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Hugh Mason

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Associate Professor
Faculty, TEMPE Campus, Mailcode 7501
Associate Professor
Faculty, TEMPE Campus, Mailcode 7501
Biography

Hugh Mason was the first to publish peer-reviewed work on the use of plants for production of vaccine antigens, showing expression of authentic hepatitis B surface antigen in tobacco (Mason et al., 1992). He has been a leader in this field for many years and continues to publish work in plant-based vaccines (Kim et al., 2015). With funding from NIH-NIAID, his lab focused on oral delivery of vaccines for enteric diseases including Norwalk virus (Mason et al., 1996) and enterotoxic E. coli (Haq et al., 1995), and demonstrated oral immunogenicity in mice after ingestion of transgenic potato tuber. These studies were seminal to a field that is now strongly developed world wide. His group's work on expression of vaccine antigens in potato led to the first human testing of plant-based vaccines, funded by NIH-NIAID. The first such trial ever conducted showed that volunteers who ate potato tuber expressing E. coli heat-labile enterotoxin B subunit (LTB) developed serum and mucosal antibodies specific for LT-B (Tacket et al., 1998). The next study demonstrated specific antibody responses in humans who ingested potatoes expressing Norwalk virus capsid protein (NVCP) (Tacket et al., 2000). A third trial showed substantial boosting of titers of serum antibodies against hepatitis B surface antigen (HBsAg) in people who were previously vaccinated with the commercial yeast-derived HBsAg vaccine (Thanavala et al., 2005). Although only a few other clinical studies have been published on plant-based vaccines, his lab's work demonstrated the potential for the strategy and spurred other research leading to plant-based verterinary vaccines (Mason et al., 2013).

With funding from DARPA, Professor Mason and coworkers developed a rapid and robust plant-based expression system using a geminivirus, bean yellow dwarf virus (Mor et al., 2003). Later, funded by NIH-NIAID, the group showed that it could produce Norwalk virus VLP at ~0.5 g per kg leaf mass (Huang et al. 2009). Moreover, it was enormously useful for co-expression of multiple different proteins, and thus allowed production of anti-Ebola monoclonal antibody at high levels (Huang et al., 2010). This work resulted in a patent for use of geminiviral vectors for rapid transient expression in plants. His latest work shows further enhancement of expression using vector refinements and ancillary elements incorporated into the geminiviral replicons (Diamos et al., 2016).

With funding fro NIH, the Mason lab used the geminiviral transient plant expression system to produce a RIC vaccine for Ebola virus (Phoolcharoen et al., 2011a). This novel approach enables production of immune complexes by expressing a self-reactive antibody via fusion of the target antigen to the C-terminus of the heavy chain and co-expression of the light chain. The Ebola RIC used the viral glycoprotein GP1 and provided protection to mice against lethal virus challenge (Phoolcharoen et al., 2011b). We further developed this system to make a universal RIC platform, by tagging vaccine antigens with the Ebola GP1 epitope. This resulted in a robust anti-dengue vaccine that produced neutralizing antibodies after only two vaccinations without adjuvant (Kim et al., 2015). These results show strong potential for RIC produced in plants with geminiviral vectors.

Education
  • Postdoctoral Research Associate, Department of Biochemistry, Texas A&M University; Research related to expression of soybean vsp genes and analysis of vspB promoter 1987-92            
  • Ph.D. Cellular and Developmental Biology, University of Arizona, Tucson. Dissertation: Alterations in Polyribosome and Messenger RNA Metabolism and Messenger Ribonucleoprotein Utilization in Osmotically Stressed Plant Seedlings 1986   
  • B.S. Molecular Biology, University of Texas-Austin 1976    
Publications
  • Mathew LG, Herbst-Kralovetz M, Mason HS. Norovirus Narita 104 virus-like particles expressed in Nicotiana benthamiana induce serum and mucosal immune responses. Biomed. Res. International: Plant-made Biologics (2014).
  • Moon K-B, Kang Y-J, Kim M, Kang S, Mason HS, Jeon J-H, Kim H-S. Overexpression and self-assembly of virus-like particles in N. benthamiana by a single-vector DNA replicon system. Appl. Microbiol. Biotechnol (2014).
  • Rattanapisit K, Bhoo SH, Hahn TR, Mason HS, Phoolcharoen W. Rapid transient expression of cholera toxin B subunit (CTB) in Nicotiana benthamiana. In Vitro Cell. Devel. Biol. – Plant (2013).
  • Castilho A, Neumann L, Daskalova S, Mason HS, Steinkellner H, Altmann F, Strasser R. Engineering of sialylated mucin-type O-glycosylation in plants. J Biol Chem (2012).
  • Miller T, Fanton M, Nickelson S, Mason H, Webb S. Safety and immunogenicity of bacterial and tobacco plant cell line derived recombinant native and mutant Escherichia coli heat-labile toxin in chickens. Avian Pathol (2012).
  • Mason HS, Herbst-Kralovetz MM. Plant-derived antigens as mucosal vaccines. Current Topics in Microbiology and Immunology , Mucosal Vaccines: Modern Concepts, Strategies, and Challenges (2012).
  • Chen Q, He J, Phoolcharoen W, Mason HS. Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants. Human Vaccines (2011).
  • Mathew LG, Maloney B, Takeda N, Mason HS. Spurious polyadenylation of Norovirus Narita 104 capsid protein mRNA in transgenic plants. Plant Mol Biol (2011).
  • Mathew LG, Maloney B, Takeda N, Mason HS. Spurious polyadenylation of Norovirus Narita 104 capsid protein mRNA in transgenic plants. Plant Mol Biol (2011).
  • Phoolcharoen W, Bhoo SH, Lai H, Ma J, Arntzen CJ, Chen Q, Mason HS. Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana. Plant Biotechnol. J (2011).
  • Phoolcharoen W, Dye JM, Kilbourne J, Piensook K, Pratt WD, Arntzen CJ, Chen Q, Mason HS, Herbst-Kralovetz MM. A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge. Proc. Natl. Acad. Sci. USA (2011).
  • Pinkhasov J, Alvarez ML, Rigano MM, Piensook K, Larios D, Pabst M, Grass J, Mukherjee P, Gendler SJ, Walmsley AM, Mason HS. Recombinant plant-expressed tumor-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice. Plant Biotechnol. J (2011).
  • Daskalova SM, Radder JE, Cichacz ZA, Olsen SH, Tsaprailis G, Mason H, Lopez LC. Engineering of N. benthamiana L. plants for production of N-acetylgalactosamine-glycosylated proteins--towards development of a plant-based platform for production of protein therapeutics with mucin type O-glycosylation. BMC Biotechnol (2010).
  • Herbst-Kralovetz M, Mason HS (corresponding author), Chen Q. Norwalk virus-like particles as vacines. Expert Rev. Vaccines (2010).
  • Huang Z, Phoolcharoen W, Lai H, Piensook K, Cardineau G, Zeitlin L, Whaley KJ, Arntzen CJ, *Mason HS, *Chen Q. High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system. Biotechnol. Bioeng (2010).
  • Martinez CA, Topal E, Giulietti AM, Talou JR, Mason HS. Exploring different strategies to express Dengue virus envelope protein in a plant system. Biotechnol. Lett (2010).
  • Pinkhasov J, Alvarez ML, Pathangey LB, Tinder TL, Mason HS, Walmsley AM, Gendler SJ, Mukherjee P. Analysis of a cholera toxin B subunit (CTB) and human mucin 1 (MUC1) conjugate protein in a MUC1-tolerant mouse model. Cancer Immunol Immunother (2010).
  • Santi L, Mason HS. Plants as biofactories for vaccine production. Encyclopedia of Biotechnology in Agriculture and Food (2010).
  • Del Prete G, Santi L, Andrianaivoarimanana V, Amedei A, Domarle O, D' Elios MM, Arntzen CJ, Rahalison L, Mason HS. Plant-derived recombinant F1, V, and F1-V fusion antigens of Yersinia pestis activate human cells of the innate and adaptive immune system. Int J Immunopathol Pharmacol (2009).
  • Huang Z, Chen Q, Hjelm B, Arntzen C, Mason H. A DNA replicon system for rapid high-level production of virus-like particles in plants. Biotechnol. Bioeng (2009).
  • Webster DE, Wang L, Mulcair M, Ma C, Santi L, Mason HS, Wesselingh SL, Coppel RL. Production and characterisation of an orally immunogenic Plasmodium antigen in plants using a virus-based expression system. Plant Biotechnol. J (2009).
  • Huang Z, LePore K, Elkin G, Thanavala Y, Mason HS. High-yield rapid production of hepatitis B surface antigen in plant leaf by a viral expression system. Plant Biotechnol. J (2008).
  • Luca Santi, Lance Batchelor, Zhong Huang, Brooke Hjelm, Jacquelyn Kilbourne, Charles Arntzen, Qiang Chen, Hugh Mason. An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles. Vaccine (2008).
  • Santi, L, Mason, Hugh S. Vaccines Produced in Transgenic Plants. Encyclopedia of Biotechnology in Agriculture and Food (2007).
  • J Van Eck, B Conlin, D Garvin, Hugh Mason, D Navarre, C Brown. Enhancing [[beta]]-carotene content in potato by RNAi-mediated silencing of the [[beta]]-carotene hydroxylase gene. Ame J Potato Res (2007).
  • Jason Collens, Hugh Mason, Wayne Curtis. Agrobacterium-mediated viral vector-amplified transient gene expression in Nicotiana glutinosa plant tissue culture. Biotechnol Prog (2007).
  • Santi, L,Mason, Hugh S (Author) . Vaccines Produced in Transgenic Plants. Encyclopedia of Biotechnology in Agriculture and Food (2007).
  • A Becerra-Arteaga, Hugh Mason, M Shuler. Production, Secretion, and Stability of Human Secreted Alkaline Phosphatase in Tobacco NT1 Cell Suspension Cultures. Biotechnol. Prog (2006).
  • K Mayo, B Gonazales, Hugh Mason. Genetic transformation of tobacco NT1 cells with Agrobacterium tumefaciens. Nature Protocols (2006).
  • L Santi, A Giritch, C Roy, S Marillonnet, V Klimyuk, Y Gleba, R Webb, C Arntzen, Hugh Mason. Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system. Proc. Natl. Acad. Sci. USA (2006).
  • L Santi, Z Huang, Hugh Mason. Virus-like particles production in green plants. Methods (2006).
  • M Alvarez, H Pinyerd, J Crisantes, M Rigano, J Pinkhasov, A Walmsley, Hugh Mason, Guy Cardineau. Plant-made subunit vaccine against pneumonic and bubonic plague is orally immunogenic in mice. Vaccine (2006).
  • S Saldaña, L Richter, C Arntzen, M Gómez-Lim, F Guadarrama, T de Jesus Olivera Flores, N Arias, S López, C Arias, R Ruiz, Hugh Mason, T Mor. Production of rotavirus-like particles in tomato (Lycopersicon esculentum L.) fruit by expression of capsid proteins VP2 and VP6 and immunological studies. Viral Immunol (2006).
  • X Zhang, Hugh Mason. Bean yellow dwarf virus replicons for high-level transgene expression in transgenic plants and cell cultures. Biotechnol Bioeng (2006).
  • X Zhang, N Buehner, A Hutson, M Estes, Hugh Mason. Tomato is a highly effective vehicle for expression and oral immunization with Norwalk virus capsid protein. Plant Biotechnol. J (2006).
  • Zhong Huang, L Santi, K LePore, J Kilbourne, C Arntzen, Hugh Mason. Rapid, high-level production of hepatitis B core antigen in plant leaf and its immunogenicity in mice. Vaccine (2006).
  • Santi, L, Huang, Z, Mason, Hugh. Virus-like particles production in green plants. (2006).
  • Thanavala, Y, Huang, Z, Mason, Hugh. Plant-derived vaccines: a look back at the highlights and a view to the challenges on the road ahead. (2006).
  • Thanavala, Y, Huang, Z, Mason, Hugh. Plant-derived vaccines: a look back at the highlights and a view to the challenges on the road ahead. (2006).
  • C Arntzen, R Mahoney, Hugh Mason, D Kirk. Oral Vaccines Derived from Transgenic Plants. Vaccines: Preventing disease and protecting health (2005).
  • C Mihalek, J Van Eck, S Webb, T Miller, M Fanton, D Kirk, G Cardineau, Hugh Mason, A Walmsley, A Artnzen. Development of plant cell produced vaccines for animal health applications. Proc. Ann. Meeting U.S. Animal Health Assoc (2005).
  • J Bryan, B Maloney, Naokazu Takeda, Yuriko Suzaki, Ami Yasushi, Tian Li, Tatsuo Miyamura, Charles Arntzen, Hugh Mason. Challenges in creating a vaccine to prevent hepatitis E. Vaccine (2005).
  • Y Thanavala, M Mahoney, S Pal, A Scott, L Richter, N Natarajan, P Goodwin, C Arntzen, Hugh Mason. Immunogenicity in humans of an edible vaccine for hepatitis B. Proc. Natl. Acad. Sci. USA (2005).
  • Zhong Huang, G Elkin, B Maloney, N Beuhner, C Arntzen, Y Thanavala, Hugh Mason. Virus-like particle expression and assembly in plants: hepatitis B and Norwalk viruses. Vaccine (2005).
  • Mason, Hugh S. Vaccines produced in transgenic plants. Encyclopedia of Plant and Crop Science (2004).
  • N Judge, Hugh Mason, A O'Brien. Plant cell-based intimin vaccine given orally to mice primed with intimin reduces time of Escherichia coli O157:H7 shedding in feces. Infect. Immun (2004).
  • Z Huang, Hugh Mason. Conformational analysis of hepatitis B surface antigen fusions in an Agrobacterium-mediated transient expression system. Plant Biotechnol. J (2004).
  • Mason, Hugh S (Author) ,Chikwamba, R (Author) ,Santi, L (Author) ,Mahoney, R T (Author) ,Arntzen, C J (Author) . Antigen delivery systems: Transgenic plants for mucosal vaccines. Mucosal Immunology, 3rd Edition. Section D. Mucosal Vaccines (2004).
  • Mor, T S (Author) ,Mason, Hugh S (Author) . Plants as a source for subunit vaccines. Handbook of Plant Physiology (2004).
  • Mor, T S (Author) ,Mason, Hugh S (Author) ,Kirk, D (Author) ,Arntzen, C J (Author) ,Cardineau, G A (Author) . Plants as a delivery vehicle for orally delivered subunit vaccines. New Generation Vaccines, Third Edition (2004).
  • A Walmsley, D Kirk, Hugh Mason. Passive immunization of mice pups through oral immunization of dams with a plant-derived vaccine. Immunology Letters (2003).
  • A Walmsley, M Alvarez, Y Jin, D Kirk, S Lee, J Pinkhasov, M Rigano, C Arntzen, Hugh Mason. Expression of the B subunit of Escherichia coli heat-labile enterotoxin as a fusion protein in transgenic tomato. Plant Cell Reports (2003).
  • H Warzecha, Hugh Mason. Benefits and risks of antibody and vaccine production in transgenic plants. J. Plant Physiol (2003).
  • H Warzecha, Hugh Mason, C Lane, A Tryggvesson, E Rybicki, A Williamson, J Clements, R Rose. Oral immunogenicity of human papillomavirus-like particles expressed in potato. Journal of Virology (2003).
  • K Palmer, T Mor, Y Moon, Hugh Mason. Geminivirus vectors for high level expression of foreign proteins in plant cells. Biotechnology & Bioengineering (2003).
  • M Smith, L Richter, C Arntzen, M Shuler, Hugh Mason. Structural characterization of plant-derived hepatitis B surface antigen employed in oral immunization studies. Vaccine (2003).
  • P Sojikul, N Buehner, Hugh Mason. A plant signal peptide-hepatitis B surface antigen fusion protein with enhanced stability and immunogenicity expressed in plant cells. Proc. Natl. Acad. Sci. USA (2003).
  • R Chikwamba, M Scott, L Mejia, Hugh Mason, K Wang. Localization of a bacterial protein in starch granules of transgenic maize kernels. Proc. Natl. Acad. Sci. USA (2003).
  • T Mor, Hugh Mason. Plants as a source for subunit vaccines. Handbook of Plant Physiology (Christou P, Klee H, Eds.) John Wiley & Sons (2003).
  • Hugh Mason. Plant-based vaccines: Expression and oral immunogenicity. Vitro Cell. Devel. Biol. - Plant (2002).
  • Hugh Mason, H Mason, M Shuler. Hepatitis B surface antigen (HBsAg) expression in plant cell culture; the kinetics of antigen accumulation in batch culture and its intracellular form. Biotechnol. Bioeng (2002).
  • Hugh Mason, H Warzecha, Tsafrir Mor, C Arntzen. Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine. Trends Mol. Med (2002).
  • J Cao, H Ibrahim, J Garcia, Hugh Mason, R Granados, E Earle. Transgenic tobacco plants carrying a baculovirus enhancin gene slow development and enhance mortality of Trichoplusia ni larvae. Plant Cell Rep (2002).
  • M Smith, M Keegan, Hugh Mason, M Shuler. Factors important in the extraction, stability and in vitro assembly of the hepatitis B surface antigen derived from recombinant plant systems. Biotechnol. Prog (2002).
  • R Chikwamba, J Cunnick, D Hathaway, J McMurray, Hugh Mason, K Wang. A functional antigen in a practical crop: Maize synthesized LT-B protects mice against Escherichia coli heat labile enterotoxin (LT) and cholera toxin (CT). Transgenic Research (2002).
  • R Chikwamba, J McMurray, B Frame, P Scott, Hugh Mason, K Wang. Expression of a bacterial antigen in maize: The role of regulatory sequences, inheritance and level of expression of the synthetic E. coli heat labile toxin B sub-unit (LT-B) in maize. Molecular Breeding (2002).
  • C Arntzen, L Richter, Q Kong, Y Thanavala, Y Yang, Hugh Mason. Oral immunization with hepatitis B surface antigen expressed in transgenic plants. Proc. Natl. Acad. Sci. USA (2001).
  • T Mor, M Sternfeld, H Soreq, C Arntzen, Hugh Mason. Expression of recombinant human acetylcholinesterase in transgenic tomato plants. Biotechnol. Bioeng (2001).
  • B Dogan, Hugh Mason, L Richter, J Hunter, M Shuler. Process options in hepatitis B surface antigen extraction from transgenic potato. Biotechnol. Progress (2000).
  • C Tacket, Hugh Mason, G Losonsky, M Estes, M Levine, C Arntzen. Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes. J. Infect. Dis (2000).
  • L Richter, Y Thanavala, C Arntzen, Hugh Mason. Production of hepatitis B surface antigen in transgenic plants for oral immunization. Nature Biotechnol (2000).
Research Activity
Summer 2019
Course NumberCourse Title
MBB 495Undergraduate Research
Summer 2018
Course NumberCourse Title
MBB 495Undergraduate Research
Summer 2017
Course NumberCourse Title
MBB 495Undergraduate Research
Spring 2017
Course NumberCourse Title
BIO 343Genetic Engineering & Society
MBB 343Genetic Engineering & Society
BIO 494Special Topics
MBB 494Special Topics
MIC 495Undergraduate Research
MBB 495Undergraduate Research
Spring 2016
Course NumberCourse Title
MBB 343Genetic Engineering & Society
BIO 343Genetic Engineering & Society
MBB 494Special Topics
MIC 495Undergraduate Research
MBB 495Undergraduate Research
Fall 2015
Course NumberCourse Title
MBB 347MolecularGenetics:GenesProtein
MBB 494Special Topics
MIC 495Undergraduate Research
MBB 495Undergraduate Research
BIO 495Undergraduate Research
MCB 500Research Methods
Spring 2015
Course NumberCourse Title
BIO 343Genetic Engineering & Society
MBB 343Genetic Engineering & Society
MIC 401Research Paper
MBB 494Special Topics
MIC 495Undergraduate Research
MBB 495Undergraduate Research
Presentations
  • Z. Huang, B. Gonzales, C. Uppalapati, L. George, L.Santi, E.Thuenemann, M. Lopker, C.J. Arntzen, H.S. Mason. Mucosal Targeting of STI Antigens: HPV L2 Capsid and HSV gD. NIH STI CRC Conference (Apr 2008).
  • Mason, Hugh. Development of Plant-based Norwalk Virus-like Particles as a Mucosal Delivery Platform. Plant-Based Vaccines & Antibodies (Jun 2007).
  • Mason, Hugh. Plant virus vectors for recombinant protein production. 16th Western Photosynthesis Conference (Jan 2007).
  • Topal, E, Alvarez, M, O'Brien, A, Mason, Hugh. Plant made intimin vaccine expressed in tomato for mucosal delivery to prevent colonization of Enterohemorragic E. coli. Symposium: New cells for new vaccines: focus on plant and insect cell technologies, Coral Gables, Fl (Sep 2006).
  • Yuan, S, Mason, Hugh. Regulated Gene Amplification in Transgenic Nicotiana Benthamiana. Symposium: New cells for new vaccines: focus on plant and insect cell technologies, Coral Gables, Fl (Sep 2006).
  • George, L, Mason, Hugh. Examination of coding sequence elements that limit the expression of a Norwalk like virus (CHIBA virus) capsid protein in transgenic plants. Penn State Symposium in Plant Physiology-RNA Biology, University Park, PA (May 2006).
  • LePore, K, Mason, Hugh. Production of orally-delivered vaccines in crop plants: biopharming for global health. Invited Seminar, Rochester Institute of Technology (May 2006).
  • Mason, Hugh, Huang, Z, Santi, L, LePore, K, Gonzales, B, Arntzen, C. Viral Vaccines from Green Plants: Progress and Prospects for Development. Viral Vaccines and Immunity Symposium, North Carolina Biotechnology Center (Apr 2006).
  • Hyunsoon, Kim, Santi, Luca, Gonzales, Barbara, Yuan, Shuo, Hjelm, Brooke, Flynn, Robert, Mary, Fee, Rose, Robert, Mason, Hugh. Plant Virus-based Expression and Assembly of Vaccine Antigens: Norwalk Virus and Human Papillomavirus Capsid Proteins. American Society of Plant Biologists Annual Meeting (Jul 2005).
  • LePore, K, Mason, Hugh. Plant-derived oral hepatitis B vaccine: Improving mucosal targeting by fusion to invasin protein from Yersinia pseudotuberculosis. American Society of Plant Biologists Annual Meeting (Jul 2005).
  • Mason, Hugh. Virus-like particle expression and assembly in plants: hepatitis B, Norwalk, and human papillomaviruses. Merieux Conference on Plant-based Vaccines & Antibodies, Annecy, France (Mar 2004).
  • Mason, Hugh. Production of Y. pestis and Norovirus Antigens in Plants. University of Pittsburgh Center for Vaccine Research Seminar Series
  • Mason, Hugh. Vaccine and Antibody Engineering in Plants. Pfizer Vaccinology Seminar Series
  • Herbst-Kralovetz, Melissa, Hjelm, Brooke, LaVigne, Daaimah, Kilbourne, Jacquelyn, Arntzen, Charles, Chen, Qiang, Mason, Hugh. Utilizing TLR Agonists to Augment Mucosal Vaccination. Keystone Symposia in Immunologic Memory
  • Mason, Hugh. HPV-16 L2 Capsid Protein Antigens Displayed on Virus-like Particles of Norwalk Virus Capsid and Hepatitis B Core Antigen. Sexually Transmitted Infection-Topical Microbicide-Cooperative Research Center Annual Meeting
Service
  • Task Force to evaluate ASU policies and funding for high performance computing, member (2015 - Present)
  • Research and Creative Activities Committee http://usenate.asu.edu/committees/rcac, member (2014 - Present)
  • Clinical and Developmental Immunology, Reviewer (2013 - Present)
  • Nature Protocols, Reviewer (2013 - Present)
  • J. Biotechnology, Reviewer (2013 - Present)
  • BMC: Biotechnology, Reviewer (2013 - Present)
  • Evidence-Based Complementary and Alternative Medicine, Reviewer (2013 - Present)
  • SoLS Safety Committee, Member (2013 - Present)
  • SoLS Safety Committee, Member (2013 - Present)
  • BMC: Plant Biology, Reviewer (2013 - Present)
  • PLOS One, Reviewer (2013 - Present)
  • North Carolina Biotechnology Center, Reviewer of proposal (2013 - Present)
  • Expert Rev. Vaccines, Reviewer (2013 - Present)
  • Plant Biotechnol. J., Reviewer (2013 - Present)
  • Vaccine, Reviewer (2013 - Present)
  • Biotechnology Advances, Reviewer (2012 - Present)
  • International J. Molec. Sciences, Reviewer (2012 - Present)
  • Molecular Biotechnol., Reviewer (2012 - Present)
  • PLOS Neglected Tropical Diseases, Reviewer (2012 - Present)
  • Plant Cell Reports, Reviewer (2012 - Present)
  • Plant Physiol. & Biochem, Reviewer (2012 - Present)
  • Protein Expression and Purification, Reviewer (2012 - Present)
  • PloS ONE, Reviewer (2011 - Present)
  • J. Virol. Methods, Reviewer (2011 - Present)
  • Protein Expression and Purification, Reviewer (2011 - Present)
  • Plant Cell Reports, Reviewer (2011 - Present)
  • J. Gen. Virol., Reviewer (2011 - Present)
  • USDA SBIR Phase I, Reviewer (2011 - Present)
  • USDA SBIR Phase II, Reviewer (2011 - Present)
  • Proc. Natl. Acad. Sci. USA, Reviewer (2011 - Present)
  • Proc. Natl. Acad. Sci. USA, Reviewer (2011 - Present)
  • BMC Biotechnology, Member Editorial Board (2011 - Present)
  • Bioengineering, Reviewer (2011 - Present)
  • Vaccine, Reviewer (2011 - Present)
  • PLoS ONE, Reviewer (2010 - Present)
  • Protein Expression and Purification, Reviewer (2010 - Present)
  • Fondazione Cariplo – Vaccine Development, Reviewer (2010 - Present)
  • Clinical and Vaccine Immunology, Reviewer (2010 - Present)
  • J. Plant Physiology, Reviewer (2010 - Present)
  • J. Plant Physiology, Reviewer (2009 - Present)
  • Biotechnology Advances, Reviewer (2009 - Present)
  • Plant Biotechnology Journal, Reviewer (2009 - Present)
  • Plant Biotechnology Journal, Reviewer (2009 - Present)
  • Vaccine, Reviewer (2009 - Present)
  • Vaccine, Reviewer (2009 - Present)
  • Human Vaccines, Reviewer (2009 - Present)
  • Human Vaccines, Reviewer (2009 - Present)
  • Plant Cell Reports, Reviewer (2009 - Present)
  • Plant Cell Reports, Reviewer (2009 - Present)
  • Biotechnology & Bioengineering, Reviewer (2009 - Present)
  • BARD_US-4190-09, Reviewer (2009 - Present)
  • SOLS Research and Training Initiatives Committee, Member (2009 - Present)
  • SOLS Research and Training Initiatives Committee, Member (2009 - Present)
  • SOLS Research and Training Initiatives Committee, Member (2009 - Present)
  • SOLS Research and Training Initiatives Committee, Member (2009 - Present)
  • SOLS Research and Training Initiatives Committee, Member (2009 - Present)
  • SOLS Research and Training Initiatives Committee, Member (2009 - Present)
  • Electronic Journal of Integrative Biosciences, reviewer (2008 - Present)
  • NIH Panel "Vaccines Against Microbial Diseases", May 19-20, 2008, Member NIH Scientific Review Study Section (2008 - Present)
  • The Plant Journal, reviewer (2008 - Present)
  • BMC - Biotechnology, Reviewer (2006 - Present)
  • BioMed Central, Member Editorial Board (2006 - Present)
  • BioMed Central, Member Editorial Board (2006 - Present)
  • Biomed Central-Biotechnology, reviewer/editor (2006 - Present)
  • Biotechnology & Bioengineering, reviewer (2006 - Present)
  • Plant Molecular Biology, reviewer (2006 - Present)
  • Graduate Steering Committee, member (2005 - Present)
  • SoLS Greenhouse Committee, member (2005 - Present)
  • SoLS Greenhouse Committee, member (2005 - Present)
  • Plant Biotechnology Journal, reviewer (2005 - Present)
  • Institutional Biosafety Committee, member (2004 - Present)
  • Institutional Biosafety Committee, member (2004 - Present)
  • Institutional Biosafety Committee, member (2004 - Present)
  • Institutional Biosafety Committee, member (2004 - Present)
  • Institutional Biosafety Committee, member (2004 - Present)
  • Institutional Biosafety Committee, member (2004 - Present)
  • Institutional Biosafety Committee, member (2004 - Present)
  • Personnel committee, Biomed/Biotech Faculty, member (2004 - Present)
  • Personnel committee, Biomed/Biotech Faculty, member (2004 - Present)
  • Personnel committee, Biomed/Biotech Faculty, member (2004 - Present)
  • Personnel committee, Biomed/Biotech Faculty, member (2004 - Present)
  • Biotechnology & Bioengineering, Reviewer (2002 - Present)
  • Plant Biotechnol. J., Reviewer (2002 - Present)
  • Plant Molecular Biol., Reviewer (2002 - Present)
  • ACNRMI Workshop Biotechnology/Biomedicine: visitors from Kazan State Technical University (Russia), Workshop presenter (2010 - 2010)
  • Wellcome Trust, Reviewer (2010 - 2010)
  • NIH ZRG1 IMM-N (12) Microbial Vaccine Development, Reviewer (2010 - 2010)
  • NIH ZRG1-IMM-N (02) Immunology, Reviewer (2010 - 2010)
  • NIH ZRG1-IMM-E (02) mmunology Special Emphasis Panel, Reviewer (2010 - 2010)
  • NIH ZRG1 IMM-E (55) R - OD-10-005 Director's Opportunity 5 Themes Immunology, Reviewer (2010 - 2010)
  • Natural Sciences and Engineering Research Council of Canada, Reviewer (2010 - 2010)
  • USDA SBIR Program Plant Production and Protection – Biology, Reviewer (2010 - 2010)
  • NIH Review Panel for ZRG1 EMNR-B(03), Reviewer (2009 - 2009)
  • NIH Review Panel for SBIR_2009/10 ZRG1 IMM-G (13) B, Reviewer (2009 - 2009)
  • NIH Review Panel for RC-1 Challenge Grants (RFA-09-003), Reviewer (2009 - 2009)
  • Nature Biotechnology, reviewer (2003 - 2004)
  • USDA-SBIR, grant reviewer (2004)
  • Personnel committee, Biomed/Biotech Faculty, chair (2003 - 2004)
  • SoLS Biomedicine & Biotechnology Faculty, Faculty Leader (2003 - 2004)
  • SoLS Executive Committee, member (2003 - 2004)
  • BARD, grant reviewer (2003)
  • Journal of Virology, reviewer (2003)
  • NIH, grant reviewer (2003)
  • Nutritional Genomics & Functional Foods, reviewer (2003)
  • Plant Cell Reports, reviewer (2003)
  • Plant Physiology, reviewer (2003)
  • Trends in Biotechnolog, reviewer (2003)
  • USDA-NRICGP, grant reviewer (2003)