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Siddhartha Angadi

Asst Professor
Faculty, DTPHX Campus, Mailcode 3020
Asst Professor
Faculty, DTPHX Campus, Mailcode 9020
Biography

My research has been primarily focused on exploring the effects of a novel, high-intensity interval exercise paradigm on cardiovascular and metabolic physiology in severe chronic diseases such as congestive heart failure and cardiac toxicity in breast cancer survivors. I specifically utilize exercise training as a pleiotropic “drug” to modify the disease process and to understand the mechanisms of disease in individuals suffering from these conditions. Furthermore, I have also been involved in the development of a novel risk score (utilizing peak oxygen uptake) for predicting the risk of major adverse cardiovascular events in patients with end-stage renal disease undergoing renal transplantation.

Education:

PhD - Arizona State University

Post-doctoral scholar - Exercise and Metabolic Disease Research Lab; University of California, Los Angeles. 

PEER-REVIEWED PUBLICATIONS (Impact factor = IF; H-index on on Google Scholar is 10. Researchgate score = 31.12)

 

1.      Angadi SS and Gaesser GA. Pre-exercise cardiology screening guidelines for asymptomatic patients with diabetes. Clin Sports Med. 2009;28:379-92. IF - 1.22.

2.      Angadi SS, Weltman A, Watson-Winfield D, Weltman J, Frick K, Patrie J and Gaesser GA. Effect of fractionized vs continuous, single-session exercise on blood pressure in adults. J Hum Hypertens. 2010;24:300-2. IF - 2.7

3.      Gaesser GA and Angadi SS. High-intensity interval training for health and fitness: can less be more? J Appl Physiol (1985). 2011;111:1540-1. IF - 3.056

4.      Gaesser GA, Angadi SS and Sawyer BJ. Exercise and diet, independent of weight loss, improve cardiometabolic risk profile in overweight and obese individuals. Phys Sportsmed. 2011;39:87-97. IF - 1.49

5.      Rynders CA, Angadi SS, Weltman NY, Gaesser GA and Weltman A. Oxygen uptake and ratings of perceived exertion at the lactate threshold and maximal fat oxidation rate in untrained adults. Eur J Appl Physiol. 2011;111:2063-8. IF - 2.187

6.      Bhammar DM, Angadi SS and Gaesser GA. Effects of fractionized and continuous exercise on 24-h ambulatory blood pressure. Med Sci Sports Exerc. 2012;44:2270-6. IF - 4.459

7.      Gaesser GA and Angadi SS. Gluten-free diet: imprudent dietary advice for the general population? J Acad Nutr Diet. 2012;112:1330-3. IF - 2.444

8.      Gaesser GA, Angadi SS, Ryan DM and Johnston CS. Lifestyle Measures to Reduce Inflammation. American Journal of Lifestyle Medicine. 2012;6:4-13. IF - 0.8

9.      Herrmann SD and Angadi SS. Children's physical activity and sedentary time and cardiometabolic risk factors. Clin J Sport Med. 2013;23:408-9. IF - 2.268

10.    Pesta DH, Angadi SS, Burtscher M and Roberts CK. The effects of caffeine, nicotine, ethanol, and tetrahydrocannabinol on exercise performance. Nutr Metab (Lond). 2013;10:71. IF - 3.26

11.    Roberts CK, Izadpanah A, Angadi SS and Barnard RJ. Effects of an intensive short-term diet and exercise intervention: comparison between normal-weight and obese children. Am J Physiol Regul Integr Comp Physiol. 2013;305:R552-7. IF - 3.106

12.    Angadi SS, Bhammar DM and Gaessser GA. Postexercise hypotension after continuous, aerobic interval, and sprint interval exercise. J Strength Cond Res. 2015. IF - 2.075

13.    Angadi SS, Mookadam F, Lee CD, Tucker WJ, Haykowsky MJ and Gaesser GA. High-intensity interval training vs. moderate-intensity continuous exercise training in heart failure with preserved ejection fraction: a pilot study. J Appl Physiol (1985). 2015;119:753-8. IF - 3.056

14.    Gaesser GA and Angadi SS. Navigating the gluten-free boom. JAAPA. 2015;28:1-7.

15.    Gaesser GA, Tucker WJ, Jarrett CL and Angadi SS. Fitness versus Fatness: Which Influences Health and Mortality Risk the Most? Curr Sports Med Rep. 2015;14:327-32. IF - 1.552

16.    Hurley JC, Hollingshead KE, Todd M, Jarrett CL, Tucker WJ, Angadi SS and Adams MA. The Walking Interventions Through Texting (WalkIT) Trial: Rationale, Design, and Protocol for a Factorial Randomized Controlled Trial of Adaptive Interventions for Overweight and Obese, Inactive Adults. JMIR Res Protoc. 2015;4:e108. IF - 4.663

17.    Roberts CK, Lee MM, Katiraie M, Krell SL, Angadi SS, Chronley MK, Oh CS, Ribas V, Harris RA, Hevener AL and Croymans DM. Strength fitness and body weight status on markers of cardiometabolic health. Med Sci Sports Exerc. 2015;47:1211-8. IF - 4.459

18.    Sawyer BJ, Bhammar DM, Angadi SS, Ryan DM, Ryder JR, Sussman EJ, Bertmann FM and Gaesser GA. Predictors of fat mass changes in response to aerobic exercise training in women. J Strength Cond Res. 2015;29:297-304. IF - 2.075

19.    Contractor A, Bhanushali A, Changrani J, Angadi S and Das BR. Pedometer assessed physical activity in urban pubertal children: first report from India. J Phys Act Health. 2014;11:1475-81. IF - 1.854

20.    Tucker WJ, Angadi SS, Gaesser GA. Excess postexercise oxygen consumption after high-intensity and sprint interval exercise, and continuous steady-state exercise. J Strength Cond Res. 2016 Mar 3. [Epub ahead of print]

 

BOOK CHAPTERS

  1. Tucker W, Angadi SS, Martin K. Dietary mushrooms: An excellent source for nutraceuticals capable of reducing risk factors for cardiovascular disease. Book title, “Nutrigenomics: Its application to the development of nutraceuticals.”
  2. Sawyer BJ, Angadi SS, Gaesser GA.  Health benefits of physical activity are independent of weight loss.  In: Wellness, Not Weight: health at Every Size and Motivational Interviewing (Glovsky E, editor), Cognella, Academic Publishing, 2013, pages 93-102.
  3. Gaesser GA, Angadi SS, Tucker WJ, Jarrett CL, Sawyer BJ. Exercise and diet improve cardiometabolic risk in overweight and obese individuals without weight loss. Book title, “Glucose Intake and Utilization in Pre-diabetes and Diabetes: Induction of Cardiovascular disease.” 2014.
  4. Pesta DH, Angadi SS, Burtscher M, Roberts CK. The effects of caffeine, nicotine, alcohol, and marijuana on exercise performance. Book title, “Sport Nutrition for Child and Adolescent Athletes.” 2016.

LAY PUBLICATIONS

  1. Contributed a chapter titled, “Exercise as cardiovascular medicine,” to the book titled “On my way to heaven… just not yet,” by Ralph Kaufer. A memoir by a patient about living for 30+ years with ischemic heart disease. In press.
  2. Wrote an article on the benefits of exercise with regard to cardiovascular health for Zocalo public square and featured on Time.com (http://time.com/3975136/healthy-living-ideas/).

 

ABSTRACTS 

  1. Contractor AA, Salgaonkar P, Shah J, Subramanium S, Angadi SS, Panda R. One-Year Follow-up of Patients with Triple Vessel Disease (Recommended CABG) on Intense Medical Management. Indian Heart Journal Sept-Oct, 2005; 57:(5).
  2. Contractor AA, Angadi SS, Franklin BA. Physical Activity levels in Indian Children. ACSM Annual Meeting, Indianapolis, IN (2008).
  3. Angadi SS, Weltman, A, Watson-Winfield D, Weltman J,  Frick,K; Patrie, J Gaesser, GA. Blood Pressure Responses Following Continuous Versus Fractionalized Exercise In Young Adults. ACSM Annual Meeting, Indianapolis, IN (2008).

4.Angadi SS, Rodriguez J, Frick K, Rutkowski J, Weltman N, Weltman A, Gaesser GA. Effects Of Glycemic Index And Dietary Fiber On Postprandial Endothelial Function. Featured Science Symposium, “Effects of exercise and diet on inflammation and vascular endothelial function,” American College of Sports medicine annual meeting, May 2009.

5.Irving BA, Rynders CA, Angadi SS, Weltman NY, Gaesser GA, Weltman A. Abdominally obese women with metabolic syndrome have higher maximal fat oxidation rates during sub-maximal treadmill exercise. American College of Sports medicine annual meeting. May 2009.

  1. Swift DL, Angadi SS, Weltman JY, Barrett EJ, Patrie J, Gaesser GA, Weltman A. Effects of Cardiorespiratory Fitness (CRF) on Endothelial Function Following a High-Fat Meal in Postmenopausal Women. Presented at the SEACSM conference at Birmingham, AL in February 2009. ACSM annual meeting in Seattle, May 2009.
  2. Angadi SS, Rynders CA, Weltman NY, Gaesser GA, Weltman A. Relationship betweein VO2 at lactate threshold (LT) and VO2 at maximal rate of fat oxidation (FATmax) across age, fitness status and sex. SEACSM conference at Birmingham, AL, February 2009; ACSM annual meeting in Seattle, May 2009.
  3. Rynders CA, Angadi SS, Weltman NY, Gaesser GA, Weltman A. VO2 at Maximal Rate of Fat Oxidation is Not Related to the Lactate Threshold in Abdominally Obese Women with Metabolic Syndrome. Presented at the SEACSM conference at Birmingham, AL in February 2009. ACSM annual meeting in Seattle,May 2009.
  4. Weltman NY, Angadi SS, Weltman A, Brock D, Rodriguez J, Patrie J, Frick K, Gaesser GA. A fiber-rich breakfast cereal attenuates postprandial triglyceridemia and associated impairment of endothelial function following a high-fat meal in youth. ADA conference in Denver, CO, October 2009.
  5. Bovbjerg VE, Crowther JQ, Gaesser GA, Gonder-Frederick LA, Nadler JL, Siadaty MS, Conaway MR, Botchwey NH, Angadi SS, Wolf AM.  Predictors of retention among participants in a diabetes and obesity lifestyle intervention: Improving Control with Activity and Nutrition.  American Diabetes Association 69th Scientific Sessions, 5-9 June, 2009, New Orleans, Louisiana.
  6. Sawyer BJ, Irving BA, Patrie J, Angadi SS, Gaesser GA. Percent body fat is positively correlated to walking and running economy/efficiency in healthy men and women. Southwest chapter meeting of the American college of sports medicine in San Diego CA (2009).
  7. Angadi SS, Rodriguez J, Weltman NY, Weltman A, Patrie J, Gaesser GA. Effects of glycemic index and dietary fiber on postprandial insulin and glycemic excursions.  Southwest chapter meeting of the American college of sports medicine in San Diego CA (2009).
  8. Angadi SS, Davis CK, Rogriguez J, Irving BA, Patrie J, Weltman A, Barret E, Brock D, Gaesser GA. Impairment of vascular endothelial function despite greater fat loss on low-carbohydrate vs. high-carbohydrate, high-fiber diet in adults with metabolic syndrome. SCAN meeting in San Diego CA (2010).
  9. Angadi SS, Rodriguez J, Weltman NY, Weltman A, Patire J, Gaesser GA. Effects of glycemic index and dietary fiber on postprandial insulin and glycemic excursions. ACSM National meeting in Baltimore, MD (2010).
  10. Sawyer BJ, Irving BA, Patrie J, Angadi SS, Gaesser GA. Percent body fat is positively correlated to walking and running economy/efficiency in healthy adults. ACSM National meeting in Baltimore, MD (2010).
  11. Angadi SS, Furmanek C, Hahn D, Gaesser GA. Post-exercise hypotension after moderate intensity continuous and high-intensity interval exercise. ACSM National meeting in Denver, CO (2011).
  12. Hahn D, Angadi SS, Gaesser GA. Effects of moderate intensity continuous and high intensity interval exercise on post-exercise oxygen uptake. ACSM National meeting in Denver, CO (2011).
  13. Bhammar D, Angadi SS, Gaesser GA. Effects of fractionized and continuous exercise on ambulatory blood pressure in prehypertensive adults. ACSM National meeting in Denver, CO (2011).
  14. Vezina JW, Meckes N, Hermann SD, Angadi SS, Sawyer BJ, Ainsworth BA. Oxygen cost of care-oriented activities in an adult population. ACSM National meeting in Denver, CO (2011).
  15. Carr N, Ryan D, Angadi SS, Sawyer BJ, Chisum J, Gaesser GA. Predictors of 2-kilometer time trial performance in female high school rowers. ACSM National meeting in Denver, CO (2011).
  16. Ryan D, Sawyer BJ, Angadi SS, Patrie J, Browning R, Gaesser GA. Percent body fat is negatively correlated to walking efficiency in a group of obese and nonobese men and women. ACSM National meeting in Denver, CO (2011).
  17. Ryan D, Sawyer B, Angadi SS, Chisum J, Gaesser GA. Effect of high-intensity interval training on 2-km ergometer time-trial performance in female high school rowers. Presented at the Southwest chapter of the American College of Sports Medicine meeting 2011. ACSM Annual meeting 2012 in San Francisco, CA.
  18. Bhammar D, Sawyer B, Angadi SS, Gaesser GA. Accuracy of SenseWear™ Armband in estimating energy expenditure in young and older adults during a controlled exercise trial. Southwest chapter of the American College of Sports Medicine meeting 2011.
  19. Sawyer B, Bhammar D, Angadi SS, Gaesser GA. Ability of the Sensewear™ Arm Band to Predict Energy Expenditure During Free-Living Activities. Southwest chapter of the American College of Sports Medicine meeting 2011.
  20. Angadi SS, Weltman NY, Weltman A, Rodriguez J, Patrie J, Gaesser GA. Dietary fiber does not attenuate postprandial glycemic responses following a high-carbohydrate meal adults and children. Presented at the Southwest chapter of the American College of Sports Medicine meeting 2011. ACSM Annual meeting 2012 in San Francisco, CA.
  21. Angadi SS, Weltman NY, Patrie J, Barrett E, Brock D, Irving BA, Davis C, Rodriguez J, Gaesser GA. Effects of a low-carbohydrate vs. high-carbohydrate, high-fiber diet on soluble cell adhesion molecules and endothelial function in adults with metabolic syndrome. Experimental Biology conference 2012 in San Diego, CA.
  22. Sawyer B, Bhammar D, Angadi SS, Ryan D, Ryder J, Gaesser GA. Heterogeneity in Total Body Fat Change After Aerobic Exercise Training is Similar in Women With Lower and Higher Amounts of Body Fat. Experimental Biology conference 2012 in San Diego, CA.
  23. Bhammar D, Sawyer B, Angadi SS, Ryder J, Ryan D, Gaesser GA. Air Displacement Plethysmography Weakly Predicts Changes in Percent Body Fat in Comparison to Dual X-ray Absorptiometry After Aerobic Exercise Training in Women. Experimental Biology conference 2012 in San Diego, CA.
  24. Bhammar D, Sawyer B, Angadi SS, Gaesser GA. Accuracy of Sensewear Pro armband in estimating energy expenditure during steady-state and non steady-state physical activity. ACSM Annual meeting 2012 in San Francisco, CA.
  25. Angadi SS, Mookadam F, Lee C, Bright G, Royter A, Walish J, Zakas D, Thompson P, Gaesser GA. High intensity interval training improves diastolic dysfunction in patients with heart failure and preserved ejection fraction. American Heart Association Conference 2012 in Los Angeles, CA.
  26. Angadi SS, Tucker WJ, Mookadam F, Lee CD, Gaesser GA. High-intensity interval training improves VO2peak in heart failure with preserved ejection fraction. Southwest chapter of American College of Sports Medicine meeting - 2013
  27. Jarrett CL, Sawyer BJ, Bhammar DM, Tucker WJ, Ryder JR, Angadi SS, Gaesser GA. Improvement in Aerobic Fitness Following a Moderate-Intensity Exercise Program is Independent of Step Count Among Sedentary Adult Females. Southwest chapter of American College of Sports Medicine meeting – 2013
  28. Jarrett CL, Tucker WJ, Hollingshead K, Hurley JC, Todd M, Gaesser GA, Adam MA, Angadi SS. Preliminary effects of mHealth adaptive interventions on vascular markers and cardiorespiratory fitness. Southwest chapter of American College of Sports Medicine meeting – 2014
  29. Jarrett CL, Moustafa S, Mookadam F, Gaesser GA, Angadi SS. Biventricular strain after  moderate-intensity and high-intensity interval training in heart failure with preserved ejection fraction. Accepted for American College of Sports Medicine meeting – 2015
  30. RJ Gonzales, P Raman, N Vijayavel, C Kerrigan, J Echeverria, JM Dickinson, TM Hale, C Carroll, and Angadi SS. Doxorubicin Reduces Proinflammatory Mediator Expression in Brain and Pial Arteries from Ovariectomized Female Rats. Accepted for the 2015 American Physiological Society conference: Cardiovascular and Metabolic diseases: Physiology and Gender.
  31. Dedmon WL, Astill BD, Cosgrave C, Katsma M, Arthur KA, Broderick TL, Hale TM, Angadi SS,  Dickinson JM, and Carroll CC. The effect of high-intensity, short-duration exercise training on tissue size and animal survival during treatment with doxorubicin. Presented at Midwestern University Student Research Day, Glendale, AZ, 2015.
  32. O’Niell L, Jarrett CL, Crawford M, Carroll CC, Hale TM, Dickinson JM, Angadi SS, Sweazea KL. Evaluation of the vasoprotective effects of high-intensity exercise prior to antrhacycline chemotherapy. Presented at Arizona Physiological Society, Glendale, AZ, 2015.
  33. Mahmood TM, D’Lugos AC, Cosgrave C, Dedmon WL, Astill BD, Patel S, Katsma M, Gonzales R, Hale TM, Carroll CC, Angadi SS, and Dickinson JM. High intensity exercise protects skeletal muscle from complications of doxorubicin treatment. Presented at Arizona Physiological Society, Glendale, AZ, 2015.
  34. D’Lugos AC, Mahmood T, Cosgrave C, Dedmon WL, Astill BD, Patel S, Katsma M, Gonzales RJ, Hale TM, Carroll CC, Angadi SS, and Dickinson JM. High intensity exercise preserves myocellular size throughout doxorubicin treatment. Presented at Arizona Physiological Society, Glendale, AZ, 2015.
  35. Herbold J, Hook BE, Jarrett CL, Tucker WJ, Bhuiyan N, Fernandes JA, Todd M, Adams MA, Angadi SS. Effects of the Walking Intervention Through Texting Trial on Novel Markers of Vascular Stiffness and Remodeling. Accepted for AHA EPI/Lifestyle 2016.
  36. Hook BE, Jarrett CL, Tucker WJ, Herbold JL, Hurley JC, Todd M, Bhuiyan N, Fernandes JA, Adams MA, Angadi SS. Changes in Glycemia and Blood Lipids Following a 4 Month Mhealth Walking Intervention. Accepted for AHA EPI/Lifestyle 2016.
  37. Jarrett CL, Tucker WJ, Hurley JC, Todd M, Hollingshead K, Adams MA, Angadi SS. Effects of a mHealth adaptive interventions on vascular markers health and cardiorespiratory fitness. Accepted for AHA EPI/Lifestyle 2016.
  38. Chakkera H, Lee CD, Dickinson JM, Kaplan B, Qaqish I, Behmen S, Heilman R, Khamash H, Huskey J, Nair S, Scott R, Steidley E, Temkit M, Angadi SS. VO2peak outperforms Troponin T for risk prediction of cardiovascular disease and all-cause mortality in patients with end stage renal disease. Accepted for American Transplant Congress 2016.
  39. Mullen SP, Cohen JD, Bullard T, Woods J, Wilund K, Schroyer R, Angadi SS, Buman M, & Wong B. Effects of exercise combined with thermal therapy on blood pressure and psychosocial outcomes: A pilot RCT. Poster to be presented at the Annual Meeting for the Society for Behavioral Medicine. Washington, DC (2016).
  40. Adams MA, Todd M, Hurley JC, Angadi SS, Hovell M, Bhuiyan N. Testing perpetually adaptive goal setting and immediate rewards for increasing physical activity: A 2x2 factorial randomized controlled trial. Accepted to International Congress on Physical Activity and Public Health 2016. Bangkok, Thailand.
  41. Adams MA, Todd M, Hurley JC, Angadi SS, Hovell M, Bhuiyan N. Testing perpetually adaptive goal setting and immediate rewards for increasing moderate-to-vigorous physical activity: A 2x2 factorial randomized controlled trial. American Public Health Association 2016. Denver, Colorado.

SCHOLARLY PRESENTATIONS

  • Featured Science session at the American College of Sports Medicine Annual conference at Seattle (2009). Session titled, “Effects of exercise and diet on inflammation and vascular endothelial function.”
  • Invited speaker at the 19th Annual Arizona Society for Cardiovascular and Pulmonary Rehabilitation 2011 conference. Talk titled, “High-intensity interval training in congestive heart failure.”
  • Invited speaker at the 20th Annual Arizona Society for Cardiovascular and Pulmonary Rehabilitation 2012 conference. Talk titled, “The Obesity paradox.”
  • Invited speaker at the Lifestyle Medicine Initiative UCLA 2012. Talking titled, “Obesity – Beautiful hypotheses, Ugly facts.”
  • Featured Science session at the American College of Sports Medicine Annual conference at Indianapolis (2013). Session titled, “Obesity: Beautiful hypotheses, Unpleasant facts.” Talk titled, “Weight loss: Do the benefits outweigh the risks?”
  • Southwest Chapter American College of Sports Medicine 2013 – Lecture titled, “Weight loss: Do the benefits outweigh the risks?”
  • Southwest Chapter American College of Sports Medicine 2014 – Lecture titled, “Exercise for the management of early and advanced cardiovascular disease,” in symposium titled, “Lifestyle for the cardiometabolic management of disease.”
  • Building Healthy Lifestyles Conference 2014 – Lecture titled, “Exercise as Vascular medicine: A systemic approach to treating cardiovascular disease.”
  • University of Arizona, Department of Basic Medical Sciences Seminar Series – Lecture titled, “Managing cardiometabolic risk with diet and exercise: Time for a paradigm shift?
  • Building Healthy Lifestyles Conference 2015 – Lecture titled, “Traditional treatments for obesity – is the cure worse than the condition?”
  • Mayo Clinic Grand Rounds Mayo 2015 – Lecture titled, “Managing cardiometabolic risk with diet and exercise: Time for a paradigm shift?”
  • Southwest Chapter American College of Sports Medicine 2015 – Symposium titled, “Exercise for the prevention of cardiometabolic complications of breast cancer chemotherapy.”
  • American Academy of Child and Adolescent Psychiatry 2015. Panelist in symposium titled, “Obesity: Challenging the assumptions of weight-focused approaches to health in children and teens.”
Research Interests

Heart failure is a major worldwide health concern and is the leading cause of hospitalization among elderly Americans. Approximately 50% of those diagnosed with heart failure have heart failure with preserved ejection fraction (HFPEF). HFPEF presents a therapeutic dilemma because pharmacological strategies that are effective for the treatment of heart failure and reduced ejection fraction have failed to show benefit in HFPEF. Aerobic exercise is an emergent treatment modality that may help improve left ventricular diastolic function in these patients. My research focuses principally on the effects of exercise intensity on markers of diastolic dysfunction and vascular function in patients with heart failure and preserved ejection fraction.

Research Activity
Spring 2017
Course NumberCourse Title
EXW 315Physiological Found/Movement
EXW 493Honors Thesis
EXW 560Cardiopulmonary Rehab
Fall 2016
Course NumberCourse Title
EXW 315Physiological Found/Movement
EXW 565Cardio-Pulmonary Physiology
Spring 2016
Course NumberCourse Title
EXW 493Honors Thesis
EXW 494Special Topics
EXW 560Cardiopulmonary Rehab
EXW 565Cardio-Pulmonary Physiology
Fall 2015
Course NumberCourse Title
EXW 315Physiological Found/Movement
KIN 442Fuel Metabolism
Spring 2015
Course NumberCourse Title
EXW 565Cardio-Pulmonary Physiology
Fall 2014
Course NumberCourse Title
EXW 315Physiological Found/Movement
Spring 2014
Course NumberCourse Title
EXW 315Physiological Found/Movement
Fall 2013
Course NumberCourse Title
EXW 315Physiological Found/Movement