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Yan Liu

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Biodesign Center for Molecular Design & Biomimetics
Associate Professor
Faculty, TEMPE Campus, Mailcode 7301
School of Molecular Sciences
Associate Professor
Faculty, TEMPE Campus, Mailcode 7301
Biography

Yan Liu received her B.S. (1993) from Shandong University Department of Applied Chemistry, specialized in colloidal chemistry. Her Ph.D. (2000) work in Columbia University was focused on using second harmonic generation to study the surface properties of colloidal particles. She did postdoctoral research in Rockefeller University and Duke University studying photobiology and photochemistry of proteins and pigment. She joined the faculty of Arizona State University at Biodesign Institute in 2004. She is currently an associate professor in the School of Molecular Science and the Biodesign Institute at ASU. Her current research interests focus on understanding the physical chemistry aspects of DNA based self-assembly and developing applications of DNA-directed assembly in nanophotonics and nanomedicine. 

 

CV
Binary Data Curriculum Vitae
Education
  • Ph.D. Columbia University 2000
  • B.S. Colloidal Chemistry, Shandong University Department of Applied Chemistry 1993
Research Interests

Our research is focused on the following three themes:

1. Chemical synthesis and photophysics of quantum materials:   Quantum-size semiconductor building blocks, such as quantum dots, quantum wires, and quantum sheets and the corresponding hetero-structures have broad applications ranging from light emitting diodes, nanolasers, nanoelectronics, solar cell devices to biological fluorescent labels. Constructing highly tunable building blocks and the corresponding hetero-structures with control over the size, shape, composition, crystalinity, and their hierarchical structures is vitally important to fully exploit these materials. We aim to develop state of the art colloidal chemistry strategy to synthesize and characterize a series of novel quantum materials with unique optical and electronic properties and investigate their applications in functional nanodevices.

2. Physical chemistry of DNA nanotechnology: DNA nanotechnology allows the design and construction of nanoscale objects that have finely-tuned dimensions, orientation, and structure with remarkable ease and convenience. With the increasing complexity of the DNA nanostructural system these days, much fundamental studies are needed to further understand the underlying physical chemistry. First, we aim to systematically investigate the thermodynamics and kinetics of DNA nanostructure formation. These thermodynamics and kinetics studies will shed light on the stability of the DNA nanostructures, push the limit on their application conditions, and improve their performance. Second, we aim to engineer synthetic DNA nanostructures to model or mimic a variety of other molecules and systems. For example, synthetic DNA nanostructures can be designed to serve as models to study the binding behavior of multi-valent molecules and gain insight into how small changes to the ligand/receptor scaffolds, such as conformational flexibility or relative distance or orientation of the multiple ligands, will affect their association equilibrium with the target molecules. This is important in understanding many multi-valent interactions in nature, like pathogen invasion, immunology recognition, cell-cell interaction.

3. DNA directed deterministic positioning of nanophotonic elements: Systematical study of photonic elements interactions with deterministic positioning at nanometer scale is very important for: a) fundamental understanding of the underlying distance dependent interactions and energy transfer between various photonic elements; b) providing useful models to understand photonic antenna systems existing in nature; c) providing crucial information for constructing artificial biophotonic systems for applications ranging from light harvesting to biosensing. Along this line, we aim to use DNA directed self-assembly to: a) study distance dependent effects between metallic nanoparticles and organic fluorophores; b) construct molecular antenna systems for efficient light harvesting; c) construct and understand geometry dependent energy transfers between fluorophores. We are also collaborating with theory group to fully understand these nanostructured photonic systems. Experiments are designed to test theoretical hypothesis and modeling. New models will be developed by taking into account of many experimental parameters resulting from the deterministic positioning of photonic elements.

Publications
  • Y. Dong. Y. Renee Yang, Y. Zhang, D. Wang, X. Wei, S. Banerjee, Y. Liu, Z. Yang, H. Yan and D. Liu. Cuboid Vesicles Formed by Frame-Guided Assembly on DNA Origami Scaffolds. Angew Chemie. Int. Ed. (2017).
  • S. Jiang, F. Hong, H. Yan, Yan Liu. Understanding the Elementary Steps in DNA Tile-based Self-assembly. ACS Nano (2017).
  • F. Hong, F. Zhang, Y. Liu, H. Yan. DNA Origami: Scaffolds for Creating Higher Order Structures. Chem. Rev. (2017).
  • C. Simmons, F. Zhang, T. MacCulloch, N. Fahmi, N. Stephanopoulos, Y. Liu, N. Seeman, H. Yan. Tuning the Cavity Size and Chirality of Self-Assembling 3D DNA Crystals. J. Am. Chem. Soc. (2017).
  • Y.R. Yang; J. Fu, S. Wootten, X. Qi, M. Liu, H. Yan, Y. Liu. 2D Enzyme Cascade Network with Efficient Substrate Channeling by Swinging Arms.   ChemBioChem (2017).
  • X. Lan, Z. Su, Y. Zhou, T. Meyer, Y. Ke, Q. Wang, W. Chiu, N. Liu, S. Zou, H. Yan, Y. Liu. Programmable Supra-Assembly of DNA Surface Adapter for Tunable Chiral Directional Self-Assembly of Gold Nanorods. Angew. Chemie. Int. Ed   (2017).
  • D. Han, X. Qi, C. Myhrvoid, B. Wang, M. Dai, S. Jiang, M. Bates, Y. Liu, B. An, F. Zhang, H. Yan, P. Ying. Single-stranded DNA and RNA origami. Science (2017)
  • C. Zhang, J. Yang, S. Jiang, Y. Liu, and H. Yan. DNAzyme-Based Logic Gate-Mediated DNA Self-Aseembly. Nano Lett. (2016).
  • Z. Zhao, J. Fu, S. Dhakal, A. Johnson-Buck, M. Liu, T. Zhang, N. Woodbury, Y. Liu, N. Walter*, H. Yan*. Nano-caged Enzymes with Enhanced Catalytic Activity and Increased Stability against Protease Digestion. Nature Commun. (2016).
  • W. Li, F. Zhang, H. Yan, Y. Liu. DNA Based Arithmetic Function: Half Adder Based on DNA Strand Displacement. Nano Scale (2016          ).
  • M. Liu, J. Fu, X. Qi, S. Wooten, N. W. Woodbury, Y. Liu, H. Yan. A three-enzyme pathway with an optimized geometric arrangement to facilitate substrate transfer. ChemBioChem (2016).
  • G. Ke, M. Liu, S. Jiang, X. Qi, Y. R. Yang, S. Wootten, F. Zhang, Z. Zhu, Y. Liu, C. J. Yang, H. Yan. Directional Regulation of Enzyme Pathways via the Control of Substrate Channeling on a DNA Origami Scaffold. Angew. Chemie. Int. Ed. (2016).
  • F. Zhang?, S. Jiang, W. Li, A. Hunt, Y. Liu, H. Yan. Self-Assembly of Complex DNA Tessellations by Using Low-Symmetry Multi-arm DNA Tiles. Angew Chemie. Int. Ed. (2016).
  • C. Simmons; F. Zhang; J. Birktoft; X. Qi; D. Han; Y. Liu; R. Sha; H. Abdallah; C. Hernandez; Y. Ohayon; N. Seeman; H. Yan. Construction and Structure Determination of a Three-dimensional DNA Crystal.       J. Am. Chem. Soc. (2016).
  • F. Hong. S. Jiang, T. Wang, Y. Liu, H. Yan. 3D Framework DNA Origami with Layered Crossovers. Angew Chemie. Int. Ed.          (2016).
  • Y. Yang, Y. Liu, H. Yan. DNA Nanostructures as Programmable Biomolecular Scaffolds. Bioconjugate Chemistry (2015).
  • F. Zhang, S. Jiang, S. Wu, C. Mao, Y. Liu, H. Yan. Complex Wireframe DNA Origami Nanostructures with Multi-arm Junction Vertices.  Nature Nanotech (2015).
  • A. Samanta, S Banerjee, Y Liu. DNA nanotechnology for nanophotonic applications. Nanoscale (2015).
  • A. Samanta, H. Yan and Y. Liu*. Fluorescence Quenching of Quantum Dots by Gold Nanoparticles: a Potential Long Range Spectroscopic Ruler. Nano Letts (2014).
  • A. Samanta, Z. Deng, Y. Liu*. Infrared Emitting Quantum Dots: DNA Conjugation and DNA Origami Directed Self-Assembly. Nanoscale (2014).
  • D. Wang, S.L. Capehart, S. Pal, M. Liu, L.Zhang, P. J. Schuck, Y. Liu, H Yan , M. B. Francis, and J. J. De Yoreo*. Hierarchical Assembly of Plasmonic Nanostructures Using Virus Capsid Scaffolds on DNA Origami Templates. ACS Nano (2014).
  • F. Zhang, J. Nangreave, Y. Liu, H. Yan*. Structural DNA Nanotechnology: State of the Art and Future Perspectives. J. Am. Chem. Soc (2014).
  • J. Flory, C. Simmons, S. Lin, T. Johnson, A. Andreoni, G. Ghirlanda, Y. Liu, H. Yan, P. Fromme*. Low Temperature Assembly of Functional 3D DNA-PNA-Protein Complexes. J. Am. Chem. Soc (2014).
  • J. Fu, Y. Yang, A. Johnson-Buck, M. Liu, Y. Liu, N. Walter, N. W. Woodbury, H. Yan*. An Engineered Multi-Enzyme Complex Utilizing Substrate Channeling by a Swinging Arm. Nature Nanotech (2014).
  • P. K. Dutta, S. Levenberg, A. Loskutov, D. Jun, R. Saer, J. Beatty, S. Lin, Y. Liu, N. W. Woodbury,* H. Yan*. A DNA-Directed Light-Harvesting/Reaction Center System. J. Am. Chem. Soc (2014).
  • P. K. Dutta, S. Lin, A. Loskutov, S. Levenberg, R. Saer, J. T. Beatty, Y. Liu, H. Yan,* N. Woodbury*. An Engineered System to Enhance and Control the Absorption Cross-section of Photosynthetic Reaction Center. J. Am. Chem. Soc (2014).
  • S. Jiang, H. Yan, Y. Liu*. Kinetics of DNA tile assembly. ACS Nano (2014).
  • W. Li, Y. Yang, S. Jiang, H. Yan, Y. Liu*. Controlled Nucleation and Growth of DNA Tile Arrays within Prescribed DNA Origami Frames and Their Dynamics. J. Am. Chem. Soc (2014).
  • X. Wei. J. Nangreave, Y. Liu*. Uncovering the Self-Assembly of DNA Nanostructures by Thermodynamics and Kinetics. Accounts of Chemical Research (2014).
  • A. Samanta, Z. Deng, H. Yan, Y. Liu*. A perspective on Functionalizing Colloidal Quantum Dots with DNA. Nano Research (2013).
  • D. Han*, S. Pal, S. Jiang, Y. Yang, J. Nangreave, Y. Liu*, H. Yan*. DNA Gridirons nanostructures based on Four-Arm Junctions. Science (2013).
  • D. Han, S. Jiang, A. Samanta, Y. Liu, H. Yan*. Unidirectional Scaffold-Strand Arrangement in DNA Origami,. Angew. Chem. Int. Ed (2013).
  • F. Zhang, H. Yan*, Y. Liu*. Complex Archimedean Tiling Self-assembled from DNA Nanostructures. J. Am. Chem. Soc (2013).
  • J. Flory, S. Shinde, S. Lin, Y. Liu, H. Yan, G. Ghirlanda, P. Fromme*. PNA-peptide Assembly in a 3D DNA Nanocage at Room Temperature. J. Am. Chem. Soc (2013).
  • M. Liu, J. Fu, C. Hejesen, Y. Yang, N. W, Woodbury, K. Gothelf, Y. Liu, H. Yan*. A DNA-Tweezer Actuated Enzyme Nnaoreactor. Nature Communications (2013).
  • O. Schultz, Z. Zhao, A. Ward, M. Koenig, F. Koberling, Y. Liu, J. Enderlein, H. Yan, R. Ros*. Tip induced fluorescence quenching for nanometer optical and topographical resolution. Optical Nanoscopy (2013).
  • Q. Mei, R. Johnson, X. Wei, F, Su, Y. Liu, L. Kelbauskas, S. Lindsey, H. Yan, D. Meldrum. On-chip Isotachophoresis Separation of Functional DNA Origami Capture Nanoarrays from Cell Lysate. Nano Research (2013).
  • S. Pal, P. Dutta, Z. Deng, H. Yan*, Y. Liu*. Quantum Efficiency Modification of Organic Fluorophores Using Gold Nanoparticles on DNA Origami Scaffolds. J. Phys. Chem. C (2013).
  • W. Li, H. Yan, Y. Liu*. 3-input Majority logic gate and multiple input logic circuit based on DNA strand displacement. Nano Lett (2013).
  • X. Liu, Y. Liu*, H. Yan*. Functionalized DNA Nanostructures for Nanomedicine,. Israel Journal of Chemistry, (2013).
  • X. Wei. J. Nangreave, H. Yan, Y. Liu*. Mapping the Thermal Behavior of DNA Origami Nanostructures. J. Am. Chem. Soc (2013).
  • Y. Yang, Z. Zhao, F. Zhang, J. Nangreave, Y. Liu*, H. Yan*. Self-assembly of DNA rings from scaffold free DNA tiles. Nano Lett (2013).
  • Z. Deng, S. Pal, A. Samanta, H. Yan, Y. Liu*,. DNA functionalization of colloidal II–VI semiconductor nanowires for multiplex nanoheterostructures. Chemical Science (2013).
  • Z. Zhao, Y. Liu, H. Yan*. DNA Origami Templated Self-assembly of Discrete Length Single Wall Carbon Nanotubes. Organic and Biomolecular Chemistry (2013).
  • Z. Zhao, Y. Liu, H. Yan*, Organic and Biomolecular Chemistry. In press, 2012. DNA Origami Templated Self-assembly of Discrete Length Single Wall Carbon Nanotubes. Organic and Biomolecular Chemistry (2013).
  • A. Pinheiro, J. Nangreave, S. Jinag, H. Yan, Y. Liu*,. Steric Crowding and the Kinetics of DNA Hybridization within a DNA Nanostructure System. ACS NANO (2012).
  • A. Samanta, Z. Deng, Y. Liu*,. Aqueous Synthesis of Glutathione-Capped CdTe/CdS/ZnS and CdTe/CdSe/ZnS Core/Shell/Shell Nanocrystal Hetero-structures. Langmuir (2012).
  • F. Zhang, J. Nangreave, Y. Liu*, H. Yan*. Reconfigurable DNA Origami to Generate Quasi-Fractal Patterns. Nano Letters (2012).
  • J. Fu, M. Liu, Y. Liu, H. Yan*. Article ASAP, DOI: 10.1021/ar200295q, 2012. Spatially-Interactive Biomolecular Networks Organized by Nucleic Acid Nanostructures. Accounts of Chemical Research (2012).
  • J. Fu, M. Liu, Y. Liu, N. Woodbury*, H. Yan*. Inter-enzyme substrate diffusion for an enzyme cascade organized on spatially addressable DNA nanostructures. J. Am. Chem. Soc (2012).
  • X. Liu, Y. Xu, T. Yu, C. Clifford, Y. Liu, H. Yan*, Y. Chang*. A DNA Nanostructure Platform for Directed Assembly of Synthetic Vaccines. Nano Letters, (2012).
  • Y. Yang, D. Han, J. Nangreave, Y. Liu*, H. Yan*. DNA origami with double stranded DNA as a Unified Scaffold. ACS Nano (2012).
  • Z. Deng, A. Samanta, J. Nangreave, H. Yan*, Y. Liu*, 134, 17424–17427, 2012. DOI: 10.1021/ja3081023 - featured in JACS Spotlights. Robust DNA-Functionalized Core/Shell Quantum Dots with Fluorescent Emission Spanning from UV–vis to Near-IR and Compatible with DNA-Directed Self-Assembly. J. Am. Chem. Soc (2012).
  • Z. Deng, D. Cao, J. He, S. M. Lindsay, Y. Liu*,. Solution Synthesis of Ultrathin Single-Crystalline SnS Nanoribbons for Photodetectors via Phase Transition and Surface Processing. ACS Nano (2012).
  • Z. Li, L. Wang, H. Yan, Y. Liu*,. Effect of DNA Hairpin Loops on the Twist of Planar DNA Origami Tiles. Langmuir (2012).
  • C. Simmons, X. Wei, A. Volosin, D. Schmitt, D-K. Seo*, Y. Liu, and H. Yan*,. Size Selective Incorporation of DNA Nanocages into Nanoporous Antimony-Doped Tin Oxide Materials. ACS Nano. 5, 6060-6068, 2011 (2011).
  • D. Han*, S. Pal, J. Nangreave, Z. Deng, Y. Liu*, H. Yan*. DNA Origami with Complex Curvatures in Three-Dimensional Space. Science (2011).
  • J. Nangreave, H. Yan, Y. Liu*. DNA Nanostructures as Models for Evaluating the Role of Enthalpy and Entropy in Polyvalent Binding. J. Am. Chem. Soc (2011).
  • P. Dutta, R. Varghese, S. Lin, H. Yan, Y. Liu*. DNA Directed Artificial Light Harvesting Antenna. J. Am. Chem. Soc. 133, , 2011 (2011).
  • Q. Mei, X. Wei, F. Su, Y. Liu, C. Youngbull, R. Johnson, S.Lindsay, H. Yan *, D. Meldrum, *. Stability of DNA origami nanoarrays in cell lysates. Nano Letts. 11, 1477–1482, 2011 (2011).
  • S. Pal, R. Varghese, Z. Deng, H. Yan*, Y. Liu*. Site specific synthesis and in-situ immobilization of fluorescent silver nanoclusters on DNA nanoscaffolds using Tollens’ reaction. Angew. Chem. Int. Ed (2011).
  • S. Pal, Z. Deng, Y. Liu*, H. Yan*,. DNA Origami Directed Self-assembly of Anisotropic Plasmonic Nanostructures. J. Am. Chem. Soc (2011).
  • X. Liu, H. Yan, Y. Liu*, Y. Chang*,. Targeted Cell-Cell Interactions by Multivalent Bi-specific Aptamers. Small, (2011).
  • Y. Liu*,. Nanomaterials: DNA Brings Quantum Dots to Order,. Nature Nanotechnology (2011).
  • Z. Deng, D. Han, Y. Liu*. Colloidal Synthesis of Metastable Zinc-Blende SnS Nanocrystals with Tunable Sizes. Nanoscale (2011).
  • Z. Deng. L. Tong, M. Flores, S. Lin, J-X Cheng, H. Yan, Y. Liu*,. High-Quality Manganese-Doped Zinc Sulfide Quantum Rods with Tunable Dual-Color and Multiphoton Emissions. J. Am. Chem. Soc (2011).
  • Z. Zhao, Erica L. Jacovetty, Y. Liu*, H. Yan*,. Encapsulation of Gold Nanoparticles in a DNA Origami Cage. Angew. Chem. Int. Ed (2011).
  • Z. Zhao, Y. Liu*, H. Yan*,. Organizing DNA Origami Tiles Into Larger Structures Using Pre-formed Scaffold Frames. Nano Letts. 11, 2997-3002, 2011 (2011).
  • Y Liu. Nanomaterials: DNA Brings Quantum Dots to Order,. (2011).
  • B. Ding, H. Wu, W.Xu, Z. Zhao, Y. Liu, H. Yu*, Hao Yan*. Interconnecting Gold Islands with DNA Origami Nanotubes. Nano Letts (2010).
  • D. Han, S. Pal, Y. Liu,* H. Yan*. DNA Folding and cutting DNA into reconfigurable topological nanostructures. Nature Nanotechnology (2010).
  • H. Pei, N. Lu, Y. Wen, S. Song, Y. Liu, H. Yan*, C. Fan*,. A DNA Nanostructure-based Biomolecular Probe Carrier Platform for Electrochemical Biosensing. Advanced Materials (2010).
  • J. Nangreave, D. Han, Y. Liu, H. Yan. DNA Origami: A History and Current Perspective. Current Opinions in Chemical Biology (2010).
  • N. Stephanopoulos, M. Liu, G.Tong, Z. Li, Y. Liu, H. Yan, M. Francis*,. Immobilization and One-Dimensional Arrangement of Virus Capsids With Nanoscale Precision Using DNA Origami. Nano. Lett (2010).
  • Q. Wang*, H. Wang, C. Lin, J. Sharma, S. Zou, Y. Liu*,. Photonic Interactions between Quantum Dots and Au Nanoparticles in DNA Directed Self-assembly. Chem. Commun (2010).
  • R. Chhabra, J. Sharma, Y. Liu, S. Rinker, H. Yan*,. DNA Self-assembly for Nanomedicine,. Advanced Drug Delivery Reviews (2010).
  • S. Pal, Z. Deng, H. Yan* and Y. Liu*. DNA Origami Directed Self-assembly of Discrete Silver Nanoparticle Architectures. Angew. Chem. Int. Ed (2010).
  • Z. Deng, H. Yan, Y. Liu*. Controlled Colloidal Growth of Magic-Sized Ultra-Thin Single-Crystal ZnS Nanowires. Angew. Chem. Int. Ed (2010).
  • Z. Deng, O. Schulz, S. Lin, B. Ding, X. Liu, X. Wei, R. Ros, H. Yan, Y. Liu*,. Aqueous Synthesis of Zinc-Blende CdTe/CdS Magic-Core/Thick-Shell Tetrahedral Shaped Nanocrystals with Near-Infrared Emission,. J. Am. Chem. Soc (2010).
  • Z. Li, M. Liu, L. Wang, H. Yan, Y. Liu*. Molecular Behavior of DNA Origami in Higher Order Self-assembly. J. Am. Chem. Soc (2010).
  • Z. Zhao, H. Yan, Y. Liu*,. A Route to Scale up DNA Origami using DNA Tiles as Folding Staples. Angew. Chem. Int. Ed (2010).
  • . Y. Ke, S. Douglas, M. Liu, J. Sharma, A. Cheng, A. Leung, Y. Liu, W. Shih*, H. Yan*,. Multilayer DNA Origami Packed on a Square Lattice,. J. Am. Chem. Soc (2009).
  • C. Lin, Y. Ke, Z. Li, J. Wang, H. Yan* and Y. Liu. Mirror Image DNA Nanostructures for Chiral Supramolecular Assemblies. Nano. Lett (2009).
  • C. Lin, Y. Liu, H. Yan. Designer DNA Nanoarchitectures. Biochemistry (2009).
  • C. S. Andersen, M. M. Knudsen, R. Chhabra, Y. Liu, H. Yan*, K. V. Gothelf. Distance Dependent Interhelical Couplings of Organic Rods Incorporated in DNA 4-Helix Bundles,. Bioconjugate Chem (2009).
  • J. Nangreave, H. Yan and Y. Liu*. Studies of Multivalent DNA Hybridization in a Nanostructured System. Biophysical J (2009).
  • J. Sharma, R. Chhabra, Anchi Cheng, Jonathan Brownell, Yan Liu, * Hao Yan*. Engineering Complex 3D Nanoparticle Architectures Through DNA Mediated Self-assembly. Science (2009).
  • L. A. Stearns, R. Chhabra, J. Sharma, Y. Liu, W. T. Petuskey, H. Yan*, J. C. Chaput*,. Template-Directed Nucleation and Growth of Inorganic Nanoparticles on DNA Scaffolds. Angew. Chem. Int. Ed (2009).
  • R. Chhabra, J. Sharma, S. Zou, S. Lin, H. Yan S. Lindsay*, Y. Liu*. Distance dependent photoluminescence quenching of molecular dyes with spatially controlled gold nanoparticles. Nanotechnology (2009).
  • S. Pal, J. Sharma, H. Yan, Y. Liu*,. Stable Silver Nanoparticle-DNA Conjugates for Directed Self-assembly of Core-Satellite Silver-Gold Nanoclusters,. Chem. Commun (2009).
  • Y. Ke, J. Sharma, K. Jahn, M. Liu, Y. Liu, H. Yan. Scaffolded DNA origami of a DNA tetrahedron molecular container,. Nano. Lett (2009).
  • Z. Deng*, H. Yan, Y. Liu*, Band Gap Engineering of Quaternary Alloyed ZnCdSSe Quantum Dots via a Facile Phosphine-Free Colloidal Method,. Band Gap Engineering of Quaternary Alloyed ZnCdSSe Quantum Dots via a Facile Phosphine-Free Colloidal Method,. J. Am. Chem. Soc (2009).
  • Z. Li, B. Wei, J. Nangreave, C. Lin, Y. Liu, Y. Mi, and H. Yan*,. A Replicable Tetrahedral Nanostructure Self-Assembled from a Single DNA Strand. J. Am. Chem. Soc, (2009).
  • Y. Liu, H. Yan*, (Invited Perspective). Designer Curvature. (2009).
  • Y. Liu, H. Yan*, (Invited News and Reviews). Self-assembly: Coordinating Corners,. (2009).
  • C. Lin, J. K. Nangreave, Z. Li, Y. Liu and H. Yan*. Signal Amplification on a DNA Tile based Biosensor with Enhanced Sensitivity. Nanomedicine (2008).
  • C. Lin, S. Rinker, X. Wang, Y. Liu, N.C. Seeman, H. Yan*. In Vivo Cloning of Artificial DNA Nanostructures. Proc. Nat. Acad. Sci (2008).
  • J. Sharma, R. Chhabra, C. S. Andersen, K. V. Gothelf, H. Yan and Y. Liu*. Towards Reliable Gold Naoparticles Patterning in Self-assembled DNA nanoscaffold. J. Am. Chem. Soc (2008).
  • J. Sharma, R. Chhabra, H. Yan and Y. Liu*. A Facile In situ Generation of Dithiocarbamate Ligands for Stable Gold Nanoparticle-Oligonucleotide Conjugates. Chem. Commun (2008).
  • J. Sharma, Y. Ke, C. Lin, R. Chhabra, Q. Wang, J. Nangreave, Y. Liu*, H. Yan*. DNA Tile Directed Self-assembly of Quantum Dots into Two-dimensional Nanopatterns,. Angew. Chem. Int. Ed (2008).
  • Q. Wang, Y. Liu, Y. Ke, and H. Yan*. Quantum Dot Bioconjugation during Core-Shell Synthesis. Angew. Chem. Int. Ed (2008).
  • S. Rinker, Y. Ke, Y. Liu, R. Chhabra, H. Yan*. Self-assembled DNA nanostructures for distance dependent multivalent ligand binding. Nature Nanotechnology (2008).
  • Y. Ke, J. Nangreave, H. Yan and Y. Liu*. Developing DNA tiles for oligonucleotide hybridization assay with higher accuracy and efficiency. Chem. Commun, (2008).
  • Y. Ke, S. Lindsay, Y. Chang, Y. Liu and H. Yan*. Self-assembled Water-soluble Nanoarrays for Label Free RNA Hybridization Assays. Science (2008).
  • Y. Liu*, G. J. Edens, J. Grzymski, D. Mauzerall*. Volume and Enthalpy Changes of Proton Transfers in the Bacteriorhodopsin Photocycle Studied by Millisecond Time-resolved Photo-Pressure Measurements. Biochemistry (2008).
  • Y. Xu, Q. Wang, P. He, F. Liu, Q. Dong, Y. Du, Y. Liu, L. Lin, H. Yan, X. H. Zhao*. Cell Nucleus Penetration by Quantum Dots Induced by Nuclear Staining Organic Fluorophore and UV-Irradiation. Advanced Material (2008).
  • Z. Li, Y. Ke, C. Lin, H. Yan, and Y. Liu*. Subtractive Assembly of DNA Nanoachitectures Driven by Fuel Strand Displacement. Chem. Commun (2008).
  • . . Advanced Drug Delivery (2008).
  • . . Encyclopedia of Complexity and System Science (2008).
  • B Williams, K Lund, Yan Liu, H Yan, J Chaput. Directed Molecular Assembly of Pepetide Nanoarrays using DNA-tagged Peptides. Angew. Chem. Int. Ed (2007).
  • C Lin, Yan Liu, H Yan. Self-assembled Combinatorial Encoding Nanoarrays for Multiplexed Biosensing. Nano. Letter (2007).
  • C. Lin, X. Wang, Y. Liu, N.C. Seeman*, H. Yan*. Rolling Circle Enzymatic Replication of a Complex Multi-Crossover DNA Nanostructure. J. Am. Chem. Soc (2007).
  • C. Lin, Y. Liu, M. Mertig, J. Gu, H. Yan*. Functional DNA Nanotube Arrays: Bottom-up Meets Top-down. Angew. Chem. Int. Ed (2007).
  • C. Lin, Yan Liu, Hao Yan. Self-assembled Combinatorial Encoding Nanoarrays for Multiplexed Biosensing. Nano Lett (2007).
  • J Sharma, R Chhabra, H Yan, Yan Liu. pH-driven Conformational Switch of "i-motif" DNA for Reversible Assembly of Gold Nanoparticles. Chem. Commum (2007).
  • Q Wang, Yan Liu, H Yan. Lay-by-layer growth of superparamagnetic, fluorescent barcode nanospheres. Nanotechnology (2007).
  • Q Wang, Yan Liu, H Yan. Layer-by-Layer Growth of Superparamagnetic, Fluorescent Barcode Nanospheres. Nanotechnology (2007).
  • Q. Wang, Y. Liu, H. Yan*. Mechanism of a Self-templating Synthesis of Monodispersed Hollow Silica Nanospheres with Tunable Size and Shell Thickness. Chem. Commun (2007).
  • Q. Wang, Y. Xu, X. Zhao, Y. Chang, Y. Liu, L. Jiang, J. Sharma, D.-K. Seo*, H. Yan*. A Facile One-step In situ Functionalization of Quantum Dots with Preserved Photoluminescence for Bioconjugation. J. Am. Chem. Soc (2007).
  • R. Chhabra, J. Sharma, Y. Ke, Y. Liu, S. Rinker, S. Lindsay, H. Yan*. Spatially Addressable Multi-protein Nanoarrays Templated by Aptamer Tagged DNA Nano-architectures. J. Am. Chem. Soc (2007).
  • . . Biological Studies and Applications of Engineered Nanostructures (2007).
  • C Lin, E Katilius, Yan Liu, Hao Yan. Self-assembled Signaling Aptamer Nanoarrays for Protein Detection. Angew. Chem. Int. Ed (2006).
  • C Lin, M Xie, J Chen, Yan Liu, H Yan. Rolling Circle Amplification of a DNA Nano-junction. Angew. Chem. Int. Ed (2006).
  • C Lin, Yan Liu, S Rinker, Hao Yan. DNA tile Based Self-assembly: Building Complex Nano-architectures. ChemPhysChem (2006).
  • J Sharma, R Chhabra, Yan Liu, Y Ke, Hao Yan. DNA templated self-assembly of two-dimensional and periodical gold nanoparticle arrays. Angew. Chem. Int. Ed (2006).
  • K Lund, B Williams, Y Ke, Yan Liu, Hao Yan. DNA nanotechnology: a rapidly evolving field. Current Nanoscience (2006).
  • K Lund, Yan Liu, Hao Yan. Combinatorial Self-assembly of DNA Nanostructures. Organic and Biomolecular Chemistry (2006).
  • L Lin, H Wang, Yan Liu, Hao Yan, S Lindsay. Recognition imaging with a DNA aptamer. Biophysical J (2006).
  • R Chhabra, J Sharma, Yan Liu, Hao Yan. Addressable Molecular Tweezers for DNA templated coupling reactions. Nano Lett (2006).
  • S Rinker, Yan Liu, H Yan. Two Dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex. Chem. Commum (2006).
  • Y J Zhang, Yan Liu, Hao Yan. Periodic Square-like gold nanoparticle arrays templated by a DNA nanogrids on a surface. Nano Lett (2006).
  • Y Ke, Yan Liu, J Zhang, Hao Yan. A Study of DNA tube formation mechanisms using 4-, 8- and 12-helix DNA nanostructures. J. Am. Chem. Soc (2006).
  • A Samokhvalov, L Hong, Yan Liu, J Garguilo, R Nemanich, G Edwards, J Simon. Oxidation Potentials of Human Eumelanosomes and Pheomelanosomes. Photochemistry and Photobiology (2005).
  • K Lund, Yan Liu, S Lindsay, Hao Yan. Self-assembling Molecular Pegboard. J. Am. Chem. Soc (2005).
  • S Park, P Yin, Yan Liu, J Reif, T LaBean, Hao Yan. Programmable DNA Self-assemblies for Nanoscale Organization of Ligands and Proteins. Nano Lett (2005).
  • Yan Liu, C Lin, H Li, Hao Yan. Aptamer directed Self-assembly of Proteins on a DNA Nanostructure. Angew. Chem. Int. Ed (2005).
  • Yan Liu, Hao Yan. Modular Self-assembly of DNA Lattice with Tunable Periodicity. Small (2005).
  • Yan Liu, J Simon. Metal Ion Interactions and the Structural Organization of Sepia Eumelanin. Pigment Cell Research (2005).
  • Yan Liu, L Hong, J Simon. Comparison of the Structural and Chemical Properties of Melanosomes Isolated from Retinal Pigment Epithelium, Iris and Choroids of Newborn and Mature Bovine Eyes. Pigment Cell Research (2005).
  • Yan Liu, L Hong, K Wakamatsu, S Ito, B Adhyaru, Chi-Yuan Cheng, C Bowers, J Simon. Comparison of Structural and Chemical Properties of Black and Red Human Hair Melanosomes. Photochemistry and Photobiology (2005).
  • Yan Liu, Y Ke, Hao Yan. Self-assembly of symmetric finite size DNA nanoarrays. J. Am. Chem. Soc (2005).
  • . . Nanotechnology: Science and Computation (2005).
  • A Samokhvalov, Yan Liu, J Simon. Characterization of the Fe(III)-binding site in Sepia eumelanin by resonance Raman confocal microspectroscopy. Photochemistry and Photobiology (2004).
  • L Hong, Yan Liu, J Simon. Binding of metal ions to melanin and Their Effects on Aerobic Reactivity. Photochemistry and Photobiology (2004).
  • Yan Liu, L Hong, V Kampf, K Wakamatsu, S Ito, J Simon. Ion-Exchange and Adsorption of Fe(III) by Sepia Eumelanin. Pigment Cell Research (2004).
  • D Mauzerall, Yan Liu, G Edens, J Grzymski. Measurement of enthalpy and volume changes in photoinitiated reactions on the ms timescale with a novel pressure cell. Photochemical and Photobiological Science (2003).
  • G Edens, Yan Liu, D Mauzerall. Pressure cell for Time-Resolved Calorimetric Measurements of Photo-Initiated Reactions: Fractional Millisecond and Longer. Review Scientific Instruments (2003).
  • Yan Liu, J Simon. The Effect of Preparation Procedures on the Morphology of Melanin from Ink Sac of Sepia officinalis. Pigment Cell Research (2003).
  • Yan Liu, V Kempf, J Nofsinger, E Weinert, M Rudnicki, K Wakamatsu, S Ito, J Simon. Comparison of the Structural and Physical Properties of Human Eumalanin Following Enzymatic or Acid/Base Extraction. Pigment Cell Research (2003).
  • Liu, Yan, Simon, J. Isolation and Biophysical Studies of Natural Eumelanins: Applications of Imaging Technologies and Ultrafast Spectroscopy. (2003).
  • J Nofsinger, Yan Liu, J Simon. Aggregation of Eumelanin mitigates photogeneration of reactive oxygen species. Free Radical Biology and Medicine (2002).
  • Simon, J, Liu, Yan, Nofsinger, J. Assembly and Aerobic Photoreactivity of Melanin. (2002).
  • E Yan, Yan Liu, K Eisenthal. In situ studies of molecular transfer between microparticles by second-harmonic generation. J. Phys. Chem. B (2001).
  • X Shang, Yan Liu, E Yan, K Eisenthal. Effect of Buffer Species in the Aqueous Solution on the Permeability of Malachite Green across Liposome Bilayer: Kinetic Study by SHG. J. Phys. Chem. B (2001).
  • Yan Liu, E Yan, K Eisenthal. Effects of bilayer surface charge density on molecular adsorption and transport across liposome bilayers. Biophys. J (2001).
  • Yan Liu, E Yan, X Zhao, K Eisenthal. Surface potential of charged liposomes determined by second harmonic generation. Langmuir (2001).
Research Activity
Spring 2019
Course NumberCourse Title
BCH 463Biophysical Chemistry
BDE 792Research
BDE 799Dissertation
Fall 2018
Course NumberCourse Title
BCH 361Principles of Biochemistry
Spring 2018
Course NumberCourse Title
BCH 467Analytical Biochemistry Lab
Fall 2017
Course NumberCourse Title
BCH 361Principles of Biochemistry
Spring 2017
Course NumberCourse Title
BCH 463Biophysical Chemistry
BCH 501Current Topics in Biochemistry
Fall 2016
Course NumberCourse Title
BCH 361Principles of Biochemistry
Spring 2016
Course NumberCourse Title
BCH 463Biophysical Chemistry
Fall 2015
Course NumberCourse Title
BCH 361Principles of Biochemistry
BCH 501Current Topics in Biochemistry
Spring 2015
Course NumberCourse Title
BCH 361Principles of Biochemistry
Presentations

  • 25. “DNA origami and Applications” Ten years of DNA origami Symposium, California Institute of Technology, March, 2016.

    24. “Thermodynamics and Kinetics of DNA Based Self-assembly” Department of Physics, ASU, Tempe, December, 2015.

    23. “Designer DNA Architectures for Programmable Self-Assembly ” National Center for NanoScience and Technology, Beijing, China. September, 2015.

    22. “Designer DNA Architectures for Programmable Self-Assembly ” Department of Chemistry, Xuetang lecture, Tsinghua University, Beijing, China. September, 2015.

    21. “DNA Based Artificial Light-Harvesting Antenna”. ChinaNano 2015. Beijing, China. September, 2015.

    20. “DNA Scaffolded Artificial Light Harvesting Antenna” Research Training Group Nano- and Biotechnologies for Packaging of Electronic Systems, Technische Universitat at Dresden, Germany. June, 2015. 

    19. “DNA Nanostructures for Nanophotonics” Colloquium of the Kurt-Schwabe Institute Meinsberg, Germany. June, 2015.  

    18. “DNA tile based self-assembly and their thermodynamics and kinetics”,  Colloquium of Department of Chemistry, Purdue University, West Lafayette, IN. March 2015.

    17. “Assembly of Nanophotonic Elements by DNA Nanostructures”  Gordon Conference, Electron Donor-Acceptor Interactions, Newport, RI. August, 2014.

    16. “Assembly of Nanophotonic Elements by DNA Nanostructures” (Keynote lecture)  Foundation of Nanosciences (FNANO14), Snowbird, UT, April, 2014.

    15. “Thermodynamics and Kinetics of DNA based self-assembly” 18th conversation. Albany Stereodynamics Symposium, Albany, New York, June, 2013.

    14. “Thermodynamic and kinetic studies of self-assembly of DNA nanostructures” J. Nangreave, Y. Liu, ACS National Meeting, Philadelphia, PA, August, 2012.

    13. “DNA nano-architectures for photonic applications”  Foundation of Nanosciences (FNANO12), Snowbird, UT, April, 2012.

    12. “DNA nano-architectures for photonic applications”  Material Research Society Meeting, San Francisco, April, 2012.

    11. “DNA nano-architectures”  International Conference on RNA Nanotechnology & Therapeutics, Cleveland, Ohio, October 2010.

    10. “DNA based self-assembly” Veeco Instruments, Santa Barbara, CA, August, 2010.

    9. “DNA based multi-valency”,  Foundation of Nanosciences (FNANO10), Snowbird, UT, April, 2010.

    8. “DNA Directed Self-Assembly of Proteins, Cells and Nanoparticles”  BNI Neuroscience Conference, Barrow Neurology Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ. March, 2010.

    7. “DNA Directed Self-Assembly for Nanophotonics”  ONR grant kickoff seminars, Columbia University, New York, NY. December, 2009.

    6. “DNA directed self-assembly of nanoparticles and proteins”  DNA Based Nanotechnology, International Workshop, Dresden, Germany.  May, 2009.

    5. “DNA-tile based biodetection”  NanoKAP, 2008, Utilizing Nano Technology for Detection Toxins and Pathogens, Phoenix, AZ. November, 2008.

    4. “DNA-based self-assembly of nanostructures”,  H. Yan, The 9th Sanken International Symposium on Nanoscience and Nanotechnology, Osaka University, Osaka, Japan, September, 2006.

    3. “Analysis of Melanosomes Isolated from Bovine Eyes: Comparison Between Ages and Tissues”,  12th Pan-American Society of Pigment Cell Research. LA, CA, June, 2004.

    2. “Comparison of Melanosomes Isolated From RPE, Iris And Choroids Of Newborn And Mature Bovine Eyes”, Pigment Development Workshop, Bethesda, MD, April, 2004.

    1. “The Structural and Reactivity of Natural Melanins”  10th Congress of the European Society for Photobiology, Vienna, Austria, September, 2003.

Service
  • New Faculty Search Committee, member (2014 - Present)
  • Ad Hoc Committee on Physical and Biophysical Chemistry Offerings in the Biochemistry Track, member (2014 - Present)
  • Committee on Graduate Program and Awards, member (2014 - Present)
  • Nature Communication, JACS, Nature Nanotechnology, manuscript reviewer (2014 - Present)
  • New Faculty search committee, member (2013 - Present)
  • Intel Science and Engineering Fair, Volunteer as grand award judge (2013 - Present)
  • National Science Foundation (BMAT, MMA), Grant reviewer (2013 - Present)
  • Army Research Office (ARO), grant reviewer (2013 - Present)
  • Faculty and Academic Professionals Awards Comittee, member (2013 - Present)
  • ARO, Proposal reviewer (2012 - Present)
  • Faculty and Academic Professionals Awards, Member (2012 - Present)
  • JACS, J. Phys. Chem., Langmuir, Angew. Chem. Int. Ed., Nature Nanotech., Chem. Commun., Advanced Materials, Nnaotechnology,, Manuscript reviewer (2012 - Present)
  • Faculty Advisory (Industry Liaison) Committee, member (2011 - Present)
  • Faculty Advisory (Industry Liaison) Committee, member (2011 - Present)
  • Graduate Admission Committee, Member (2011 - Present)
  • New Faculty Search Committee, member (2010 - Present)
  • National Institute of Health, Panelist: (2008 - Present)
  • North Carolina Biotechnology Center, Ad Hoc Reviewer (2008 - Present)
  • Graduate Admission Committee, member (2007 - Present)
  • Graduate Admission Committee, member (2007 - Present)
  • Graduate Admission Committee, member (2007 - Present)
  • US-Israel Binational Science Foundation research grant, grant eviewer (2014 - 2014)
  • JACS, JPC, Langmuir, Angew. Chem. Int. Ed., Nature Nanotech., Nano Lett., ACS Nano., Manuscript Reviewer (2013 - 2013)
  • Industrial Liaison Committee, Biodesign Institute, member (2013 - 2013)
  • National Science Foudation, Reviewer (2009 - 2009)
Expertise Areas
Physical Chemistry
Materials Science
Nanoscience