Mark A. Hayes holds an associate professorship in the School of Molecular Sciences at Arizona State University, where he serves as an active researcher, mentor, teacher and colleague. His academic career has produced significant results across several disciplines within the analytical, clinical, biological, and physical chemistry communities that includes aspects of engineering, physics, biology and medicine. While contributing to the knowledge base, he has energetically and creatively supported the wider profession at local, regional, national and international levels.
He initially worked in private industry at a ‘mom & pop’ analytical laboratory and at J&W Scientific capillary gas chromatography column manufacturer (now part of Agilent) after earning his undergraduate degree at Humboldt State University (California). He then entered graduate school at Penn State University and studied under Professor Andrew G. Ewing (currently the Marie Currie Chair at University of Gothenburg, Sweden), developing electrokinetic approaches to neuroscience and building new instrumentation. Postdoctoral studies were with Dr. Werner Kuhr at the University of California, Riverside focused on biosensor develop exploiting enzymes.
Professor Hayes has contributed to several different research areas, ranging from creating bionanotubules from liposomes with electric fields to establishing a framework for vastly improved microscale array-based separations in more than 80 publications and book chapters. He has served as Program Chair, Governing Board Chair, Long Range Planning Chair and Marketing Chair for Federation of Analytical Chemistry and Spectroscopy Societies (FACSS) over a several-year period of time and was instrumental in altering the management structure and changing the name of the North American meeting to SciX Conference. He recently served as president (ending in 2015) of AES Electrophoresis Society. He has mentored 60 undergraduate and graduate students, producing 16 doctorates while supporting them with research funds and prestigious fellowships (NSF, Kirkbright, ACS, Fulbright, FLAS and local awards).
Ph.D. Pennsylvania State University 1993
My research is focused on developing new technology for ultrasmall volume biological fluids and tissue analysis. New technologies will allow the full chemical and bioactive analysis of incredibly small samples—on the order of a few nanoliters or a cube about one-tenth the diameter of a human hair. The idea of these ultrasmall volume biological assays opens the door to a wide variety of revolutionary applications, including inexpensive disposable clinical assays chips, implantable micro health monitoring systems, millions of parallel assays from a single microscopic sample (proteomic and genomic application—leading to personalized medical care), the ability to chemically map tissues at high spatial resolution, non-invasive sampling and local disease treatment among other interesting applications. To develop and apply these new technologies, our group’s research interests span chemistry, physics, biochemistry, engineering, medical science and biology. Much of the details of accomplishing our tasks lie in fundamental issues including surface chemistry, materials design, micro- and nanofluidics, dynamic interfacial physics & chemistry, and microfluidic/microelectronic chip design and fabrication.
One long-term goal is provide truly predictive pattern recognition for early disease detection for individuals, and by definition, define various states of wellness. The earliest a disease can be detected is when the wellness state begins to falter. All of the bioanalytical technical advances can be related to developing the ability to map the detailed chemical patterns of an active biological system. This map includes the idea of pattern recognition in the sense of varying concentrations of ‘markers’ for specific disease states and pattern recognition of those concentrations over time. One of the biggest challenges in proposing to address early disease detection is defining quantitatively the baseline or normal fluctuations of the operating biological system. A clearly ideal starting point for developing these capabilities is the observation of established chemical markers of stress. Arguable, a system under stress is the first step away from wellness and toward disease.
Our current projects focus on enabling the accurate and precise measurement of important bio-particles and molecules, which is a very difficult task. The huge variety and subtle differences between bio-particles and molecules presents a massive challenge to isolate and concentrate the important materials away from the unimportant. We have pioneered a new separation scheme enabled by the electronics industry fabrication strategies, resulting in micro and nanofluidics, where unheard of control of electric and flow fields can uniquely capture targets. We have demonstrated this on human and pathogen cells, along with a variety of important proteins.
Fall 2019 | |
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Course Number | Course Title |
CHM 326 | Advanced Analytical Chem Lab |
BIO 495 | Undergraduate Research |
Spring 2018 | |
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Course Number | Course Title |
CHM 325 | Analytical Chemistry |
Fall 2017 | |
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Course Number | Course Title |
CHM 326 | Advanced Analytical Chem Lab |
Spring 2017 | |
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Course Number | Course Title |
CHM 501 | Current Topics in Chemistry |
Fall 2016 | |
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Course Number | Course Title |
CHM 326 | Advanced Analytical Chem Lab |
CHM 598 | Special Topics |
Spring 2016 | |
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Course Number | Course Title |
CHM 328 | Instrumental Analysis Lab |
CHM 524 | Separation Science |
Fall 2015 | |
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Course Number | Course Title |
CHM 598 | Special Topics |
Spring 2015 | |
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Course Number | Course Title |
CHM 328 | Instrumental Analysis Lab |