Michael Sierks

School for Engineering of Matter, Transport and Energy

Professor

Faculty, TEMPE Campus, Mailcode 6106

Biography

Michael Sierks is a professor of chemical engineering in the School for Engineering of Matter, Transport and Energy at Arizona State University. Sierks' research interests include antibody based therapeutics for treating neurodegenerative diseases such as Alzeimer's and Parkinson's Diseases. Other areas of interest in the Sierks group include ligand/receptor interactions, catalytic antibodies and enzyme mechanisms.

Education

Ph.D. Chemical Engineering, Iowa State University 1988
M.S. Chemical Engineering, Colorado State 1982
B.S. Chemical Engineering, Stanford University 1978

Research Interests

Antibody based therapeutics for treating neurodegenerative diseases such as Alzeimer's and Parkinson's Diseases. Other areas include Ligand/receptor interactions, catalytic antibodies and enzyme mechanisms. Expertise: Neurodegenerative Disease Protein Engineering Enymology.

Research Activity

Petuskey,William T*, Bimonte-Nelson,Heather, Coon,David Wayne, Gonzalez,Graciela H, Hecht,Sidney Michael, Sierks,Michael Richard, Smith,Brian. FY14: Arizona Alzheimer's Disease Consortium. AADC(12/22/2014 - 6/30/2014).
Sierks,Michael Richard*. Oligomeric Protein Variants as Biomarkers for AD and TBI Susceptibility. DOD-ARMY-USAMRAA(9/15/2014 - 9/14/2017).
Stabenfeldt,Sarah E*, Kleim,Jeffrey Allan, Kodibagkar,Vikram D, Rege,Kaushal, Sierks,Michael Richard. Detecting and Treating Traumatic Brain Injury Pathology Progression from the Inside-Out. HHS-NIH-NICHD(9/15/2014 - 8/31/2019).
Sierks,Michael Richard*. 14-3-3s as Regulators of Prion-like Mode of Alpha-Synuclein Toxicity. UNIV OF ALABAMA BIRMINGHAM(8/1/2014 - 7/31/2015).
Petuskey,William T*, Bimonte-Nelson,Heather, Coon,David Wayne, Gonzalez,Graciela H, Hecht,Sidney Michael, Sierks,Michael Richard, Smith,Brian, Wang,Yalin. FY15: Arizona Alzheimer's Consortium. AADC(7/1/2014 - 6/30/2015).
Sierks,Michael Richard*. Nanobodies selective for oligomeric Tau species isolated from AD brain. HHS-NIH-NIA(9/30/2013 - 6/30/2016).
Sierks,Michael Richard*. Development of nanobodies that target amyloid- oligomers for individual diagnosis in Alzheimers disease. Mayo Clinic, Fla(2/1/2013 - 1/31/2015).
Sierks,Michael Richard*. Affinity Maturation of an Antibody Based Therapeutic Targeting Microglial Activation. ASU-Mayo Seed Grant(1/1/2013 - 12/31/2013).
Sierks,Michael Richard*. Oligomeric Neuronal Protein Aggregates as Biomarkers for Traumatic Brain Injury (TBI) and Alzheimer Disease (AD). DOD-ARMY-USAMRMC(9/25/2012 - 3/24/2015).
Sierks,Michael Richard*. Developing Diagnostic Nanobodies Against Aggregated TDP-43 Species. HHS-NIH-NIA(8/1/2012 - 7/31/2015).
Gonzalez,Graciela H*, Bimonte-Nelson,Heather, Burleson,Mary, Coon,David Wayne, Mcclain,Darya Denise, Sierks,Michael Richard. FY 13: Arizona Alzheimer's Disease Consortium. AADC(7/1/2012 - 6/30/2013).
Sierks,Michael Richard*. Intracellular Tools to Study Specific Misfolded Protein Variants in Human Disease. HHS-NIH-NIA(8/1/2011 - 7/31/2014).
Gonzalez,Graciela H*, Gonzalez,Graciela H*, Sierks,Michael Richard*, Burleson,Mary, Burleson,Mary, Coon,David Wayne, Coon,David Wayne, Mcclain,Darya Denise, Mcclain,Darya Denise, Sierks,Michael Richard, Sierks,Michael Richard. CS: Arizona Alzheimer's Disease Core Center. AADC(7/1/2011 - 6/30/2012).
Sierks,Michael Richard*. Morphology specific anti-synuclein nanobodies as therapeutics for PD. MJFF(11/1/2010 - 5/16/2013).
Sierks,Michael Richard*, Prasad,Shalini. Identifying and localizing toxic oligomeric a-syn with morphology specific nanobodies. MJFF(11/1/2010 - 2/28/2012).
Sierks,Michael Richard*. High Throughput Tau Oligomer Assay for Drug Screening for Alzheimer's Disease. OLIGOMERIX(8/1/2010 - 7/31/2012).
Sierks,Michael Richard*. YR1: Intracellular Targeting and Clearance of Toxic Synuclein Aggregates. ABRC(7/1/2010 - 6/30/2012).
Sierks,Michael Richard*. In vivo SPECT Imaging of synuclein aggregation with morphology specific antibody based ligands. MJFF(5/1/2010 - 8/23/2011).
Renaut,Rosemary Anne*, Bimonte-Nelson,Heather, Coon,David Wayne, Gonzalez,Graciela H, Marchant,Gary E, Sierks,Michael Richard. AZ ASU Alzheimer's Research Center Project - 12. AADC(7/1/2009 - 6/30/2010).
Sierks,Michael Richard*. In vivo SPECT Imaging of synuclein aggregation with morphology specific antibody based ligands. MJFF(1/1/2009 - 3/31/2010).
Sierks,Michael Richard*. Targeted Hydrolysis of B-amyloid with Engineered Antibody Fragments. ISOA(1/1/2009 - 12/31/2009).
Renaut,Rosemary Anne*, Bimonte-Nelson,Heather, Coon,David Wayne, Johnston,Stephen Albert, Marchant,Gary E, Sierks,Michael Richard, Ye,Jieping. AZ ASU Alzheimer's Reserach Center Project- Year 11. AADC(7/1/2008 - 6/30/2009).
Sierks,Michael Richard*. High Throughput Tau Oligomer Assay for Drug Screening for Alzheimer's Disease. OLIGOMERIX(6/16/2008 - 5/1/2009).
Sierks,Michael Richard*. Conformation-specific Single-chain Antibodies as Neurodegeneration Research Tools. HHS-NIH-NINDS(4/1/2008 - 3/31/2011).
Sierks,Michael Richard*. Intrabody Targeting of Toxic Huntington Aggregates. CHDI(2/1/2008 - 1/31/2009).
Renaut,Rosemary Anne*, Aiken,Leona S, Bimonte-Nelson,Heather, Coon,David Wayne, Farin,Gerald E, Johnston,Stephen Albert, Sierks,Michael Richard. AZ ASU Alzheimer's Research Center Project - Year 10. AADC(7/1/2007 - 6/30/2008).
Sierks,Michael Richard*. Morphology Specific Antibodies to Beta-Amyloid. BrightFocus(4/1/2007 - 3/31/2009).
Arntzen,Charles*, Jacobs,Bertram Lewis, Leket-Mor,Tsafrir Shlomo, Mason,Hugh S, Sierks,Michael Richard. BiaCore Instrument Purchase. HHS-NIH(3/1/2007 - 2/28/2009).
Sierks,Michael Richard*. Intracellular Targeting of Oligomeric a-Synuclein as a Potential Therapeutic for Parkinson's Disease. MJFF(11/1/2006 - 10/31/2007).
Sierks,Michael Richard*. Morphology Specific Antibodies for Treating Parkinson's - Year 3. ABRC(7/1/2006 - 6/30/2007).
Alexander,Gene Evans*, Bimonte-Nelson,Heather, Coon,David Wayne, Farin,Gerald E, Johnston,Stephen Albert, Renaut,Rosemary Anne, Sierks,Michael Richard. AZ ASU Alzheimer's Research Center Project. AZ ADCC(7/1/2006 - 6/30/2007).
Booksh,Karl S*, Sierks,Michael Richard. Development of a Modular, Fiber Optic Surface Plasmon Resonance Sensor for Quantitation of Diagnostic Proteins for Healing of Burns and Wounds. NASA-NATL SPACE BIOMED RES INS(1/1/2006 - 1/31/2007).
Sierks,Michael Richard*. Single Chain Antibody Binding Variable Domains (scFv) Development to Various Morphologies of Htt Aggregation. CHDI(10/1/2005 - 12/31/2006).
Sierks,Michael Richard*. Translational Research on Abeta Metabolism, From Synthesis to Clearance. SUN HEALTH RESEARCH INST(9/1/2005 - 8/31/2008).
Sierks,Michael Richard*. Morphology Specific Antibodies for Treating Parkinson's - Year 2. ABRC(7/1/2005 - 6/30/2006).
Sierks,Michael Richard*. Development of an Early Diagnostic and Treatment for Alzheimer's Disease. MAYO CLINIC SCOTTSDALE(9/29/2004 - 12/31/2005).
Booksh,Karl S*, Khairallah,Philip A, Nieman,Ronald A, Sierks,Michael Richard. Fiber Optic Surface Plasmon Resonance Sensor for Protein Biomarkers. HHS-NIH-NIBIB(9/1/2004 - 6/30/2008).
Sierks,Michael Richard*, Lyubchenko,Yuri. Morphology Specific Antibodies for Treating Parkinson's. ABRC(7/1/2004 - 6/30/2005).
Sierks,Michael Richard*. Role of Protein-Lipid Bilayer Interactiontism in a-Synuclein Aggregation. HHS-NIH-NIA(5/1/2004 - 4/30/2007).
Chang,Yung*, Brophy,Colleen M, Jacobs,Bertram Lewis, Misra,Rajeev, Pettit,George Robert, Sierks,Michael Richard, Zautra,Alex John. THE BD FACSARIA, A NEW FLOW CYTOMETER SORTER. HHS-NIH-NCRR(4/1/2004 - 3/31/2005).
Sierks,Michael Richard*, Lyubchenko,Yuri. Morphology Specific Antibodies as Potential Therapeutics. MJFF(12/18/2003 - 12/31/2005).
Sierks,Michael Richard*, Lyubchenko,Yuri. Oligomers Against Huntington Aggregation Using Atomic Force Microscopy. HDF-HEREDITARY DISEASE FDN(11/1/2003 - 7/31/2005).
Sierks,Michael Richard*, Lyubchenko,Yuri. CONTROLLING -SYNUCLEIN AGGREGATION AS A TOOL FOR STUDYING PARKINSON'S. ABRC(4/1/2002 - 3/31/2004).
Sierks,Michael Richard*. TARGETED PROTEOLYTIC ANTIBODIES FOR TREATING ALZHEIMER'S DISEASE. ALZHEIMER'S ASSN(9/1/2001 - 8/31/2004).
Sierks,Michael Richard*. BISPECIFIC PROTEOLYTIC ANTIBODIES FOR TREATING ALZHEIMER'S. BrightFocus(4/1/2001 - 12/31/2002).
Sierks,Michael Richard*. INHIBITING AGGREGATION WITH PHAGE DISPLAY ANTIBODIES. HHS-NIH-NIA(5/1/2000 - 4/30/2005).

Courses

Fall 2019
Course Number	Course Title
CHE 492	Honors Directed Study
BIO 495	Undergraduate Research
BME 592	Research
CHE 592	Research
CHE 593	Applied Project
BME 599	Thesis
CHE 599	Thesis
BME 792	Research
CHE 792	Research
CHE 799	Dissertation

Summer 2019
Course Number	Course Title
CHE 792	Research
CHE 795	Continuing Registration

Spring 2019
Course Number	Course Title
CHE 493	Honors Thesis
BME 592	Research
CHE 592	Research
CHE 593	Applied Project
CHE 599	Thesis
BME 599	Thesis
CHE 792	Research
BME 792	Research
BDE 792	Research
CHE 799	Dissertation

Fall 2018
Course Number	Course Title
CHE 492	Honors Directed Study
BIO 495	Undergraduate Research
BME 592	Research
CHE 592	Research
CHE 593	Applied Project
BME 599	Thesis
CHE 599	Thesis
BME 792	Research
CHE 792	Research
CHE 799	Dissertation

Summer 2018
Course Number	Course Title
CHE 792	Research
CHE 795	Continuing Registration

Spring 2018
Course Number	Course Title
CHE 493	Honors Thesis
BME 592	Research
CHE 592	Research
CHE 593	Applied Project
BME 599	Thesis
CHE 599	Thesis
BME 792	Research
CHE 792	Research
CHE 799	Dissertation

Fall 2017
Course Number	Course Title
CHE 492	Honors Directed Study
BIO 495	Undergraduate Research
CHE 592	Research
CHE 593	Applied Project
CHE 599	Thesis
CHE 792	Research
CHE 799	Dissertation

Summer 2017
Course Number	Course Title
CHE 792	Research
CHE 795	Continuing Registration

Spring 2017
Course Number	Course Title
CHE 493	Honors Thesis
CHE 592	Research
CHE 593	Applied Project
CHE 599	Thesis
CHE 792	Research
CHE 799	Dissertation

Fall 2016
Course Number	Course Title
CHE 492	Honors Directed Study
CHE 592	Research
CHE 593	Applied Project
CHE 599	Thesis
CHE 792	Research
CHE 799	Dissertation

Summer 2016
Course Number	Course Title
CHE 792	Research
CHE 795	Continuing Registration

Spring 2016
Course Number	Course Title
CHE 592	Research
CHE 593	Applied Project
CHE 599	Thesis
CHE 792	Research
CHE 799	Dissertation

Fall 2015
Course Number	Course Title
CHE 592	Research
CHE 593	Applied Project
CHE 599	Thesis
CHE 792	Research
CHE 799	Dissertation

Summer 2015
Course Number	Course Title
CHE 792	Research
CHE 795	Continuing Registration
CHE 799	Dissertation

Spring 2015
Course Number	Course Title
CHE 592	Research
CHE 593	Applied Project
CHE 599	Thesis
CHE 792	Research
CHE 799	Dissertation

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Michael Sierks