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Dr. Xiaojun Tian is an assistant professor in the School of Biological and Health Systems Engineering. His expertise includes Systems Biology, Computational Biology, Multiscale Modeling, Epigenetics. His lab combines multidisciplinary modeling and quantitative experimental approaches to address biological fundamental problems. Previously, he worked as a Postdoctoral Associate at the University of Pittsburgh and Virginia Tech and focused on Epithelial-Mesenchymal Transition and epigenetics.
1. Tian, X.-J.*, Zhang, H.*, Sannerud, J., and Xing, J., Achieving diverse and monoallelic olfactory receptor selection through dual-objective optimization design. PNAS, 2016. 113: E2889-98 (*co-first authors, the work solved a decades-long Nobel-Prize-winning puzzle, Reported by 24 news outlets：Phys.org, UPI.com, AAAS, Dailymail, Pittsburgh's National Public Radio Station, NSF)
2. Zhang, J.*, Tian, X.-J.*, Zhang, H., Teng, Y., Li, R., Bai, F., Elankumaran, S., and Xing, J., TGFβ-induced epithelial-to-mesenchymal transition proceeds through stepwise activation of multiple feedback loops. Sci Signal, 2014. 7: ra91 (*co-first authors) (Quantitative experimental verification of the predictions from my mathematical model of EMT).
3. Zhang, H., Tian, X.-J., Mukhopadhyay, A., Kim, K. S., and Xing, J., Statistical mechanics model for the dynamics of collective epigenetic histone modification. Phys Rev Lett, 2014. 112: 068101.
4. Tian, X.-J., Zhang, H., and Xing, J., Coupled reversible and irreversible bistable switches underlying TGFβ-induced epithelial to mesenchymal transition. Biophys J, 2013. 105: 1079-89. (First mathematical model for EMT).
5. Tian, X.-J.*, Zhang, H., Zhang, J., and Xing, J.* mRNA-miRNA Reciprocal Regulation Enabled Bistable Switch Directs Cell Fate Decision. FEBS Letters, 2016. Accepted. doi: 10.1002/1873-3468.12379. (*Co-corresponding authors)
6. Tian, X.-J., Liu, F., Zhang, X. P., Li, J., and Wang, W., A two-step mechanism for cell fate decision by coordination of nuclear and mitochondrial p53 activities. PLoS One, 2012. 7: e38164.
7. Tian, X.-J., Zhang, X. P., Liu, F., and Wang, W., Interlinking positive and negative feedback loops creates a tunable motif in gene regulatory networks. Phys Rev E, 2009. 80: 011926.
8. Zhang, J., Tian, X.-J., and Xing, J., Signal Transduction Pathways of EMT Induced by TGFβ, SHH, and WNT and Their Crosstalks. J Clin Med, 2016. 5.
9. Zhang, Q. H., Tian, X.-J., Liu, F., and Wang, W., A switch-like dynamic mechanism for the initiation of replicative senescence. FEBS Lett, 2014. 588: 4369-74.
10. Wang, P., Song, C., Zhang, H., Wu, Z., Tian, X.-J., and Xing, J., Epigenetic state network approach for describing cell phenotypic transitions. Interface Focus, 2014. 4: 20130068.
11. Hu, Y., Ru, N., Xiao, H., Chaturbedi, A., Hoa, N. T., Tian, X.-J., Zhang, H., Ke, C., Yan, F., Nelson, J., Li, Z., Gramer, R., Yu, L., Siegel, E., Zhang, X., Jia, Z., Jadus, M. R., Limoli, C. L., Linskey, M. E., Xing, J., and Zhou, Y. H., Tumor-specific chromosome mis-segregation controls cancer plasticity by maintaining tumor heterogeneity. PLoS One, 2013. 8: e80898.
12. Xing, J., Yu, J., Zhang, H., and Tian, X.-J., Computational modeling to elucidate mechanisms of epigenetic memory, in Epigenetic Technological Applications (Elsevier, Editor: George Zheng), Elsevier (2015).