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Abhinav Acharya

Biography

Abhinav Acharya is an assistant professor of chemical engineering and an ImmunoEngineer who works at the interface of immune system and engineering. He has two approaches to research – (a) utilizing materials to modulate the immune system function as a whole and (b) utilizing the tools of the immune system to modulate an organ at the molecular scale for inducing overall favorable health outcomes.

In his lab in the School for Engineering of Matter, Transport and Energy, Acharya utilizes techniques such as chemical synthesis to generate novel materials, isolation of immune cells for in vitro studies, specialized in vivo animal models, patient derived tissue samples, isolation and identification of biomarkers of diseases, and isolation and identification of natural therapeutics from cells. Moreover, Acharya collaborates heavily with physicians and physician-scientists to develop translational technologies.  

Education
  • Ph.D. Materials Science and Engineering, University of Florida, Gainesville, FL 2010
  • M.S. Materials Science and Engineering, University of Florida, Gainesville, FL 2008
  • B.Tech. Metallurgical Engineering, National Institute of Technology, Tiruchirappalli, India 2005

 

 

Publications
  1. TW Fuller*, AP Acharya*, T Meyyappan, M Yu, G Bhaskar, SR Little, TV Tarin, “Comparison of Bladder Carcinogens in the Urine of E-cigarette Users Versus Non E-cigarette Using Controls”, Scientific reports, 2018, 8 (1), 507. * - Equal Contributions.
  2. MP Hwang, X Ding, J Gao, AP Acharya, SR Little, Y Wang, “A biocompatible betaine-functionalized polycation for coacervation”, Soft Matter, 2018,14, 387-395.
  3. ML Ratay, SC Balmert, AP Acharya, AC Greene, T Meyyappan, SR Little, “TRI Microspheres prevent key signs of dry eye disease in a murine, inflammatory model”, Scientific reports, 2017, 7 (1), 17527
  4. AP Acharya, KM Theisen, A Correa, T Meyyappan, A Apfel, T Sun, TV Tarin, SR Little, “An inexpensive, point-of-care urine test for bladder cancer in patients undergoing hematuria evaluation”, Advanced Healthcare Materials, 2017 Nov;6(22).
  5. Ratay ML, Glowacki AJ, Balmert SC, Acharya AP, Polat J, Andrews LP, Fedorchak MV, Schuman JS, Vignali DAA, Little SR., “Treg-recruiting microspheres prevent inflammation in a murine model of dry eye disease.”, Journal of Controlled Release.2017 Jul 28;258:208-217.
  6. AP Acharya, M Sinha, ML Ratay, X Ding, SC Balmert, CJ Workman, Y Wang, DAA Vignali, SR Little “Localized Multi-Component Delivery Platform Generates Local and Systemic Anti-Tumor Immunity.”, Advanced Functional Materials, 2017, 27, 1604366.
  7. JD Fisher, AcharyaAP, Little SR, “Micro and nanoparticle drug delivery systems for preventing allotransplant rejection.”, Clinical Immunology, 160, 1, 24–35, 2015.
  8. Acharya AP, Little SR, “Stapled endosome disrupting alginate particles for cytosolic delivery of cations.”, Journal of Drug Targeting – In honor of Prof. Bob Langer, 23 (7-8), 690-697, 2015.
  9. Acharya AP, P Sen, K Aran, AB Gardner, M Rafi, D Dean, N Murthy., “A turn‐off fluorescent substrate for horseradish peroxidase improves the sensitivity of ELISAs.”, Journal of Polymer Science Part A: Polymer Chemistry – In honor of Prof. Jean M.J. Fréchet, 53 (2), 206-210, 2015. 
  10. Aran K, Parades J, Rafi M, Yau JF, Acharya AP, Zibinsky M, Liepmann D, Murthy N., “Stimuli-responsive electrodes detect oxidative stress and liver injury.”  Advanced Materials.2015 Feb 25;27(8):1433-6
  11. Acharya AP, Rafi M, Woods EC, Gardner AB, Murthy N, “Metabolic engineering of lactate dehydrogenase rescues mice from acidosis.” Sci Rep.2014 Jun 5;4:5189.
  12. Acharya AP, Nafisi P, Gardner A, MacKay J, Kundu K, Kumar S, Murthy N, “A fluorescent peroxidase probe increases the sensitivity of ELISAs by 2 orders of magnitude.”49 (88), 10379-10381–ChemComm, 2013.
  13. AB Gardner, SKC Lee, EC Woods,AP Acharya, “Biomaterials-Based Modulation of the Immune System”, BioMed research international2013.
  14. Dasari M, Acharya AP, Kim D,Lee S, Lee S, Rhea J, Molinaro R., Murthy N, “H-Gemcitabine: A New Gemcitabine Prodrug for Treating Cancer”, Bioconjug. Chem. 2013, 16;24(1):4-8.
  15. Acharya AP, Murthy N, “Synthetic vaccines: Immunity without harm” Nature Materials, 2011,10(3):166-168.
  16. Acharya AP, Carstens MR, Lewis JS, Dolgova N, Xia CQ, Clare-Salzler MJ, Keselowsky BG “A cell-based microarray to investigate combinatorial effects of microparticle-encapsulated adjuvants on dendritic cell activation”, Journal of Materials Chemistry B, In Press 2015.
  17. Carstens MR, Fisher RC, Acharya AP, Butterworth EA, Scott E, Huang EH, Keselowsky BG, “Drug-eluting microarrays to identify effective chemotherapeutic combinations targeting patient-derived cancer stem cells”, PNAS,2015 Jul 14;112(28):8732-7.
  18. Han C, Choe SW, Kim YH, Acharya AP, Keselowsky BG, Sorg BS, Lee YJ, Oh SP, “VEGF neutralization can prevent and normalize arteriovenous malformations in an animal model for hereditary hemorrhagic telangiectasia 2.” Angiogenesis. 2014 Oct;17(4):823-30.
  19. Lewis JS, Dolgova NV, Chancellor TJ, Acharya AP, Karpiak JV, Lele TP, Keselowsky BG, “The effect of cyclic mechanical strain on activation of dendritic cells cultured on adhesive substrates”, Biomaterials2013, 34 (36), 9063-9070 .
  20. Acharya AP, Lewis JS, Keselowsky BG. “Combinatorial Co-Encapsulation of Hydrophobic Molecules in Poly(lactide-co-glycolide) Microparticles” Biomaterials. 2013, 34(13):3422-30 
  21. Berglund IS, Brar HS, Dolgova N, Acharya AP, Keselowsky BG, Sarntinoranont M, Manuel MV “Synthesis and characterization of Mg-Ca-Sr alloys for biodegradable orthopedic implant applications”, J Biomed Mater Res B Appl Biomater. 2012, 100(6):1524-34.
  22. Xu Y, Zhang C, Wang R, Barish P, Vernon M, Chen L, Govindarajan SS, Acharya AP, Li S, Boykin E, O’Donnell JM, Ogle W. “Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway” Neuroscience. 2011;182:71-81.
  23. Xu Y, Li S, Barish P, Zhang C, Vernon M, Boykin E, Acharya AP,Shyamala S, Pan J, Ogle W. “Curcumin modulation of neuroplasticity against corticosterone toxicity and the role of the 5-HT dependent molecular pathway in rat cortical neurons”J Neurochem. 2011;118(5):784-95.
  24. Acharya AP, Dolgova NV, Clare-Salzler MJ, Keselowsky BG. “Adhesive Substrates Modulates Activation and Stimulatory Capacity of Non-Obese Diabetic Mouse-Derived Dendritic Cells” Acta Biomaterialia2010, 7(1):180-92.
  25. Acharya AP, Dolgova NV, Xia CQ, Clare-Salzler MJ,Becker M, Moore N, Gallant N, Keselowsky BG“Integrin-Mediated Peptide Adhesion Based Controlled Activation of Dendritic Cells” Biomaterials2010,31(29):7444-54.
  26. Choe SW, Acharya AP, Keselowsky BG, Sorg BS. “Intravital microscopy imaging of macrophage and tissue response to immunogenic particles” Acta Biomaterialia2010, 6(9):3491-8.
  27. Choe SW, Acharya AP, Keselowsky BG, Sorg BS (2009). “Spectral and fluorescence imaging of immune system and tissue response to an immunogenic agent” Proceedings of SPIE, 7313: article 731305, 1-10 - Refereed Conference Proceedings.
  28. Acharya AP, Clare-Salzler MJ, Keselowsky BG. “A High-Throughput Microparticle Microarray Platform for Dendritic Cell-Targeting” Biomaterials2009, 30: 4168-77.
  29. Acharya AP, Dolgova NV, Clare-Salzler MJ, Keselowsky BG. “Adhesive Substrate Modulation of Adaptive Immune Responses” Biomaterials2008, 29: 4736-4750.

 

Fall 2019
Course NumberCourse Title
CHE 592Research
CHE 593Applied Project
CHE 792Research
BDE 792Research
BDE 799Dissertation
Summer 2019
Course NumberCourse Title
CHE 792Research
BDE 792Research
Spring 2019
Course NumberCourse Title
CHE 352Chemical Engineering Lab I
CHE 792Research
Professional Associations

Society for Biomaterials (SFB)                                              

Biomedical Engineering Society (BMES)                              

Controlled Release Society (CRS)

Materials Science & Technology (MS&T)