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Xuan Wang

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Asst Professor
Faculty, TEMPE Campus, Mailcode 4501
Biography

Xuan Wang is a microbiologist who is interested in developing new microbial fermentation processes for the production of bio-based chemicals.

His lab combines genetics and metabolic engineering in a concerted effort to address two great challenges in the applied microbiology field. Those challenges include first, how to increase the efficiency of microbes to use sugars from renewable biomass; and second, how to expand cellular metabolisms to produce new “value-added” chemicals such as industrial bulk chemicals, nutrition supplements, pharmaceuticals and biological polymers.

Education

Ph.D. University of Michigan-Ann Arbor 2008

 

Research Interests

Our lab aims to design and construct recombinant microorganisms to produce industrial-scale valuable chemicals and materials from renewable sources to replace petroleum-based chemicals. Deep understanding of microbial metabolism and physiology, metabolic engineering and protein engineering will be the key tools to achieve our goal. We will create an collaborative environment and mark our contribution in the field of microbial technology.

Publications

Publications at ASU:

  • Sievert, C., Nieves, L. M., Panyon, L. A., Loeffler, T., Morris, C., Cartwright, R., Wang, X. (2017) Experimental evolution reveals a novel avenue to release catabolite repression via mutations in XylR. PNAS.114, 7349-7354.
  • Flores, A., Kurgan, G., Wang, X. (2016). Engineering bacterial sugar catabolism and tolerance toward lignocellulose conversion. Chapter Six in Engineering microorganisms for the production of chemicals and biofuels from renewable sources. G. Gosset ed. (Springer) ISBN 9783319517285 pp. 147-180
  • Immethun, C.M., Henson, W.R., Wang, X., Nielsen, D.R. and Moon T.S. (2016). Engineering Central Metabolism for Production of Higher Alcohol-based Biofuels. Chapter One in Biotechnologies for Biofuel Production and Optimization. C. Eckert and C. Trinh ed. (Elsevier) ISBN 9780444634757 pp. 1-34
  • Nieves, L. M., Panyon, L. A., Wang, X. (2015) Engineering sugar utilization and microbial tolerance toward lignocellulose conversion. Front. Bioeng. Biotechnol. 3:17. doi: 10.3389/fbioe.2015.00017.

Representative publications prior to ASU:

  • Geddes, R. D., Wang, X., Yomano, L. P., Miller, E. N., Zheng, H., Shanmugam, K. T., Ingram, L. O. Polyamine Transporters and Polyamines Increase Furfural Tolerance During Xylose Fermentation with Ethanologenic Escherichia coli strain LY180. Appl Environ Microbiol (2014).80, 5955-5964.
  • Wang, X., Yomano, L.P., Lee, J.Y., Sean, S.Y., Zheng, H., Mullinnix, M.T., Shanmugam K. T., Ingram, L.O. (2013) Engineering furfural tolerance in Escherichia coli improves thefermentation of lignocellulosic sugars into renewable chemicals. PNAS.110, 4021-4026.
  • Wang, X., Miller, E.N., Yomano, L.P., Shanmugam K. T., Ingram, L.O. (2012) Cryptic ucpA gene increases furan-tolerance in Escherichia coli biocatalysts. Appl Environ Microbiol. 78, 2452-2455.
  • Wang, X.*, Miller, E.N.*, Yomano, L.P., Zhang, X. Shanmugam K. T., Ingram, L.O. (2011)Increased furfural tolerance due to overexpression of NADH-dependent oxidoreductaseFucO in Escherichia coli strains engineered for the production of ethanoland lactate. Appl Environ Microbiol. 77, 5132-5140. *Equally contributed.
  • Zhang, X. *, Wang, X. *, Shanmugam K. T., Ingram, L.O. (2011).L-Malate production by metabolically engineered Escherichia coli.Appl Environ Microbiol. 77, 427-434. *Equally contributed.
  • Wang, X., Zhou, Y., Ren, J., Hammer, N. D. and Chapman, M. R. (2010). Gatekeeper residues in major curlin subunit modulate bacterial amyloid fiber biogenesis. PNAS. 107, 163-168.
  • Wang, X. and Chapman, M. R. (2010). Functional Microbial Amyloids: Protein Misfolding Done Right. In Functional Amyloid Aggregation, S. Rigacci and M. Bucciantini, ed. (ISBN: 978-81-308-0425-5) pp. 21-35.
  • Wang, X. and Chapman, M. R. (2008). Curli provide the template for understanding controlled amyloid propagation. Prion. 2, 57-60.
  • Wang, X. and Chapman, M. R. (2008). Sequence determinants of bacterial amyloid formation. J Mol Biol. 380, 570-580.
  • Wang, X., Hammer, N. D. and Chapman, M. R. (2008). The molecular basis of bacterial amyloid polymerization and nucleation. J Biol Chem. 283, 21530-21539. *Selected by Faculty of 1000 Biology
  • Wang, X., Smith, D. R., Jones, J. W., and Chapman, M. R. (2007). In vitro polymerization of a functional Escherichia coli amyloid protein. J Biol Chem. 282, 3713-3719.
Research Activity
  • Nielsen,David Ross*, Wang,Xuan. SusChEM: Enhancing Tolerance and Performance of a Renewable Aromatic Biorefinery. NSF-ENG-CBET(6/15/2015 - 5/31/2018).
Fall 2017
Course NumberCourse Title
BIO 189Life Sciences Career Paths
MBB 492Honors Directed Study
MBB 494Special Topics
BCH 494Special Topics
BME 494Special Topics
BIO 494Special Topics
MBB 495Undergraduate Research
BIO 495Undergraduate Research
MIC 495Undergraduate Research
MIC 501Foundations in Microbiology
MCB 598Special Topics
BCH 598Special Topics
BME 598Special Topics
BIO 598Special Topics
Summer 2017
Course NumberCourse Title
BIO 495Undergraduate Research
Spring 2017
Course NumberCourse Title
MIC 220Biology of Microorganisms
MIC 495Undergraduate Research
MBB 495Undergraduate Research
BIO 495Undergraduate Research
BIO 499Individualized Instruction
Fall 2016
Course NumberCourse Title
MBB 494Special Topics
BCH 494Special Topics
BME 494Special Topics
BIO 494Special Topics
MBB 495Undergraduate Research
BIO 495Undergraduate Research
MIC 495Undergraduate Research
MIC 501Foundations in Microbiology
MCB 598Special Topics
BCH 598Special Topics
BIO 598Special Topics
BME 598Special Topics
Summer 2016
Course NumberCourse Title
BIO 495Undergraduate Research
Spring 2016
Course NumberCourse Title
MIC 220Biology of Microorganisms
MBB 495Undergraduate Research
BIO 495Undergraduate Research
MIC 495Undergraduate Research
BIO 499Individualized Instruction
BDE 792Research
Fall 2015
Course NumberCourse Title
MIC 401Research Paper
BME 494Special Topics
MBB 494Special Topics
BIO 494Special Topics
BCH 494Special Topics
MBB 495Undergraduate Research
MIC 495Undergraduate Research
BIO 495Undergraduate Research
MIC 591Seminar
BME 598Special Topics
BCH 598Special Topics
BIO 598Special Topics
MCB 598Special Topics
Summer 2015
Course NumberCourse Title
BIO 495Undergraduate Research
Spring 2015
Course NumberCourse Title
MIC 401Research Paper
MIC 495Undergraduate Research
MBB 495Undergraduate Research
BIO 495Undergraduate Research
BIO 499Individualized Instruction
Fall 2014
Course NumberCourse Title
BIO 189Life Sciences Career Paths
MIC 360Bacterial Physiology
MIC 495Undergraduate Research
BIO 495Undergraduate Research
Summer 2014
Course NumberCourse Title
BIO 495Undergraduate Research
Spring 2014
Course NumberCourse Title
BIO 495Undergraduate Research
Fall 2013
Course NumberCourse Title
MIC 205Microbiology
Service
  • the SCience and ENgineering Experience (SCENE) high school program organized by Dr. Dr. Nathan Newman and School for Engineering of Matter, Transport & Energy, Mentor for high school students (2015 - Present)
  • 2015 Annual meeting of Society for Industrial Microbiology and Biotechnology, Conference session organizer and co-chair (2015 - Present)
  • "High School Summer Research program" organized by Ira A. Fulton Schools of Engineering, Mentor for high school students (2015 - Present)
  • Mesa Community College, Mentor for the minority undergraduates (2015 - Present)
  • SOLS Safety Committee, GEB group representative (2015 - Present)