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Carlo Maley

Assoc Professor
Faculty, TEMPE Campus, Mailcode 4501
Biography

Carlo Maley is a biologist who specializes in cancer, evolution and computational biology. He works at the intersection of these fields.

Professor Maley and his research team apply evolutionary and ecological theory to three problems in cancer. First, they investigate neoplastic progression: the evolutionary dynamics among cells of a tumor that drive progression from normal tissue to malignant cancers. Second, they examine acquired therapeutic resistance: the evolutionary dynamics by which therapies select for resistance and fail to cure cancer. Third, they look into the evolution of cancer suppression mechanisms in large, long-lived animals such as elephants and whales (a problem called Peto’s Paradox).

His team uses genomic data mining, phylogenetics, computational modeling and wet lab techniques to solve these problems. In their work, the Maley team focus on developing better methods to prevent cancer and improve cancer management.

Education
  • Ph.D. Massachusetts Institute of Technology 1998
  • M.Sc. University of Oxford 1993
  • B.A. Oberlin College 1991
Videos
Research Interests

Professor Maley is a cancer biologist, evolutionary biologist and computational biologist, working at the intersection of those fields. His team applies evolutionary and ecological theory to three problems in cancer: (1) Neoplastic progression: the evolutionary dynamics among cells of a tumor that drive progression from normal tissue to malignant cancers, (2) Acquired therapeutic resistance: the evolutionary dynamics by which our therapies select for resistance and we fail to cure cancer, and (3) the evolution of cancer suppression mechanisms in large, long-lived animals like elephants and whales (a problem called Peto’s Paradox). They use genomic data mining, phylogenetics, computational modeling, as well as wet lab techniques to solve these problems. In all of this work, their goals are to develop better methods to prevent cancer and improve cancer management.

Publications
  • Walther, V., Hiley, C.T., Shibata, D., Swanton, C., Turner, P.E., and Maley C.C.: Can oncology recapitulate paleontology? Lessons from species extinctions. Nature Reviews Clinical Oncology, Published online: 17 February 2015 | doi:10.1038/nrclinonc.2015.12
  • Aktipis, C.A., Boddy, A.M., Gatenby, R.A., Brown, J.S., Maley, C.C.: Life history tradeoffs in cancer evolution. Nature Reviews Cancer, 13:883-892, 2013.
  • Kostadinov, R.L., Kuhner, M.K., Li, X., Sanchez, C.A., Galipeau, P.C., Paulson, T.G., Sather, C.L., Srivastava, A., Odze, R.D., Blount, P.L., Vaughan, T.L., Reid, B.J., Maley, C.C.: NSAIDs modulate clonal evolution in Barrett’s esophagus. PLOS Genetics, 9:e1003553, 2013. PMCID: PMC3681672
  • Greaves, M. & Maley, C.C.: Clonal evolution in cancer. Nature. 481:306-313, 2012. PMCID: PMC3367003
  • Caulin, A.F. and Maley, C.C.: Peto's Paradox: Evolution's Prescription for Cancer Prevention. Trends in Evolution and Ecology, 26:175-82, 2011. PMCID: PMC3060950

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  • Maley, C.C., Koelble, K., Natrajan, R., Aktipis, A., Yuan, Y. An ecological measure of immune-cancer colocalization as a prognostic factor for breast cancer. Breast Cancer (2105).
  • Andor, N., Graham, T.A., Jansen, M., Xia1, L.C., Aktipis, C.A., Petritsch, C., Ji*, H.P., Maley*, C.C. Pan-cancer analysis of the extent and consequences of intra-tumor heterogeneity. Nature Medicine (2016).
  • Abegglen, L.M., Caulin, A.F., Chan, A., Lee, K., Robinson, R., Campbell, M.S., Kiso, W.K., Schmitt, D.L., Waddell, P.J., Bhaskara, S., Jensen, S.T., Maley*, C.C., Schiffman*, J. D. Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans. JAMA (2015).
  • Aktipis, C.A., Boddy, A.M., Jansen, G., Hibner, U., Hochberg, M.E., Maley, C.C., Wilkinson, G.S. Cancer across the tree of life: Cooperation and cheating in multicellularity. Philosophical Transactions of the Royal Society of London B (2015).
  • Caulin, A.F., Graham, T.A., Wang., L.-S., Maley, C.C. Solutions to Peto’s Paradox Revealed by Mathematical Modeling and Cross-Species Cancer Gene Analysis. Philosophical Transactions of the Royal Society of London B (2015).
  • Li, X., Paulson, T.P., Galipeau, P.C., Sanchez, C.A., Liu, K., Kuhner, M.K., Maley, C.C., Self, S.G., Vaughan, T.L., Reid, B.J., Blount, P.L. Assessment of esophageal adenocarcinoma risk using somatic chromosome alterations in longitudinal samples in Barrett's esophagus. Cancer Prevention Research (2015).
  • Nunney, L., Maley, C.C., Breen, M., Hochberg, M.E., Schiffman, J.D. Peto’s paradox and the promise of comparative oncology. Philosophical Transactions of the Royal Society of London B (2015).
  • Paguirigan, A.L., Smith, J., Meshinchi, S., Carroll, M., Maley, C.C., Radich, J.P. Single-cell genotyping demonstrates complex clonal diversity in acute myeloid leukemia. Science Translational Medicine (2015).
  • Timmer*, M.R., Martinez*,P., Lau, C.T., Westra, W.M., Silvia Calpe1, Rygiel, A.M., Rosmolen, W.D., Meijer, S.L., ten Kate, F.J.W., Dijkgraaf, M.G.W., Mallant-Hent, R.C., Naber, A.H.J., van Oijen, A.H.A.M., Baak, L.C., Scholten, P., Böhmer, C.J.M., Fockens, P., Maley, C.C., Graham, T.A., Bergman, J.J.G.H.M., Krishnadath, K.K. Derivation of Genetic Biomarkers for Cancer Risk Stratification in Barrett's Oesophagus: A Prospective Cohort Study. Gut (2015).
  • Walther, V., Hiley, C.T., Shibata, D., Swanton, C., Turner, P.E., and Maley, C.C. Can oncology recapitulate paleontology? Lessons from species extinctions. Nature Reviews Clinical Oncology (2015).
  • . Cancer across life: Peto's paradox and the promise of comparative oncology. (2015).
  • Alcock, J., Maley, C.C., Aktipis, C.A. Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms. Bioessays (2014).
  • Li, X., Galipeau, P.C., Sanchez, C.A., Paulson, T.P., Arnaudo, J., Liu, K., Sather, C.L., Kostadinov, R.L., Odze, R.D., Kuhner, M.K., Maley, C.C., Self, S.G., Vaughan, T.L., Blount, P.L., Reid, B.J. Temporal and Spatial Evolution of Somatic Chromosomal Alterations: A Case-Cohort Study of Barrett's Esophagus. Cancer Prevention Research (2014).
  • Aktipis, C.A., Boddy, A.M., Gatenby, R.A., Brown, J.S., Maley, C.C. Life history tradeoffs in cancer evolution. Nature Reviews Cancer (2013).
  • Datta, R.S., Gutteridge, A., Swanton, C., Maley, C.C., Graham, T.A. Modeling the evolution of genetic instability during tumour progression. Evolutionary Applications (2013).
  • Kostadinov, R.L., Kuhner, M.K., Li, X., Sanchez, C.A., Galipeau, P.C., Paulson, T.G., Sather, C.L., Srivastava, A., Odze, R.D., Blount, P.L., Vaughan, T.L., Reid, B.J., Maley, C.C. NSAIDs modulate clonal evolution in Barrett’s esophagus. PLoS Genetics (2013).
  • Sprouffske, K., Aktipis, C.A., Radich, J.P., Carroll, M., Nedelcu, A.M., Maley, C.C. An evolutionary explanation for the presence of cancer non-stem cells in neoplasms. Evolutionary Applications (2013).
  • Greaves, M. and Maley, C.C. Clonal evolution in cancer. Nature (2012).
  • Kosoff, R.E., Gardiner, K.L., Merlo, L.M.F., Pavlov, K., Rustgi, A.K., Maley, C.C. Development and Characterization of an Organotypic Model of Barrett’s Esophagus. Journal of Cellular Physiology (2012).
  • Roche, B., Hochberg, M.E., Caulin, A.F., Maley, C.C., Gatenby, R.A., Missé, D., Thomas, F. Natural resistance to cancers: a Darwinian hypothesis to explain Peto's paradox. BMC Cancer (2012).
  • Sprouffske, K., Merlo, L.M.F., Gerrish, P.J., Maley, C.C., Sniegowski, P.D. Cancer in light of experimental evolution. Current Biology (2012).
  • Aktipis, C.A., Kwan, V.S.Y., Johnson, K.A., Neuberg, S.L., Maley, C.C. Overlooking evolution: A systematic analysis of cancer relapse and therapeutic resistance research. PLoS ONE (2011).
  • Aktipis, C.A., Maley, C.C., Pepper, J.W. Dispersal evolution in neoplasms: The role of disregulated metabolism in the evolution of cell motility. Cancer Prevention Research (2011).
  • Chen, J., Sprouffske, K., Huang, Q., Maley C.C. Solving the puzzle of metastasis: The evolution of cell migration in neoplasms. PLoS ONE (2011).
  • Martens, E.A., Kostadinov, R., Maley, C.C., Hallatschek, O. Spatial structure increases the waiting time for cancer. New Journal of Physics (2011).
  • Merlo, L.M.F., Kosoff, R.E., Gardiner, K.L., Maley, C.C. An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition. BMC Cancer (2011).
  • Sprouffske, K., Pepper, J. W. & Maley, C. C. Accurate reconstruction of the temporal order of mutations in neoplastic progression. Cancer Prevention Research (2011).
  • Lai, L.A., Kostadinov, R., Barrett, M.T., Peiffer, D.A., Pokholok, D., Odze, R.D., Sanchez, C.A., Maley, C.C., Reid, B.J., Gunderson, K., Rabinovitch, P.S. Deletion at fragile sites is a common and early event in Barrett's Esophagus. Mol Cancer Res (2010).
  • Merlo, L.M.F., Shah, N.A., Li, X., Blount, P., Vaughan, T.L., Reid, B.J., Maley, C.C. A comprehensive survey of clonal diversity measures in Barrett’s esophagus as biomarkers of progression to esophageal adenocarcinoma. Cancer Prevention Research (2010).
  • Paulson, T.G., Maley, C.C., Chao, D., Li, X., Li, X., Zhang, G., Sanchez, C.A. Odze, R., Vaughan, T., Blount, P., Ayub, K., Reid, B.J. Copy number alterations in Barrett’s esophagus and esophageal adenocarcinoma. Clinical Cancer Research (2009).
  • Pepper, J.W., Findlay, C.S., Kassen, R., Spencer, S.L., and Maley, C.C. Cancer research meets evolutionary biology. Evolutionary Applications (2009).
  • Liu, Z., Venkatesh, S.S., Maley, C.C. Sequence space coverage, entropy of genomes and the potential to detect non-human DNA in human samples. BMC Genomics (2008).
Research Activity
  • Maley,Carlo Casbier*. Modeling Neoplastic Progression in Barrett's Esophagus. HHS-NIH-NCI(9/1/2015 - 7/31/2019).
  • Maley,Carlo Casbier*. (PQC3) Genomic and Microenvironmental Diversity as Drivers of Metastasis in DCIS. DUKE UNIV(6/1/2015 - 5/31/2016).
  • Maley,Carlo Casbier*. Barrett's Esophagus: Predictors of Progression. Hutchinson Cancer Res(4/1/2015 - 3/31/2016).
  • Maley,Carlo Casbier*. Stem Cells Differentiation and Therapeutic Resistance in AML. UNIV OF PENNSYLVANIA(2/1/2015 - 1/31/2016).
  • Maley,Carlo Casbier*. Barrett's Esophagus: Predictors of Progression. Hutchinson Cancer Res(1/1/2015 - 3/31/2015).
Fall 2017
Course NumberCourse Title
BIO 189Life Sciences Career Paths
BIO 345Evolution
BIO 492Honors Directed Study
BIO 493Honors Thesis
BIO 495Undergraduate Research
Spring 2017
Course NumberCourse Title
BIO 492Honors Directed Study
BIO 493Honors Thesis
BIO 495Undergraduate Research
Fall 2016
Course NumberCourse Title
BIO 394Special Topics
BIO 492Honors Directed Study
BIO 493Honors Thesis
Spring 2016
Course NumberCourse Title
BIO 492Honors Directed Study
BIO 493Honors Thesis
BIO 494Special Topics
BIO 591Seminar
Fall 2015
Course NumberCourse Title
BIO 492Honors Directed Study
Service
  • SOLS Postdoc Committee, Chair (2015 - Present)
Consulting

Strategic advice and recruitment consulting for the Norton Thoracic Institute at St. Joseph's Hospital and Medical Complex in Phoenix.