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Guy Cardineau

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Faculty, DTPHX Campus, Mailcode 9520
Emeritus Professor
Faculty, DTPHX Campus, Mailcode 9520
Faculty, DTPHX Campus, Mailcode 9520
Faculty, DTPHX Campus, Mailcode 9520
Faculty, DTPHX Campus, Mailcode 9520

Guy Cardineau began his career in the field of Agricultural Biotechnology in 1983 as a scientist at a small start-up company, Sungene Technologies, where he also served a short time as manager of market development. He moved to Agrigenetics in 1989 as director of molecular biology. In 1993, Agrigenetics was acquired by Mycogen Corporation and Cardineau assumed responsibility as director for molecular biology and biochemistry. In 1996, he became director of technology development, involved in strategic planning and implementation regarding intellectual property and the identification, evaluation and acquisition of technology directed toward future product development. He received the Mycogen President’s Award in 1996 and 1998 for his contributions to the company. Dow AgroSciences acquired Mycogen in 1998 and he returned to research assuming the positions of Global Leader R&D, Output Agriculture Gene Discovery and Site Leader for the San Diego, CA, Research Facility, a four building campus with more than 160 research and business related personnel. In 2002, he became Global Leader for Science and Technology with responsibilities involved in strategic research planning. He received a Dow AgroSciences Inventors Award in 1998, 1999, 2000, 2001 and 2002. His laboratory groups contributed to the development of several agricultural biotechnology products in the market place and in commercial development, including Herculex Insect Resistant Corn, Widestrike Cotton and the first transgenic plant made pharmaceutical approved and licensed by a regulatory authority any place in the world, a Newcastle Disease Virus subunit vaccine produced in tobacco cell culture, for which he received a Dow Vision Award in 2006. 

In January 2003, he joined Arizona State University with appointments in the Center for Infectious Diseases and Vaccinology of the Biodesign Institute, the School of Life Sciences and the Sandra Day O’Connor College of Law, where he helped to establish several new teaching and entrepreneurial programs, including the Technology Ventures Clinic, providing a transactional experience in technology transfer to students from law, business, engineering and science curriculums. He served on a team empanelled by the President of ASU to develop a conceptual center for entrepreneurship, which resulted in a proposal to create an “Innovation Institute,” as an original member of Advisory Board of both ASU Technopolis and the University as Entrepreneur Initiative “Student Pathways” and also on the curriculum committee for the Kaufmann Entrepreneurial Campuses Initiative at ASU. He was named as Associated Students of Arizona State University Centennial Professor in April of 2008 for his contributions to teaching and to mentoring his students. In July 2008, Cardineau retired from ASU and was named Professor Emeritus by ASU President Michael Crow for his contributions to the university. 

He then moved to Tecnologico de Monterrey in August 2008 to be Director of the Centro de Agrobiotecnologia. He served as a professor in Escuela de Biotecnología y Ciencias de la Salud and Escuela Nacional de Posgrado en Ciencias Ingeniería y Tecnologías, and was the founding director of a new undergraduate student program, the Catedra i4, established to promote the development of imagination, investigation, innovation and incubation within the student population of Biotechnology. In a recent survey of ITESM Alumni asked to identify Faculty whose “legacy of knowledge and passion for teaching, were and continue to be important in your professional and personal life,” he has been identified as one of the “Profesores que Dejaron Huella,” or professors who have left their mark. He is currently a member of CONACyT Sistema Nacional de Investigadores (SNI) and was admitted into the Mexican Academy of Sciences in November 2015.

Cardineau retired from Tec de Monterrey on May 31, 2016, and returned to the Sandra Day O’Connor College of Law at ASU as an instructor where he is co-teaching courses related to biotechnology and health technologies, and remains a faculty fellow in the Center for Law, Science and Innovation, and also Professor Emeritus at the university.

His academic credentials include bachelor's degrees in American civilization and microbiology and a doctorate in molecular and cellular biology. He has co-authored more than 30 scientific papers, book chapters and a book, and has been included in a number of Who’s Who listings as well as Men and Women of Science. He served on the Science Advisory Board for the County of San Diego, CA, the Advisory Boards of ASU Technopolis and The Technology Ventures Clinic at AzTE, has been a Biotechnology Expert for both the U.S. Grains Council and the Organization of American States, has served as an advisor and consultant to the start-up biotechnology companies ERAbiotech, Algal Technologies and Sonora Transplant, is member of the Flinn Foundation BioAgriculture Research and Technology Platform Committee for Arizona and served the United States Secretary of Agriculture as a member of the Advisory Committee on Biotechnology and 21st Century Agriculture (AC21).  He is an inventor of 30 issued and 20 published and pending U.S. patent applications in the plant sciences, with more than 140 patents and applications worldwide, including broad enabling patents describing the earliest production of vaccines in transgenic plants, the synthesis of genes to improve their expression in a foreign host and the only plant made vaccine approved by a regulatory authority for commercial release in the U.S.  

  • Ph.D. Molecular and Cellular Biology
  • B.A. American Civilization
  • B.S. Microbiology
  • Curtiss, R. III, Jagusztyn-Krynicka, E.K., Hansen, J.B., Smorawinska, M., Abiko, Y., and Cardineau, G.A. 1982. Expression of Streptococcus mutans plasmid and chromosomal gene in Escherichia coli K-12. In: Microbial

    Drug resistance, S. Mitsuhashi (ed.), Japan Scientific Societies Press, Tokyo and University Park press, Baltimore, Vol. 3, pp. 15-27.


                   Murchison, H.H., Barrett, J.F., Cardineau, G.A., and Curtiss III, R. 1986. Transformation of Streptococcus mutans with chromosomal and shuttle plasmid (pYA629) DNA's. Infection and Immunity 54: 273-282.


                   Cardineau, G.A. and Curtiss III, R. 1987. Nucleotide sequence of the asd gene of Streptococcus mutans: identification of the promoter region and evidence for attenuator like sequences preceding the structural gene. J. Biol. Chem.262: 3344-3353.


                   Adang, M.J., Brody, M., Cardineau, G.A., Eagan, N., Roush, R.T., Shewmaker, C.K., Jones, A., Oakes, J.V., and McBride, K.E. 1993. The construction and expression of a Bacillus thuringiensis cryIIIA gene in protoplasts and potato plants. Plant Mol. Biol. 21: 1131-1145


                   Mehra-Palta, A., A. Graves, M. Craker, G. Cardineau, C. Poutre, N. Eagan, and L. Sernyk. 1994. "Field trial of transgenic canola containing phaseolin gene." Cruciferae Newsletter (United Kingdom)


                   Stewart, C. Neal, Jr., Adang, Michael J., All, John N., Boerma, Roger, Cardineau, Guy A., Tucker, Donna and Parrot, Wayne A. 1996.  Genetic transformation, recovery and characterization of fertile soybean transgenic for a synthetic Bacillus thuringiensis cryIA(c) gene.  Plant Physiology 112:121-129


                   Singsit, C., Adang, M.J., Lynch, R.E., Anderson, W.F., Wang, A., Cardineau, G.A. and Ozias-Akins, P. 1997.  Expression of a Bacillus thuringiensis cryIA(c) gene in transgenic peanut plants and its efficacy against lesser cornstalk borer.  Transgenic Research 6:169-176.


                   Ellis, R. Tracy, Stockhoff, Brian A., Stamp, Lisa, Schnepf, H. Ernest, Schwab, George E., Knuth, Mark, Russell, Josh, Cardineau, Guy A. and Narva, Kenneth E.  2002. Novel Bacillus thuringiensis Binary Insecticidal Crystal Proteins Active on Western Corn Rootworm, Diabrotica virgifera LeConpte.  Applied and Environmental Microbiology 68:1137-1145.


    Mor, Tsafrir S., Mason, Hugh S., Kirk, Dwayne D., Arntzen, Charles J. and Cardineau, Guy A., Plants as a Production and Delivery Vehicle for Orally Delivered Subunit Vaccines.  In: Levine, M.M., Woodrow, G.C., Kaper, J.B., Cobon, G.S., eds. New Generation Vaccines, Third Edition, pp. 305-311, New York: Marcel Dekker, January 2004.


    Alvarez, M. Lucrecia, Pinyerd, Heidi, Crisantes, Iason, Mason, Hugh S. and Cardineau, Guy A.

    Production in tomato of edible vaccines for pneumonic and bubonic plague.  In: Proceedings of the REDBIO Congress, June 21-24, 2004, Santo Domingo, the Dominican Republic.


                   Mihaliak, Charles A., Steven Webb, Timothy Miller, Matt Fanton, Dwayne. Kirk, Guy Cardineau, Hugh Mason, Amanda Walmsley, Charles Arntzen, Joyce Van Eck.  Development of Plant Cell Produced Vaccines for

    Animal Health Applications.  In: Proceedings of the 108th Annual Meeting of the U.S. Animal Health Association (October 21-27, 2004, Greensboro, NC), Richmond, VA, 2005.


    Alvarez, M. Lucrecia, Heidi Pinyerd, Jason Crisantes, M. Manuela Rigano, Julia Pinkhasov,  Amanda M. Walmsley, Hugh S. Mason, and Guy A. Cardineau.   2006.  Plant-Made Subunit Vaccine against Pneumonic and Bubonic Plague is Orally Immunogenic in Mice.  Vaccine 24:2477-2490


                    Alvarez, M. Lucrecia, Heidi L. Pinyerd, Emel Topal and Guy A. Cardineau.  2008. P19-dependent and P19-independent reversion of f1-v gene silencing in tomato. Plant Molecular Biology, 68: 61-79.



                   Matsuda, R., Kubota, C., Alvarez, L.M. and Cardineau, G.A. 2008. Preliminary evaluation of transgenic tomato plants expressing a Yersinia pestis antigen fusion protein F1-V grown in a greenhouse. Acta Horticlturae, (ISHS) 797:381-385.


                   Matsuda, R., Kubota, C., Alvarez, L.M. and Cardineau, G.A. 2009.  Biopharmaceutical protein production under controlled environments: growth, development and vaccine productivity of transgenic tomato plants grown hydroponically in a greenhouse.  HortScience 44(6) 1594-1599.


                   Alvarez, M. Lucrecia, Emel Topal, Federico Martin and Guy A. Cardineau.  2009.  Higher Accumulation of F1-V Fusion Recombinant Protein in Plants After Induction of Protein Body Formation.  Plant Molecular Biology, online September 30 (DOI 10.1007/s11103-009-9552-4), and in print 2010, 72(1)75-89.


    Alvarez, M. Lucrecia and Guy A. Cardineau.  2010.  Prevention of Bubonic and Pneumonic Plague Using Plant-Derived Vaccines.  Biotechnology Advances, 28(1)184-196.


    Qiang Chen, Hugh S. Mason, Tsafrir Mor, Alec Sutherland, Guy A. Cardineau, Charles J. Arntzen, and Carol O. Tacket, Subunit Vaccines Produced Using Plant Biotechnology.  2010 In: Levine, M.M., Dougan, G, Good, M.F., Liu, M.A., Nabel, G.J., Nataro, J.P., Rappuoli, R., eds., New Generation Vaccines, Fourth Edition (ISBN 9781420060737, 1420060732), pp306-314, New York: Informa Healthcare USA, Inc., January 2010.


    Alvarez, M. Lucrecia and Guy A. Cardineau.  2010.  New Strategies to Solve an Ancient Problem:  Prevention of Bubonic and Pneumonic Plague Using Plant-Derived Vaccines.   In: Albin Holmgren and Gerhard Borg, eds., Handbook of Disease Outbreaks: Prevention, Detection and Control, Nova Science Publishers, May 1 2010, ISBN: 978-1-60876-224-8.


                   Huang, Zhong , Waranyoo Phoolcharoen, Huafang Lai, Khanrat Piensook, Guy Cardineau, Larry Zeitlin, Kevin J. Whaley, Charles J. Arntzen, Hugh S. Mason and Qiang Chen.  2010.  High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system.  Biotechnology and Bioengineering, 106(1):9-17.


    Matsuda, R., Kubota, C., Alvarez, L.M. and Cardineau, G.A. 2010.  Determining the Optimal Timing of Fruit Harvest in Transgenic Tomato Expressing F1-V, a Candidate Subunit Vaccine against Plague.  HortScience 45(3) 347-351.


    Matsuda, R., Kubota, C., Alvarez, L.M. and Cardineau, G.A. 2012.  Effect of high electrical conductivity of hydroponic nutrient solution on vaccine protein content in transgenic tomato.  HortTechnology 22(3)362-367.


    Alvarez ML, Done SC, Cardineau GA (2013) Reverse Vaccination and Treatment of Type 1 Diabetes Using Plant-Produced Autoantigens and Anti-inflammatory Cytokines. J Clin Cell Immunol S2: 007. doi:10.4172/2155-9899.S2-007


    Gary E. Marchant & Guy A. Cardineau (2013) The Labeling Debate in the United States. GM Crops and Food: Biotechnology in Agriculture and the Food Chain 4(3)1-9; PMID: 23982076


    Amy Klocko, Richard Meilan, Rosalind R. James, Venkatesh Viswanath, Manuela Huso, Cathleen Ma, Peggy Payne, Lawrence Miller, Jeffrey S. Skinner , Brenda Oppert, Guy A. Cardineau, and Steven H. Strauss.  (2013/2014) Bt-Cry3A expression reduces insect damage and improves growth in field-grown hybrid poplar.  Canadian Journal of Forest Research, Published on the web 28 October 2013, 10.1139/cjfr-2013-0270 and in print

    Canadian Journal of Forest Research, 2014, 44(1): 28-35


                   Dania O. Govea-Alonso, Guy A. Cardineau and Sergio Rosales-Mendoza. Principles of Plant-Based Vaccines. 2014. In: Sergio Rosales-Mendoza, Ed., Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases: An Integrated View (ISBN 978-1-4939-0850-9), pp 1-14.  Springer, June 2014.


    Sergio A Garcia-Echauri and Guy A Cardineau. 2015. TETX a novel nuclear selection marker for Chlamydomonas reinhardtii transformation. Plant Methods, 11:27  doi:10.1186/s13007-015-0064-8


    Miguel A. Gutiérrez-Monreal, Luis Villela, Severiano Baltazar, Yocanxochitl Perfecto-Avalos, Guy A. Cardineau  and Sean-Patrick Scott, 2015. A PER3 polymorphism is associated with better overall survival in Diffuse large B-cell lymphoma in Mexican Population. Cancer Biomarkers 15(5)699-705.


    Rebeca García-Varela, Rebeca M. García-García, Bertha A. Barba-Dávila, Oscar R. Fajardo-Ramírez, Sergio O. Serna-Saldivar, and Guy A. Cardineau, 2015. Antimicrobial activity of Rhoeo discolor phenolic rich extracts determined by flow cytometry. Molecules 20(10)18685-18703.


    Rebeca García-Varela, Oscar Raúl Fajardo Ramírez, Sergio O. Serna-Saldivar, Julio Altamirano, Guy A. Cardineau.  2016. Cancer cell specific cytotoxic effect of Rhoeo discolor extracts and solvent fractions. Journal of Ethnopharmacology 190:46-58.


    Benítez Azaola, Ricardo; Garcia Varela, Rebeca; Garcia Garcia, Rebeca; Suarez Jacobo, Angela; Cardineau, Guy A; Altamirano, Julio; Serna-Saldivar, Sergio. 2017. Listeria monocytogenes growth inhibition in inoculated fresh Panela cheese by the addition of Rhoeo discolor aqueous extracts combined with potassium sorbate. Revista Mexicana de Ingeniería Química 16(2)425-434.


    Soledad Mora Vásquez, Silverio García Lara, Guy A. Cardineau, 2018. Phenotypic traits of Mexican soybean seeds and their correlation with in vitro shoot induction and susceptibility to Agrobacterium infection. Acta Botanica Mexicana 126(1)


    Ramírez-Alanis, Israel; Renaud, Justin; García-Lara, Silverio;Menassa, Rima;and Cardineau, Guy A. 2018.

    Transient co-expression with three O-glycosylation enzymes allows production of GalNAc-O-glycosylated Granulocyte-Colony Stimulating Factor in N. benthamiana. Plant Methods14:98


                   Soledad Mora Vásquez , Silverio García Lara, Edgardo J. Escalante Vázquez, and Guy Albert Cardineau. 2019. Improvement of Direct Regenration of Mexican Soybean from Cotyledonary Nodes. Agrociencia, accepted and in press.

Research Activity: 
Fall 2020
Course NumberCourse Title
LAW 703Law, Science, and Technology
LAW 714Biotechnology
Spring 2020
Course NumberCourse Title
HON 494Special Topics
LAW 617Genetics and the Law
BIO 691Seminar
LAW 791Seminar
BIO 791Seminar
Fall 2019
Course NumberCourse Title
LAW 691Seminar
LAW 703Law, Science, and Technology
Spring 2019
Course NumberCourse Title
HON 494Special Topics
LAW 617Genetics and the Law
BIO 691Seminar
LAW 791Seminar
BIO 791Seminar
Fall 2018
Course NumberCourse Title
LAW 691Seminar
LAW 703Law, Science, and Technology
Spring 2018
Course NumberCourse Title
HON 494Special Topics
LAW 617Genetics and the Law
LAW 791Seminar
BIO 791Seminar
Fall 2017
Course NumberCourse Title
HON 494Special Topics
LAW 691Seminar
LAW 703Law, Science, and Technology
Spring 2017
Course NumberCourse Title
HON 494Special Topics
LAW 791Seminar
BIO 791Seminar
  • Cardineau, Guy. Plants as a Production System for Value Added Proteins and Molecules: Plant Made Vaccines for Animal Health. 3rd Annual BIGMAP Symposium: Understanding and Communicating Issues in Agricultural Biotechnology (Apr 2006).
  • Cardineau, Guy. Plants as a Production System for Value Added Proteins and Molecules: With an emphasis on Vaccines. 1st International Symposium of Biotechnology, Tecnologico de Monterry (Mar 2006).
  • Cardineau, Guy. Exactly what are Genetically Modified Foods anyway?. Arizona Science Center, First Friday Lecture Series (Oct 2005).
  • Cardineau, Guy. A Guide for Due Diligence for Technologies and Compounds. Conference on Plant Made Pharmaceuticals (Jan 2005).
  • Cardineau, Guy. Farms to Pharma: Plant Made Pharmaceuticals and the Evolution of Plant-based Subunit Vaccines. Arizona Bioindustry Association Oktober BioFest (Oct 2004).
  • Cardineau, Guy. Plant Made Pharmaceuticals: Evolution of Plant-based Subunit Vaccines and Veterinary Applications. APHIS Veterinary Biologics Public Meeting, Iowa State University (Apr 2004).
  • Cardineau, Guy. Impact of Biotechnology on the Corn Industry: Past, Present and Future. US Grains Council Japan Tour: Value Enhanced Grains (Feb 2004).
  • Cardineau, Guy. Applications of Plant Biotechnology. Organization of American States, Workshop on Hemispheric Policies on Scientific and Technological Development in the Americas (Dec 2003).
  • Cardineau, Guy. Farms to Pharma: Plant Made Pharmaceuticals from Concept to Commercialization. Conference on Plant Made Pharmaceuticals, The Center for Business Intelligence, Sheraton National Arlington (Dec 2003).
  • Cardineau, Guy. Plant Based Production of Vaccines in Food Crops. The 2003 American Association of Cereal Chemists Annual Meeting (Sep 2003).
  • Webb, S, Kirk, D, Cardineau, Guy, Fanton, M, Mason, H, Van Eck, J, Miller, T, Arntzen, C. Serological and clinical response in poultry following the administration of a plant-made vaccine against avian influenza. International Vaccine & Veterinary Diagnostic Conference (Jul 2003).
  • Miller, T, Fanton, M, Cardineau, Guy, Mason, H, Arntzen, C. Clinical and Serological Response in Chickens Following the Administration of Plant Made Vaccine Against Newcastle Disease Virus. 6th International Vaccine Conference (May 2003).
  • Cardineau, Guy. Bio-Pharming: Agricultural Biotechnology from Input to Output (where we've been, where we are and where we're going). The Agri-Business Council of Arizona Annual Meeting and Agricultural Biotech Conference (Apr 2003).
  • Cardineau, Guy. Plant Based Production and Delivery of Vaccines for Oral Immunization: How Do We Make It a Reality. The GE3LS Winter Symposium 2003, Genome Canada (Feb 2003).
  • Cardineau, Guy. Antigen Engineering or ? How Can We Improve the Production and Delivery of Vaccines for Oral Immunization. The proVacs Conference, the Flinn Foundation (Nov 2002).
  • Cardineau, Guy. The Application of Agricultural Biotechnology to the Production and Delivery of Vaccines for Oral Immunization. BIOTEC Thailand, National Science and Technology Development Agency (Nov 2002).
  • Cardineau, Guy. Agricultural Biotechnology from Input to Output Traits. CropLife Asia Technology Conference, More People, Less Land: Technology's Role in Sustainable Agriculture in Asia (Nov 2002).
  • Cardineau, Guy. Plant Based Systems for the Production and Delivery of Vaccines: Rationale, Perspective, Issues and Challenges. Agricultural Biotechnology International Conference, Agbiotech: Cultivating Convergence (Sep 2002).
  • Cardineau, Guy. Current Development, Production and Biosafety of Biotech Corn and Soybeans. Grains Symposium Forestry Research Institute (Jul 2002).
  • Cardineau, Guy. Current Development, Production and Biosafety of Biotech Corn and Soybeans. Korean Food and Drug Administration (Jun 2002).
  • Cardineau, Guy. Current Development, Production and Biosafety of Biotech Corn and Soybeans. National Agricultural Biotechnology Institute (Jun 2002).
  • Cardineau, Guy. Current Development, Production and Biosafety of Biotech Corn and Soybeans. Swine Feed, Feeding and Management Seminar, National Pingtung University of Science and Technology (Jun 2002).
  • Cardineau, Guy. Agricultural Biotechnology: the Past, the Present and the Promise of the Future. Crop Functional Genomics Center, Seoul National University (Jun 2002).
  • Cardineau, Guy. Agricultural Biotechnology: the Past, the Present and the Promise of the Future. Great Lakes Forum on Agriculture, Pennsylvania State University (Jun 2002).
  • Cardineau, Guy. Current Development, Production and Biosafety of Biotech Corn and Soybeans. Feed Manufacturing Short Course, National Chung Hsing University (Jun 2002).
  • Cardineau, Guy. Oral Immunization Using Transgenic Plants: A New Delivery Vehicle for Vaccines. The Development of Second Generation Transgenic Crops, The National Institute of Agrobiological Sciences (Mar 2002).
  • Cardineau, Guy. Agricultural Biotechnology: Past, Present and Future. The U.S. Grains Council Asian Regional Biotechnology Information Conference (Sep 2001).
  • Cardineau, Guy. Orally Delivered, Plant Based Vaccines: Rationale, Successes, Issues and Challenges. The Phytochemical Society of Europe (Jun 2001).
  • Cardineau, Guy. A Biotechnology Transition in Manufacturing from the Steel Plant to the Green Plant. Food and Ag Symposium Agricultural Biotechnology: From Farm to Pharm BIO2001 (Jun 2001).
  • Cardineau, Guy. Functional Genomics with Plant Viral Expression Systems. The San Diego Center for Molecular Agriculture Symposium New Tools for Plant Biology, Frederic de Hoffmann Auditorium of the Salk Institute (Oct 2000).
  • Cardineau, Guy. Opportunities for Plant Produced Renewable Materials: Plant Derived Oral Vaccines. The Advance of BioAgriculture Products Into the 21st Century, CalBioSummit (Oct 2000).
  • Cardineau, Guy. Plant Based Production Systems for Orally Delivered Vaccines. Cornell-in-India Biotechnology Initiative: Biotechnology for Development (Sep 2000).
  • Cardineau, Guy. Engineered Plants: Ag Biotech 101 Plant-Derived Biologics for Human and Veterinary Applications. Iowa State University (Apr 2000).
  • Cardineau, Guy. Plant Based Production of Orally Delivered Vaccines. University of Georgia (Mar 2000).
  • Flinn Foundation, Arizona Biotechnology Roadmap, BioAgriculture Research & Technology Platform Committee (2006 - Present)
  • Arizona Town Hall, Junior Varsity Head Coach (2005 - Present)
  • Mountain Pointe Pride Lacrosse, Junior Varsity Head Coach (2004 - Present)
  • USDA CREES SBIR Grants Review Panel, Panelist (2004 - Present)
  • Office of Science and Technology, Organization of American States, Invited Biotechnology Expert (2003 - Present)
  • Poway Unified School District, Volunteer (1998 - 2003)
  • County of San Diego Board of Supervisors, State of California, Science Advisory Board (2001 - 2003)