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Brian Smith

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Professor
Faculty, TEMPE Campus, Mailcode 4501
Trustees of ASU Professor
Faculty, TEMPE Campus, Mailcode 4501
Biography

Brian Smith is a behavioral neuroscientist who studies how animals learn about odors in order to predict important events, such as an encounter with food, a mate or predator. His research employs detailed behavioral studies of learning and memory. He and his research team also use a combination of electrophysiological, bioimaging, molecular and computational techniques to directly link changes in behavior to changes in the brain.

Smith’s research focuses on learning and memory systems in both insects and mammals. His work is being applied to studies of human diseases, such as Alzheimer's and Parkinson's, as well as to the negative effects of heavy metal poisoning on learning and memory.

Education

PhD, 1985, University of Kansas

Videos
Publications
  • Bazhenov M, Huerta R, Smith BH (2013) A computational framework for understanding decision making through integration of basic learning rules. J Neuroscience 13: 5686-5697. PMID: 23536082
  • Locatelli FF, Fernandez PC, Villareal F, Mezzinoglo K, Huerta R, Galizia CG, Smith BH. (2012) Non-associative plasticity alters competitive interactions among mixture components in early olfactory processing. European J Neuroscience. 37:63-79. Epub 2012 Nov 21. PMID: 23167675
  • Hladun KR, Smith BH, Mustard JA, Morton RR, Trumble JT (2012) Selenium toxicity to honey bee (Apismellifera L.) pollinators: effects on behaviors and survival. PLoS One. 2012;7(4):e34137. Epub  2012 Apr 13. PMID: 22514621.
  • Sinakevitch I, Mustard JA, Smith BH (2011) Distribution of the octopamine receptor AmOA1 in the honey bee brain. PLOS One. 2011 Jan 18;6(1):e14536. PMID: 21267078.
  • Chandra SBC, Wright GW, Smith BH (2010) An analysis of the CS pre-exposure effect in the honeybee, Apismellifera. Anim Cognition 13: 805-815. PMID: 20521073.

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  • Chen JY1, Marachlian E2, Assisi C1, Huerta R3, Smith BH4, Locatelli F5, Bazhenov M6. Learning modifies odor mixture processing to improve detection of relevant components. J Neurosci. 2015 Jan 7;35(1):179-97 (2015).
  • Brian H. Smith1, Christina M. Burden1. A Proboscis Extension Response Protocol for Investigating Behavioral Plasticity in Insects: Application to Basic, Biomedical, and Agricultural Research. Brian H. Smith1, Christina M. Burden1 (2014).
  • Szyszka P1, Gerkin RC2, Galizia CG3, Smith BH2. High-speed odor transduction and pulse tracking by insect olfactory receptor neurons. Proc Natl Acad Sci U S A (2014).
  • Sinakevitch I, Mustard JA, Smith BH. (2011). Distribution of the octopamine receptor AmOA1 in the honey bee brain. PLoSONE (2011).
  • Ahn S, Smith BH, Borisyuk A, Terman D. Analyzing neuronal networks using discrete-time dynamics. Physica D: Nonlinear Phenomena (2010).
  • Chandra SBC, Wright GW, Smith BH. An analysis of the CS preexposure effect in the honeybee, Apis mellifera. Anim Cognition (2010).
  • Drezner-Levy T, Smith BH, Shafir S. The effect of foraging specialization on various learning tasks in the honey bee (Apis mellifera). Behavioral Ecology & Sociobiology (2009).
  • Fernandez PC, Locatelli FF, Rennell N, Deleo G, Smith BH. Reinforcement tunes spatiotemporal dynamics of early olfactory processing. J Neuroscience (2009).
  • Mustard JA, Pham PM, Smith BH. Modulation of motor behavior by dopamine and the D1-like dopamine receptor AmDOP2 in the honey bee. J Insect Physiol (2009).
  • Wiegmann DD, Smith BH. Incentive relativity and the specificity of reward expectations in honey bees. Int J Comparative Psychology (2009).
  • Wright GA, Carlton M, Smith BH. A honeybee’s ability to learn, recognize, and discriminate odours depends upon odour sampling time and concentration. Behavioral Neuroscience (2009).
  • Dacher M, Smith BH. Olfactory Interference during Inhibitory Backward Pairing in Honey Bees. PLoS ONE 3(10) (2008).
  • Heather Mattila, Brian Smith. Learning and memory in workers reared by nutritionally stressed honey bee (Apis mellifera L.) colonies. Physiology & Behavior (2008).
  • Dhruba Naug, Brian Smith. Experimentally induced change in infectious period affects transmission dynamics in a social group. Proceedings of the Royal Society: Bological Sciences (2007).
  • Geraldine Wright, Julie Mustard, Sonya Kottcamp, Brian Smith. Olfactory memory formation and the influence of reward pathway during appetitive learning by honey bees. Journal of Experimental Biology (2007).
  • B Fussnecker, Brian Smith, J Mustard. Octopamine and tyramine influence the behavioral profile of locomotor activity in the honey bee (Apis mellifera). J Insect Physiology (2006).
  • Smith, Brian (Author) ,Wright, G A (Author) ,Daly, K S (Author) . Learning-based recognition and discrimination of floral odors. The Biology and Chemistry of Floral Scents (2006).
  • G Wright, A Lutmerding, N Dudareva, Brian Smith. Intensity and the ratios of compounds in the scent of snapdragon flowers affect scent discrimination by honey bees (Apis mellifera). J. Comparative Physiology (2005).
  • J Latshaw, Brian Smith. Heritable variation in learning performance affects foraging preferences in the honey bee (Apis mellifera). Behavioral Ecology Sociobiology (2005).
  • S Shafir, G Menda, Brian Smith. Caste-specific difference in risk sensitivity in honeybees. Animal Behavior (2005).
  • A Borisyuk, Brian Smith. Odor interactions and learning in a model of the insect antennal lobe. Neurocomputing (2004).
  • G Wright, Brian Smith. Different thresholds for detection and discrimination of odors in the honeybee (Apis mellifera). Chemical Senses (2004).
  • K Daly, G Wright, Brian Smith. Molecular features of odorants systematically influence slow temporal responses across clusters of coordinated antennal lobe units in the moth Manduca sexta. J. Neurophysiology (2004).
  • T Farooqui, H Vaessin, Brian Smith. Octopamine receptors in the honeybee (Apis mellifera) brain and their disruption by RNA-mediated interference. Journal of Insect Physiology (2004).
  • Daly, K, Christensen, T, Lei, H, Smith, Brian, Hildebrand, J. Learning modulates the ensemble representations for odors in primary olfactory networks. (2004).
  • Wright, G, Smith, Brian. Variation in complex olfactory stimuli and its influence on odour recognition. (2004).
  • T Farooqui, K Robinson, H Vaessin, Brian Smith. Modulation of early olfactory processing by an identified octopaminergic reinforcement pathway in the honeybee. J. Neuroscience (2003).
  • G Wright, B Skinner, Brian Smith. Ability of honeybee, Apis mellifera, to detect and discriminate odors of varieties of canola (Brassica rapa and Brassica napus) and snapdragon flowers (Antirrhinum majus). J Chem. Ecol (2002).
  • S Shafir, T Waite, Brian Smith. Context-dependent violations of rational choice in honeybees (Apis mellifera) and gray jays (Perisoreus canadensis). Behav. Ecology Sociobiology (2002).
  • C Chandra, G Hunt, Brian Smith. Quantitative trait loci associated with reversal learning and latent inhibition in honeybees (Apis mellifera). Behavior Genetics (2001).
  • H Ferguson, S Cobey, Brian Smith. Sensitivity to a change in reward is heritable in the honey bee, Apis mellifera. Animal Behaviour (2001).
  • K Daly, C Chandra, M Durtschi, Brian Smith. Generalization of olfactory-based conditioned response reveals unique but overlapping odour representations in the moth, Manduca sexta. J. Experimental Biology (2001).
  • K Daly, M Durtschi, Brian Smith. Olfactory-based discrimination learning in the moth, Manduca sexta. J. Insect Physiology (2001).
  • C Chandra, J Hosler, Brian Smith. Heritable variation for latent inhibition and its correlation to reversal learning in the honey bee, Apis mellifera. J. Comparative Psychology (2000).
  • J Hosler, Brian Smith. The intensity of blocking in odor mixtures is dependent on the identities of the odorants. J. Experimental Biology (2000).
  • J Hosler, K Buxton, Brian Smith. Differential impairment of olfactory discrimination by blockade of GABA and nitric oxide activity in the honey bee antennal lobes. Behavioral Neuroscience (2000).
  • K Daly, Brian Smith. Associative olfactory conditioning of the moth, Manduca sexta. J. Experimental Biology (2000).
  • K Robinson, H Ferguson, S Cobey, H Vaessin, Brian Smith. Sperm-mediated transformation of the honey bee, Apis mellifera. Insect Molecular Biology (2000).
  • R Masterman, Brian Smith, M Spivak. Brood odor discrimination abilities in hygenic honey bees (Apis mellifera L.) using proboscis extension reflex conditioning. J Insect Behavior (2000).
  • Y Ben-Shahar, C Thompson, S Hartz, Brian Smith, G Robinson. Performance on a reversal test is associated with division of labour in the honeybee, Apis mellifera. Animal Cognition (2000).
  • Y-S Kim, Brian Smith. Effect of an amino acid on feeding preferences and learning behavior in the honey Bee, Apis mellifera. J. Insect Physiology (2000).
Research Activity
Spring 2017
Course NumberCourse Title
BIO 492Honors Directed Study
BIO 493Honors Thesis
BIO 495Undergraduate Research
Fall 2016
Course NumberCourse Title
BIO 492Honors Directed Study
BIO 493Honors Thesis
BIO 494Special Topics
BIO 495Undergraduate Research
NEU 598Special Topics
ANB 598Special Topics
Summer 2016
Course NumberCourse Title
BIO 495Undergraduate Research
Spring 2016
Course NumberCourse Title
BIO 360Animal Physiology
BIO 394Special Topics
BIO 492Honors Directed Study
BIO 493Honors Thesis
BIO 495Undergraduate Research
Fall 2015
Course NumberCourse Title
BIO 189Life Sciences Career Paths
BIO 492Honors Directed Study
BIO 493Honors Thesis
BIO 494Special Topics
BIO 495Undergraduate Research
ANB 594Conference and Workshop
ANB 598Special Topics
NEU 598Special Topics
NEU 790Reading and Conference
Summer 2015
Course NumberCourse Title
BIO 495Undergraduate Research
Spring 2015
Course NumberCourse Title
BIO 492Honors Directed Study
BIO 493Honors Thesis
BIO 495Undergraduate Research
ANB 602Current Issues In Behavior
Fall 2014
Course NumberCourse Title
BIO 492Honors Directed Study
BIO 495Undergraduate Research
BIO 591Seminar
NEU 790Reading and Conference
Summer 2014
Course NumberCourse Title
BIO 495Undergraduate Research
Spring 2014
Course NumberCourse Title
BIO 495Undergraduate Research
Fall 2013
Course NumberCourse Title
BIO 189Life Sciences Career Paths
BIO 495Undergraduate Research
NEU 790Reading and Conference
Summer 2013
Course NumberCourse Title
BIO 495Undergraduate Research
Spring 2013
Course NumberCourse Title
BIO 495Undergraduate Research
ANB 602Current Issues In Behavior
Fall 2012
Course NumberCourse Title
BIO 467Neurobiology
NEU 790Reading and Conference
Presentations
  • Smith BH. Distributed memory in honey bees. Colloquium in Honor of Prof Randolf Menzel (Jun 2101).
  • Smith BH. Univ Konstanz, Germany. Zukunftskollege (Jun 2101).
  • Smith Bh. Bioimaging of olfaction. ASU AIMS Conference (May 2101).
  • BH Smith. Two invited presentations. Beijing/APACE meetigns on Chemical Ecology (Oct 2011).
  • BH Smith. Invited presentation. European Symposium on Insect Taste and Olfaction (Sep 2011).
  • BH Smith. Invited presentation. Janelia Farm honey bee/ fly meeting (May 2011).
  • BH Smith. Invited participation. Cold Spring Harbor Laboratory leadership in Bioscience (Feb 2011).
  • BH Smith. Invited presentation. MURI annual meeting (Jan 2011).
  • Smith, Sinakevitch, Bazhenov, Huerta, Strube-Bloss. Total of 5 poster presentations. Society for Neuroscience Conference (Nov 2010).
  • Smith BH. Basic research on honey bees. European Entomological Congress (Sep 2010).
  • Smith BH. Olfactory plasticity in honey bees. Brazil Apiculture Workshop (Jul 2010).
  • Smith BH. Dynamical processing of odors. Univ Sussex Olfaction Workshop (Jun 2010).
  • Smith, BH, Huerta R, Bazhanov M. Dynamics of Olfactory Processing. Association for Chemoreception (Apr 2010).
  • Smith BH. Olfaction in honey bees. Univ California Riverside Neuroscience Program (Feb 2010).
  • Smith BH. Insect Olfaction. UCSD MURI/ONR workshop (Jan 2010).
  • BH Smith. Nonassociative plasticity in early olfactory processing. Pavlovian Society meeting Burlington VT (Oct 2009).
  • BH Smith. Workshop. CETMONS (Oct 2009).
  • M Strube-Bloss, MA Herrera-Valdez, BH Smith. Representation of single odors and mixtures at the input and the output stages of the honey bee Mushroom Body. Society for Neuroscience 2009 (Oct 2009).
  • I Sinakevitch, S Birman, BH Smith. Octopamine receptor 1 (OA1) is expresses by inhibitory neurons of olfactory and learning and memory centers in honey bee and Drosophila. Society for Neuroscience 2009 (Oct 2009).
  • BH Smith. Plasticity in early olfactory processing. University Wuerzburg Germany (Jul 2009).
  • BH Smith. Plasticity in early olfactory processing. Telluride Workshop on Neuromorphic Engineering (Jul 2009).
  • BH Smith. Plasticity in early olfactory processing. Olfactory coding meeting Berlin Germany (Jul 2009).
  • BH Smith. Plasticity in early olfactory processing. Insect Learning & Memory meeting France (Jun 2009).
  • BH Smith. Plasticity in early olfactory processing. COSYNE meeting (Mar 2009).
  • BH Smith. Plastitcity in early olfactory processing. Max Plank Inst Heidelberg (Dec 2008).
  • BH Smith. Plasticity of early olfactory processing. Janelia Farm/HHMI research conference (Nov 2008).
  • BH Smith. Plasticity of early olfactory processing. University of VA (Oct 2008).
  • BH Smith. Plasticity of early olfatory processing. U of AZ/ASU Coll of Medicine (Sep 2008).
  • BH Smith. Plasticity of early olfactory processing. Tellurie workshop on Neuromorphic Engineering (Jul 2008).
  • BH Smith. Ecology opf insect learning. International Congree of Entomology (Jul 2008).
  • Matthieu DACHER, Fernando LOCATELLI, Sharon M. CROOK, Brian H. SMITH. Olfactory interference: an attention-like process in the honey bee Apis mellifera ?. FENS Congress in Geneva (Switzerland) (Jul 2008).
  • Matthieu DACHER, Brian H. SMITH. Olfactory interference: is learning really similar in free-flying and restrained bees?. European Conference of Behavioural Biology in Dijon (France) (Jul 2008).
  • Matthieu DACHER, Sharon M. CROOK, Brian H. SMITH. Spatio-temporal activity of neurons in the insect antennal lobe: a data driven computational model. International Symposium on Olfaction and Taste in San Francisco (Jul 2008).
  • Fernández, P., Locatelli F., Yoshihiro A, Bramble R., & Smith B. Discrimination and generalization in natural floral blends. International Symposium on Olfaction and Taste (ISOT) (Jul 2008).
  • Matthieu DACHER, Sharon M. CROOK, Brian H. SMITH. -temporal activity of neurons in the insect antennal lobe: a data driven computational model. ("Neurobiology de l’invertébré" (May 2008).
  • BH Smith. Plasticity in early olfactory processing. Univ of Ill Entomology department seminar (Feb 2008).
  • Smith, Brian. Conference on Chemosensory Modulation
  • Smith, Brian. Joint Mathematics Meetings
  • Smith, Brian. 'Insect CNS-MMX' meeting
  • Smith, Brian. Chemoreception Sciences Meeting
  • Smith, Brian. Computational Neuroscience meeting
  • Smith, Brian. Conference on Mathematical Neuroscience
  • Smith, Brian. Gordon Research Conference on 'Genes & Behavior'
  • Smith, Brian. International Entomology Congress
  • Smith, Brian. NSF Collaborative Research on Computational Neuroscience meeting
  • Smith, Brian. Society for Mathematical Biology
  • Smith, Brian. 7th European Symposium for Insect Taste and Olfaction Grass Foundation lecture Eastern Nerve Net meetings
  • Smith, Brian. Department of Neurobiology & Behavior
  • Smith, Brian. Entomological Society of America
  • Smith, Brian. European IUSSI meetings
  • Smith, Brian. Minibrain Symposium
  • Smith, Brian. The Hebrew University of Jerusalem
  • Smith, Brian. Association for Chemical Senses
  • Smith, Brian. Association for the Study of Animal Behaviour
  • Smith, Brian. Department of Biology, Indiana University
  • Smith, Brian. Department of Biology, Vanderbilt University
  • Smith, Brian. Department of Horticulture and Crop Science, Purdue University
  • Smith, Brian. Gordon Conference on Neuroethology
  • Smith, Brian. IUSSI meetings
  • Smith, Brian. Rothamsted Agricultural Research Station
  • Smith, Brian. Symposium on Neuroscience, Gordon Conference on Floral Chemistry
  • Smith, Brian. Virginia Commonwealth University, Department of Biology
  • Smith, Brian. Case Western Reserve IGERT program
  • Smith, Brian. Entomological Society of America
  • Smith, Brian. University of Florida Center for Smell and Taste
  • Smith, Brian. Washington State University
  • Smith, Brian. Winter Conference on Learning & Memory
  • Smith, Brian. Hebrew University
  • Smith, Brian. Insect Sensors and Robotics meeting
  • Smith, Brian. International Congress of Entomology
  • Smith, Brian. Workshop on "Coherence and Coordination in the Brain: Perspectives From Olfaction And Birdsong"
  • Smith, Brian. Building a Community to Foster New approaches to Study Genes Brain and Behavior with the Honey Bee
  • Smith, Brian. NASA Center for Advanced Studies in the Space Life Sciences symposium on Invertebrate Sensory Information Processing
  • Smith, Brian. North Carolina State University
  • Smith, Brian. Progress In Invertebrate Neurobiology
  • Smith, Brian. XXI International Congress of Entomology
Service
  • PNAS J Comp Physiol PLoSOne Zukunftskolleg NSF CRCNS NIH BRAIN PRS-B Anim Beh Current Biol, Reviewer (2014 - Present)
  • NIH NICHD, Site visit for intramural research program (2011 - Present)
  • School of Life Sciences, Director (2011 - Present)
  • NIH NIDCD, grant review (2011 - Present)
  • PLOSOne, Reviewer (2011 - Present)
  • Current Biology, Reviewer (2011 - Present)
  • NSF, Grant proposal review (2011 - Present)
  • National Institutes of Health, Reviewer for grant proposals (2011 - Present)
  • PNAS, Reviewer (2011 - Present)
  • President's Faculty Advisory Committee, member (2011 - Present)
  • Preparing Future Faculty Program, Discussant (2010 - Present)
  • Provost's meeting with Univ of Toledo group, participant (2010 - Present)
  • Faculty Advisory Council for President, member (2010 - Present)
  • Interdisciplinary Graduate Program in Neuroscience, Director (2010 - Present)
  • OISB, Faculty Leader (2010 - Present)
  • Frontier in Neuroscience, Reviewer (2009 - Present)
  • Journal of Comparative Neurology, Reviewer (2009 - Present)
  • Dean's Faculty/Scientific Advisory Committee Keck Lab, member (2009 - Present)
  • Marsden Fund (New Zealand), Reviewer (2009 - Present)
  • NIH S10 proposals, Reviewer (2009 - Present)
  • Faculty Leader OISB, Faculty Leader (2009 - Present)
  • Chemical Senses, Reviewer (2009 - Present)
  • NIH NIDCD Special Emphasis Panel, Reviewer (2009 - Present)
  • Journal of Neuroscience, Reviewer (2009 - Present)
  • National Institutes of Health, Reviewer (2009 - Present)
  • CRCNS France, Reviewer (2009 - Present)
  • National Science Foundation, Reviewer (2009 - Present)
  • Frontiers in Systems Neuroscience, Review Editor/Editorial Board (2008 - Present)
  • NIH-National Inst of Child Health and Development, Program review (2008 - Present)
  • Interdisciplinary Graduate Program in Neuroscience, Director (2008 - Present)
  • Genes, Brain and Behavior, reviewer (2008 - Present)
  • NIH-National Inst of Deafness and other Communication Disorders, Study section (2008 - Present)
  • J Experimental Biology, reviewer (2008 - Present)
  • Journal of Neuroscience, reviewer (2008 - Present)
  • University Promotion & Tenure Committee, Chair (2007 - Present)
  • Center for Adaptive Neural Systems, Executive Committee member (2007 - Present)
  • Interdisciplinary Graduate Program in Neuroscience, Director (2007 - Present)
  • SoLS Promotion & Tenure Committee, (2007 - Present)
  • ASU-BNI 2nd Annual Neuroscience Symposium, Co-organizer (2006 - Present)
  • SOLS, Director (2014 - 2014)
  • IDGP Neuroscience, Director (2011 - 2011)
  • Leadership Fellows Program, Participant (2011 - 2011)
  • OISB/SOLS, Faculty Leader (2011 - 2011)
  • Univ Wuerzburg, Germany, External examiner for Habilitation (2010 - 2010)
  • University of Dunnedin, New Zealand, External thesis examiner (2010 - 2010)
  • University Promotion & Tenure, Chair (2010 - 2010)
  • University Promotion & Tenure Committee, Chair (2009 - 2009)
  • HEXAPODIUM, Organizer (2008 - 2008)
  • University of Califonia Los Angeles, Promotionand tenure review (2008 - 2008)
  • SOLUR, Organized SOLUR program seminar (2008 - 2008)
  • PNAS, Ad hoc reviewer (2006 - 2007)
  • iGEP in Neuroscience and now Neuroscience & Behavior working group, Committee member and now Chair of N&B working group (2006 - 2006)
  • National Institutes of Health, Outside reviewer for site visit at NICHD (2006 - 2006)
  • National Institutes of Health, Ad hoc review Learning & Memory IFCN-7 study section (2006 - 2006)
  • NIH IFCN-7 study section, Ad hoc reviewer (2005 - 2005)
  • NIH BRLE study section, Panel member/reviewer (1998 - 2005)
  • College of Biological Sciences, Member, Promotion & Tenure committee (2001 - 2004)
  • Dean's Advisory Committee, College of Biological Sciences, Member (2001 - 2003)