Michael Sierks is a professor of chemical engineering in the School for Engineering of Matter, Transport and Energy at Arizona State University. Sierks' research interests include antibody based therapeutics for treating neurodegenerative diseases such as Alzeimer's and Parkinson's Diseases. Other areas of interest in the Sierks group include ligand/receptor interactions, catalytic antibodies and enzyme mechanisms.
Education
Ph.D. Chemical Engineering, Iowa State University 1988
M.S. Chemical Engineering, Colorado State 1982
B.S. Chemical Engineering, Stanford University 1978
Research Interests
Antibody based therapeutics for treating neurodegenerative diseases such as Alzeimer's and Parkinson's Diseases. Other areas include Ligand/receptor interactions, catalytic antibodies and enzyme mechanisms. Expertise: Neurodegenerative Disease Protein Engineering Enymology.
Sierks,Michael Richard*. Nanobodies selective for oligomeric Tau species isolated from AD brain. HHS-NIH-NIA(9/30/2013 - 6/30/2016).
Sierks,Michael Richard*. Development of nanobodies that target amyloid- oligomers for individual diagnosis in Alzheimers disease. Mayo Clinic, Fla(2/1/2013 - 1/31/2015).
Sierks,Michael Richard*. Affinity Maturation of an Antibody Based Therapeutic Targeting Microglial Activation. ASU-Mayo Seed Grant(1/1/2013 - 12/31/2013).
Sierks,Michael Richard*. Oligomeric Neuronal Protein Aggregates as Biomarkers for Traumatic Brain Injury (TBI) and Alzheimer Disease (AD). DOD-ARMY-USAMRMC(9/25/2012 - 3/24/2015).
Renaut,Rosemary Anne*, Aiken,Leona S, Bimonte-Nelson,Heather, Coon,David Wayne, Farin,Gerald E, Johnston,Stephen Albert, Sierks,Michael Richard. AZ ASU Alzheimer's Research Center Project - Year 10. AADC(7/1/2007 - 6/30/2008).
Sierks,Michael Richard*. Morphology Specific Antibodies to Beta-Amyloid. BrightFocus(4/1/2007 - 3/31/2009).
Sierks,Michael Richard*. Intracellular Targeting of Oligomeric a-Synuclein as a Potential Therapeutic for Parkinson's Disease. MJFF(11/1/2006 - 10/31/2007).
Sierks,Michael Richard*. Morphology Specific Antibodies for Treating Parkinson's - Year 3. ABRC(7/1/2006 - 6/30/2007).
Alexander,Gene Evans*, Bimonte-Nelson,Heather, Coon,David Wayne, Farin,Gerald E, Johnston,Stephen Albert, Renaut,Rosemary Anne, Sierks,Michael Richard. AZ ASU Alzheimer's Research Center Project. AZ ADCC(7/1/2006 - 6/30/2007).
Booksh,Karl S*, Sierks,Michael Richard. Development of a Modular, Fiber Optic Surface Plasmon Resonance Sensor for Quantitation of Diagnostic Proteins for Healing of Burns and Wounds. NASA-NATL SPACE BIOMED RES INS(1/1/2006 - 1/31/2007).
Sierks,Michael Richard*. Single Chain Antibody Binding Variable Domains (scFv) Development to Various Morphologies of Htt Aggregation. CHDI(10/1/2005 - 12/31/2006).
Sierks,Michael Richard*. Translational Research on Abeta Metabolism, From Synthesis to Clearance. SUN HEALTH RESEARCH INST(9/1/2005 - 8/31/2008).
Sierks,Michael Richard*. Morphology Specific Antibodies for Treating Parkinson's - Year 2. ABRC(7/1/2005 - 6/30/2006).
Sierks,Michael Richard*. Development of an Early Diagnostic and Treatment for Alzheimer's Disease. MAYO CLINIC SCOTTSDALE(9/29/2004 - 12/31/2005).
Booksh,Karl S*, Khairallah,Philip A, Nieman,Ronald A, Sierks,Michael Richard. Fiber Optic Surface Plasmon Resonance Sensor for Protein Biomarkers. HHS-NIH-NIBIB(9/1/2004 - 6/30/2008).
Sierks,Michael Richard*, Lyubchenko,Yuri. Morphology Specific Antibodies for Treating Parkinson's. ABRC(7/1/2004 - 6/30/2005).
Sierks,Michael Richard*. Role of Protein-Lipid Bilayer Interactiontism in a-Synuclein Aggregation. HHS-NIH-NIA(5/1/2004 - 4/30/2007).
Chang,Yung*, Brophy,Colleen M, Jacobs,Bertram Lewis, Misra,Rajeev, Pettit,George Robert, Sierks,Michael Richard, Zautra,Alex John. THE BD FACSARIA, A NEW FLOW CYTOMETER SORTER. HHS-NIH-NCRR(4/1/2004 - 3/31/2005).
Sierks,Michael Richard*, Lyubchenko,Yuri. Morphology Specific Antibodies as Potential Therapeutics. MJFF(12/18/2003 - 12/31/2005).
Sierks,Michael Richard*, Lyubchenko,Yuri. Oligomers Against Huntington Aggregation Using Atomic Force Microscopy. HDF-HEREDITARY DISEASE FDN(11/1/2003 - 7/31/2005).
Sierks,Michael Richard*, Lyubchenko,Yuri. CONTROLLING -SYNUCLEIN AGGREGATION AS A TOOL FOR STUDYING PARKINSON'S. ABRC(4/1/2002 - 3/31/2004).
