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Wonsuk Yoo

Assoc Research Professor
Faculty, DTPHX Campus, Mailcode 9020
Biography

Wonsuk Yoo graduated from Medical University of South Carolina with a doctorate in biostatistics in 2005 after completing a master's degree in statistics with the Department of Statistics at University of Florida in 1999. Yoo is an experienced biostatistician on both collaborative and methodological research experience in health science, health disparity, genomic and environmental epidemiology, cancer prevention and translational research. Yoo’s scholarly accomplishments include almost 50 peer-reviewed publications in health, medicine, epigenetics and biostatistics, and good track records of several NIH funded-projects (NIMHD, DOD, NCI, RWJF, etc) experiences as principal investigator and co-investigator. 

Yoo has research goal to develop statistical and quantitative approaches that utilize big data to problems in health, medicine, and public health. Through my research career, I have used national survey datasets (NHANES, BRFSS, NIS, NHIS), cancer surveillance data (SEER), Health Service and Medicare Data (HCUP, CMS data), and biology and genomics databases (dbGaP, GEO) to apply biostatistical and bioinformatics methods to solve health problems for the purpose of better understanding of fundamental causes of human diseases. ​My current and future research includes (1) Population-based Health disparity and surveillance studies using existing big data, (2) Health-informatics studies with epigenetic approach using machine-learning methods, (3) Statistical modeling for longitudinal biomarkers on early detection within fully Bayesian framework, and (4) Mendelian randomization. Yoo is crrently leading the biostatistics core (BC) at the College of Health Solutions. 

Education
  • Ph.D. Biostatistics, Medical University of South Carolina, Charleston, SC
  • Pre-doctoral Intership. Wyeth Pharmaceutical Research, Collegeville, PA
  • M.S. Statistics, University of Florida-Gainesville 
  • B.A. Yonsei University, Seoul Korea 
Research Interests

I have research goal to develop statistical and quantitative approaches that utilize big data to problems in health, medicine, and public health. Through my research career, I have used national survey datasets (NHANES, BRFSS, NIS, NHIS), cancer surveillance data (SEER), Health Service and Medicare Data (HCUP, CMS data), and biology and genomics databases (dbGaP, GEO) to apply biostatistical and bioinformatics methods to solve health problems for the purpose of better understanding of fundamental causes of human diseases. ​My current and future research includes (1) Population-based Health disparity and surveillance studies using existing big data, (2) Health-informatics studies with epigenetic approach using machine-learning methods, (3) Statistical modeling for longitudinal biomarkers on early detection within fully Bayesian framework, and (4) Mendelian randomization. 

Current research involves HPV-related diseases and vaccination. , I have been performing two data-driven studies using various big health database. (1) I am conducting a study to examine behavioral, social, and community-level disparities based on identifying distinct trajectory patterns in longitudinal HPV-associated cancer risk using SEER cancer registry data and CMS’ CAHPS data. I have submitted this study to NIH/NIA (R21) last October cycle. (2) I am developing a study related to mathematical epidemiologic models to predict HPV-associated cancer risk and economic burden. I plan to develop a manuscript of simulation studies based on epidemic models, and to submit this study to NIH (PAR-18-331) on February or June cycle. 

Publication:

Yoo W, Kim S, Huh W, Dilley S, Chung Y, Dicks V, Partridge E, Bae S. Recent trends in racial and regional disparities in cervical cancer incidence and mortality. PLOS ONE, 2017;12(2): e0172548.

Yoo W, Koskan A, Scotch M, Pottinger H, Huh WK, Helitzer D. Patterns and Disparities in Human Papillomavirus (HPV) Vaccine Uptake for Young Female Adolescents among US States: NIS-Teen (2008-2016). Cancer Epidemiology, Biomarkers & Prevention. Accepted, Nov. 2019.

Publications

Here are my Selected Publications. For full list, go to the PUBMED (https://www.ncbi.nlm.nih.gov/pubmed/?term=wonsuk+yoo

Yoo W, Koskan MA, Scotch M, Pottinger HL, Huh WK, Helitzer DL. Patterns and Disparities in Human Papillomavirus (HPV) Vaccine Uptake for Young Female Adolescents among US States: NIS-Teen (2008-2016). Cancer Epidemiology, Biomarkers, & Prevention, Accepted on Nov. 18, 2019 (Under publication)

Sharman S, Islam B, Hou Y, Singh N, Sridhar S, Berger F, Yoo W, Browning D. Cyclic-GMP elevating agents suppress polyposis in Apc min mice by targeting the preneoplastic epithelium. Cancer Prevention Research, 2018. Jan 4. doi: 10.1158/1940-6207.CAPR-17-0267. PMID: 29301746

 Yoo W, Kim S, Huh WK, Dilley S, Coughlin SS, Partridge E, Chung Y, Dicks V, Lee JK, Bae S. Recent trends in racial and regional disparities in cervical cancer incidence and mortality in United States. PLoS ONE, 2017;12(2): e0172548. doi:10.1371/journal. pone.0172548

 Kim S, Campbell J, Yoo W, Taylor JA, Sandler DP. Systemic levels of estrogens and PGE2 synthesis in relation to postmenopausal breast cancer risk. Cancer Epidemiology, Biomarkers & Prevention, 2016 Nov 18. pii: cebp.0556.2016. [Epub ahead of print] PMID: 27864342.

Gates ML, Wilkins T, Ferguson E, Walker V, Bradford RK, Yoo W. Gender and race disparities in weight gain among offenders prescribed antidepressant and antipsychotic medications. Health Justice, 2016;4:6. PMID: 27340612

Yoo W, De S, Wilkins T, Smith SA, Blumenthal D. Age, Race, and regional Disparities in Colorectal Cancer Incidence Rates in Georgia between 2000 and 2012. Annals of Public Health and Research, 2016;3(2):1040

Ansa B, Yoo W, Whitehead M, Coughlin S, Smith S. Beliefs and Behaviors about Breast Cancer Recurrence Risk Reduction among African American Breast Cancer Survivors. Int J Environ Res Public Health, 2015 Dec 23;13(1). pii: E46. doi: 10.3390/ijerph13010046.

Yoo W, Smith SA, Coughlin SS. Evaluation of genetic risk scores for prediction of dichotomous outcomes. Int J Mol Epidemiol Genet, 2015;6(1):1-8. eCollection 2015 PMID: 26417399

 Yoo W, Coughlin SS, Lillard JW. Trends in cancer incidence rates in Georgia, 1982-2011. jGPHA, 2015;5(1):96-100. PMID: 26336654

Yoo W, Mayberry R, Bae S, He Q, Singh K. A Study of Effects of Multicollinearity in the Multivariable Analysis. International Journal of Applied Science and Tech., 2014;4(5):9-19.

Yoo W, Ference BA, Cote ML, Schawartz AG. A comparison of logistic regression, classification tree, Random Forest and logic regression to detecting SNP interaction. International Journal of Applied Science and Technology, 2012;2(7):268-284. PMCID:PMC3686280

Ference BA, Yoo W, Alesh I, Mahajan N, Mirowska KK, Mewada A, Kahn J, Afonso L , Williams KA, Flack JM. Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease: A Mendelian Randomized Analysis. Journal of the American College of Cardiology 2012;60(25):2631-9. doi:10.1016/j.jacc.2012.09.017. Epub 2012 Oct 17.

Ference BA, Yoo W, Flack FM, Clarke MD. A common KIF6 Polymorphism increases vulnerability to low-density lipoprotein cholesterol: Two meta-analysis and a meta-regression analysis. PLoS One, 2011;6 12):e28834. PMCID:PMC3244415

Sala-Mercado JA, Wilder J, Undyala V, Jahania S, Yoo W, Mentzer M, Gottlieb RA, Przyklenk K. Profound Cardioprotection with Chloramphenicol Succinate in the Swine Model of Myocardial Ischemia-Reperfusion Injury. Circulation, 2010;122;S179-S184. PMCID:PMC3355994

Kim CJ, Romero R, Kusanovic JP, Yoo W, Dong Z, Topping V, Gotsch F, Yoon BH, Chi JG, Kim JS. The Frequency, Clinical Significance and Pathological Features of Chronic Chorioamnionitis: A Major Lesion Associated with Spontaneous Preterm Birth. Modern Pathology, 2010;23(7):1000-11. PMCID:PMC3096929

Cote ML, Yoo W, Wenzlaff AS, Prysak GM, Santer S, Claeys GB, VanDyke AL, Land SJ, Schwartz AG. Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. Carcinogenesis, 2009;30(4):626-635. PMCID:PMC2664455

Research Activity

ON-GOING Grants:  
1.  1 R01 AG062823-01A1 NIH/NIA (PI: Green, Ellen) 9/1/2019 - 5/31/2024
     Title: A Simulation Study of the Medicare Access and Chip Reauthorization Act - Resubmission
     Amount: $2,360,761
     Role: Co-I (5%)

2.  1 R01 CA239612-01A1 NIH/NCI (PI: Buman, Matt) 7/24/2019 - 7/23/2022
     Title: StandUpTV: Reducing sedentary screen - Resubmission - 1
     Amount: $2,201,203
     Role: Co-I (5-10%)

3.  5 R01 DA044125 02 NIH/NIDA (PI: Leischow S) 09/30/2017 - 06/30/2022
     Title: Varenicline OTC Trial on Ecacy and Safety
     Amount: $569,415
     Role: Statistician (5%)

4.  16435 Michael J. Fox Foundation (PI: Peterson D) 1/16/2019 - 1/16/2021
     Title: Protective step training in people with PD and Postural Disturnamces
     Amount: $409,013
     Role: Co-I (10%)

5.  PG12270 DPC-RID ASU/CHS Pilot (PI: Yoo W) 7/01/2019 - 6/30/2020
     Title: Disparities in HPV-associated cancer risk
     Amount: $13,000
     Role: PI

Editorial Board:
1. 2015 - Present MAYFEB Journal of Medicine
2. 2015 - Present International Journal of Chronic Diseases & Therapy (IJCDT)
3. 2016 - Present JSM Women's Health

Journal Reviewer/Referee

1. 2012 - Present PLOS ONE
2. 2015 - Present BMC Public Health, BMC Cardiovascular Disorders
3. 2016 - Present Int'l J. of Environ Research and Public Health (IJERPH)
4. 2015 - Present JMIR mHeath and uHealth

Research and Scienti  Committee:
1. 2014 - Present: Cancer Cluster Joint Meeting at Research Centers in Minority Institutions
Program (RCMI) Transitional Reserach Network
2. 2014 - Present: Advisory Committee at AcademyHealth Disparities workgroup

 

Spring 2020
Course NumberCourse Title
BMI 482Capstone I
BMI 483Capstone II
BMI 515App Biostats Med & Informatics
BMI 560Teachng Biomedical Informatics
BMI 584Internship
BMI 593Applied Project
BMI 790Reading and Conference
BMI 792Research
Fall 2019
Course NumberCourse Title
BMI 484Internship
BMI 517Biostats w/Compu Applications
BMI 560Teachng Biomedical Informatics
BMI 584Internship
BMI 590Reading and Conference
BMI 593Applied Project
BMI 790Reading and Conference
BMI 792Research
Summer 2019
Course NumberCourse Title
BMI 484Internship
BMI 584Internship
BMI 792Research
Spring 2019
Course NumberCourse Title
BMI 515App Biostats Med & Informatics
BMI 560Teachng Biomedical Informatics
Fall 2018
Course NumberCourse Title
BMI 598Special Topics