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Sharon Crook

Professor
Faculty, TEMPE Campus, Mailcode 4501
Professor
Faculty, TEMPE Campus, Mailcode 1804
Biography

Sharon Crook earned her doctorate in applied mathematics at the University of Maryland in College Park and performed her dissertation research with John Rinzel at the Mathematical Research Branch of the National Institutes of Health. While there she developed coupled oscillator models to represent the dynamics of the cortex in collaboration with Bard Ermentrout of the University of Pittsburgh. She then held a Postdoctoral Fellowship at the Center for Computational Biology at Montana State University with John Miller and Gwen Jacobs. There she performed joint work in neurophysiology, mathematical modeling, and neuroinformatics.

Professor Crook now holds a joint appointment with the School of Mathematical and Statistical Sciences and the School of Life Sciences at Arizona State University. She uses computational approaches to study the dynamics of neurons and networks of neurons, as well as the mechanisms that underly changes in these cells and networks due to trauma, learning, or disease. She also contributes to the development of NeuroML, an international effort to create a common standard for describing computational models for neuroscience research.

Education

Ph.D. Applied Mathematics, University of Maryland-College Park 1996

Research Interests

Sharon Crook studies the mechanisms and algorithms underlying neural computation. Using mathematical models, analysis and computer simulations, she and her research team examine the dynamics of neurons and networks of neurons. In particular, their focus is on understanding the ability that neurons have to change at a cellular or network level due to trauma, rehabilitation, learning, development, or aging.

Professor Crook and her collaborators are also developing a cyber infrastructure for describing and sharing neuroscience models, as well as new formats to describe neuron anatomy at macro and micro levels, neural network connectivity, and the membrane properties of neurons. This approach is used by software applications to help reproduce simulations of complex models and share models after publication.

 

 

Publications
  • Kurian, M., S.M. Crook, R. Jung (2012) Motoneuron model of self-sustained firing after spinal cord injury. Journal of Computational Neuroscience. 31(3):625-645.
  • Crook, S.M., J.A. Bednar, S.D. Berger, R.C. Cannon, A.P. Davison, M. Djurfeldt, J. Eppler, B. Kriener, S. Furber, B. Graham, M. Hull, H.E. Plesser, L. Schwabe, L. Smith, V. Steuber, S. van Albada (2012) Creating, documenting and sharing network models.Network: Computation in Neural Systems. 23(4): 131-149.
  • Gleeson, P., S. Crook, R. Cannon, M. Hines, G. Billings, M. Farinella, T.M. Morse, A. Davison, S. Ray, U. Bhalla, S.R. Barnes, Y.D. Dimitrova, R.A. Silver (2010) NeuroML: a simulator-independent language for describing data-driven models of neurons and networks with a high degree of biological realism. PLOS Computational Biology. 6(6):e1000815. Doi:10.1371/journal.pcbi.1000815.
  • Crook, S., P. Gleeson, F. Howell, J. Svitak, R.A. Silver (2007) MorphML: Level 1 of the NeuroML standards for neuronal morphology data and model specification. Neuroinformatics 5(2):96-104.
  • Crook, S.M., G.B. Ermentrout, J.M. Bower (1998) Spike frequency adaptation affects the synchronization properties of cortical networks. Neural Computation. 10:837-854.

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  • Sharon Crook, D Beeman, P Gleeson, F Howell. XML for model specification in neuroscience: An introduction and workshop summary. Brains, Minds, and Media (2005).
Research Activity
Fall 2017
Course NumberCourse Title
MAT 451Mathematical Modeling
APM 792Research
Summer 2017
Course NumberCourse Title
APM 792Research
Spring 2017
Course NumberCourse Title
MBB 355Intro to Computation Molec Bio
MAT 355Intro to Computation Molec Bio
BIO 355Intro to Computation Molec Bio
BIO 493Honors Thesis
APM 792Research
AML 792Research
CSE 792Research
AML 799Dissertation
APM 799Dissertation
Fall 2016
Course NumberCourse Title
MAT 451Mathematical Modeling
BIO 492Honors Directed Study
APM 792Research
Summer 2016
Course NumberCourse Title
APM 792Research
Spring 2016
Course NumberCourse Title
MBB 355Intro to Computation Molec Bio
MAT 355Intro to Computation Molec Bio
BIO 355Intro to Computation Molec Bio
MAT 493Honors Thesis
CSE 790Reading and Conference
APM 792Research
CSE 792Research
AML 792Research
AML 799Dissertation
APM 799Dissertation
Fall 2015
Course NumberCourse Title
BIO 189Life Sciences Career Paths
MAT 451Mathematical Modeling
APM 792Research
Summer 2015
Course NumberCourse Title
APM 792Research
Spring 2015
Course NumberCourse Title
MAT 355Intro to Computation Molec Bio
BIO 355Intro to Computation Molec Bio
MBB 355Intro to Computation Molec Bio
MAT 493Honors Thesis
APM 530Mathematical Cell Physiology.
CSE 790Reading and Conference
APM 790Reading and Conference
CSE 792Research
APM 792Research
AML 792Research
APM 799Dissertation
AML 799Dissertation
Fall 2014
Course NumberCourse Title
MAT 243Discrete Math Structures
MAT 492Honors Directed Study
APM 792Research
Summer 2014
Course NumberCourse Title
APM 792Research
Spring 2014
Course NumberCourse Title
MBB 355Intro to Computation Molec Bio
MAT 355Intro to Computation Molec Bio
BIO 355Intro to Computation Molec Bio
CSE 790Reading and Conference
APM 790Reading and Conference
CSE 792Research
AML 792Research
AML 799Dissertation
Fall 2013
Course NumberCourse Title
MAT 243Discrete Math Structures
AML 792Research
Summer 2013
Course NumberCourse Title
AML 799Dissertation
Spring 2013
Course NumberCourse Title
BIO 355Intro to Computation Molec Bio
MBB 355Intro to Computation Molec Bio
MAT 355Intro to Computation Molec Bio
MAT 494Special Topics
CSE 790Reading and Conference
CSE 792Research
AML 792Research
AML 799Dissertation