Research
Spring 2017
Course NumberCourse Title
BIO 493Honors Thesis
Fall 2016
Course NumberCourse Title
BIO 495Undergraduate Research
Spring 2016
Course NumberCourse Title
BIO 493Honors Thesis
Fall 2015
Course NumberCourse Title
BIO 492Honors Directed Study
BIO 495Undergraduate Research
Honors / Awards: 
  • Member, ASU Chapter National Academy of Inventors, 2019.
  • Honors Faculty, Barrett, The Honors College at Arizona State University, 2014.
  • AZTe Achievement Award for Technology Licensing to Synbody Biotechnology, Inc., 2013.
Editorships: 

Reviewer: Current Medical Chemistry, PLoS One, Food Chemistry, Antibiotics, Journal of Virological Methods, RSC Advances, Molecular Pharmaceutics, Analytical Chemistry, Biomacromolecules, and Journal of Medicinal Chemistry.

 

Professional Associations: 

American Chemical Society, Member.

Service: 
  • Reviewer: NIH Small Business: Non-HIV Microbial Vaccine Research ZRG1 IMM-R (12)
  • Reviewer: NIH PR-INBRE Research Grant Program
  • Reviewer: Medical Research Council Antimicrobial Target Discovery and Validation (AMR TDV)
  • T-100 Shared Instrument Steering Committee, Member (2008 - 2014)

  • Judge, Intel International Science and Engineering Fair; ASU Edson Student Entrepreneurship Contest; Arizona First Lego League State Science Tournament;

  • Mentor, ASU College of Technology & Entrepreneurship; ASU Student Entrepreneurship Program