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Tsafrir Mor

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Biodesign Center for Immunotherapy, Vaccines and Virotherapy
Professor
Faculty, TEMPE Campus, Mailcode 7501
School of Life Sciences
Professor
Faculty, TEMPE Campus, Mailcode 7501
Biography

Tsafrir Mor is a molecular biologist and biochemist whose research focuses on using plants to produce useful and therapeutic polypeptides, proteins and enzymes.

In the advent of the "genomic revolution,” biology is transforming from a discipline limited by information, to one hindered only by our ability to process and use the overwhelming amount of data gathered. A major challenge is to use this information to support innovations in agriculture, medicine, and engineering, that benefit humans and the environment.

In this context, plants hold a special place since they are the basis of our food supply and source for medicinal compounds and raw materials. Mor’s team focuses its research on Pharming — a biotechnology frontier that links plant biology and medicine. Mor is a member of the Center of Infectious Diseases and Vaccinology at ASU’s Biodesign Institute.

CV
Binary Data Curriculum Vitae
Education

PhD, Hebrew University of Jerusalem

Research Website
https://biodesign.asu.edu/tsafrir-mor
Publications
  • Gong Z, Kessans SA, Song L, Dorner K, Lee HH, Meador LR, LaBaer J, Hogue BG, *Mor TS, *Fromme P. Recombinant expression, purification, and biophysical characterization of the transmembrane and membrane proximal domains of HIV-1 gp41. Protein Sci (2014).
  • Lee HH, Cherni I, Yu H, Fromme R, Doran JD, Grotjohann I, Mittman M, Basu S, Deb A, Dorner K, Aquila A, Barty A, Boutet S, Chapman HN, Doak RB, Hunter MS, James D, Kirian RA, Kupitz C, Lawrence RM, Liu H, Nass K, Schlichting I, Schmidt KE, Seibert MM, Shoeman RL, Spence JC, Stellato F, Weierstall U, Williams GJ, Yoon C, Wang D, Zatsepin NA, Hogue BG, Matoba N, *Fromme P, *Mor TS. Expression, purification and crystallization of CTB-MPR, a candidate mucosal vaccine component against HIV-1. IUCrJ. IUCrJ (2014).
  • Meador LR, Mor TS. Meeting Report VLPNPV: Session 5: Plant based technology. Hum Vaccin Immunother (2014).
  • Schneider JD, Castilho A, Neumann L, Altmann F, Loos A, Kannan L, Mor TS, Steinkellner H. Expression of human butyrylcholinesterase with an engineered glycosylation profile resembling the plasma-derived orthologue. Biotechnol J (2014).
  • Schneider JD, Marillonnet S, Castilho A, Gruber C, Werner S, Mach L, Klimyuk V, Mor TS, Steinkellner H. Oligomerization status influences subcellular deposition and glycosylation of recombinant butyrylcholinesterase in Nicotiana benthamiana. Plant Biotechnol J (2014).
  • *Geyer BC, *Larrimore KE, *Kilbourne J, *Kannan L, §Mor TS. Reversal of Succinylcholine Induced Apnea with an Organophosphate Scavenging Recombinant Butyrylcholinesterase. PLOS One (2013).
  • *Kessans SA, *Linhart, MD, §*Matoba N, and §Mor TS. Biological and biochemical characterization of HIV-1 Gag/dgp41 virus-like particles expressed in Nicotiana benthamiana. Plant Biotechnol J (2013).
  • *Larrimore KE, *Barcus MJ, *Kannan L, Gao Y, Zhan C-G, Brimijoin S, §Mor TS. Plants as a source of butyrylcholinesterase variants designed for enhanced cocaine hydrolase activity. Chem-Biol Interact (2013).
  • *Geyer BC, Ben-Ari S, §Mor TS and §Soreq H. Nicotinic stimulation induces Tristetraprolin over-production and attenuates inflammation in muscle. Biochim Biophys Acta-Mol Cell Res (2012).
  • *Matoba N, *Shah NR, and §Mor TS. Humoral immunogenicity of an HIV-1 envelope residue 649-684 membrane-proximal region peptide fused to the plague antigen F1-V. Vaccine (2011).
  • *Geyer BC, *Kannan L, *Garnaud PE, Broomfield CA, Cadieux CL, *Cherni I, Hodgins SM, Kasten SA, Kelley K, *Kilbourne J, Oliver ZP, Otto TC, *Puffenberger I, Reeves TE, *Robbins N, 2nd, *Woods RR, Soreq H, Lenz DE, Cerasoli DM, §Mor TS. Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Proc Natl Acad Sci U S A (2010).
  • *Geyer, BC, *Kannan, L, *Cherni, I, *Woods, RR, *Soreq, H, and §Mor TS. Transgenic plants as a source for the bioscavenging enzyme, human butyrylcholinesterase. Plant Biotechnol J (2010).
  • *Matoba N, Kajiura H, *Cherni I, *Doran JD, Alfsen A, Bomsel M, Fujiyama K and §Mor TS. Biochemical and immunological characterization of the plant-derived candidate HIV-1 mucosal vaccine CTB MPR649 684. Plant Biotechnol J (2009).
  • *Geyer GC, Evron T, §Mor TS and §Soreq H. Organophosphate Intoxication: Molecular Consequences, Mechanisms and Solutions. Toxicology of Chemical Warfare Agents (2009).
  • *1Geyer BC, *1Woods RR, §Mor TS. Increased organophosphate scavenging in a butyrylcholinesterase mutant. Chemico-Biological Interactions (2008).
  • *1Woods RR, *1Geyer BC, §Mor TS. Production of recombinant human acetylcholinesterase in hairy root cultures. BMC Biotechnology (2008).
  • *Matoba N, *Griffin TA, *Mittman M, *Doran JD, Alfsen A, Montefiori DC, Hanson CV, Bomsel M, and §Mor TS. Transcytosis-blocking abs elicited by an oligomeric immunogen based on the membrane proximal region of HIV-1 gp41 target non-neutralizing epitopes. Curr HIV Res 6:218-229. Current HIV Research (2008).
  • Berson A, Knobloch M, Hanan M, Diamant S, Sharoni M, Schuppli D, *Geyer BC, Ravid R, Mor TS, Nitsch RM and §Soreq H. Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology. Brain (2008).
  • Mor I, Sklan EH, Podoly E, Pick M, Kirschner M, Yogev L, Bar-Sheshet Itach S, Schreiber L, *Geyer B, *Mor T, Grisaru D, and §Soreq H. Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008).
  • *1Geyer BC and *1Fletcher SP, *Griffin TA, *Lopker MJ, Soreq H and §Mor, TS. Translational control of recombinant human acetylcholinesterase accumulation in plants. BMC Biotechnol (2007).
  • 1Evron T and *1Geyer BC, *Cherni I, *Muralidharan M, *Kilbourne J, *Fletcher SP, Soreq H and §Mor TS. Plant-derived human acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath. FASEB J (2007).
  • *Matoba N, *Geyer BC, *Kilbourne J, Alfsen A, Bomsel M and §Mor TS (2006) Humoral immune responses by prime-boost heterologous route immunizations with CTB-MPR649-684, a mucosal subunit HIV/AIDS vaccine candidate. Vaccine 24:5047-5055. Humoral immune responses by prime-boost heterologous route immunizations with CTB-MPR649-684, a mucosal subunit HIV/AIDS vaccine candidate. Vaccine (2006).
  • Nobuyuki Matoba, B Geyer, J Kilbourne, A Alfsen, M Bomsel, Tsafrir Mor. Humoral immune responses by prime-boost heterologous route immunizations with CTB-MPR649-684, a mucosal subunit HIV/AIDS vaccine candidate. Vaccine (2006).
  • S Saldaña, L Richter, C Arntzen, M Gómez Lim, F Guadarrama, T de Jesús Olivera Flores, N Arias, S López, C Arias, R Ruiz, H Mason, Tsafrir Mor. Production of rotavirus-like-particles in tomato (Lycopersicon esculentum L.) fruit by expression of capsid proteins VP2 and VP6 and immunological studies. Viral Immunol (2006).
  • S Saldaña, L Richter, C Arntzen, M Gómez Lim, F Guadarrama, T de Jesús Olivera Flores, N Arias, S López, C Arias, R Ruiz, H Mason, Tsafrir Mor. Production of rotavirus-like-particles in tomato (Lycopersicon esculentum L.) fruit by expression of capsid proteins VP2 and VP6 and immunological studies. Viral Immunol (2006).
  • Saldaña S, Guadarrama FE, de Jesús Olivera Flores T, Arias N, López S, Arias C, Ruiz R, Mason H, *Mor T, Richter L, Arntzen CJ and §Gómez Lim MA. Production of rotavirus-like-particles in tomato (Lycopersicon esculentum L.) fruit by expression of capsid proteins VP2 and VP6 and immunological studies. Viral Immunol (2006).
  • MATOBA, NOBUYUKI,Mor, Tsafrir S. PLANT-DERIVED SUBUNIT VACCINES. Plant Genetic Engineering Vol. 8: Metabolic Engineering & Molecular Farming II (2006).
  • Fletcher, S, Soreq, H, Mor, Tsafrir, Geyer, B, Evron, E, Cherni, I, Muralidharan, M, Kilbourne, J. Plant-Derived Human Acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath: The U.S. Army Medical Research Institute of Chemical Defense. (2006).
  • *Geyer BC, *Muralidharan M, *Cherni I, *Doran J, *Fletcher SP, Evron, T, Soreq H and §Mor TS (. Purification of Transgenic Plant-Derived Recombinant Human Acetylcholinesterase-R. Chemico-Biological Interactions (2005).
  • *Muralidharan M, Soreq H and §Mor, TS. Characterizing pea acetylcholinesterase. Chemico-Biological Interactions (2005).
  • Geyer, B, Evron, T, Cherni, I, Muralidharan, M, Patel, A, Fletcher, S, Soreq, H, Mor, Tsafrir. N. benthamiana Produced Human Acetylcholinesterase Completely Protects Mice from Lethal Doses of Organophosphate Toxins. (2005).
  • Matoba, M, Magerus, A, Geyer, B, Zhang, Y, Alfsen, A, Arntzen, C, Bomsel, M, Mor, Tsafrir. Humoral immunity induced by CTB-P1 for the Prevention of HIV-1 Mucosal Transmission/infection. (2005).
  • Matoba, M, Magerus, A, Geyer, B, Zhang, Y, Alfsen, A, Arntzen, C, Bomsel, M, Mor, Tsafrir. Towards an oral plant-derived HIV-1 subunit vaccine. (2005).
  • Matoba, N, Magérus, A, Geyer, B, Alfsen, A, Hanson, C, Arntzen, C, Bomsel, M, Mor, Tsafrir. Humoral immunity induced by CTB-MPR649-684 towards the prevention of HIV-1 mucosal transmission/infection. (2005).
  • Mor, Tsafrir S, Soreq, H. Encyclopedia of Plant & Crop Science, R.M. Goodman, ed. Human cholinesterases from Plants for detoxification (2004).
  • *Fletcher SP, *Geyer BC, Smith A, Evron T, Joshi L, Soreq H and §Mor TS. Tissue Distribution of Cholinesterases and Anticholinesterases in Native and Transgenic Tomato Plants. Plant Mol. Biol (2004).
  • *Matoba N, Magérus A, *Geyer BC, Zhang Y, *Muralidharan M, Alfsen A, Arntzen CJ, Bomsel M and §Mor TS. Mucosally-Targeted Subunit Vaccine Candidate Eliciting HIV-1 Transcytosis-blocking Antibodies. Proc. Natl. Acad. Sci. USA (2004).
  • Mor, Tsafrir S, Mason, H S, Kirk, D, Arntzen, C J, Cardineau, G A. Plants as a delivery vehicle for orally delivered subunit vaccines. In: New Generation Vaccines. (2004).
  • Mor, Tsafrir S (Author) ,Mason, H S (Author) . Transgenic plants as a source for subunit vaccines. Handbook of Plant Biotechnology (2004).
  • Mor, Tsafrir S (Author) ,Mason, H S (Author) ,Kirk, D D (Author) ,Arntzen, C J (Author) ,Cardineau, G A (Author) . Plants as a production and delivery vehicle for orally delivered subunit vaccines. Current Vaccines (2004).
  • Fletcher, S, Geyer, B, Muralidharan, M, Arntzen, C, Soreq, H, Mor, Tsafrir. Chemical warfare countermeasures: Expression of human acetylcholinesterase in plants. (2004).
  • Matoba, M, Magerus, A, Geyer, B, Zhang, Y, Alfsen, A, Arntzen, C, Bomsel, M, Mor, Tsafrir. A subunit vaccine candidate to prevent HIV-1 transmission. HIV Vaccine Development. (2004).
  • Muralidharan, M, Fletcher, S, Geyer, B, Soreq, H, Mor, Tsafrir. Characterizing pea acetylcholinesterase. (2004).
  • *Mor TS, Moon Y-S, Palmer, KE and §Mason, HS. Geminivirus Vectors for High Level Expression of Foreign Proteins in Plant Cells. Biotechnol. Bioeng (2003).
  • Mor, Tsafrir S, Mason, H S. Plants as a source for subunit vaccines. In: Handbook of Plant Physiology. (2003).
  • Mor, Tsafrir S, Soreq, H. Transgenic plants expressing human acetylcholinesterase: What they can do for us and what we may learn from them. In Encyclopedia of Plant & Crop Science. (2003).
  • Mor, Tsafrir S (Author) ,Arntzen, C J (Author) . Plants and Human Health: Delivery of vaccines via transgenic plants. Plant Biotechnology 2002 and Beyond (2003).
  • Fletcher, S, Geyer, B, Muralidharan, M, Joshi, L, Soreq, H, Mor, Tsafrir. Transgenic plants expressing human acetylcholinesterase: what they may do for us and what we may learn from them. (2003).
  • Mason HS, Warzecha H, *Mor T and §Arntzen CJ. Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine. Trends Mol. Med (2002).
  • §Mor TS, Sternfeld M, Arntzen CJ, Soreq H and Mason, HS. Expression of recombinant human acetylcholinesterase in transgenic tomato plants. Biotechnol Bioeng (2001).
Research Activity
Spring 2020
Course NumberCourse Title
MBB 492Honors Directed Study
MBB 493Honors Thesis
MBB 495Undergraduate Research
MCB 500Research Methods
BIO 584Internship
BDE 792Research
BDE 799Dissertation
Fall 2019
Course NumberCourse Title
BIO 181General Biology I
MBB 492Honors Directed Study
MBB 495Undergraduate Research
BIO 584Internship
BDE 792Research
Summer 2019
Course NumberCourse Title
MBB 495Undergraduate Research
BIO 495Undergraduate Research
BDE 792Research
Spring 2019
Course NumberCourse Title
MBB 492Honors Directed Study
MBB 493Honors Thesis
MBB 495Undergraduate Research
MCB 500Research Methods
BIO 584Internship
BDE 792Research
Fall 2018
Course NumberCourse Title
MBB 495Undergraduate Research
BDE 792Research
Summer 2018
Course NumberCourse Title
MBB 495Undergraduate Research
BIO 495Undergraduate Research
BDE 792Research
Spring 2018
Course NumberCourse Title
MBB 492Honors Directed Study
MBB 493Honors Thesis
MBB 495Undergraduate Research
MCB 500Research Methods
BIO 584Internship
Fall 2017
Course NumberCourse Title
BIO 181General Biology I
MBB 492Honors Directed Study
MIC 495Undergraduate Research
MBB 495Undergraduate Research
MBB 499Individualized Instruction
MCB 500Research Methods
BIO 584Internship
BDE 792Research
Summer 2017
Course NumberCourse Title
MBB 495Undergraduate Research
BIO 495Undergraduate Research
BDE 792Research
Spring 2017
Course NumberCourse Title
MBB 493Honors Thesis
MBB 495Undergraduate Research
BIO 495Undergraduate Research
MCB 500Research Methods
BIO 584Internship
Fall 2016
Course NumberCourse Title
BIO 181General Biology I
BIO 189Life Sciences Career Paths
MBB 492Honors Directed Study
MIC 495Undergraduate Research
MBB 495Undergraduate Research
MBB 499Individualized Instruction
MCB 500Research Methods
BIO 584Internship
BDE 792Research
Summer 2016
Course NumberCourse Title
MBB 495Undergraduate Research
BIO 495Undergraduate Research
BDE 792Research
Spring 2016
Course NumberCourse Title
MBB 493Honors Thesis
MBB 495Undergraduate Research
MCB 500Research Methods
BIO 584Internship
Fall 2015
Course NumberCourse Title
BIO 181General Biology I
MBB 492Honors Directed Study
MBB 495Undergraduate Research
MBB 499Individualized Instruction
MCB 500Research Methods
BIO 584Internship
BDE 792Research
Summer 2015
Course NumberCourse Title
MBB 495Undergraduate Research
BDE 792Research
Presentations
  • *!Larrimore KE, *Kannan L, *Kendle RP, *Jamal T, *Barcus M, and §Mor TS. Plant-derived human enzymes modified for enhanced anti-cocaine activity. Arizona State University Molecular and Cellular Biology Department Colloquium. Tempe, AZ. October 3, 2014. Arizona State University Molecular and Cellular Biology Department Colloquium. Tempe, AZ. October 3, (Oct 2014).
  • *Deb A, *Johnson W, *Srinivas D, *Dickey R, *Chen L, Fromme P and §Mor TS. Towards a crystal structure of the HIV-1 membrane protein, Vpu. BioDesign After Hours- Center for Infectious Diseases and Vaccinology, Arizona State University, Tempe, AZ, 28th August 2014. BioDesign After Hours- CIDV, ASU, Tempe, AZ, 28th August 2014 (Aug 2014).
  • !*Gong Z, Fromme R, Craciunescu F, §Mor TS and §Fromme P. Structural Study of the transmembrane and membrane proximal domains of HIV-1 gp41 by X-ray Crystallography. 2014 IUCr. Montreal, Quebec, Canada. August 5-12, 2014 (Aug 2014).
  • !*Larrimore KE, *Kannan L, *Kendle RP, *Yun K, *Jamal T, Gao Y, Brimijoin S, and §Mor TS. Large scale production in plants of recombinant human butyrylcholinesterase and variants thereof. Plant Biology 2014. Portland, OR. July 12-16, 2014 (Jul 2014).
  • !*Kendle RP, *Kannan L, *Larrimore KE, *Yun K, and §Mor TS. Production and humanization of recombinant cocaine hydrolase butyrylcholinesterase in plants. Plant Biology 2014. Portland, OR. July 12-16, 2014 (Jul 2014).
  • !*Meador L, *Martin T, Jacobs, BL, Mason HS, Blattman JN, and §Mor TS. Production of LCMV glycoprotein virus-like particles in Nicotiana benthamiana as a murine model of protective vaccination strategies for HIV. 2014 Arizona Bio (AZBIO) Expo. Scottsdale, AZ. June 19, 2014 (Jun 2014).
  • !*Meador L, *Martin T, Jacobs, BL, Mason HS, Blattman JN, and §Mor TS. Production of LCMV glycoprotein virus-like particles in Nicotiana benthamiana as a murine model of protective vaccination strategies for HIV. Virus-Like Particle and Nanoparticle Vaccines International Conference (VLPNP 2014). La Jolla, CA. 4-6 June 2014. VLPNP 2014. a Jolla, CA. 4-6 June 2014 (Jun 2014).
  • Mor TS. Optimization and characterization of an HIV vaccine using replicating vaccinia virus and plant-produced Gag and dgp41 virus-like particles. VLPNP 2014. a Jolla, CA. 4-6 June 2014 (Jun 2014).
  • !*Todhunter N, *Kannan L, *Patel H, *Jauregui E, *Segerson N and §Mor TS. Human intercellular adhesion molecule-1 For Crystallization. School of Life Sciences Undergraduate Research Symposium. Tempe, AZ. April 4, 2014 (Apr 2014).
  • !*Martin TB, *Meador LR, Blattman JN and §Mor TS. Expression of LCMV virus-like particles in Nicotiana Benthamiana. School of Life Sciences Undergraduate Research Symposium. Tempe, AZ. April 4, 2014 (Apr 2014).
  • !*Todhunter N, *Kannan L, *Patel H, *Jauregui E, *Segerson N and §Mor TS. Human intercellular adhesion molecule-1 For Crystallization. Ctr for Membrane Proteins in Infectious Diseases, 3rd Annual Meeting, Tempe, AZ, March 13-14, 2014 (Mar 2014).
  • !*Judd R, *Deb A, *Johnson W, and §Mor TS. Expression of the HIV-1 Deconstructed Membrane-protein gp41. Center for Membrane Proteins in Infectious Disease 3rd Annual Meeting. Ctr for Membrane Proteins in Infectious Diseases, 3rd Annual Meeting, Tempe, AZ, March 13-14, 2014 (Mar 2014).
  • !*Patel H, *Kannan L, *Todhunter N, and §Mor TS. Plant expression of African Swine Fever Virus Lectin-Like Protein EP153R: Expression and Characterization. Ctr for Membrane Proteins in Infectious Diseases, 3rd Annual Meeting, Tempe, AZ, March 13-14, 2014 (Mar 2014).
  • !*Kannan L, *Todhunter N, *Patel H, *Jauregui E, *Segerson N and §Mor TS. Plant expression of human intercellular adhesion molecule 1 (ICAM 1/CD54): Purification and Characterization. Ctr for Membrane Proteins in Infectious Diseases, 3rd Annual Meeting, Tempe, AZ, March 13-14, 2014 (Mar 2014).
  • !*Gong Z, *Kessans SA, Dörner K, *Lee H-S, *Meador LR, Hogue BG, §Mor TS, and §Fromme P. Structural study of the transmembrane and membrane proximal domains of HIV-1 gp41 by X-ray crystallography (MPID-020). Ctr for Membrane Proteins in Infectious Diseases, 3rd Annual Meeting, Tempe, AZ, March 13-14, 2014 (Mar 2014).
  • !*Gong Z, *Kessans SA, Dörner K, *Lee H-S, *Meador LR, Hogue BG, §Mor TS, and §Fromme P. Structural study of the transmembrane and membrane proximal domains of HIV-1 gp41 by X-ray crystallography (MPID-020). Ctr for Membrane Proteins in Infectious Diseases, 3rd Annual Meeting, Tempe, AZ, March 13-14, 2014 (Mar 2014).
  • !*Deb A, *Johnson W, *Srinivas D, *Dickey R, Chen L, Fromme P and §Mor TS. Towards a crystal structure of the HIV-1 membrane protein, Vpu. Ctr for Membrane Proteins in Infectious Diseases, 3rd Annual Meeting, Tempe, AZ, March 13-14, 2014 (Mar 2014).
  • *Larrimore KE and §Mor TS. Plant-derived nerve-agent antidotes. Arizona State University President’s Weekend. Tempe, AZ. November 15, 2013. Invited talk/demonstrat (Nov 2013).
  • Mor TS. "Plant-produced butyrylcholinesterase variants as versatile bioscavengers". Invited seminar at: Arid-Land Agricultural Research Center, USDA(USDA-ARS), Maricopa, AZ (Oct 2013).
  • Mor TS. "Plant-made vaccines". OECD sponsored workshop on Plant-made vaccines as an alternative to antibiotics (Sep 2013).
  • Mor TS. "Plant-produced butyrylcholinesterase variants as versatile bioscavengers". PBVA 5: Plant-Based Vaccines, Antibodies & Biologics, Verona, Italy, June 4-7 2013 (Jun 2013).
  • *Meador LR, *Kessans SA, *Beaumont DM, *Kilbourne J, Denzler KL, Kibler KV, Jacobs BJ, and §Mor TS. Testing an HIV vaccine using live vaccinia virus and plant-produced Gag and dgp41 virus-like particles. Plant Based Vaccines, Antibodies, and Biologics. Verona, Italy. 4-7 June 2013 (Jun 2013).
  • *Larrimore KE, *Kannan L, *Barcus M, *Kendle RP, Yun K, Gao Y, Brimijoin S, and §Mor TS. Production of human butyrylcholinesterase-based cocaine hydrolases in Nicotiana benthamiana. Plant-Based Vaccines, Antibodies and Biologics. Verona, Italy. June 5-7, 2013 (Jun 2013).
  • *Segerson N, *Kannan L, *Jauregui E, §Mor TS. Human Membrane Protein - Furin Convertase For Crystallization. Center for Membrane Proteins in Infectious Diseases, 2nd Annual Meeting, Tempe, AZ, USA, March 14 – (Mar 2013).
  • *Johnson W, *Deb A, *Srinivas D, and §Mor TS. Expression and purification of Tobacco Etch Virus Protease for proteolytic cleavage of HIV-I membrane protein, Viral Protein U, from its fusion with Mistic. Center for Membrane Proteins in Infectious Diseases, 2nd Annual Meeting, Tempe, AZ, USA, March 14 – (Mar 2013).
  • *Deb A, *Srinivas D, *Johnson W and §Mor TS. Expression, purification and characterization of the HIV-1 membrane–protein Vpu. Center for Membrane Proteins in Infectious Diseases, 2nd Annual Meeting, Tempe, AZ, USA, March 14 – (Mar 2013).
  • *Jauregui E, *Kannan L, *Segerson N, §Mor TS. Human Membrane Protein – Inter Cellular Adhesion Molecule-1 For Crystallization. Center for Membrane Proteins in Infectious Diseases, 2nd Annual Meeting, Tempe, AZ, USA, March 14 – (Mar 2013).
  • *Kessans SA, *Linhart M, Matoba N, and §Mor TS. Biochemical and immunological characterization of plant-produced HIV-1 Gag/dgp41 enveloped virus-like particles. PSI:Biology Technologies Workshop, Bethesda, MD, December 12, 2012 (Dec 2012).
  • *Deb A, *Srinivas D, and §Mor TS. Expression and purification of the HIV-1 membrane–protein Vpu. RoadMap Membrane Protein Technologies. RoadMap Membrane Protein Technologies. San Francisco, CA. November 28-30, 2012 (Nov 2012).
  • *Deb A, *Srinivas D, and §Mor TS. Expression and purification of the HIV-1 membrane–protein Vpu. RoadMap Membrane Protein Technologies. PSI:Biology Technologies Workshop, Bethesda, MD (Nov 2012).
  • Mor, TS. Plant-produced human butyrylcholinesterase. Defense Advanced Research Project Agency (DARPA) rBuChE Kick-off Meeting. Arlington, VA, November 9 (Nov 2012).
  • Mor TS. Plant expression of chimeric Gag/gp41 virus-like particles as a mucosally-targeted subunit vaccine against HIV-1. 1. Virus-Like Particle & Nano-Particle Vaccines - VLPNPV, Cannes, France, November 28-30, 2012 (Nov 2012).
  • *Gong Z, *Kessans SA, Lee H-HA, Dorner K, §Mor TS and §Fromme P. Production and Purification of Recombinant Truncated HIV-1 gp41 Consisting of the Membrane Proximal and Transmembrane Domains for Structure Determination. RoadMap Membrane Protein Technologies. San Francisco, CA. November 28-30, 2012 (Nov 2012).
  • Mor TS. Plant-produced butyrylcholinesterase variants as versatile bioscavengers. 2. The XIth International Meeting on Cholinesterases, Kazan, Russia, June 4-9, 2012 (Jun 2012).
  • *Gong Z, *Kessans SA, §Mor TS and §Fromme P. Production and Purification of Recombinant Truncated HIV-1 gp41 Consisting of the Membrane Proximal and Transmembrane Domains for Structure Determination. Keystone Structural Biology Meeting. Keystone, Colorado. 22 January 2012 (Jan 2012).
  • *Kessans SA, *Linhart M, Matoba N, and §Mor TS. Biochemical and immunological characterization of plant-produced HIV-1 Gag/dgp41 enveloped virus-like particles. Keystone Structural Biology Meeting. Keystone, Colorado. 22 January 2012 (Jan 2012).
  • *Kessans SA, *Frater J, *Matoba N, and *Mor T. Plant expression of chimeric Gag/gp41 virus-like particles as a mucosally-targeted subunit vaccine against HIV-1. Arizona BIOFest 2010. Scottsdale, Arizona. 27 October 2010 (Oct 2010).
  • 2. *Kannan L, *Geyer BC, *Garnaud PE, Broomfield CA, Cadieux CL, *Cherni I, Hodgins SM, Kasten SA, Kelley K, *Kilbourne J, Oliver ZP, Otto TC, *Puffenberger I, Reeves TE, *Robbins N, 2nd, *Woods RR, Soreq H, Lenz DE, Cerasoli DM, §Mor TS. Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents. Arizona BIOFest 2010. Scottsdale, Arizona. 27 October 2010 (Oct 2010).
  • §Mor, TS. Rapid and large-scale plant-based production of catalytic nerve agent bioscavengers. 4th Annual NIH CounterACT Network Research Symposium, San Francisco, CA, June 22-24, 2010 (Jun 2010).
  • §Mor, TS. Rapid and large-scale plant-based production of catalytic nerve agent bioscavengers. 4th Annual NIH CounterACT Network Research Symposium, San Francisco, CA, June 22-24, 2010 (Jun 2010).
  • Mor TS. "Rapid & Large-Scale Plant-based Production of human cholinesterases as effective Nerve-Agent Bioscavengers. 1. US Army Medical Research Inst for Chemical Defense, Aberdeen Proving Grounds, MD, May 3 2010 (May 2010).
  • *Kessans SA, *Frater J, *Matoba N, and *Mor T. Plant expression of chimeric Gag/gp41 virus-like particles as a mucosally-targeted subunit vaccine against HIV-1. National Academy of Engineering Grand Challenges Summit 2010. Phoenix, Arizona. 8-9 April 2010 (Apr 2010).
  • *$Cherni I, *Vassal A, *Kessans S, *Matoba N, and §Mor TS. Membrane proximal region-hepatitis B core antigen fusion virus-like particles and their immunogenicity in mice. AIDS Vaccine 2008. Cape Town, South Africa, Oct 13-16, 2008 (Oct 2008).
  • Mor TS. "Biochemical and immunological characterization of the plant-derived candidate HIV-1 mucosal vaccine CTB-MPR649-684". Modern Mucosal Vaccines, Adjuvants & Microbicides, Oporto, Portugal, October 22-24 2008 (Oct 2008).
  • *$Geyer BC, *Kilbourne J, §Mor TS. Advanced Bioscavengers for the Emergency Treatment of Nerve Agent / Pesticide Poisoning. American College of Emergency Physicians Scientific Assembly. Chicago, IL. September 27-30 2008 (Sep 2008).
  • *$Garnaud P-EE, *Kannan L, *Puffenberger I, §Mor TS. Rapid and large-scale plant-based production of catalytic nerve-agent bioscavenger paraoxonase-1. 3rd International Conference on Paraoxonases, Los Angeles, CA, September 7–10 2008 (Jul 2008).
  • Mor TS. "Plant Production of Human Cholinesterases for Protection against Nerve Agents". Bioscience Review 2008, Hunt Valley, MD, June 1-6 2008 (Jun 2008).
  • Mor TS. Plant produced human cholinesterases and plant cholinesterase(s). Current Progress in Biotechnology Seminar Series, UC Davis, Davis CA, 5/8-9/2008 (May 2008).
  • *$Matoba N, Kajiura H, *Cherni I, *Doran JD, Bomsel M, Fujiyama K, and §Mor TS. In planta expression and molecular characterization of the candidate HIV-1 mucosal vaccine CTB-MPR649–684. P-1002. 2008 World Congress on In Vitro Biology, Tucson, AZ, June 14-18 2008 (May 2008).
  • *$Kannan L, *Geyer BC, *Garaud P-E, *Woods RR, *Muralidharan M, *Cherni I, and §Mor TS. Partial characterization and purification of plant derived butyrylcholinesterase to treat organophosphate poisoning. P-2011. 2008 World Congress on In Vitro Biology, Tucson, AZ, June 14-18 2008 (May 2008).
  • *$Cherni I, *Vassal A, *Matoba N, and §Mor TS. MPR649-684-Hep B Core Antigen fusion forms virus-like particles in plants and is immunogenic in mice. P-2013. 2008 World Congress on In Vitro Biology, Tucson, AZ, June 14-18 2008 (May 2008).
  • *$Garnaud P-EE, *Kannan L, and §Mor TS. Rapid and large-scale plant-based production of catalytic nerve-agent bioscavenger paraoxonase-1. P-2016. 2008 World Congress on In Vitro Biology, Tucson, AZ, June 14-18 2008 (May 2008).
  • $§Mor TS, *Geyer BC, *Muralidharan M, *Cherni I, Fletcher SP, Evron T, and Soreq H. Plant Produced Human Cholinesterases and Plant Cholinesterase. P-2021. 2008 World Congress on In Vitro Biology, Tucson, AZ, June 14-18 2008 (May 2008).
  • 11. *Muralidharan M, * Skalecka-Ball A, and §Mor TS. Characterizing cholinesterase like enzyme in A. thaliana. P-2035. 2008 World Congress on In Vitro Biology, Tucson, AZ, June 14-18 2008 (May 2008).
  • *$Kessans S, §Mor TS, and *Matoba N. Plant Expression of chimeric Gag/gp41 virus-like particles as a subunit vaccine against HIV-1. P-2051. 2008 World Congress on In Vitro Biology, Tucson, AZ, June 14-18 2008 (May 2008).
  • *$Namrata Shah, *Matoba N, *Chang H, *Hu J, and §Mor TS. Plague antigen fusions with gp41 membrane proximal region as HIV vaccine candidate. P-2052. 2008 World Congress on In Vitro Biology, Tucson, AZ, June 14-18 2008 (May 2008).
  • *$Delisle JP, *Geyer BC, and §Mor TS. Characterizing the cholinergic anti-inflammatory pathway in skeletal muscles. A-3005. 2008 World Congress on In Vitro Biology, Tucson, AZ, June 14-18 2008 (May 2008).
  • $§Mor, TS. Rapid and large-scale plant-based production of catalytic nerve agent bioscavengers. CounterACT – Countermeasures against Chemical Threats – 2nd Annual Network Research Symposium, Washi (Apr 2008).
  • *Matoba N, *Griffin TA, *Mittman M, *Doran JD, Alfsen A, Montefiori DC, Hanson CV, Bomsel M, $§Mor TS. Transcytosis-blocking Abs target non-neutralizing epitopes in the membrane proximal region of the HIV-1 envelope protein gp41. 2008 STI/TM CRC Annual Meeting, Chapel Hill, NC, April 13-14, 2008 (Apr 2008).
  • $*Matoba N, *Griffin TA, *Mittman M, *Doran JD, Alfsen A, Montefiori DC, Hanson CV, Bomsel M, §Mor TS. Transcytosis-blocking Abs target non-neutralizing epitopes in the membrane proximal region of the HIV-1 envelope protein gp41. HIV vaccines: Progress and Prospects, Keystone Symposium, Banff, AB, Canada, March 27-April 1, 2008 (Mar 2008).
  • Matoba, Nobuyuki, Mittman, M., Griffin, T., Cherni, Irene, Arntzen, Charles, Mor, Tsafrir. Expression of an HIV-1 vaccine candidate expressed in N. benthamiana plan. PBVA 2: Plant Expression Systems for Recombinant Pharmacologic (Jun 2007).
  • Geyer, B., Ben-Ari, S., Delisle, J., Soreq, H., Mor, Tsafrir. The “readthrough” variant of acetylcholinesterase abrogates anticholinesterase-induced immunosupression by stimulating TNFa production in murine skeletal muscle. The IXth International Meeting on Cholinesterases (May 2007).
  • Mor, Tsafrir. Plant-derived human cholinesterases for protection against Nerve Agents. The IXth International Meeting on Cholinesterases, (May 2007).
  • Mor, Tsafrir. Rapid and large scale plant-based production of catalytic nerve agent bioscavengers. CounterACT – Countermeasures against Chemical Threats – 1st Annual Network Research Symposium (Apr 2007).
  • Matoba, Nobuyuki, Mittman, M., Griffin, T., Cherni, Irene, Mor, Tsafrir. Expression of a mucosal subunit HIV-1 vaccine candidate in transgenic N. benthamiana. Annual meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry (Mar 2007).
  • Mor, Tsafrir. Plant production of human cholinesterases for protection against nerve agents. 16th Western Photosynthesis Conference (Jan 2007).
  • Mor, Tsafrir. Fighting the HIV/AIDS Pandemic: Developing Vaccines Aimed at Blocking HIV-1 Transmission. Institute of Life Sciences Special Seminar at the Hebrew University of Jerusalem, Jerusalem, Israel (Dec 2006).
  • Mor, Tsafrir, Matoba, N, Geyer, B, Alfsen, A, Arntzen, C, Bomsel, M. Humoral immunity directed at gp41-MPR for the prevention of HIV-1 mucosal transmission. International AIDS Vaccine 2006 Conference, Amsterdam, The Netherlands, August 29 - September 1 2006 (Sep 2006).
  • Cherni, I, Geyer, B, Matoba, N, Mor, Tsafrir. MPR649-684-HBsAg Fusion as a Vaccine Candidate against HIV-I Infection. . International AIDS Vaccine 2006 Conference, Amsterdam, The Netherlands, August 29 - September 1 20 (Sep 2006).
  • Mor, Tsafrir. Humoral immunity directed at gp41-MPR for the Prevention of HIV-1 Mucosal Transmission. International AIDS Vaccine 2006 Conference (Aug 2006).
  • *$Cherni I, *Geyer BC, *Matoba N and §Mor TS. MPR649-684-HBsAg Fusion as a Vaccine Candidate against HIV-I Infection. International AIDS Vaccine 2006 Conference, Amsterdam, The Netherlands, August 29 - September 1, 20 (Aug 2006).
  • Geyer, B, Evron, E, Cherni, I, Muralidharan, M, Kilbourne, J, Fletcher, S, Soreq, H, Mor, Tsafrir. Plant-Derived Human Acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath. Bioscience Medical Defense Review 2006, Hunt Valley, MD, June 4-9 2006 (Jun 2006).
  • Muralidharan, M, Soreq, H, Mor, Tsafrir. Characterizing a cholinesterase homologue in Plants. Genomes, Evolution, & Bioinformatics (GEB2006), Tempe, Arizona, May 24-May 28, 2006 (May 2006).
  • Geyer, B, Ben-Ari, S Cherni, Evron, E, Soreq, H, Mor, Tsafrir. Preventable Induction of Muscle Alternative Splicing in Organophosphate-Exposed Mice Treated with Recombinant Human Acetylcholinesterase. Genomes, Evolution, & Bioinformatics (GEB2006), Tempe, Arizona, from May 24-May 28, 2006 (May 2006).
  • Chelladurai, S, Muralidharan, M, Mor, Tsafrir. Gene expression analysis for cholinesterase homologs in plants. Genomes, Evolution, & Bioinformatics (GEB2006), Tempe, Arizona, May 24-May 28, 2006 (May 2006).
  • Geyer, B, Evron, T, Cherni, I, Muralidharan, M, Patel, A, Fletcher, S, Soreq, H, Mor, Tsafrir. N. benthamiana Produced Human Acetylcholinesterase Completely Protects Mice from Lethal Doses of Organophosphate Toxins. Annual Meeting of the American Society of Plant Biologists, Seattle, Washington, July 16-20, 2005 (Aug 2005).
  • *$Geyer BC, Ben-Ari S, *Delisle J, Soreq H, and §Mor TS. Cholinergic Excitation Modulates Chemokine Signaling in Skeletal Muscle. XIII International Symposium on Cholinergic Mechanisms. Foz do Iguaçu - Brazil, August 16-20 2008 (Aug 2005).
  • Matoba, M, Magerus, A, Geyer, B, Alfsen, A, Arntzen, C, Bomsel, M, Mor, Tsafrir. Humoral immunity induced by CTB-P1 for the Prevention of HIV-1 Mucosal Transmission/infection. Plant-Based Vaccines & Antibodies. PBVA 2005 - 8-10 June 2005, Radisson SAS Hotel, Prague, Czech Rep (Jun 2005).
  • Matoba, M, Magerus, A, Geyer, B, Alfsen, A, Arntzen, C, Bomsel, M, Mor, Tsafrir. Humoral immunity induced by CTB-P1 for the Prevention of HIV-1 Mucosal Transmission/infection: Plant-Based Vaccines & Antibodies. PBVA 2005 (Jun 2005).
  • Matoba, M, Magerus, A, Geyer, B, Zhang, Y, Alfsen, A, Arntzen, C, Bomsel, M, Mor, Tsafrir. Towards an oral plant-derived HIV-1 subunit vaccine. Plant-Based Vaccines & Antibodies. PBVA 2005 (Jun 2005).
  • Mor, Tsafrir. Towards an oral plant-derived HIV-1 subunit vaccine. Plant-Based Vaccines & Antibodies (Jun 2005).
  • Matoba, M, Magerus, A, Geyer, B, Zhang, Y, Alfsen, A, Arntzen, C, Bomsel, M, Mor, Tsafrir. Humoral immunity induced by CTB-P1 for the Prevention of HIV-1 Mucosal Transmission/infection. 12th International Congress of Mucosal Immunology, Boston, MA, June 25-30, 2005 (Apr 2005).
  • Matoba, M, Magerus, A, Geyer, B, Zhang, Y, Alfsen, A, Arntzen, C, Bomsel, M, Mor, Tsafrir. Humoral immunity induced by CTB-P1 for the Prevention of HIV-1 Mucosal Transmission/infection. HIV Vaccine Development: Progress and Prospects, Keystone Symposium, Banff, AB, Canada, April 9-15 (Apr 2005).
  • Matoba, M, Magerus, A, Geyer, B, Zhang, Y, Alfsen, A, Arntzen, C, Bomsel, M, Mor, Tsafrir. Towards an oral plant-derived HIV-1 subunit vaccine. HIV Vaccine Development: Progress and Prospects, Keystone Symposium, Banff, AB, Canada, April 9-15 (Apr 2005).
  • Mor, Tsafrir. Human Acetylcholinesterase Isoforms from transgenic Plants. Principal Investigator Conference on Pathogen Countermeasures, Ft. Lauderdale, FL, March 9-11, 2005 (Mar 2005).
  • Mor, Tsafrir. Translational control of recombinant humanacetylcholinesterase accumulation in plants. VIIIth International Meeting on Cholinesterases. Perugia, Italy. September 26-30, 2004 (Sep 2004).
  • Muralidharan, M, Fletcher, S, Geyer, B, Soreq, H, Mor, Tsafrir. Characterizing Pea Acetylcholinesterase. VIIIth International Meeting on Cholinesterases. Perugia, Italy. September 26-30, 2004 (Sep 2004).
  • Matoba, N, Mor, Tsafrir, Arntzen, C. Heat-stable oral vaccines from transgenic plants. Pharmaceutical Sciences World Congress 2004, Kyoto, Japan, May 30-June 3, 2004 (Jun 2004).
  • Mor, Tsafrir. Human Acetylcholinesterase Isoforms from transgenic Plants. Principal Investigator Conference on Unconventional Pathogen Countermeasures (May 2004).
  • Matoba, N, Mor, Tsafrir, Arntzen, C. Heat-stable oral vaccines from transgenic plants. Pharmaceutical Sciences World Congress 2004 (May 2004).
  • Matoba, Nobuyuki, Magerus, Audé, Geyer, Brian, Zhang, Yunfang, Alfsen, Annette, Arntzen, Charles, Bomsel, Morgane, Mor, Tsafrir. A Subunit Vaccine Candidate to Prevent HIV-1 Transmission. HIV Vaccine Development: Progress and Prospects, Keystone Symp, Whistler, BC Canada, 04/12-15/2004 (Apr 2004).
  • Mor, Tsafrir. Molecular Pharming: Producing Protein Pharmaceuticals in Transgenic Plants. Special Seminar at Institute Cochin, Paris, France. February, 8 2004 (Feb 2004).
  • Mor, Tsafrir. Molecular Pharming: Producing Protein Pharmaceuticals in Transgenic Plants. Special seminar, Biological Chem. Dept., Hebrew University, Jerusalem, Israel. 02/04/04 (Feb 2004).
  • Matoba, N, Bomsel, M, Arntzen, C, Mor, Tsafrir. Towards a mucosal vaccine against HIV. Congress on In Vitro Biology, Portland, OR. May 31-June 04, 2003 (Jun 2003).
  • Fletcher, S, Geyer, B, Muralidharan, M, Arntzen, C, Soreq, H, Mor, Tsafrir. Chemical warfare countermeasures: Expression of human acetylcholinesterase in plants. In-vitro Cell Dev Biol Plant 39:28-A (May 2003).
  • Mor, Tsafrir. Human acetylcholinesterase isoforms from transgenic plants. DARPA Topical Meeting on Immunomodulators (Oct 2002).
  • Muralidharan, M, Geyer, B, Soreq, H, Mor, Tsafrir. Role for acetylcholinesterase in gravitropic responses. ASPB Meeting, Denver, CO. August 3-7, 2002 (Aug 2002).
  • Fletcher, S, Geyer, B, Soreq, H, Mor, Tsafrir. Acetylcholinesterase and plants: An inquiry to plant biochemistry and a biotechnology application. ASPB Meeting, Denver, CO. August 3-7, 2002 (Aug 2002).
  • Mor, Tsafrir. Human acetylcholinesterase isoforms from transgenic plants. DARPA Principal Investigator Conference on Unconventional Pathogen Countermeasures (Feb 2001).
  • Mor, Tsafrir. A system for the high-level expression of recombinant proteins in plants. International Society for Plant Molecular Biology 2000 Meeting Quebec (Jun 2000).
  • Mor, Tsafrir. TRANSGENIC PLANTS EXPRESSING HUMAN ACETYLCHOLINESTERASE: WHAT THEY MAY DO FOR US AND WHAT WE MAY LEA. 7th International Congress on Plant Molecular Biology
Service
  • BMC Biotechnology, Ad Hoc Reviewer (2208 - Present)
  • University of CapeTown, Reviewer/Referee (2014 - Present)
  • Virology Journal, ad hoc reviewer (2014 - Present)
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  • Barry M Goldwater Fellowship, Reader (2014 - Present)
  • Intel International Science and Engineering Fair (Phoenix, May 12-17, 2013)., Grand Award Judge (2013 - Present)
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  • Chemico-Biological Interactions, Ad Hoc Reviewer (2008 - Present)
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  • Biotechnology Letters (A Springer Journal), Associate Editor (2005 - Present)
  • Biotechnology Letters (A Springer Journal), Associate Editor (2005 - Present)
  • Biotechnology Letters (A Springer Journal), Associate Editor (2005 - Present)
  • Biotechnology Letters (A Springer Journal), Associate Editor (2005 - Present)
  • Biotechnology Letters (A Springer Journal), Associate Editor (2005 - Present)
  • Biotechnology Letters (A Springer Journal), Associate Editors (2005 - Present)
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  • Adjunct and Affilaiated Faculty Committee, Member (2005 - Present)
  • Adjunct and Affilaiated Faculty Committee, Member (2005 - Present)
  • Adjunct and Affilaiated Faculty Committee, Member (2005 - Present)
  • Adjunct and Affilaiated Faculty Committee, Member (2005 - Present)
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Expertise Areas
Biotechnology
Molecular Biology
Plant Biology
Proteins
Vaccines
Viruses