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Jeffrey Jensen

Professor
Faculty, TEMPE Campus, Mailcode 4501
Professor
Faculty, TEMPE Campus, Mailcode 4501
Biography

Jeff Jensen is a population geneticist and Professor in the ASU School of Life Sciences, the Center for Evolution and Medicine, and the Center for Mechanisms of Evolution.

The Jensen Lab develops theory and statistical methodology for describing and quantifying evolutionary processes, and analyzes natural population data to describe the relative roles of these processes during the colonization of novel environments. The lab also analyzes experimental evolution data in order to gain insights into the underlying distribution of selective effects and fitness landscapes.

Education
  • Postdoctoral. NSF Biological Informatics Fellow at UCSD and UC Berkeley, co-advised by Doris Bachtrog, Peter Andolfatto, and Rasmus Nielsen. 2007-2009
  • Ph.D. Molecular Biology & Genetics, Cornell University, co-advised by Charles Aquadro and Carlos Bustamante. 2002-2006
  • BS/BA  Ecology & Evolutionary Biology and Biological Anthropology, University of Arizona, co-advised by Michael Nachman and Brian Charlesworth. 1998-2002
Research Interests

We are a dry lab, using a variety of approaches from population genetics in order to study fundamental evolutionary processes. This work can be summarized in to two primary research areas:

(i) Population Genetic Theory, Methodology, & Analysis: This line of research involves developing theory, as well as likelihood and approximate Bayesian based statistical approaches, for quantifying and untangling the evolutionary pressures driving populations. Our empirical applications of these developments are generally focused upon the forces at play during the colonization of novel environments.

(ii) Experimental & Virus Evolution: We also work in systems where we can control aspects of demography experimentally, and artificially generate mutations, in order to study the shape of the distribution of fitness effects and the underlying fitness landscapes. Within this context, we have a major interest in the evolution of drug resistance in influenza virus, and in the demographic and selective processes underlying human cytomegalovirus (HCMV) infection. 

Publications

Ten Recent, Representative Publications

  • Matuszewski S, M Hildebrandt, G Achaz, and JD Jensen, 2018. Coalescent processes with skewed offspring distributions and non-equilibrium demography. Genetics 208: 323-38.
  • Renzette N, SP Pfeifer, S Matuszewski, TF Kowalik, and JD Jensen, 2017. On the analysis of intra-host and inter-host viral populations: human cytomegalovirus as a case study of pitfalls and expectations. Journal of Virology 91: e01976-16.
  • Bank C, S Matuszewski, R Hietpas, and JD Jensen, 2016. On the (un)predictability of a large intragenic fitness landscape. PNAS 113: 14085-90.
  • Bank C, N Renzette, P Liu, S Matuszewski, H Shim, M Foll, D Bolon, T Kowalik, R Finberg, J Wang, and JD Jensen, 2016. An experimental evaluation of drug-induced mutational meltdown as an antiviral treatment strategy. Evolution 70: 2470-84.
  • Ewing G, and JD Jensen, 2016. The consequences of not accounting for background selection in demographic inference. Molecular Ecology 25: 135-141.
  • Renzette N, T Kowalik, and JD Jensen, 2016. The relative roles of background selection and genetic hitchhiking in shaping human cytomegalovirus diversity. Molecular Ecology 25: 403-13.
  • Montano V, X Didelot, M Foll, B Linz, Y Moodley, and JD Jensen, 2015. Worldwide population structure, long term demography, and local adaptation of Helicobacter pylori. Genetics 200: 947-63.
  • Jensen JD, 2014. On the unfounded enthusiasm for soft selective sweeps. Nature Communications 5: 5281.
  • Bank C, R Hietpas, A Wong, D Bolon, and JD Jensen, 2014. A Bayesian MCMC approach to assess the complete distribution of fitness effects of new mutations: uncovering the potential for adaptive walks in challenging environments. Genetics 196: 841-52.
  • Foll M, YP Poh, N Renzette, A Ferrer-Admetlla, H Shim, AS Malaspinas, G Ewing, C Bank, P Liu, D Wegmann, D Caffrey, K Zeldovich, D Bolon, J Wang, T Kowalik, C Schiffer, R Finberg, and JD Jensen, 2014. Influenza drug resistance: a time-sampled population genetics perspective. PLOS Genetics 10: e1004185.
Fall 2018
Course NumberCourse Title
BIO 498Pro-Seminar
BIO 591Seminar
Spring 2018
Course NumberCourse Title
BIO 345Evolution
Fall 2017
Course NumberCourse Title
BIO 498Pro-Seminar
BIO 591Seminar
Expertise Areas