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Pamela Marshall

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School of Mathematical and Natural Sciences
Professor
Faculty, WEST Campus, Mailcode 2352
New College Environmental Health Science Scholars (NCEHSS)
Principal Investigator
Faculty, WEST Campus, Mailcode 2352
Biography

Pamela A. Marshall was born and raised in Denton, TX. Her father is a chemistry professor, and in her youth, she and her brother participated in many types of exothermic reactions. She remembers distinctly learning about the process of DNA replication, transcription and translation in 10th-grade biology. This was a transformative moment in her life as as she decided that genetics and cell biology were extremely elegant and that was what she wanted to study when she grew up. Subsequently, she attended Southern Methodist University in Dallas, TX, majoring in biological sciences, and minoring in chemistry and women's studies. She  was very interested in cellular processes and attended the University of Texas Southwestern Medical School in Dallas, TX, studying the yeast peroxisome in the lab of Joel M. Goodman, earning her doctorate in cell regulation. At UT Southwestern, she won the Ida M. Green Award for outstanding service to the graduate school community. fShe performed postdoctoral research in the Biochemistry Department at UT Southwestern, as well, in the lab of Bruce Horazdovsky researching the yeast vacuole.

Her first faculty appointment was at SUNY College at Fredonia in Fredonia, NY, in 2000. She was drawn to the West campus of ASU in 2003 because of its commitment to the students. She engages undergraduate students in her laboratory research and won the 2008 ASU Faculty Achievement Award for Excellence in Student Mentoring. Since coming to ASU at the West campus, she has mentored more than 100 undergraduate students, many of whom have gone on to medical school. 

Education
  • Ph.D. Cell Regulation, UT Southwestern Medical Center
  • B.S. Biological Sciences, minors: Chemistry and Women's Studies, Southern Methodist University

 

 

Research Website
http://marshall.labs.asu.edu
Google Scholar
Google Scholar Profile
Research Interests

Dr. Marshall's focuses on the biogenesis and functions of the vacuole of the budding yeast, Saccharomyces cerevisiae. The yeast vacuole is roughly equivalent to the mammalian lysosome in that it has degradative, recycling, and storage functions. There are many human disorders in which lysosomal function is impaired, including Tay-Sachs disease, Krabbe disease, certain forms or cancer, and some types of coronary artery disease. Creating a lysosome and filling it with proteins is a very complex process. Because of this complexity, it is difficult to study lysosome formation in human cells. Therefore, the Marshall lab has chosen the yeast vacuole as a model organism in which to study cellular responses. S. cerevisiae has been shown to be a very effective model system for lysosomal function and biogenesis. The Marshall lab has been focusing on four main areas: vacuolar protein trafficking in general, volutin granule formation, mathematical modeling of calcium homeostasis and gene networks, and microarray analysis of yeast with chronic losses of vacuolar function. All of the research in the Marshall laboratory is performed with undergraduates.

Trained in a Pharmacology Department for her dissertation, she has always had an interest in therapeutics, rational drug design, and toxicology.  She is also part of an interdisciplinary team, with Drs. Carl Wagner and Peter Jurtuka, to synthesize and evaluate novel RXR agonists and antagonists for treatment of cancers and Alzheimer's Disease. 

Dr. Marshall is interested in science pedagogy, and the way students learn science.  She has been designing, implementing, and assessing multi-week lab modules in the West Life Sciences curriculum.  She is  also interested in learning modalities and science education as well as compacted versus protracted learning sessions.  She has recently begun researching the mastery learning modality of learning and how it can be implemented in a college course.  Other curricular items of interest include increasing writing in the sciences, implementing online learning exercises, and integrating science disciplines in learning communities.

Publications

For a current list of publications and research activity since joining ASU visit

ASU_Experts

 

 

Research Activity
  • Todd Sandrin, Lara Ferry, Sîan Mooney, Pamela A. Marshall, and Susie Sandrin.  Collaborative Research: Train (Transfer To Interdisciplinary Natural Sciences): A Community College-University Consortium To Increase Community College Student Transfer And Success.  NSF S-STEM (10/2017-8/2021).
  • Pamela A. Marshall, Jennifer Broatch, Jennifer Foltz-Sweat, Jennifer Hackney Price, Ken Sweat.  Course-Based Undergraduate Research for All: Preparing the Future STEM Workforce.  NSF IUSE (9/2016-8/2019).
  • Carl Wagner, Peter Jurutka, and Pamela A. Marshall. Development of Next Generation Therapeutics to Combat Alzheimers Dementia and Neurodegenerative Disorders (ASUF 30000770). ASU FDN(6/1/2015 - 5/31/2016).
  • Pamela A. Marshall, Sharon Smith. TRiO Student Support Services Program- STEM Focused - ASU West. ED-PSE(9/1/2011 - 8/31/2015).
  • Carl Wagner, Peter Jurutka, and Pamela A. Marshall. Modeling Synthesis and Biological Evaluation of Potential RXR Selective Agents. HHS-NIH-NCI(1/1/2011 - 12/31/2015).
  • Sharon Smith and Pamela A. Marshall. TRiO Student Support Services Program- West campus. ED(9/1/2010 - 8/31/2011).
  • Douglas Dennis, Charles Deutch, Matthew Kwiatkowski, Pamela A. Marshall, Ken Sweat. An Integrated Core Curriculum of Cell Biology, Genetics, and Ecology Using the Desert Tree Lizard as a Thematic Organism. NSF-EHR(9/15/2004 - 8/31/2007).
  • Pamela A. Marshall. Molecular Mechanisms of Lysosomal Biogenesis. AMER HEART ASSN(8/20/2003 - 6/30/2005).
Fall 2019
Course NumberCourse Title
PTX 432Fundamentals of Pharmacology
LSC 432Fundamentals of Pharmacology
LSC 486Peer Mentoring in STEM
LSC 492Honors Directed Study
LSC 499Individualized Instruction
Spring 2019
Course NumberCourse Title
LSC 388Research for Natural Sciences
FOR 388Research for Natural Sciences
PTX 388Research for Natural Sciences
LSC 486Peer Mentoring in STEM
LSC 493Honors Thesis
BIO 499Individualized Instruction
LSC 499Individualized Instruction
Fall 2018
Course NumberCourse Title
LSC 394Special Topics
LSC 432Fundamentals of Pharmacology
PTX 432Fundamentals of Pharmacology
LSC 484Internship
LSC 486Peer Mentoring in the Sciences
STP 499Individualized Instruction
LSC 499Individualized Instruction
Spring 2018
Course NumberCourse Title
LSC 294Special Topics
LSC 363Genes, Race, Gender & Society
LSC 493Honors Thesis
LSC 499Individualized Instruction
BIO 499Individualized Instruction
Fall 2017
Course NumberCourse Title
LSC 484Internship
LSC 486Peer Mentoring in Life Science
LSC 499Individualized Instruction
Summer 2017
Course NumberCourse Title
LSC 388Research for Natural Sciences
LSC 484Internship
Spring 2017
Course NumberCourse Title
LSC 294Special Topics
LSC 363Genes, Race, Gender & Society
LSC 493Honors Thesis
LSC 499Individualized Instruction
BIO 499Individualized Instruction
Fall 2016
Course NumberCourse Title
LSC 347Fundamentals of Genetics
LSC 348Fundamentals of Genetics Lab
LSC 484Internship
LSC 486Peer Mentoring in Life Science
LSC 492Honors Directed Study
LSC 499Individualized Instruction
Summer 2016
Course NumberCourse Title
LSC 484Internship
Spring 2016
Course NumberCourse Title
LSC 294Special Topics
LSC 363Genes, Race, Gender & Society
LSC 486Peer Mentoring in Life Science
LSC 493Honors Thesis
LSC 499Individualized Instruction
Fall 2015
Course NumberCourse Title
LSC 347Fundamentals of Genetics
LSC 348Fundamentals of Genetics Lab
LSC 484Internship
LSC 486Peer Mentoring in Life Science
LSC 492Honors Directed Study
LSC 493Honors Thesis
LSC 499Individualized Instruction
Summer 2015
Course NumberCourse Title
LSC 484Internship
LSC 493Honors Thesis
Spring 2015
Course NumberCourse Title
LSC 294Special Topics
LSC 484Internship
LSC 486Peer Mentoring in Life Science
LSC 492Honors Directed Study
LSC 493Honors Thesis
LSC 499Individualized Instruction
Presentations
  • Samantha Elliott, Pamela Marshall, Andrea Rediske. Incorporating Responsible Conduct of Research (RCR) in Your Teaching Toolbox: Lessons from the JMBE Theme Issue on Scientific Ethics. American Society for Microbiology Conference for Undergraduate Educators (May 2015).
  • Pamela A. Marshall, Agnes S. Pascual, Marianne Gelter, Thanh-Thanh Tran, Gabrielle Sandstedt, and Pedro I. Chavez. Antifungal Activity of Herbal Extracts from a Botánica in Phoenix, Arizona. American Society for Microbiology 115th General Meeting (May 2015).
  • Carl E. Wagner, Peter W. Jurutka, Pamela A. Marshall, Arjan van der Vaart. Modeling, synthesis, and biological evaluation of potent retinoid-X-receptor agonists: Novel analogs of bexarotene, LGD100268, and CD3254. American Chemical Society 248th National Meeting (Aug 2014).
  • Carl E. Wagner, Pamela A. Marshall, Thomas M. Cahill. Visually following the hydrogenation of curcumin to tetrahydrocurcumin in a natural product experiment that also enhances student understanding of NMR spectroscopy. American Chemical Society 248th National Meeting (Aug 2014).
  • Pamela A. Marshall. Investigating Cell Volume Changes in Response to Hyperosmotic Shock in Saccharomyces cerevisiae. American Society for Microbiology 114th Meeting (May 2014).
  • Pamela A. Marshall. Foldables as Convenient Study Guides. American Society for Microbiology Conference for Undergraduate Educators (May 2014).
  • Pamela A. Marshall. Integrating Ethics into Science Case Studies. Science CaseNet: Case Study and PBL in STEM Education (May 2013).
  • Lorenzo G. Sanchez, Jennifer L. Kepler, Pamela A. Marshall. Characterization of the Low Affinity Calcium Channel of Saccharomyces cerevisiae. American Society for Microbiology 113th General Meeting (May 2013).
  • Jennifer L. Kepler, Zinyada Nektalova, Haiyan Wang, Francisco J. Solis, Pamela A. Marshall. Deletion Mutation Analysis Demonstrates a Biphasic Response to An Extracellular Calcium Pulse in Saccharomyces cerevisiae: Implications for a Mathematical Model of Calcium Homeostasis. American Society for Microbiology 112th Annual Meeting (Jun 2012).
  • Carl E. Wagner, Peter W. Jurutka, Arjan van der Vaart, Pamela A. Marshall, Luis A Montano, Gary Landreth, Paige E Cramer. Modeling, synthesis and biological evaluation of Retinoid-X-Receptor (RXR) selective agonists with potential to treat Alzheimer's disease. 243rd American Chemical Society National Meeting & Exposition (Mar 2012).
  • Pamela A. Marshall. How do Yeast Compensate for Loss of Vacuolar Function?. American Society for Microbiology 111th Annual Conference (May 2011).
  • Carl E. Wagner, Thomas M. Cahill, Pamela A. Marshall. Extraction, purification and spectroscopic characterization of a mixture of capsaicinoids. American Chemical Society 241st National Meeting, Anaheim CA (Mar 2011).
  • Julie K. Furmick, Carl E. Wagner, Pamela A. Marshall, and Peter W. Jurutka. Modeling, Synthesis and Biological Evaluation of Potential Retinoid-X-Receptor (RXR) Selective Agonists for the Treatment of Cutaneous T-cell Lymphoma. American Society for Cell Biology 49th Annual Meeting (Dec 2009).
  • Pamela A. Marshall, Francisco J. Solis, and Haiyan Wang. Deletion Mutation Analysis Demonstrates a Biphasic Response to An Extracellular Calcium Pulse in Saccharomyces cerevisiae: Implications for a Mathematical Model of Calcium Homeostasis. American Society for Cell Biology 49th Annual Meeting (Dec 2009).
  • Anthony Witten, Joseph Doggett, Erika T. Camacho, Stephen Wirkus, and Pamela A. Marshall. In Vivo Microarray Analysis and Nonlinear Differential Equations: An Interdisciplinary Approach to Gene Network Regulation. Frontiers in Applied and Computation Mathematics (Jun 2009).
  • Pamela A. Marshall, Francisco Solis, Haiyan Wang. Mathematical modeling and analysis of calcium regulation in yeast cells with periodic extracellular stimuli. Joint Conference of the Society for Mathematical Biology and the Chinese Society for Mathematical Bi (Jun 2009).
  • Carl Edward Wagner, Peter W. Jurutka, Pamela A. Marshall, Mark E. Graeber, Erik Matro, Ivy T. Tran, Jamie N. Tedeschi, Reina O. Khamees, Jeng E. Kwon, Shahram Moosavi, Julie K. Furmick, Belinda V. Miguel*, Darci K. Grupe*, Josh S. Philp*, Amina Danishyar*, and Justin W. Hart. Synthesis and biological evaluation of potential RXR selective agonists: Novel bexarotene analogs. American Chemical Society 237th National Meeting (May 2009).
  • Julie K. Furmick, Carl E. Wagner, Pamela A. Marshall, and Peter W. Jurutka. Biological Evaluation of Novel Bexarotene Analogs for the Treatment of Cutaneous T-cell Lymphoma. Arizona Nevada Academy of Science 53rd Annual Meeting (Apr 2009).
  • Zach J. Hernandez, Tim A. Widener, Pamela A. Marshall, Peter W. Jurutka. Discovery of Novel Vitamin D Receptor Interacting Proteins (VIPs): The Role of Vitamin D as a Mediator of Heart Health. Arizona Nevada Academy of Science 53rd Annual Meeting (Apr 2009).
  • Haiyan Wang, Francisco Solis, and Pamela A. Marshall. A Mathematical Model for Calcium Regulation in Yeast Cells. Mathematical Biosciences Institute, the Ohio State University (Oct 2008).
  • Haiyan Wang, Francisco Solis, and Pamela A. Marshall. A mathematical model for calcium regulation in yeast cells. SIAM Annual Meeting (Jul 2008).
  • Haiyan Wang, Francisco Solis, and Pamela A. Marshall. A mathematical model for calcium regulation in yeast cells. Differential Equations and Applications to Mathematical Biology, Le Havre, France (Jun 2008).
  • Haiyan Wang, Francisco Solis, and Pamela A. Marshall. A mathematical model for calcium regulation in yeast cells. 7th AIMS International Conference on Dynamical Systems, Differential Equations and Applications (May 2008).
  • Marshall, Pamela. Volutin Granule Formation in the Vacuole of Saccharomyces cerevisiae is Intact in Several vps Mutants. American Society for Microbiology 108th Annual Meeting (May 2008).
  • David E. Carlson and Pamela A. Marshall. Assessing the Assessor: Approaches and Strategies for Reflecting on Teaching Practices. Arizona Wakonse Fellowship (May 2008).
  • Brandin D. Essary, Matthew D. Eggleston, Pamela A. Marshall. FUN1 Dye Targeting to the Yeast Vacuole is Mediated by an Unknown Protein that Transits from the Golgi to the PVC and Recycles back to the Golgi. Arizona Nevada Academy of Science 52nd Annual Meeting (Apr 2008).
  • Belinda V. Miguel, Mark E. Graeber, Jeng Eun Sarah Kwon, Erik Matro, Ivy T. Tran, Jamie N. Tedeschi, Peter Jurutka, Carl Wagner, Pamela A. Marshall. Assaying Analogues of Bexarotene to Determine Mutagenicity and Toxicity. Arizona Nevada Academy of Science 52nd Annual Meeting (Apr 2008).
  • Nick S. Netzel, Jillian L. Wisby, Pamela A. Marshall. Determining Compensatory Mechanisms for Loss of Vacuolar Function in Saccharomyces cerevisiae. Arizona Nevada Academy of Sciences 52nd Annual Meeting (Apr 2008).
  • Tim Widener, Pamela A. Marshall, Peter W. Jurutka. Elucidation of Novel Vitamin D Receptor Interaction Proteins: Implications for Human Disease. Arizona Nevada Academy of Science 52nd Annual Meeting (Apr 2008).
  • Eggleston, Matthew, Marshall, Pamela. Putative Mechanism of FUN-1 Dye Import into Vacuoles of Saccharomyces cerevisiae. ASU at the West campus Faculty Research Poster Session (Oct 2007).
  • Marshall, Pamela. Using Saccharomyces cerevisiae to Test the Mutagenicity of Household Compounds: An Open-Ended Hypothesis-Driven Teaching Lab. International ChemEd Conference (Jul 2007).
  • Marshall, Pamela, Dennis, Douglas, Deutch, Charles. Integrating the Undergraduate Natural Sciences Curriculum Using a Thematic Organism. International ChemEd Conference (Jul 2007).
  • Eggleston, Matthew, Marshall, Pamela. Putative Mechanism of FUN-1 Dye Import into Vacuoles of Saccharomyces cerevisiae. General Meeting American Society for Microbiology (May 2007).
  • Marshall, Pamela. Guided Notes as a Method of Increased Learning and Retention. Wakonse - Arizona Fellowship (May 2007).
  • Deutch, Charles, Marshall, Pamela, Dennis, Douglas. Use of a Thematic Organism to Link the Curriculum. Arizona Nevada Academy of Science 51st Annual Meeting (Mar 2007).
  • Dixit, Neha, Marshall, Pamela, Deutch, Charles, Dennis, Douglas. The Urosaurus Ornatus Genome Project at ASU-West Campus. Arizona Nevada Academy of Science 51st Annual Meeting (Mar 2007).
  • Moore, Elisabeth, Deutch, Charles, Dennis, Douglas, Marshall, Pamela. Cell Biology and Genetics Laboratory Modules Incorporating the Desert Tree Lizard as a Model Organism. Arizona Nevada Academy of Science 51st Annual Meeting (Mar 2007).
  • Dennis, Douglas, Deutch, Charles, Marshall, Pamela, Moore, Elisabeth, Dixit, Neha. Employing the Desert Tree Lizard (Urosaurus Ornatus) as a Thematic Organism to Integrate the Curriculum. Society for Integrative and Comparative Biology Annual Meeting (Jan 2007).
  • Lemau, Jana, Marshall, Pamela, Jurutka, Peter. Characterization and Functional Evaluation of Novel Vitamin D Receptor Interacting Proteins (VIPs) Required for Bone Development. Society for Integrative and Comparative Biology Annual Meeting
  • Lemau, Jana, Marshall, Pamela, Jurutka, Peter. Discovery of Novel Vitamin D Receptor Interacting Proteins (VIPs) Involved in Apoptosis and Bone Mineral Homeostasis. Arizona Nevada Academy of Science 51st Annual Meeting
Honors / Awards

2016-2017          Top Multiple SUN Award Recipient for Calendar year 

2015-2017          American Society for Microbiology Distinguished Lectureship                                                                 

2015                   Arizona Nevada Academy of Science Outstanding Service Award                                                         

2014-2015         Participant in ASU Leadership Academy Cohort 2                                                                                  

2014                  New College Award for Excellence for “Outstanding Service”                                                                

2013                  Fellow of the Arizona Nevada Academy of Science                                                                                

2013                  TRiO Supporter of the Year                                                                                                                   

2013                  Faculty Mentoring Award, Arizona State University, Faculty Women’s Association                               

2012                  Volunteer of the Year, Copperwood Elementary School, Peoria Unified School District

2011                   Lincoln Center for Applied Ethics, Lincoln Teaching Fellowship

2011                   ASU Parent’s Association Professor of the Year Special Recognition Awardee                                     

2010                   ASU Promotion and Tenure Exemplar                                                                                                   

2009                  New College Award for Excellence for “Outstanding Teaching”                                                             

2008                  Arizona State University Faculty Excellence Award for Undergraduate Mentorship Recipient              

2005                 Outstanding Commitment to Students Nominee                                                                                    

 

Service

In addition to her research interests, Dr. Marshall is committed to science and education for all. In 2012, she won volunteer of the year for Copperwood Elementary School (Peoria USD) for her work bringing science to the students.  In 2013, she won the Faculty Women's Association Faculty Mentor of the year for her comitment to mentoring undergradates in her lab, in the TRiO Programs, and in the School in general.  In 2013 she also won the TRiO Supporter of the year for her work the the West campus STEM TRiO SSS program.  For the TRiO STEM Program, she acts as the Faculty Instructor, presenting workshops on a vriety of topics including experimental design, personal statements, and letter of recommendation, as well as teaching the spring Freshman Seminar course for the program.  In June 2013, she was elected a Fellow of the Arizona Nevada Academy of Science for her service to the Academy and her research record.  In 2014 she was awarded the New College Outstanding Service Award for her commitment to science education. In 2015, she received the Outstanding Service Award from the Arizona Nevada Academy of Science for her work with that group and Science Olympiad. Pamela was chosen for the American Society of Microbiology Distinguished Lecture Series for 2015-2017. And recently she won the ASU SUN Award for Excellence for her student-focused commitment to ASU.

 

Outreach: Dr. Marshall is available for school visits within a 10 mile radius of ASU West campus, time permitting.  Topics she can cover include:
Microbiology, Disease Prevention, and/or Disease Spreading
Atoms and The Periodic Table (she owns an almost complete collection of the naturally occuring elements)
Radioactivity 
Animal Behavior (Mealworms) 
Yeast Fermentation 
Yeast Flocculation 
Additional topics potentially available by mutual conversation

  • Arizona Nevada Academy of Science Outstanding Teacher Award Committee, Chair (2014 - Present)
  • New College Teaching Innovation and Excellence Collaborative, Co-Director (2014 - Present)
  • New College of Interdisciplinary Arts and Sciences Promotion and Tenure Committee, Member (2014 - 2016)
  • Arizona Nevada Academy of Science, Annual Meeting Poster Session Chair (2014 - 2015)
  • Intellectual Property and Institutional Review Committee (IPIRC), Member (2013 - Present)
  • Limited Submissions Standing Review Committee, Member (2013 - 2016)
  • Arizona Science Olympiad-Experimental Design, Supervisor (2013 - 2016)
  • Arizona Middle School Science Bowl, volunteer (2013 - 2014)
  • FWA Executive Board, West campus member (2011 - Present)
  • Antonie van Leeuwenhoek, Ad Hoc Manuscript Reviewer (2011 - Present)
  • Advances In Microbiology, Editorial Board Member (2011 - Present)
  • Journal of Microbiology and Biology Education, Editorial Board Member (2010 - Present)
  • TRIO SSS STEM, Faculty Instructor (2010 - Present)
  • JCE (Journal of Chemical Education), Ad hoc Manuscript Reviewer (2007 - Present)
  • Arizona Nevada Academy of Science, President (2013 - 2015)
  • Annual Biomedical Research Conference for Minority Students, Abstract Evaulator (2014 - 2014)
  • University Standards Committee, member (2011 - 2013)
  • American Society for Microbiology Undergraduate Research Fellowship, Application Reviewer (2013 - 2013)
  • New College SRCA Grants Evaluation, Reviewer (2012 - 2012)
  • Arizona Nevada Academy of Science, Membership Secretary (2008 - 2011)
Expertise Areas
Genetics
Cell biology
Science Education
Pharmaceuticals