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Carl Wagner

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Associate Professor
Faculty, WEST Campus, Mailcode 2352
Associate Professor
Faculty, WEST Campus, Mailcode 2352
Biography

I was born in Phoenix, Arizona, and I spent several summers and winters in Flagstaff during my childhood.  My father, who has a Ph.D. in international relations, taught history, French, and economics in high school, and he endowed me with a love for reading, writing and classical music.  My mother endowed me with a love of psychology and an abiding intuition that there is something more than what we feel and know.  As a scientist, it is searching for the binding connections between distant and seemingly unrelated things that interests me.  Perhaps I chose chemistry as a focus, since I have always felt that matter has its own mind regardless of its form or animation.  

Research Interests

My current research focuses are two-fold.  In one project, I focus on the design and synthesis of small molecules that target the retinoid-X-receptor, a central nuclear receptor for which synthetic agonists have proven to be effective in the treatment of various forms of human cancers.  In the second project, I work on the design and construction of triarylamines with potential applications as hole transport materials in photonic devices.  Several undergraduate students actively participate in these research projects each semester.

 

Additionally, understanding how students learn chemistry and developing more effective methods for teaching organic chemistry, both in lecture and laboratory classes, are top priorities for me.  To this end, I continue to develop and assess new teaching tools and laboratory experiments with the help of my colleagues.  Since the West campus has recently acquired a nuclear magnetic resonance (NMR) spectrometer, I will be developing a laboratory experiment that will introduce undergraduates to this vital instrument for organic chemists.

Publications
  • Carl E. Wagner, Pamela A. Marshall, Thomas M. Cahill, Zeynab Mohamed. Visually Following the Hydrogenation of Curcumin to Tetrahydrocurcumin in a Natural Product Experiment That Enhances Student Understanding of NMR Spectroscopy. Journal of Chemical Education (2013).
  • Peter W. Jurutka, Ichiro Kaneko, Joanna Yang, Jaskaran S. Bhogal, Johnathon C. Swierski, Christa R. Tabacaru, Luis A. Montano, Chanh C. Huynh, Rabia A. Jama, Ryan D. Mahelona, Joseph T. Sarnowski, Lisa M. Marcus, Alexis Quezada, Brittney Lemming, Maria A. Tedesco, Audra J. Fischer, Said A. Mohamed, Joseph W. Ziller, Ning Ma, Geoffrey M. Gray, Arjan van der Vaart, Pamela A. Marshall, Carl E. Wagner. Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-{1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic Acid (CD3254). Journal of Medicinal Chemistry (2013).
  • Shane Batie, Jamie H. Lee, Rabia A. Jama, Drew O. Browder, Luis A. Montano, Chanh C. Huynh, Lisa M. Marcus, Dorian G. Tsosie, Zeynab Mohammed, Vu Trang, Pamela A. Marshall, Peter W. Jurutka, Carl E. Wagner. Synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists. Bioorganic & Medicinal Chemistry (2013).
  • Julie K. Furmick,[a] Ichiro Kaneko,[a] Angela N. Walsh,[a] Joanna Yang,[a] Jaskaran S. Bhogal,[a] Geoffrey M. Gray, Juan C. Baso, Drew O. Browder, Jessica L. S. Prentice, Luis A. Montano, Chanh C. Huynh, Lisa M. Marcus, Dorian G. Tsosie, Jungeun S. Kwon, Alexis Quezada, Nicole M. Reyes, Brittney Lemming, Puneet Saini Arjan van der Vaart, Thomas L. Groy, Pamela A. Marshall, Peter W. Jurutka, and Carl E. Wagner. Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor-Selective Agonists: Novel Halogenated Analogues of 4-[1-(3,5,5,8,8-Pentamethyl- 5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene). ChemMedChem (2012).
  • Carl E. Wagner and Thomas L. Groy. 2-Fluoro-4-(methoxycarbonyl)benzoic acid. Acta Crystallographica Section E (2010).
Research Activity
Spring 2019
Course NumberCourse Title
CHM 234General Organic Chemistry II
LSC 493Honors Thesis
LSC 499Individualized Instruction
Fall 2018
Course NumberCourse Title
CHM 233General Organic Chemistry I
LSC 484Internship
LSC 486Peer Mentoring in the Sciences
LSC 492Honors Directed Study
LSC 499Individualized Instruction
BIO 499Individualized Instruction
Summer 2018
Course NumberCourse Title
LSC 592Research
Spring 2018
Course NumberCourse Title
CHM 234General Organic Chemistry II
LSC 493Honors Thesis
BIO 495Undergraduate Research
LSC 499Individualized Instruction
Fall 2017
Course NumberCourse Title
CHM 233General Organic Chemistry I
CHM 237Gen Organic Chemistry Lab I
LSC 484Internship
LSC 486Peer Mentoring in Life Science
LSC 492Honors Directed Study
LSC 499Individualized Instruction
BIO 499Individualized Instruction
Spring 2017
Course NumberCourse Title
CHM 234General Organic Chemistry II
LSC 493Honors Thesis
BIO 495Undergraduate Research
LSC 499Individualized Instruction
Fall 2016
Course NumberCourse Title
CHM 233General Organic Chemistry I
CHM 237Gen Organic Chemistry Lab I
LSC 484Internship
LSC 486Peer Mentoring in Life Science
LSC 492Honors Directed Study
LSC 499Individualized Instruction
Spring 2016
Course NumberCourse Title
CHM 234General Organic Chemistry II
CHM 238Gen Organic Chemistry Lab II
LSC 484Internship
LSC 486Peer Mentoring in Life Science
LSC 493Honors Thesis
BIO 495Undergraduate Research
LSC 499Individualized Instruction
Fall 2015
Course NumberCourse Title
CHM 233General Organic Chemistry I
LSC 484Internship
LSC 486Peer Mentoring in Life Science
LSC 492Honors Directed Study
LSC 499Individualized Instruction
Spring 2015
Course NumberCourse Title
LSC 484Internship
LSC 486Peer Mentoring in Life Science
LSC 492Honors Directed Study
LSC 493Honors Thesis
LSC 499Individualized Instruction
Fall 2014
Course NumberCourse Title
CHM 233General Organic Chemistry I
CHM 237Gen Organic Chemistry Lab I
LSC 484Internship
LSC 486Peer Mentoring in Life Science
LSC 499Individualized Instruction
Presentations
  • Carl E. Wagner, Peter W. Jurutka, Pamela A. Marshall, Arjan van der Vaart. Modeling, synthesis, and biological evaluation of potent retinoid-X-receptor agonists: Novel analogs of bexarotene, LGD100268, and CD3254. American Chemical Society 248th National Meeting, San Fransisco, CA (Aug 2014).
  • Carl E. Wagner, Pamela A. Marshall, Thomas M. Cahill. Visually following the hydrogenation of curcumin to tetrahydrocurcumin in a natural product experiment that also enhances student understanding of NMR spectroscopy. American Chemical Society 248th National Meeting, San Fransisco, CA (Aug 2014).
  • Carl E. Wagner. Searching for Novel Retinoid X Receptor Agonists. Midwestern University Seminar, Glendale AZ (Dec 2013).
  • Carl E Wagner, Peter W Jurutka, Arjan van der Vaart, Pamela A Marshall, Luis A Montano, Gary Landreth, Paige E Cramer. Carl E Wagner, Peter W Jurutka, Arjan van der Vaart, Pamela A Marshall, Luis A Montano, Gary Landreth, Paige E Cramer. American Chemical Society 243rd National Meeting (Mar 2012).
  • Carl E. Wagner, Thomas M. Cahill, Pamela A. Marshall. Extraction, purification and spectroscopic characterization of a mixture of capsaicinoids. American Chemical Society 241st National Meeting, Anaheim CA (Mar 2011).
  • Julie K. Furmick, Carl E. Wagner, Arjan van der Vaart, Syed L. Badshah, Pamela A. Marshall, Peter W. Jurutka. Modeling, synthesis and biological evaluation of potential retinoid-X-receptor (RXR) selective agonists for the treatments of cutaneous T-cell lymphoma. The Endocrine Society (Jun 2010).
  • Julie K. Furmick, Carl E. Wagner, Arjan van der Vaart, Syed L. Badshah, Pamela A. Marshall, Peter W. Jurutka. Modeling, synthesis and biological evaluation of potential retinoid-X-receptor (RXR) selective agonists for the treatment of cutaneous T-cell lymphoma. Arizona-Nevada Academy of Science 54th Annual Meeting (Apr 2010).
  • Carl E. Wagner, Peter W. Jurutka, Pamela A. Marshall, Mark E. Graeber, Erik Matro, Ivy T. Tran, Jamie N. Tedeschi, Reina O. Khamees, Jungeun Kwon, Shahram Moosavi, Julie K. Furmick, Belinda V. Miguel, Darci K. Grupe, Joshua S. Philp, Amina Danishyar, Justin W. Hart. Synthesis and biological evaluation of potential RXR selective agonists: Novel bexarotene analogs. American Chemical Society 237th National Meeting, Salt Lake City UT (Mar 2009).
Service
  • ACS Medicinal Chemistry Letters, Reviewer (2014 - 2014)
  • Journal of Medicinal Chemistry, Reviewer (2014 - 2014)
  • ChemMedChem, Reviewer (2014 - 2014)
  • Journal of Medicinal Chemistry, Reviewer (2014 - 2014)
  • Journal of Chemical Education, Reviewer (2013 - 2013)
  • Bioorganic & Medicinal Chemistry, Reviewer (2013 - 2013)
  • Nature, Reviewer (2013 - 2013)
  • Tonopah Valley High School, Speaker (2013 - 2013)
  • Bioorganic & Medicinal Chemistry, Reviewer (2013 - 2013)
  • Journal of Chemical Education, Reviewer (2012 - 2012)
  • New College Sabbatical Review Committee, Member (2011 - 2011)
  • Chemistry Articulation Task Force, Representative (2011 - 2011)
  • ACS Medicinal Chemistry Letters, Reviewer (2011 - 2011)
  • Journal of Chemical Education, Reviewer (2011 - 2011)
  • AMSA at ASU West, Interviewer (2010 - 2010)
  • New College Sabbatical Review Committee, Chair (2010 - 2010)
  • Emergency Evacuation Committee, Member (2009 - 2010)
  • Journal of Luminescence, Reviewer (2010 - 2010)
  • Chemistry Articulation Task Force, Representative (2009 - 2010)
  • Chemistry Articulation Task Force, Representative (2008 - 2009)
  • National Science Foundation, Reviewer (2008 - 2008)
  • Chemistry Articulation Task Force, Representative (2008 - 2008)
  • Arizona Science & Engineering Fair, Judge (2007)
Expertise Areas