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Timothy Karr

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Adjunct Faculty
Faculty, Tempe Campus,
Biography

Timothy Karr received his PhD in Chemistry in 1981 at the University of California, Santa Barbara.  Dr. Karr was a Jane Coffin Child Postdoctoral Fellow with Bruce Alberts (1981-84) and a American Cancer Society Fellow (1984-87) with Thomas Kornberg in the Department of Biochemistry and Biophysics, UC San Francisco where he began his work on fertilization and early Drosophila embryogenesis.  Subsequently at the University of Illinios, Urbana and The University of Chicago (1987-2002), Dr. Karr continued studies of fertilization and and sperm biology in Drosophila.  In 2002 Dr. Karr received a prestigious Wolfson-Royal Society Merit Award and moved to the University of Bath, United Kingdom, as a Reader in Biology.  In 2006 and 2010, Dr. Karr published the first functional genomic and evolutionary analyses of the Drosophila and mouse sperm proteomes.  In 2008 he moved to the Biodesign Institute at Arizona State University where he continues to elucidate the functional genomics and biochemistry of the mammalian sperm proteomes.

 

Dr. Karr has also pioneered studes into the biology of Wolbachia in Drosophila.  Wolbachia, an obligate intracellular microbe, affects sperm function in infected males leading to a unique form of male paternal effect known as "Cytoplasmic Incompatibility" (CI).  Dr. Karr studies Wolbachia to identify, and then exploit, the molecular mechanism of CI to develop rational strategies for the biocontrol of insect pest populations.

Publications
  • Dorus, S., Skerget, S. and Karr, T.L. Proteomic discovery of diverse immunity molecules in mammalian spermatozoa. Systems Biology in Reproductive Medicine (2012).
  • Fischer, B. E., Wasbrough, E., Meadows, L. A., Randlet, O., Dorus, S., Karr, T. L., and Russell, S. Conserved properties of Drosophila and human spermatozoal mRNA repertoires. Proc Biol Sci (2012).
  • Fischer, B.E., Wasbrough, E., Meadows, L.A., Randlet, O., Dorus, S., Karr, T.L., and Russell, S. Conserved Properties of Drosophila and Human Spermatozoal MRNA Repertoires. Proc Royal Soc Biol B (2012).
  • Konikoff, C. E., Karr, T. L., McCutchan, M., Newfeld, S. J. & Kumar, S. Comparison of embryonic expression within multigene families using the FlyExpress discovery platform reveals more spatial than temporal divergence. Developmental Dynamics (2012).
  • Konikoff, C. E., Karr, T. L., McCutchan, M., Newfeld, S. J., and Kumar, S. Comparison of embryonic expression within multigene families using the flyexpress discovery platform reveals more spatial than temporal divergence. Dev Dyn (2012).
  • Vibranovski, M. D., Zhang, Y. E., Kemkemer, C., Lopes, H. F., Karr, T. L., and Long, M. Re-analysis of the larval testis data on meiotic sex chromosome inactivation revealed evidence for tissuespecific gene expression related to the drosophila X chromosome. BMC Biol (2012).
  • Vibranovski, M. D., Zhang, Y. E., Kemkemer, C., Vankuren, N. W., Lopes, H. F., Karr, T. L., and Long, M. Segmental dataset and whole body expression data do not support the hypothesis that non-random movement is an intrinsic property of Drosophila retrogenes. BMC Evol Biol (2012).
  • Kumar, S., Konikoff, C., Van Emden, B., Busick, C., et al. FlyExpress: visual mining of spatiotemporal patterns for genes and publications in Drosophila embryogenesis. Bioinformatics (2011).
  • Snook, R.R., Hosken, D.J., and Karr, T.L. The biology and evolution of polyspermy: insights from cellular and functional studies of sperm and centrosomal behavior in the fertilized egg. (2011).
  • Vibranovski, M. D. Lopes, H. F. , Karr, T. L., Long, M. Meiotic X inactivation and its consequences to Drosophila melanogaster genes. PLoS Genet (2009).
  • Dorus, S., Freeman, Z.N., Parker, E.R., Heath, B.D., and Karr, T.L. Recent origins of sperm genes in Drosophila. Molecular Biology and Evolution (2008).
  • Karr, T. L. Application of proteomics to ecology and population biology. Heredity (2008).
  • Karr, T. L. and Dorus, S. Evolution of sperm proteomes. In Sperm Biology: an Evolutionary Approach (T.R. Birkhead, D.J. Hosken and S. Pitnick, eds.) pp 305-365. (2008).
  • Karr, T. L. and Dorus, S. Evolution of sperm proteomes. Sperm Biology: an Evolutionary Approach (2008).
  • Karr, T. L., Snook, R.R. and Swanson, W. The evolutionary significance of variation in sperm-egg interactions. Sperm Biology: an Evolutionary Approach (2008).
Research Activity
Summer 2017
Course NumberCourse Title
BDE 792Research
Spring 2017
Course NumberCourse Title
BDE 799Dissertation
Fall 2016
Course NumberCourse Title
BDE 792Research
BDE 799Dissertation
Summer 2016
Course NumberCourse Title
BDE 792Research
Spring 2016
Course NumberCourse Title
BDE 799Dissertation
Fall 2015
Course NumberCourse Title
BDE 792Research
BDE 799Dissertation
Summer 2015
Course NumberCourse Title
BDE 792Research
Spring 2015
Course NumberCourse Title
BDE 792Research
BDE 799Dissertation
Fall 2014
Course NumberCourse Title
BDE 792Research
BDE 799Dissertation
Summer 2014
Course NumberCourse Title
BDE 792Research
Spring 2014
Course NumberCourse Title
BIO 493Honors Thesis
BDE 792Research
BDE 799Dissertation
Fall 2013
Course NumberCourse Title
BIO 492Honors Directed Study
MIC 495Undergraduate Research
BDE 792Research
BDE 799Dissertation
Spring 2013
Course NumberCourse Title
BIO 493Honors Thesis
MIC 495Undergraduate Research
BIO 495Undergraduate Research
BIO 499Individualized Instruction
Fall 2012
Course NumberCourse Title
BIO 495Undergraduate Research
Service
  • BMC Genomics, Associate Editor (2012 - Present)
  • BMC Genomics, Associate Editor (2012 - Present)
  • PhD research committee, Chair (2012 - Present)
  • PhD research committee, Chair (2010 - Present)
  • PhD research committee, Committee member (2010 - Present)
  • PhD research committee, Chair (2010 - Present)
  • PhD research committee, Committee member (2010 - Present)
  • Faculty of 1000, Editor (2007 - Present)
  • Faculty of 1000, Editor (2007 - Present)