Dr. Li Liu is an assistant professor of biomedical informatics and the director of the Bioinformatics Core Facility at Arizona State University. She holds an MD in medicine and a master's degree in information systems. As a trained clinician and a bioinformatics researcher, she fully appreciates the critical roles genomic medicine and bioinformatics play in advancing precision medicine. By integrating genomic, phylogenetic, population genetic, statistical and machine-learning techniques, Dr. Liu and her research team investigate clinical and molecular signatures of human diseases, and develop novel computational methods to discover biomarkers for early diagnosis and accurate prediction of therapeutic responses for individual patients. Before joining ASU, Dr. Liu helped build and directed the bioinformatics core facility at University of Florida.
Dr. Liu’s research focuses on developing and applying computational methods to advance precision medicine, with a special aspect of incorporating evolutionary and functional information in model construction. Via close collaborations with biomedical and clinical researchers world-wide, she aims to translate bioinformatics discoveries into improvements in patient care. Her past and current research projects include:
Related Links:
Complete List of Published Work in MyBibliography:
Selected Publications
Kumar S, Sanderford M, Gray VE, Ye J, Liu L (2012) Evolutionary Diagnosis Method for Variants in Personal Exomes. Nature Methods 9(9):855-6
Kumar S, Liu L. (2014) No positive selection for G-allele in a p53 response element in Europeans. Cell 157(7):1497-1499
Liu L, Tamura K, Sanderford M, Gray VE, Kumar S (2016) A Molecular Evolutionary Reference for the Human Variome. Molecular Biology and Evolution 33(1):245-54
Liu L, Kumar S. (2013) Evolutionary balancing is critical for correctly forecasting disease associated amino acid variants. Molecular Biology and Evolution 30(6):1252-7
Liu L, Chang Y, Yang T, Noren DP, Long B, Kornblau S. Qutub A, Ye J (2016) Evolution-informed Modeling Improves Outcome Prediction for Cancers. Evolutionary Applications 10.1111/eva.12417
Gerek ZN, Liu L, Gerold K, Biparva P, Thomas ED, Kumar S. (2015) Evolutionary Diagnosis of non-synonymous variants involved in differential drug response. BMC Medical Genomics 8(1):534
Yin L, Liu L, Sun Y, Hou W, Lowe AC, Gardner BP, Salemi M, Williams WB, Farmerie WG, Sleasman JW, Goodenow MM (2012) High-resolution deep sequencing reveals biodiversity, population structure, and persistence of HIV-1 quasispecies within host ecosystems. Retrovirology 9:108
Sun Y, Cai YP, Liu L, Yu F, Farrell M, McKendree W, Farmerie WG. (2009) ESPRIT: estimating species richness using large collectins of 16S rRNA shotgun sequences. Nucleic Acid Research 37(10):e76
Moroz LL, Edwards JR, Puthanveettil SV, Kohn A, Ha T, Heyland A, Knudsen B, Sahni A, Yu F, Liu L, Jezzini S, Sadreyev R, Lovell P, Iannucculli W, Chen M, Nguyen T, Sheng H, Shaw R, Kalachikov S, Panchin Y, Farmerie WG, Russo JJ, Ju J, Kandel ER (2006) The Neuronal Transcriptome of Aplysia californica: A Platform for the Neurogenomics of Defined Neurons, Neuronal Compartments and Neuronal Circuitry. Cell. 127(7):1453-1467
Cousins RJ, Blanchard RK, Popp MP, Liu L, Cao J, Moore JB and Green CL. (2003) A Global View of the Selectivity of Zinc Deprivation and Excess on Genes Expressed in Human THP-1 Mononuclear Cells, PNAS, 100:6952-6957.
Spring 2021 | |
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Course Number | Course Title |
BMI 312 | Modeling Biomedical Data |
BMI 330 | Topics Trans Bioinformatics |
BMI 482 | Capstone I |
BMI 483 | Capstone II |
BMI 484 | Internship |
BMI 560 | Teachng Biomedical Informatics |
BMI 584 | Internship |
BMI 590 | Reading and Conference |
BMI 790 | Reading and Conference |
BMI 792 | Research |
BMI 799 | Dissertation |
Fall 2020 | |
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Course Number | Course Title |
BMI 201 | Intro to Clinical Informatics |
BMI 311 | Modeling Biomedical Knowledge |
BMI 482 | Capstone I |
BMI 484 | Internship |
BMI 560 | Teachng Biomedical Informatics |
BMI 584 | Internship |
BMI 590 | Reading and Conference |
BMI 593 | Applied Project |
BMI 790 | Reading and Conference |
BMI 792 | Research |
BMI 799 | Dissertation |
Summer 2020 | |
---|---|
Course Number | Course Title |
BMI 482 | Capstone I |
BMI 483 | Capstone II |
BMI 484 | Internship |
BMI 560 | Teachng Biomedical Informatics |
BMI 584 | Internship |
BMI 792 | Research |
Spring 2020 | |
---|---|
Course Number | Course Title |
BMI 312 | Modeling Biomedical Data |
BMI 330 | Topics Trans Bioinformatics |
BMI 482 | Capstone I |
BMI 483 | Capstone II |
BMI 484 | Internship |
BMI 560 | Teachng Biomedical Informatics |
BMI 584 | Internship |
BMI 593 | Applied Project |
BMI 790 | Reading and Conference |
BMI 792 | Research |
BMI 799 | Dissertation |
Fall 2019 | |
---|---|
Course Number | Course Title |
BMI 311 | Modeling Biomedical Knowledge |
BMI 484 | Internship |
BMI 560 | Teachng Biomedical Informatics |
BMI 584 | Internship |
BMI 590 | Reading and Conference |
BMI 593 | Applied Project |
BMI 790 | Reading and Conference |
BMI 792 | Research |
BMI 799 | Dissertation |
Summer 2019 | |
---|---|
Course Number | Course Title |
BMI 484 | Internship |
BMI 584 | Internship |
BMI 792 | Research |
Spring 2019 | |
---|---|
Course Number | Course Title |
BMI 312 | Modeling Biomedical Data |
BMI 330 | Topics Trans Bioinformatics |
BMI 484 | Internship |
BMI 493 | Honors Thesis |
BMI 560 | Teachng Biomedical Informatics |
BMI 593 | Applied Project |
BMI 790 | Reading and Conference |
BMI 792 | Research |
BMI 799 | Dissertation |
Fall 2018 | |
---|---|
Course Number | Course Title |
BMI 311 | Modeling Biomedical Knowledge |
BMI 484 | Internship |
BMI 492 | Honors Directed Study |
BMI 560 | Teachng Biomedical Informatics |
BMI 584 | Internship |
BMI 590 | Reading and Conference |
BMI 593 | Applied Project |
BMI 790 | Reading and Conference |
BMI 792 | Research |
BMI 799 | Dissertation |
Summer 2018 | |
---|---|
Course Number | Course Title |
BMI 584 | Internship |
BMI 792 | Research |
Spring 2018 | |
---|---|
Course Number | Course Title |
BMI 330 | Topics Trans Bioinformatics |
BMI 484 | Internship |
BMI 493 | Honors Thesis |
BMI 499 | Individualized Instruction |
BMI 560 | Teachng Biomedical Informatics |
BMI 593 | Applied Project |
BMI 790 | Reading and Conference |
BMI 792 | Research |
BMI 799 | Dissertation |
Fall 2017 | |
---|---|
Course Number | Course Title |
BMI 311 | Modeling Biomedical Knowledge |
BMI 484 | Internship |
BMI 492 | Honors Directed Study |
BMI 499 | Individualized Instruction |
BMI 560 | Teachng Biomedical Informatics |
BMI 570 | BMI Symposium |
BMI 593 | Applied Project |
BMI 790 | Reading and Conference |
BMI 792 | Research |
BMI 799 | Dissertation |
Summer 2017 | |
---|---|
Course Number | Course Title |
BMI 584 | Internship |
BMI 593 | Applied Project |
BMI 792 | Research |
BMI 799 | Dissertation |
Spring 2017 | |
---|---|
Course Number | Course Title |
BMI 330 | Topics Trans Bioinformatics |
BMI 560 | Teachng Biomedical Informatics |
BMI 590 | Reading and Conference |
BMI 593 | Applied Project |
BMI 790 | Reading and Conference |
BMI 792 | Research |
BMI 799 | Dissertation |
Fall 2016 | |
---|---|
Course Number | Course Title |
BMI 311 | Modeling Biomedical Knowledge |
BMI 560 | Teachng Biomedical Informatics |
BMI 570 | BMI Symposium |
BMI 593 | Applied Project |
BMI 792 | Research |