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Joseph Blattman

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Associate Professor
Faculty, TEMPE Campus, Mailcode 5401
Lincoln Fellow
Faculty, TEMPE Campus, Mailcode 5401
Associate Professor
Faculty, TEMPE Campus, Mailcode 5401
Biography

Joseph Blattman is an immunologist who studies how the immune system responds to vaccination and viral infection. Focusing on T cell immune responses, he is investigating how vaccines affect the balance between immunologic protection from infection or tumor growth, and disease enhancement due to immunopathology.

Professor Blattman and his research team use quantitative mathematical models to describe the kinetics of infection and immune responses in the body. This allows them to predict which aspects of a T cell response protect the body and which contribute to disease progression.

The team tests show T cell responses affect susceptibility to infection, disease severity after infection and subsequent pathogen transmission.Their work is being used to develop safer and more effective vaccines for humans.

Education

Ph.D. Emory University 2001

Research Interests

T cell receptor diversity vs. efficacy – In order to recognize and combat a diverse array of invading pathogens, T cells express a large repertoire of clonotypic ab dimeric T cell receptors (TCR), with few cells on average expressing TCR specific for any given antigen but an enormous number of specificities at the population level within an individual. Accurately estimating total TCR diversity is problematic, as this is a function of both the CDR3 diversity within each TCR chain due to recombination between V, D, and J gene segments, and P- and N-nucleotide addition or deletion at gene segment joints, as well as diversity due to pairing of different TCRa and TCRb chains. Current methods for obtaining both TCRa and TCRb CDR3 sequences from individual cells in large populations are unfeasible; single cell sorting is too expensive and molecular strategies have not been adequately developed. We have developed DNA origami nanostructures that can be transfected into T cells to capture and protect both TCR mRNA, as well as molecular techniques for linking these CDR3 into a single cDNA for paired-end high-throughput next-generation sequencing. We have begun to apply the DNA origami approach for quantitating cellular diversity to cancer in order to refine clinical therapy approaches.

T cell response pathology vs. protection – CD8 T cell responses are important for the control of a number of human and animal pathogens at the portal(s) of entry, as well as providing systemic immunity after infection. We are currently evaluating a number of different strategies for selectively targeting vaccine-induced T cell responses to mucosal sites as a means of improving containment at the portal of entry. However, narrowly focused CD8 T cell responses are insufficient to either provide coverage for the large number of circulating strains of some viruses or to prevent selection of mutant viruses after infection that are able to evade CTL recognition. We seek to understand what limits the generation of T cell responses to sub-dominant epitopes, and conversely what facilitates responses to immunodominant epitopes by systematically analyzing the efficiency of generation and stability of epitopes from protein substrates and how these parameters change in different antigen-presenting cell types (including direct and cross-presentation. The data from these studies can then be used to predict which epitopes from an immunogen will be immunodominant after vaccination, to design immunogens to increase the levels of subdominant epitopes on the cell surface as a means of improving responses to these epitopes, and to selectively target public T cell precursors that are present in the naïve repertoire such that a majority of individuals will be able to generate broader responses.

Linking immunologic and epidemiologic measures of vaccine efficacy – Vaccination remains one of the most potent strategies for preventing human diseases caused by pathogens. The empirical approach to vaccine development, employing attenuated versions of pathogens or subunit vaccines has resulted in protective efficacy against a number of viral and bacterial pathogens. However, relatively modest subsequent progress has been made in the improvement of empirically defined vaccines or in the development of new, efficacious vaccines. This is in part due to an incomplete quantitative understanding of the immunological mechanisms that are required to reduce susceptibility to infection, disease pathogenesis, or subsequent transmission. We are using animal models of vaccination and viral infection to explicitly link vaccine-induced immunological responses with epidemiological measures of vaccine efficacy including reduction in susceptibility, disease, and subsequent transmission. This will allow us to develop a quantitative framework for understanding how immunological responses induced by certain types of vaccines might provide protection against infection and/or disease during subsequent pathogen exposure. 

Immunotherapy of Persistent Viral Infection and Metastatic Cancer – During prolonged antigen stimulation, as occurs during persistent viral infection or prolonged tumor burden, T cell responses become silenced as a means of preventing pathology to the host.  However, in some viral infection and cancer settings, it is desirable to “reactivate” these T cells in order to provide additional protection. We are using persistent viral infection and cancer models to understand the molecular interactions that program T cell exhaustion in order to develop strategies for improving therapeutic approaches. Using both immune checkpoint blockade and metabolic approaches, we have developed new avenues for therapy of refractory tumors and persistent viral infection. 

Publications

 

  • Zarnitsyna VI, Johnson PLF, Blattman JN, Antia R (2017) Modelling Immunopathology During Persistent Viral Infections in “Mathematical Models and Immune Cell Biology (tentative)”, Molina-Paris K & Lythe G ed, Springer Publishers (in press)
  • Brusch GA, Gopal B, Blattman JN, Denardo DF (2017) Reproduction alters hydration state but does not impact the positive effects of dehydration on innate immune function in Children's pythons (Antaresia childreni), Physiological and Biochemical Zoology (in press).
  • Franco LS, Mujica V, Blattman JN, Garcia AA, (2016) Successive Optimization of Homogeneous Immunoassays Using Gold Nanoparticles for Antibody Detection, PLoS One (in revision).
  • Meador LR, Kessans SA, Kilbourne J, Kibler KV, Pantaleo G, Esteban ME, Blattman JN, Jacobs BL, Mor TS (2017) A heterologous prime-boosting strategy with replicating Vaccinia virus vectors and plant-produced HIV-1 Gag/dgp41 virus-like particles, Virology 507:242-256.
  • Lussier DM, Appel N, Blattman JN (2017) Immune Checkpoint Blockade in Osteosarcoma: Subjugation of the Masses in “Osteosarcoma – Biology, Behavior and Mechanisms”, K. Honoki ed, InTech Open Publishers.
  • Holechek SA, McAfee MS, Nieves L, Guzman V, Manhas K, Bagley K, Fouts T, Blattman JN (2016) DNA Vaccination with Retinaldehyde Dehydrogenase 2 as a Molecular Adjuvant for Enhancement of Mucosal CD8 T Cell Immunity During DNA Vaccination, Vaccine 34(43):5629-5635.
  • Lussier DM, Woolf EC, Johnson JL, Brooks KS, Blattman JN, Scheck AC (2016) Enhanced Immunity in a Model of Malignant Glioma is Mediated by a Therapeutic Ketogenic Diet, BMC Cancer 16:310.
  • Lettieri C, Lussier DM, Appel N, Labban N, Blattman JN, Hingorani P (2016) Progress and Opportunities for Immune Therapeutics in Osteosarcoma, Immunotherapy 8(10):1233-1244.
  • McAfee MS, Hungh T, Johnson JL, Jacobs BJ, Blattman JN (2015) Interaction Between Unrelated Viruses during Co-infection to Limit Pathology and Immunity, Virology 484:153-162.
  • Lussier DM, Johnson JL, Hingorani P, Blattman JN (2015) Combination Immunotherapy with α-CTLA4 and α-PD-L1 Antibody Blockade Prevents Immune Escape and Leads to Complete Control of Metastatic Osteosarcoma, J ImmunoTher Cancer 3:21.
  • Schoettle LN, Poindexter ME, Blattman JN (2015) T Cell Receptors, Encyclopedia of Life Sciences, John Wiley & Sons.           
  • Lussier DM, O'Neill L, Nieves LM, McAfee MS, Holechek SA, Collins AW, Dickman P, Jacobsen J, Hingorani P, Blattman JN (2015) Enhanced T-Cell Immunity to Osteosarcoma Through Antibody Blockade of PD-1/PD-L1 Interactions, J Immunother 38(3):96-106.
  • Chowell D, Krishna S, Becker PD, Cocita C, Shu J, Tan X, Greenberg PD, Klavinskis LS, Blattman JN, Anderson KS (2015) TCR Contact Residue Hydrophobicity is a Hallmark of Immunogenic CD8+ T Cell Epitopes, Proc Natl Acad Sci (USA) 112(14):E1754-1762.
  • Blattman NN, Lagunoff M, Blattman JN, Corey L (2014) Nuclear Factor Kappa B is Required for the Production of Infectious Human Herpesvirus 8 Virions, Front Microbiol 5:129.
  • Zarnitsyna VI, Evavold BD, Schoettle LN, Blattman JN, Antia R (2013) Estimating the Completeness, Redundancy and Cross-Reactivity of the T Cell Repertoire, Front Immunol 4:485.
  • Demidenko AA, Blattman JN, Blattman NN, Greenberg PD, Nibert ML (2013) Engineering Recombinant Reoviruses with Tandem Repeats and a Tetravirus 2A-like Element for Exogenous Polypeptide Expression, Proc Nat Acad Sci (USA) 110(20):E1867-76.
  • Wegmann F, Gartlan KH, Harandi AM, Brinckmann SA, Coccia M, Hillson WR, Kok W-L, Cole S, Ho L-P, Lambe T, Puthia M, Svanborg C, Scherer EM, Krashias G, Williams A, Blattman JN, Greenberg PD, Flavell R, Moghaddam A, Sheppard NC, Sattentau QJ (2012) Polyethyleneimine is a Potent Mucosal Adjuvant for Viral Glycoprotein Antigens, Nat Biotech 30(9):883-888.
  • Stromnes IM, Fowler CC, Blattman JN, Georgopolos C, McAfee MS, Tan X, Greenberg PD (2012) Abrogation of Src Homology Region 2 Domain-Containing Phosphatase 1 in Tumor-Specific T Cells Improves Efficacy of Adoptive Immunotherapy by Enhancing the Effector Function and Accumulation of Short-Lived Effector T Cells In Vivo, J Immunol 189(4):1812-1825.
  • McAfee MS, §Blattman JN (2012) Combating Chronic T Cell Exhaustion, Immunotherapy 4(6):567-560.
  • Schietinger A, Delrow JJ, Basom RS, Blattman JN, Greenberg PD (2012) Rescued Tolerant CD8 T cells are Preprogrammed to Reestablish the Tolerant State, Science 335(6069):723-727.
  • Tan X, Sande JL, Pufnock JS, Blattman JN, Greenberg PD (2011) Use of Retinoic Acid as an Adjuvant to Imprint Mucosal Homing Properties to Vaccine-Induced T Cells, J Virol 85(16):8316-8327.
  • Johnson PLF, Kochin BF, McAfee MS, Stromnes IM, Regoes RR, Ahmed R, Blattman JN, Antia R (2011) Vaccination Alters the Balance between Protective Immunity, Exhaustion, and Pathology Following Disseminated Viremia, J Virol 85(11):5565-5570.
  • Rhee EG, Blattman JN, Kasturi SP, Kelley RP, Kaufman DR, Lynch DM, LaPorte A, Simmons NL, Clark SL, Pulendran B, Greenberg PD, Barouch DH (2011) Multiple Redundant Innate Immune Pathways Contribute to the Immunogenicity of Recombinant Adenoviral Vectors, J Virol 85(1):315-323.
  • Stromnes IM, Blattman JN, Tan X, Jeevanjee S, Gu H, Greenberg PD (2010) Abrogating Cbl-b- in Effector CD8(+) T Cells Improves the Efficacy of Adoptive Therapy of Leukemia in Mice, J Clin Inv 120(10):3722-3734.
  • Fowler CC, Pao L, Blattman JN, Greenberg PD (2010) SHP-1 in T Cells Limits the Production of CD8 Effector Cells Without Impacting the Formation of Long-lived Central Memory Cells, J Immunol 185(6):3256-3267.
  • Blattman JN, Wherry EJ, Ha SJ, van der Most RG, Ahmed R (2009) The Impact of Epitope Escape on PD-1 Expression and CD8 T Cell Exhaustion During Chronic Infection, J Virol 83(9):4386-4394.
  • Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, Kalia V, Subramaniam S, Blattman JN, Barber DL, Ahmed R (2007) Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection, Immunity 27(4):670-684.
  • Shin H, Blackburn S, Blattman JN, Wherry EJ (2007) Viral Antigen and Extensive Division Maintain Virus-Specific CD8 T Cells During Chronic Infection, J Exp Med 204(4):941-949.
  • Blattman JN, Greenberg PD (2006) PD-1 Blockade: Rescue from a Near-Death Experience, Nat Immunol 7(3):227-228.
  • Wherry, EJ, Blattman JN, Ahmed R (2005) Low CD8 T-cell Proliferative Potential and High Viral Load Limit the Effectiveness of Therapeutic Vaccination, J Virol 79(14):8960-8968.
  • Wherry EJ, Barber DL, Kaech SM, Blattman JN, Ahmed R (2004) Antigen-Independent Memory CD8 T Cells do not Develop during Chronic Viral Infection, Proc Nat Acad Sci USA 101(45):16004-16009.
  • Zhang Y, Blattman JN, Kennedy NJ, Duong J, Nguyen T, Wang Y, Davis RJ, Greenberg PD, Flavell RA, Dong C (2004) Regulation of Innate and Adaptive Immune Responses by MAP Kinase Phosphatase 5, Nature 430(7001):793-797.
  • Blattman JN, Greenberg PD (2004) Cancer Immunotherapy: A Treatment for the Masses, Science 305(5681):200-205.
  • van der Most RG, Murali-Krishna K, Lanier JG, Wherry EJ, Puglielli MT, Blattman JN, Zajac AJ, Sette AD, Ahmed R (2003) Changing Immunodominance Patterns in Antiviral CD8 T cell Responses after Loss of Epitope Presentation or Chronic Antigen Stimulation, Virology 315(1):93-102.
  • Topp M, Riddell S, Akatsuka Y, Jensen MC, Blattman JN, Greenberg PD (2003) Restoration of CD28 Expression in CD28-CD8+ Memory Effector T-cells Reconstitutes Antigen-Induced IL-2 Production, Brief Definitive Report, J Exp Med 198(6):947-955.
  • Blattman JN, Grayson JM, Wherry EJ, Kaech SM, Smith KA, Ahmed R (2003) Therapeutic Use of IL-2 to Enhance Antiviral T-cell Responses In Vivo, Nat Med 9(5):540-547.
  • Wherry EJ, Blattman JN, Murali-Krishna K, van der Most RG, Ahmed R (2003) Viral Persistence Alters CD8 T-cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment, J Virol 77(8):4911-4927.
  • Ho WY, Blattman JN, Dossett M, Yee C, Greenberg PD (2003) Adoptive Immunotherapy: Engineering T Cell Responses as Biologic Weapons for Tumor Mass Destruction, Cancer Cell 3(5):431-437.
  • Seiffert M, Custodio JM, Wolf I, Harkey M, Liu Y, Blattman JN, Greenberg PD, Rohrscneider LR (2003) Gab3-Deficient Mice Exhibit Normal Development and Hematopoiesis and are Immunocompetent, Mol Cell Biol 23(7):2415-2424.
  • Slifka MK, Blattman JN, Sourdive DJD, Liu F, Huffman DL, Wolfe T, Hughes A, Oldstone MBA, Ahmed R, von Herrath MG (2003) Preferential Escape of Subdominant CD8+ T cells during Negative Selection Results in an Altered Antiviral T cell Hierarchy, J Immunol 170(3):1231-1239.
  • Blattman JN, Cheng LE, Greenberg PD (2002) CD8+ T cell responses: It’s all downhill after their prime…, Nat Immunol 3(7):601-602.
  • Blattman JN, Antia R, Sourdive DJD, Murali-Krishna K, Wang X, Kaech SM, Altman JD, Ahmed R (2002) Estimating the Precursor Frequency of Naïve Antigen-Specific CD8+ T Cells, Brief Definitive Report, J Exp Med 195(5):657-664.
  • Blattman JN, Sourdive DJD, Murali-Krishna K, Ahmed R, Altman JD (2000) Evolution of the T Cell Repertoire during Primary, Memory, and Recall Responses to Viral Infection, J Immunol 165(11):6081-6090.
  • Blattman JN, Zajac AJ, Murali-Krishna K, Sourdive DJD, Suresh M, Altman JD, Ahmed R (1999) T Cell Anergy During Chronic Viral Infection in “Factors in the Emergence and Control of Rodent-borne Diseases (Hantaviral and Arenal Diseases)”, J.F. Saluzzo and B. Dodet, ed., Elsevier, Paris, pp. 243-253.
  • Zajac AJ, Murali-Krishna K, Blattman JN, Ahmed R (1998) Therapeutic Vaccination Against Chronic Viral Infection: The Importance of Cooperation Between CD4+ and CD8+ T Cells, Curr Opin Immunol 10(4):444-449.
  • Zajac AJ, Blattman JN, Murali-Krishna K, Sourdive DJD, Suresh M, Altman JD, §Ahmed R (1998) Viral Immune Evasion due to Persistence of Activated T Cells Without Effector Function, J Exp Med 188(12):2205-2213.
Research Activity
  • Anderson,Karen S*Blattman,Joseph NathanYan,Hao. Single Cell Technologies for Rapid Detection of Tumor Heterogeneity. HHS-NIH-NCI(9/1/2015 - 7/31/2018).
  • Blattman, Joseph Nathan (Sub-Project I). A Novel Mucosal Adjuvant for an HIV DNA Vaccine. HHS-NIH-NGMS (7/1/2016-6/32/2018).
  • Blattman,Joseph Nathan*. Quantifying the balance between vaccine-induced T cell protection and pathology. EMORY UNIV(2/1/2014 - 1/31/2016).
  • Blattman, Joseph Nathan, DNA Origami Nanostructures for Single-Cell Multi-Gene Analysis without Single Cell Sorting. HHS-NIH-NCI (7/1/2016 - 6/31/2018).
Fall 2017
Course NumberCourse Title
MIC 420Immun: Molecular&Cell Foundtns
BIO 420Immun: Molecular&Cell Foundtns
MIC 492Honors Directed Study
MBB 492Honors Directed Study
BIO 492Honors Directed Study
MIC 495Undergraduate Research
MBB 495Undergraduate Research
MIC 501Foundations in Microbiology
MIC 584Internship
MIC 591Seminar
MIC 598Special Topics
MCB 598Special Topics
BDE 792Research
BDE 799Dissertation
Summer 2017
Course NumberCourse Title
BDE 792Research
Spring 2017
Course NumberCourse Title
MIC 421Experimental Immunology
MIC 425Advanced Immunology
BIO 492Honors Directed Study
MIC 493Honors Thesis
BIO 493Honors Thesis
MBB 493Honors Thesis
MBB 495Undergraduate Research
MCB 591Seminar
MIC 598Special Topics
BDE 792Research
Fall 2016
Course NumberCourse Title
BIO 189Life Sciences Career Paths
MIC 420Immun: Molecular&Cell Foundtns
BIO 420Immun: Molecular&Cell Foundtns
MBB 492Honors Directed Study
MIC 492Honors Directed Study
MIC 495Undergraduate Research
MBB 495Undergraduate Research
MIC 501Foundations in Microbiology
MIC 584Internship
MIC 598Special Topics
MCB 598Special Topics
BDE 792Research
Summer 2016
Course NumberCourse Title
BDE 792Research
Spring 2016
Course NumberCourse Title
MIC 421Experimental Immunology
MIC 425Advanced Immunology
BIO 492Honors Directed Study
MBB 493Honors Thesis
BIO 493Honors Thesis
MIC 493Honors Thesis
MBB 495Undergraduate Research
MIC 598Special Topics
Fall 2015
Course NumberCourse Title
BIO 189Life Sciences Career Paths
MIC 401Research Paper
BIO 420Immun: Molecular&Cell Foundtns
MIC 420Immun: Molecular&Cell Foundtns
BIO 492Honors Directed Study
MBB 492Honors Directed Study
MIC 492Honors Directed Study
MBB 495Undergraduate Research
MIC 495Undergraduate Research
MIC 584Internship
MIC 591Seminar
MIC 598Special Topics
MCB 598Special Topics
Summer 2015
Course NumberCourse Title
MIC 401Research Paper
Spring 2015
Course NumberCourse Title
MIC 401Research Paper
MIC 421Experimental Immunology
MIC 425Advanced Immunology
BIO 492Honors Directed Study
MBB 493Honors Thesis
BIO 493Honors Thesis
MBB 495Undergraduate Research
MIC 598Special Topics
MCB 701Seminar:Molecular/Cellular Bio
Fall 2014
Course NumberCourse Title
MIC 401Research Paper
MIC 420Immun: Molecular&Cell Foundtns
BIO 420Immun: Molecular&Cell Foundtns
BIO 492Honors Directed Study
MBB 492Honors Directed Study
MIC 495Undergraduate Research
MBB 495Undergraduate Research
BIO 495Undergraduate Research
MIC 584Internship
MIC 598Special Topics
MCB 598Special Topics
MCB 701Seminar:Molecular/Cellular Bio
Summer 2014
Course NumberCourse Title
MIC 401Research Paper
Spring 2014
Course NumberCourse Title
MIC 421Experimental Immunology
MIC 425Advanced Immunology
BIO 492Honors Directed Study
MIC 493Honors Thesis
BIO 495Undergraduate Research
MIC 598Special Topics
MCB 701Seminar:Molecular/Cellular Bio
Fall 2013
Course NumberCourse Title
BIO 189Life Sciences Career Paths
MIC 420Immun: Molecular&Cell Foundtns
BIO 420Immun: Molecular&Cell Foundtns
MIC 492Honors Directed Study
MIC 495Undergraduate Research
MIC 598Special Topics
MCB 598Special Topics
MCB 701Seminar:Molecular/Cellular Bio
Spring 2013
Course NumberCourse Title
MIC 421Experimental Immunology
MIC 425Advanced Immunology
BIO 493Honors Thesis
MIC 493Honors Thesis
MIC 495Undergraduate Research
MIC 598Special Topics
MCB 701Seminar:Molecular/Cellular Bio
Presentations
  • Guzman VP, Holechek SA, Nieves LM, Russell DM, Blattman JN. Chronic Viral Infections: Decoding the Mystery of LCMV Transmission Using Immunological and Epidemiological Models. American Society for Microbiology, Arizona and Southern Nevada Chapter 52nd Annual Meeting (May 2104).
  • Schoettle LN, Garcia-Neuer MI, Johnson P, Antia R, Yan H, Blattman JN. DNA Origami – Single Cell Analysis of T Cell Receptors Without Single Cell Sorting. The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2014 (May 2104).
  • Chowell Puente D, Sundaresan SK, Tan X, Becker P, Klavinskis L, Greenberg PD, Blattman JN, Anderson K. A Novel Neuro Network Prediction of MHC-I Immunogenicity for 3 HIV-1 Isolates. The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2014 (May 2104).
  • Guzman VP, Holechek SA, Nieves LM, Russell DM, Blattman JN. Chronic Viral Infections: Decoding the Mystery of LCMV Transmission Using Immunological and Epidemiological Models. 2014 Annual Biomedical Research Conference for Minority Students (ABRCMS) (Nov 2014).
  • JN Blattman. Single Cell Analysis of T cell Receptors Without Single Cell Sorting. Immunogenomics 2014 (Oct 2014).
  • JN Blattman. An Immuno-Epidemiological Model for Virus Infectivity, Disease, and Transmission. 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue (Aug 2014).
  • Franco L, McAfee M, Holechek SA, Garcia A, Blattman JN. Detection of RNA Viruses using Antibody-Conjugated Gold Nanoparticles. 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue an (Aug 2014).
  • Nieves LM, Holechek SA, McAfee MS, Frear C, Blattman JN. ATRA as a Vaccine Adjuvant to Enhance CD8+ T Cell Responses specific to HIV Gag Proteins and Mucosal Protection from Viral Challenge. 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue an (Aug 2014).
  • Johnson J, McAfee MS, Hyung T, Jacobs BJ, Blattman JN. Modulation of Virus Replication, Immunity and Disease During Heterologous Co-Infection. 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue an (Aug 2014).
  • Guzman VP, Holechek SA, Nieves LM, Russell DM, Blattman JN. Chronic Viral Infections: Decoding the Mystery of LCMV Transmission Using Immunological and Epidemiological Models. 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue an (Aug 2014).
  • Manhas K, Nieves LM, Holechek SA, McAfee MS, Blattman JN. Programming Effector T cells for Homing to Epithelial Sites of Virus Transmission. 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue an (Aug 2014).
  • McKay J, Contreras C, Holechek SA, Blattman JN, Castillo-Chavez C. Modeling the Lymphocytic Choriomeningitis Virus: Insights into understanding its epidemiology in the wild. 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue an (Aug 2014).
  • Chowell Puente D, Sundaresan SK, Tan X, Becker P, Klavinskis L, Greenberg PD, Blattman JN, Anderson K. A Novel Neuro Network Prediction of MHC-I Immunogenicity for 3 HIV-1 Isolates. 1st International and Interdisciplinary Workshop on the Ecology, Evolution and Dynamics of Dengue an (Aug 2014).
  • Joshi A, Reed A, Galloway E, Schoettle LN, Wei X, Yan H, Blattman JN. Development of DNA Origami Nanostructures for Analysis of Polyclonal TCR?d. AZBIO Expo (Jun 2014).
  • Schoettle LM, Wei X, Yan H, Blattman JN. A Direct Measure of TCR Diversity Using DNA Origami Nanostructures. The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2014 (May 2014).
  • Blattman JN. The Immune Assault on Virus Infection. Spirit of the Senses Art Salon Seminar Series (May 2014).
  • Jarvis J, McAfee MS, Suresh M, Ahmed R, Greenberg PD, Blattman JN. The Role of Tumor Necrosis Factor Receptors p55 and p75 in Acute IL-2 Toxicity in Chronic Viral Infections. 13th Annual Celebrating Honors Symposium of Thesis and Creative Projects (Apr 2014).
  • Nieves LM, Holechek SA, Blattman JN. 1,25(OH)3D3 as a Vaccine Adjuvant. American Society for Microbiology, Arizona and Southern Nevada Chapter 52nd Annual Meeting (Apr 2014).
  • Nieves LM, Holechek SA, Blattman JN. 1,25(OH)3D3 as a Vaccine Adjuvant. 21st Annual Undergraduate Research Poster Symposium, Arizona State University (Apr 2014).
  • Garcia-Neuer MI, Schoettle LN, Johnson P, Robins H, Antia R, Blattman JN. The Public Versus Private Nature of Naïve T Cell Receptor Gene Recombination Profiling. 21st Annual Undergraduate Research Poster Symposium, Arizona State University (Apr 2014).
  • Frear C, Holechek SA, McAfee MS, Nieves LM, Guzman VP, Blattman JN. RALDH2 as a Mucosal Adjuvant for DNA-Based HIV Vaccines. 21st Annual Undergraduate Research Poster Symposium, Arizona State University (Apr 2014).
  • Miller CK, Guzman VP, Holechek SA, Blattman JN. First Evidence of Lymphocytic Choriomeningitis Virus in Peromyscus maniculatus Sampled from the Walker River Basin of Nevada and California. 21st Annual Undergraduate Research Poster Symposium, Arizona State University (Apr 2014).
  • Guzman V, Holechek SA, Nieves L, Bruce CA, Blattman JN. Role of CD4+ T-Cell Help in Maintaining CD8 T-Cells and B-Cells in Suppression of LCMV Transmission. SOLUR 2014 (Mar 2014).
  • Garcia-Neuer MI, Schoettle LN, Johnson P, Robins H, Antia R, Blattman JN. The Public Versus Private Nature of Naïve T Cell Receptor Gene Recombination Profiling. The American Association for the Advancement of Science (Feb 2014).
  • JN Blattman. Single Cell Sequencing Without Single Cell Sorting. Dublin City University/Arizona State University Joint Symposia (Jan 2014).
  • Blattman JN. Balancing Immune Diversity versus Immune Protection. Sigma Xi, The Scientific Research Honor Society, Arizona State University Chapter, Fall 2013 Lun (Nov 2013).
  • Blattman JN. How to Interview for an Academic Position (or How I Learned to Be the Bomb). Arizona State University School of Life Sciences Graduate Student Retreat (Oct 2013).
  • Blattman JN. A Quantitative Understanding of Vaccination for Disease. Department of Immunology Seminar, Mayo Clinic (Oct 2013).
  • Blattman JN. Nanostructure linkage of T cell receptor mRNA for single cells without single cell sorting. Biodesign Institute Industrial Liaison Program Symposia, Session on Human Health (Sep 2013).
  • Blattman JN. A DNA Origami Deep Sequencing Approach to Directly Measure Total TCR Diversity. Neurogenomics Division Seminar, Translational Genomics Research Institute (Aug 2013).
  • Blattman JN. Lymphocytic choriomeningitis virus: Immunology Insights from a Human Pathogen. Arizona State University Environmental Health & Safety Summer Compliance Office (Jul 2013).
  • Schoettle LN, Blattman JN. Illumina Paired-End Deep Sequencing Using of DNA Origami Nanostructure Templates to Directly Measure TCRaß Diversity. 7th Illumina Sequencing Expert Panel 2013 (Jun 2013).
  • Blattman JN. Single Cell Analysis of Gene Expression without Single Cell Sorting. American Association of Immunologists 100th Annual Meeting: IMMUNOLOGY 2013 (May 2013).
  • Schoettle LM, Wei X, Yan H, Blattman JN. Development of DNA origami nanostructure for isolation of TCR alpha and beta mRNA from Individual Cells. The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2013 (May 2013).
  • McAfee MS, Johnson PLF, Antia R, Blattman JN. A Direct Correlation Between Memory Virus-Specific CD8 T Cells Numbers and Virus Inoculum Resulting in Maximal Disease During Virus Infection. The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2013 (May 2013).
  • Holechek SA, Nieves L, McAfee MS, Guzman V, Bruce C, Blattman JN. Using the Lymphocytic Choriomeningitis Virus Mouse Model of Infection to Link Specific Immune Responses with Epidemiological Outcomes. The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2013 (May 2013).
  • Schoettle LM, Wei X, Yan H, Blattman JN. Development of DNA origami nanostructure for isolation of TCR alpha and beta mRNA from Individual Cells. The American Association of Immunologists Annual Meeting: IMMUNOLOGY 2013 (May 2013).
  • Bruce C, Holechek SA, Antia R, Blattman JN. Modeling Lymphocytic Choriomeningitis Virus Epidemiology. ASU School of Human Evolution and Social Change, Undergraduate Research Symposium (Apr 2013).
  • Garcia-Neuer M, Schoettle LN, Johnson PLF, Antia R, Blattman JN. The Public versus Private Nature of Naïve T Cell Receptor Gene Recombination Profiling. American Society for Microbiology, Arizona and Southern Nevada Chapter 52nd Annual Meeting (Apr 2013).
  • Guzman V, Holechek SA, Nieves L, Bruce CA, Blattman JN. Role of CD4+ T-Cell Help in Maintaining CD8 T-Cells and B-Cells in Suppression of LCMV Transmission. American Society for Microbiology, Arizona and Southern Nevada Chapter 52nd Annual Meeting (Apr 2013).
  • Nieves L, Holechek SA, Guzman V, Bruce CA, Blattman JN. Introducing a Lymphocytic Choriomeningitis Virus Transmission Model to Study the Epidemiological Relationships in Chronic Infections. American Society for Microbiology, Arizona and Southern Nevada Chapter 52nd Annual Meeting (Apr 2013).
  • Holechek SA, Bruce C, Blattman JN. Linking Immunological and Epidemiological Models of Immunity and Virus Persistence. American Society for Microbiology, Arizona and Southern Nevada Chapter 52nd Annual Meeting (Apr 2013).
  • Bruce C, Holechek SA, Antia R, Blattman JN. Modeling Lymphocytic Choriomeningitis Virus Epidemiology. American Society for Microbiology, Arizona and Southern Nevada Chapter 52nd Annual Meeting (Apr 2013).
  • Bruce CA, Holechek SA, Antia R, Blattman JN. Modeling Lymphocytic Choriomeningitis Virus Epidemiology. Celebrating Honors Symposium, Barrett Honors College, Arizona State University (Apr 2013).
  • Guzman V, Holechek SA, Nieves L, Bruce CA, Blattman JN. Role of CD4+ T-Cell Help in Maintaining CD8 T-Cells and B-Cells in Suppression of LCMV Transmission. ASU SOLUR Undergraduate Research Symposium (Mar 2013).
  • Nieves L, Holechek SA, Guzman V, Bruce CA, Blattman JN. Introducing a Lymphocytic Choriomeningitis Virus Transmission Model to Study the Epidemiological Relationships in Chronic Infections. ASU SOLUR Undergraduate Research Symposium (Mar 2013).
  • Guzman V, Holechek SA, Nieves L, Bruce CA, Blattman JN. Role of CD4+ T-Cell Help in Maintaining CD8 T-Cells and B-Cells in Suppression of LCMV Transmission. More Graduate Education @ Mountain States Alliance and Western Alliance to Expand Student Opportunit (Mar 2013).
  • Nieves L, Holechek SA, Guzman V, Bruce CA, Blattman JN. Introducing a Lymphocytic Choriomeningitis Virus Transmission Model to Study the Epidemiological Relationships in Chronic Infections. More Graduate Education @ Mountain States Alliance and Western Alliance to Expand Student Opportunit (Mar 2013).
  • Joseph N. Blattman. Ignorance Exhaustion and Death – Punk Rock as Preparation for Science. Microdevils, the ASU Microbiology Club, Monthly Meeting, Arizona State University, Tempe, AZ (Oct 2012).
  • Joseph N. Blattman. Increasing All-Trans Retinoic Acid Signaling during Vaccination to Improve Mucosal and Systemic Immunity. Molecular and Cellular Biology Program Colloquium, Arizona State University, Tempe, AZ (Aug 2012).
  • McAfee M.S., P. Johnson, R. Antia and J.N. Blattman. A Direct Correlation Between Memory Virus-Specific CD8 T Cells Numbers and Virus Inoculum Resulting in Maximal Disease During Virus Infection. Molecular and Cellular Biology Graduate Program Retreat, Arizona State University, Tempe (Aug 2012).
  • Holechek S.A., M.S. McAfee, L. Idouraine and J.N. Blattman. Applying Immunological and Epidemiological Lessons from LCMV to Sin Nombre Hantavirus. Department of Microbiology and Immunology Seminar, University of Nevada, Reno, NV (Jun 2012).
  • Joseph N. Blattman. Linking Immunological and Epidemiological Measures of Vaccine Efficacy. Department of Microbiology and Immunology Seminar, University of Nevada, Reno, NV (Jun 2012).
  • Joseph N. Blattman. A Quantitative Understanding of Vaccination for Disease. American Society for Microbiology, Arizona and Southern Nevada Chapter 51st Annual Meeting, Arizo (Apr 2012).
  • McAfee M.S., I.M. Stromnes, P. Johnson, R. Antia and J.N. Blattman. Both Naïve and Memory Virus-Specific CD8 T Cells Can Mediate Enhanced Pathology During Viral Infection. American Society for Microbiology, Arizona and Southern Nevada Chapter 51st Annual Meeting, Arizona (Apr 2012).
  • Holechek S.A., L. Idouraine, M.S. McAfee, S.C. St. Jeor and J.N. Blattman. Assessment of anti-mouse antibodies reactivity against deer mice (Peromyscus maniculatus). American Society for Microbiology, Arizona and Southern Nevada Chapter 51st Annual Meeting, Arizona (Apr 2012).
  • Griffith K., M.S. McAfee, S. LeGall and J.N. Blattman. Defining limitations to Broad T Cell Responses to HIV. American Society for Microbiology, Arizona and Southern Nevada Chapter 51st Annual Meeting, Arizona (Apr 2012).
  • Creevy E., M.S. McAfee, N.N. Blattman and J.N. Blattman. Understanding Vaccination for Disease. American Society for Microbiology, Arizona and Southern Nevada Chapter 51st Annual Meeting, Arizona (Apr 2012).
  • Garcia-Neuer M., M.S. McAfee, P. Johnson, R. Antia and J.N. Blattman. Using Single-Chain TCR Transgenic Mice to Estimate Total TCRaß Diversity. American Society for Microbiology, Arizona and Southern Nevada Chapter 51st Annual Meeting, Arizona (Apr 2012).
  • McAfee M.S., I.M. Stromnes, P. Johnson, R. Antia and J.N. Blattman. Both Naïve and Memory Virus-Specific CD8 T Cells Can Mediate Enhanced Pathology During Viral Infection. 2nd Conference on Systems Approaches in Immunology: Advances and Challenges in Multi-Scale Modeling, (Jan 2012).
  • Joseph N. Blattman. Protective vs Pathologic T Cell Immunity. 2nd Conference on Systems Approaches in Immunology: Advances and Challenges in Multi-Scale Modeli (Jan 2012).
  • Joseph N. Blattman. Understanding the Limitations to Elicitng Broad T Cell Responses to HIV Vaccines and Targeting Potentially Protective Epitopes. Collaboration for AIDS Vaccine Discovery Annual Meeting (Dec 2011).
  • Joseph N. Blattman. All-Trans Retinoic Acid Promotes Increased Effector T Cells at Mucosal Sites and Increased Central Memory Systemic T Cells During Vaccination. Novel Vaccines: Adjuvants & Delivery Systems / ImVacS–the Immunotherapeutics & Vaccine Summit (Aug 2011).
  • Joseph N. Blattman. Ignorance, Exhaustion, and Death: Understanding the Balance Between Protective and Pathologic T Cell Immunity. Emory University Graduate Division of Biological & Biomedical Sciences Seminar Series (Aug 2011).
  • Joseph N. Blattman. Ignorance, Exhaustion, and Death: Understanding the Balance Between Protective and Pathologic T Cell Immunity. Arizona State University Faculty Recruitment (Mar 2011).
  • Joseph N. Blattman. Immunologic Memory: Balancing Vaccine-Induced Protection vs. Pathology. RAPIDD Workshop on Generation and Maintenance of Immune Memory: Immunologic Models and Epidemiologic (Mar 2011).
Service
  • Macrosystems Biology Faculty Search Committee, Committee member (2014 - Present)
  • Microbiology Graduate Program, ASU, Co-director (2014 - Present)
  • SOLS Director Search Committee, Committee member (2014 - Present)
  • Student-Faculty Policy Committee, Committee member (2014 - Present)
  • International Journal of Immunology and Immunotherapy, Editorial Board (2014 - Present)
  • Advances in Genetic Engineering & Biotechnology, Editorial Board (2014 - Present)
  • 1st International Workshop on Artificial Immune Systems: Systems 2014, Program Committee Member (2014 - Present)
  • College of Liberal Arts and Sciences Senate, SOLS Senator (2014 - Present)
  • Frontiers in Immunology, Ad-hoc reviewer (2014 - Present)
  • Journal of Proteome Research, Ad-hoc reviewer (2014 - Present)
  • Molecular and Cellular Biology Graduate Program, Committee member (2014 - Present)
  • PLosOne, Ad-hoc reviewer (2014 - Present)
  • University Faculty Senate, SOLS Senator (2014 - Present)
  • Molecular and Cell Biology Graduate Program Executive Committee, Member (2012 - Present)
  • College of Liberal Arts and Sciences Senate, Member (2012 - Present)
  • Frontiers in Mucosal Immunity, Review Editor (2012 - Present)
  • Program Committee Member, 11th International Conference on Artificial Immune Systems 201, Program Committee Member (2012 - Present)
  • Microbiology Graduate Program Admissions Committee, Member (2012 - Present)
  • Molecular and Cell Biology Graduate Program Admissions Committee, Member (2012 - Present)
  • Frontiers in Mucosal Immunity, Review Editor (2011 - Present)
  • Frontiers in Mucosal Immunity, Review Editor (2011 - Present)
  • College of Liberal Arts and Sciences Faculty Senate, Member (2013 - 2013)
  • Journal of Proteome Research, Ad-hoc reviewer (2013 - 2013)
  • Molecular and Cell Biology Graduate Program Executive Committee, Member (2013 - 2013)
  • Career Service Employer Panel for Science Careers, Panelist (2012 - 2012)