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Jeffrey LaBelle

SUM/WTR Faculty Research
Faculty, TEMPE Campus, Mailcode 9709
Asst Professor
Faculty, TEMPE Campus, Mailcode 9709
Biography

 

Jeffrey T La Belle is currently an Assistant  Professor in the School of Biological Health and Systems Engineering and the Biodesign Institute at Arizona State University.  He has a Ph.D. and Masters in Bioengineering from ASU and a MS and BS in Electrical Engineering from Western New England University in Springfield Massachusetts.  The lab includes students from bioengineering, electrical engineering, mechanical engineering, chemical engineering, computer science engineering, as well as biology and chemistry programs at ASU.  Our research focus revolves around label-free, noninvasive sensing and point-of-care technologies.

Research Interests

In the La Belle Group, we are currently developing electrochemical sensors for noninvasive glucose sensing, the novelty of our design is to obtain tear fluid for tear to blood glucose correlation in a noninvasive means to increase patient compliance.  The next leap in technology for diabetes care is a multiplexed sensor that will add more depth of information for a self-monitoring blood glucose devices, here five accepted markers for DM care and management, including glucose, HbA1c, among others are simultaneously monitored on a single strip sensor.  This technology we are developing could also allow for continuous and single use stress sensing technologies.  Other applications of the sensing technologies include small molecule, DNA, protein, and whole cell detection to address changing climate in point-of-care technologies and medicine.  On the activation side of our research, we are fabricating nitinol staggered muscle arrays that mimic skeletal muscle and we have recently demonstrated over 30% compression in our SMA’s similar to muscle bundles. Our approach to design is simple, look at what the user needs and/or wants and apply a unique solution.  We have bioengineering, chemical, electrical, mechanical engineers in the group as well as biology and chemistry, a well diversified group to tackle the challenges in health care today.

Publications
  1. Gabriel A. Montaño, Ben P. Bowen, Jeffrey T. LaBelle, Neal W. Woodbury, Vincent B. Pizziconi, Robert E. Blankenship (2003). Characterization of Chlorobium tepidum chlorosomes. A calculation of bacteriochlorophyll c per chlorosome and oligomer modeling. Biophys. J. 85: 2560-2565.
  2. Jared Q Gerlach, Tanin Tangkuaram, Veer P Bhavanandan, Jeffrey T La Belle, Joseph Wang.  (2006). Sensitive and Rapid Electrochemical Bioassay of Glycosidase Activity.  Glycobiology 16, 11, 1155.
  3. Joseph Wang, Yun Xiang, Zong Dai, Jared Gerlach, Jeffrey La Belle, Lokesh Joshi. (2006). Nanoparticle Based Sensing of Glycan-Lectin Interactions. Glycobiology 16, 11, 1155.
  4. Zong Dai, Abdel-Nasser Kawde, Yun Xiang, Jeffrey T. La Belle, Jared Q. Gerlach, Veer P. Bhavanandan, Lokesh. Joshi, Joseph Wang. (2006). Nanoparticle-Based Bioelectronic Sensing of Glycan-Lectin Interactions.  JACS.  128, 10018-9.
  5. Tanin Tangkuaram, Jared Q. Gerlach, Yun Xiang, Abdel-Nasser Kawde, Zong Dai, Veer P. Bhavanandan, Jeffrey T. La Belle, Waret Veerasai, Lokesh Joshi, Joseph Wang.  (2006). Sensitive and Rapid Electrochemical Bioassay of Glycosidase Activity.  The Analyst. 131, 889-891.
  6. Sridharan, A., Muthuswamy, J., LaBelle, J., Pizziconi. V. (2007). Characterization of covalently immobilized chlorosomes on indium tin oxide conductive glass substrate.  Biophys J 331A-331A Suppl. S.
  7. Joseph Wang, Zong Dai, , Abdel-Nasser Kawde, Yun Xiang, Jeff La Belle, Jared Gerlach, Veer Bhavandan, Sergei Svarovsky, Lokesh Joshi. (2007). Nanocrystal-based electrochemical biosensors of glycan-lectin interactions suitable for point-of-care use. Nanomedicine: Nanotechnology, Biology and Medicine, 2(4), 314.
  8. Jeffrey T. La Belle, Jared Q. Gerlach, Sergei Svarovsky and Lokesh Joshi.  Rapid Label-Free Impedimetric Detection of Glycan-Lectin Interactions (2007).  Analy Chem. 79, 6959-64.
  9. Jeffrey T. La Belle, Kinjal Bhavsar*, Sergei Svarovsky, Peiming Zhang, Veer Bhavanandan, James Sweeney, Terry Alford, Joseph Wang, Lokesh Joshi. (2007). A Cytokine Immunosensor Based Upon Label-Free Electrochemical Impedance Spectroscopy. Biosens Bioelec 23, 428-31.
  10. Andrea Kagie*, Daniel K. Bishop, Jeffrey T. La Belle, Robert Dymond, Robin Felder, Joseph Wang (2008).  Flexible Rolled Thick-Film Miniaturized Flow-cell for Minimally Invasive Amperometric Sensing.  Electroanalysis.20, 1610-4.
  11. Avi Cagan*, Donglai Lu*, Karel Cizek, Jeff La Belle and Joseph Wang. (2008). Reliable, rapid and simple voltammetric detection of urea nitrate explosive.  The Analyst. 133, 585-7.
  12. Yongkang Ye, Wen Wen*, Yun Xiang*, Xiaodong Qi, Jeffrey T. La Belle, Julian J. L. Chen, Joseph Wang.  (2008). Direct Electrochemical Monitoring of RNase Activity.  Electroanalysis.  20, 8, 919-22.
  13. Vivek Nandakumar*, Jeffrey T. La Belle, Justin Reed, Miti Shah, Douglas Cochran, Lokesh Joshi, T.L. Alford. (2008). A Methodology for Rapid Detection of Salmonella typhimurium using Label-free Electrochemical Impedance Spectroscopy.  Biosensors and Bioelectronics. 24, 1045-8.
  14. Arati Sridharan, Jit Muthuswamy, Jeffrey T. LaBelle, and Vincent B. Pizziconi. (2008). Immobilization of Functional Light Antenna Structures Derived From The Filamentous Green Bacterium Chloroflexus aurantiacus.  Langmuir. 24, 8078-89.
  15. Jeffrey T. La Belle, Miti Shah, Justin Reed, Vivek Nandakumar*, T.L. Alford, James W. Wilson, Cheryl A. Nickerson, Lokesh Joshi.  (2009). Label-Free and Ultra-Low Level Detection of Salmonella enterica serovar Typhimurium Using Electrochemical Impedance Spectroscopy. Electroanalysis. (2009) 21:20, 2267-71.
  16. Kinjal Bhavsar*, Aaron Fairchild, Eric Alonas, Daniel K. Bishop, Jeffrey T. La Belle, James Sweeney, T.L. Alford, Lokesh Joshi. (2009) A Cytokine Immunosensor for Multiple Sclerosis Detection Based Upon Label-Free Electrochemical Impedance Spectroscopy Using Electroplated Printed Circuit Board Electrodes. Biosensors & Bioelectronics 25(2) 506-509.
  17. John Benedet*, Donglai Lu*, Karel Cizek, Jeff La Belle and Joseph Wang.  (2009). Amperometric Sensing of Hydrogen Peroxide Vapor for Security Screening.  Analytical & Bioanalytical Chemistry 395(2) 371-6.
  18. Jiaying Cai, Karel Cizek, Brent Long, Kenyon McAferty, Casey G. Campbell, David R. Allee, Bryan D. Vogt, Jeff La Belle and Joseph Wang (2009).  Flexible Thick-Film Electrochemical Sensors: Impact of Mechanical Bending and Stress on the Electrochemical Behavior.  Sens Actu. B. 137, 379-85.
  19. Karel Cizek, Chad Prior, Chongdee Thammakhet, Michal Galik, Kevin Linker, Ray Tsui, Avi Cagan*, John Wake, Jeff La Belle and Joseph Wang (2010). Integrated Explosive Preconcentrator and Electrochemical Detection System for TNT Vapor.  Analytica Chimica Acta. 661: 117-21.
  20. Daniel K. Bishop, Jeffrey T. La Belle, Stephen R. Vossler, Dharmendra R. Patel, and Curtiss B. Cook (2010).  A disposable tear glucose biosensor – part 1: design and concept testing.  Journal Diabetes Science and Technology. 2:6, 299-306.
  21. Jeffrey T. La Belle, Daniel K. Bishop, Stephen R. Vossler, Dharmendra R. Patel, and Curtiss B. Cook (2010).  A disposable tear glucose biosensor – part 2: system integration and model validation.  Journal Diabetes Science and Technology. 2:6, 307-11.
  22. Donglai Lu, Jeff La Belle, Celine Le Ninivin, Stephane Mabic, Telis Dimitrakopoulos.  (2010). In situ electrochemical detection of trace metal vapors at bismuth doped carbon screen printed electrodes. Journal of Electroanalytical Chemistry.  642:2, 157-9.
  23. Vivek Nandakumar, Daniel Bishop, Eric Alonas, Jeffrey LaBelle, Lokesh Joshi, Terry L. Alford. (2011). A Low-cost Electrochemical Biosensor for Rapid Bacterial Detection.  IEEE Sensors, Vol. 11, No. 1, Pgs 210-6.
  24. Jeffrey T. La Belle, Ugur Korcan Demirok, Dharmendra R. Patel, Curtiss B. Cook. (2011). Development of a Novel Single Sensor Multiplexed Marker Assay.  Analyst.  Vol. 136, No. 7, Pgs 1496-1501.
  25. Mingzhi Dai*, Lingyan Song, Jeffrey T. LaBelle, and Bryan D. Vogt.  (2011). Ordered mesoporous carbon composite films containing cobalt and vanadium for electrochemical applications. Chemistry of Materials. Vol. 23, Iss. 11, pgs. 2869-2878.
  26. Kenneth Lan, Kenyon McAferty, Pankti Shah, Erica Lieberman, Dharmendra R. Patel, Curtiss B. Cook, Jeffrey T. La Belle. (2011). A disposable tear glucose biosensor – part 3: assessment of enzymatic specificity. Journal Diabetes Science and Technology. Vol. 5, Iss. 5, Pgs 1-5.
  27. Mingzhi Dai*, Stephanie Maxwell, Bryan D. Vogt, Jeffrey T. La Belle. (2012) Mesoporous carbon amperometric glucose sensors using inexpensive, commercial methacrylate-based binders. Analytica Chimca Acta. Aug 13;738:27-34.
  28. Teagan Leigh Adamson, Francis Ang Eusebio, Curtiss B. Cook, and Jeffrey T. LaBelle. (2012). The promise of electrochemical impedance spectroscopy as novel technology for the management of patients with diabetes mellitus. Analyst.  137 (18) 4179-87.
  29. Sandra Ivonne Gonzalez, Jeffrey T. La Belle. (2012). The development of an at-risk biosensor for cardiovascular disease.  Biosensors Journal. Vol. 1, 1-5.
  30. Mingzhi Dai*, Brittney Haselwood, Bryan D. Vogt, and Jeffrey T. LaBelle.  (2013). Amperometric sensing of norepinephrine at picomolar concentrations using screen printed, high surface area mesoporous carbon.   Analytica Chimica Acta.  Vol. 788, Pgs. 32-38.
  31. Jeffrey T. La Belle, Aaron Fairchild, Ugur K. Demirok, Aman Verma. (2013). Method for fabrication and verification of conjugated nanoparticle-antibody tuning elements for multiplexed electrochemical biosensors. Methods. Vol. 61, Pgs. 39-51.
  32. Ugur Korcan Demirok, Aman Verma, and Jeffrey T La Belle. (2013). The Development of a Label-Free Electrochemical Impedance Based Point of-care Technology for Multimarker Detection.  J Biosens Bioelectron Special Issue 12, Pgs1-7.
  33. Teagan Adamson, Curtiss Cook, Jeffrey T. La Belle. (2014) Detection of 1,5-Anhydroglucitol by electrochemical impedance spectroscopy and potential for use in a multi-marker glycemic assessment platform for patients with diabetes mellitus. Journal Diabetes Science and Technology. Vol. 8, Iss. 2, Pgs 350-5.
  34. Jeffrey T. La Belle, Erica Engelschall, Kenneth Lan, Pankti Shah, Neil Saez, Stephanie Maxwell, Teagan Adamson, Michelle Abou-Eid, Kenyon McAferty,  Dharmendra R. Patel, Curtiss B. Cook. (2014). A Disposable Tear Glucose Biosensor—Part 4: Preliminary Animal Model Study Assessing Efficacy, Safety and Feasibility. Journal Diabetes Science and Technology. Vol. 8, Iss. 1, Pgs 109-16.
  35. Brittney A Haselwood, Jeffrey T. La Belle. (2015) Development of electrochemical methods to enzymatically detect traumatic brain injury biomarkers. Biosensors & Bioelectronics. Vol 67, Pgs 752-6.
  36. Aldin Malkoc, Edgar Sanchez, Michael R. Caplan, Jeffrey T. La Belle. (2015). Electrochemical-Nucleic Acid Detection with Enhanced Specificity and Sensitivity. J. Biosensors and Bioelectronics Vol. 6, Iss. 2., Pgs 1-5.
  37. Jeffrey T. La Belle, Anngela Adams, Chi-En Lin, Erica Engelschall, Breanna Pratt and Curtiss B. Cook (2016). Self-monitoring of tear glucose: the development of a tear based glucose sensor as an alternative to self-monitoring of blood glucose. (Feature Article) Chem. Commun., 2016, 52, 9197-9204.
  38. Steven Lathers and Jeffrey La Belle. (2016) Advanced Manufactured Fused Filament Fabrication 3D Printed Osseointegrated Prosthesis for a Transhumeral Amputation Using Taulman 680 FDA. 3D Printing and Additive Manufacturing. 3(3): 166-174.
  39. Jeffrey T. La Belle, (2016). Game Lab! KEEN-zine Aug 30, 2016: 36-7.
  40. Koji Sode, Noya Loew, Yosduke Ohnishi, Hayato Tsuruta, Kazushhige Mori, Katsushiro Kojima, Wakako Tsugawa, Jeffrey T. La belle, David C Klonoff. (2017). Novel fungal FAD glucose dehydrogenase derived from Aspergillus niger for glucose enzyme sensor strips. Biosens Bioelectron. 2017, 87, 305-311.
  41. Steven Lathers, Mohammad Mousa and Jeffrey La Belle. (2017) Additive Manufacturing Fused Fabrication Three-Dimensional Printed Pressure Sensor for Prosthetics with Low Elastic Modulus and High Filler Ratio Filament Composites. 3D Printing and Additive Manufacturing. 4(1): 30-40.
  42. Chi-Ei Lin, Lindsey Ryder, David Probst, Michael Caplan, Mark Spano, Jeffrey La Belle. (2017). Feasibility in the Development of a Multi-marker Detection Platform. Biosensors & Bioelectronics. 2017, 89, 743-749. 4.      
  43. Malkoc A, Probst D, Lin C, Khanwalker M, Beck C, Cook C, La Belle J (2017) Enhancing Glycemic Control via Detection of Insulin using Electrochemical Impedance Spectroscopy. Journal of Diabetes Science and Technology. ACCEPTED
  44. Malkoc A, Lin C, Probst D, Honikel M, La Belle J (2017) Toward the Future Development of an Electrochemical Continuous Biosensor for Enhanced Glycemic Management. Journal of Diabetes Science and Technology. SUBMITTED
  45. Adams A, Malkoc A, La Belle J (2017) The Development of a Glucose Dehydrogenase 3D Printed Glucose Sensor. Journal of Diabetes Science and Technology. SUBMITTED
  46. Lathers, S., La Belle J. (2017) Initial cadaver fixation strength and polymer leaching of FFF 3D printed osseointegration screw for long-term transhumeral amputation implants. Additive Manufacturing SUBMITTED
  47. Lin C, Breanna P, Alaina J, Bhavna R, Amnah A, La Belle J (2017) Towards The Development Of A Glucose Dehydrogenase Based Saliva Glucose Sensor Without The Need For Sample Preparation. ACCEPTED.
  48. Cardinell, B.A., Addington, C.P., Stabenfeldt, S.E., and La Belle, J.T. (2017) Rat traumatic brain injury and time-course study to develop a multi-analyte blood diagnostic. Annals of Biomedical Engineering. IN PREPARATION.
  49. Cardinell, B.A., and La Belle, J.T. (2017) Multi-Antibody Mesoporous Carbon Encapsulation towards Simultaneous Detection of TBI Blood Markers . Biosensors and Bioeletronics. IN PREPARATION.
  50. Uchimura, K., Adamson, T., Karaniuk, K., Spano, M., La Belle, J. (2017) A Comparative Study on the Feasibility of Commercially Marketed Health Devices for Potential Clinical Application. IEEE Sensors. SUBMITTED.
Research Activity
Fall 2017
Course NumberCourse Title
ASU 101-BMEThe ASU Experience
BME 382Biomedical Prod Dsgn & Dev III
BME 394Special Topics
CHE 492Honors Directed Study
BME 492Honors Directed Study
BME 493Honors Thesis
BME 527Biomedical Device Design
CHE 592Research
Summer 2017
Course NumberCourse Title
BME 394Special Topics
Spring 2017
Course NumberCourse Title
BME 394Special Topics
BME 492Honors Directed Study
MAE 493Honors Thesis
BIO 493Honors Thesis
BME 493Honors Thesis
CHE 493Honors Thesis
BME 527Biomedical Device Design
BME 590Reading and Conference
CHE 592Research
BME 593Applied Project
CHE 593Applied Project
Fall 2016
Course NumberCourse Title
ASU 101-BMEThe ASU Experience
BME 382Biomedical Prod Dsgn & Dev III
BME 394Special Topics
CHE 492Honors Directed Study
BME 492Honors Directed Study
BME 493Honors Thesis
CHE 592Research
BME 592Research
BME 593Applied Project
BME 598Special Topics
Spring 2016
Course NumberCourse Title
BME 394Special Topics
BME 492Honors Directed Study
BME 493Honors Thesis
MAE 493Honors Thesis
BIO 493Honors Thesis
BME 494Special Topics
BME 590Reading and Conference
SCM 591Seminar
CHE 592Research
BME 593Applied Project
CHE 593Applied Project
BME 598Special Topics
BMD 598Special Topics
HCR 598Special Topics
Fall 2015
Course NumberCourse Title
ASU 101-BMEThe ASU Experience
BME 382Biomedical Prod Dsgn & Dev III
BME 394Special Topics
BME 492Honors Directed Study
BME 493Honors Thesis
BME 593Applied Project
Summer 2015
Course NumberCourse Title
BME 394Special Topics
Spring 2015
Course NumberCourse Title
BME 394Special Topics
BME 492Honors Directed Study
BME 493Honors Thesis
BIO 493Honors Thesis
SCM 494Special Topics
BME 494Special Topics
BME 590Reading and Conference
SCM 591Seminar
BME 593Applied Project
BMD 598Special Topics
BME 598Special Topics
HCR 598Special Topics
Fall 2014
Course NumberCourse Title
ASU 101-BMEThe ASU Experience
BME 382Biomedical Prod Dsgn & Dev III
BME 492Honors Directed Study
BME 493Honors Thesis
BME 494Special Topics
CSE 499Individualized Instruction
BME 593Applied Project
BME 598Special Topics
Spring 2014
Course NumberCourse Title
BME 382Biomedical Prod Dsgn & Dev III
BME 492Honors Directed Study
BIO 492Honors Directed Study
BME 493Honors Thesis
CSE 499Individualized Instruction
BME 593Applied Project
BME 598Special Topics
Fall 2013
Course NumberCourse Title
ASU 101-BMEThe ASU Experience
BIO 495Undergraduate Research
CSE 499Individualized Instruction
BME 593Applied Project
BME 598Special Topics
Spring 2013
Course NumberCourse Title
BME 103Intro to BME III
BME 404Capstone IV
BME 405Capstone V
BME 590Reading and Conference
BME 593Applied Project
BME 598Special Topics
Fall 2012
Course NumberCourse Title
BME 103Intro to BME III
BME 494Special Topics
BME 593Applied Project
BME 598Special Topics
Presentations
  • La Belle, Jeffrey, Pizziconi, V, Montaño, G, Blankenship, R. Nanoscale Biophotonic Hybrid Biosensor. Abstracts BioMEMS & Biomedical NANOtechnology World
  • La Belle, Jeffrey, Montaño, G, Blankenship, R, Pizziconi, V. Nanoengineered Biophotonic Hybrid Device. Abstracts Second Joint EMBS-BMES Conference, Houston Texas
  • La Belle, Jeffrey, Montaño, G, Blankenship, R, Pizziconi, V. Nanoengineered Interface for Biophotonic Hybrid Device components. Abstracts in BioDevice Interface - Science and Technology Workshop