Integrated Search Menu

Bertram Jacobs

Profile photo
Director and Professor
Faculty, TEMPE Campus, Mailcode 5401
Director (FSC) & Professor
Faculty, TEMPE Campus, Mailcode 5401
Director (FSC) & Professor
Faculty, TEMPE Campus, Mailcode 4501
Biography

Bertram Jacobs is currently serving as School of Life Sciences Director and as a professor of virology. As part of ASU’s Biodesign Institute, his research is focused on developing a vaccine for HIV — one that prevents infection or extends the lives of HIV patients. Jacobs also leads a group of students every summer to sub-Saharan Africa to teach AIDS prevention to the international community.

Jacobs is one of the world’s foremost experts on a poxvirus called vaccinia, a cousin of the smallpox virus. He has genetically engineered vaccinia as a vehicle against a number of infectious agents, bioterrorism threats, cancer, and other viruses, including HIV.

He also assists HIV/AIDS-related support organizations. He currently serves on the Board of Director’s for Aunt Rita’s Foundation, on the Advisory Board for Support for International Change, and on the Board of Directors for HEAL.

Education

PhD, University of California, Berkeley

Publications
  • Wellensiek BP, Larsen AC, Flores J, Jacobs BL, Chaput JC. A leader sequence capable of enhancing RNA expression and protein synthesis in mammalian cells. Protein Sci (2013).
  • Wellensiek BP, Larsen AC, Stephens B, Kukurba K, Waern K, Briones N, Liu L, Snyder M, Jacobs BL, Kumar S, Chaput JC. Genome-wide profiling of human cap-independent translation-enhancing elements. Nature Methods (2013).
  • Arndt W, Mitnik C, Denzler KL, White S, Waters R, Jacobs BL, Rochon Y, Olson VA, Damon IK, Langland JO. In vitro characterization of a nineteenth-century therapy for smallpox. PLoS One. 2012;7(3):e32610. doi: 10.1371 (2012).
  • White SD, Jacobs BL. The amino terminus of the vaccinia virus E3 protein is necessary to inhibit the interferon response. J. Virology (2012).
  • Denzler KL, Babas T, Rippeon A, Huynh T, Fukushima N, Rhodes L, Silvera PM, Jacobs BL. Attenuated NYCBH vaccinia virus deleted for the E3L gene confers partial protection against lethal monkeypox virus disease in cynomolgus macaques. Vaccine (2011).
  • Denzler KL, Rice AD, MacNeill AL, Fukushima N, Lindsey SF, Wallace G, Burrage AM, Smith AJ, Manning BR, Swetnam DM, Gray SA, Moyer RW, Jacobs BL. The NYCBH vaccinia virus deleted for the innate immune evasion gene, E3L, protects rabbits against lethal challenge by rabbitpox virus. Vaccine (2011).
  • Denzler KL, Schriewer J, Parker S, Werner C, Hartzler H, Hembrador E, Huynh T, Holechek S, Buller RM, Jacobs BL. The attenuated NYCBH vaccinia virus deleted for the immune evasion gene, E3L, completely protects mice against heterologous challenge with ectromelia virus. Vaccine (2011).
  • Jancovich JK, Jacobs BL. Innate immune evasion mediated by the Ambystoma tigrinum virus eukaryotic translation initiation factor 2alpha homologue. J. Virology (2011).
  • Kibler KV, Gomez CE, Perdiguero B, Wong S, Huynh T, Holechek S, Arndt W, Jimenez V, Gonzalez-Sanz R, Denzler K, Haddad EK, Wagner R, Sékaly RP, Tartaglia J, Pantaleo G, Jacobs BL, Esteban M. Improved NYVAC-based vaccine vectors. PLoS One (2011).
  • White SD, Conwell K, Langland JO, Jacobs BL. Use of a negative selectable marker for rapid selection of recombinant vaccinia virus. Biotechniques (2011).
  • Jacobs BL, Langland JO, Kibler KV, Denzler KL, White SD, Holechek SA, Wong S, Huynh T, Baskin CR. Vaccinia virus vaccines: past, present and future. Antiviral Res (2009).
  • Zhang P, Langland JO, Jacobs BL, Samuel CE. Protein kinase PKR-dependent activation of mitogen-activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L. J Virol (2009).
  • Y Ye, K Hauns, J Langland, Bertram Jacobs, B Hogue. Mouse Hepatitis Coronavirus A59 Nucleocapsid Protein is a Type I Interferon Antagonist. J Virol (2007).
  • J Langland, J Kash, V Carter, M Thomas, M Katze, Bertram Jacobs. Suppression of proinflammatory signal transduction and gene expression by the dual nucleic acid binding domains of the vaccinia virus E3L proteins. J Virol (2006).
  • Jeffrey Langland, Jason Cameron, Michael Heck, James Jancovich, Bertram Jacobs. Inhibition of PKR by RNA and DNA viruses. Virus Research (2006).
  • Langland, J, Cameron, J, Heck, M, Jancovich, J, Jacobs, Bertram. Inhibition of PKR by RNA and DNA viruses. (2006).
  • J Jancovich, E Davidson, N Parameswaran, J Mao, V Chinchar, J Collins, Bertram Jacobs, A Storfer. Evidence for emergence of an amphibian iridoviral disease because of human-enhanced spread. Mol Ecol (2005).
  • T Brandt, M Heck, S Vijaysri, G Jentarra, J Cameron, Bertram Jacobs. The N-terminal domain of the vaccinia virus E3L-protein is required for neurovirulence, but not induction of a protective immune response. Virology (2005).
  • C Auch, R Saha, F Sheikh, X Liu, Bertram Jacobs, K Pahan. Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia. FEBS Lett (2004).
  • J Langland, Bertram Jacobs. Inhibition of PKR by vaccinia virus: role of the N- and C-terminal domains of E3L. Virology (2004).
  • K Kibler, A Miyazato, V Yedavalli, A Dayton, Bertram Jacobs, G Dapolito, S Kim, K Jeang. Polyarginine Inhibits gp160 Processing by Furin and Suppresses Productive Human Immunodeficiency Virus Type 1 Infection. J Biol Chem (2004).
  • J Jancovich, J Collind, Bertram Jacobs, J Mao, V Chinchar, C Wyatt, S Case, Sudhir Kumar, G Valente, S Subramanian, E Davidson. Genomic Sequence of a Ranavirus (Family Iridoviridae) Associated with Salamander Mortalities in North America. Virology (2003).
  • J Jancovich, James Collins, Bertram Jacobs, J Mao, V Chinchar, C Wyatt, S Case, S Kumar, G Valente, S Subramanian, E Davidson. Genomic sequence of a ranavirus (family Iridoviridae) associated with salamander mortalities in North America. Virology (2003).
  • J Langland, P Kao, Bertram Jacobs. Regulation of IL-2 gene expression and nuclear factor-90 translocation in vaccinia virus-infected cells. J Interferon Cytokine Res (2003).
  • S Vijaysri, L Talasela, A Mercer, C McInnes, Bertram Jacobs, J Langland. The Orf virus E3L homologue is able to complement deletion of the vaccinia virus E3L gene in vitro but not in vivo. Virology (2003).
  • Y Kim, M Muralinath, T Brandt, M Pearcy, K Hauns, K Lowenhaupt, Bertram Jacobs, A Rich. A role for Z-DNA binding in vaccinia virus pathogenesis. Proc Natl Acad Sci U S A (2003).
  • J Langland, Bertram Jacobs. The Role of the PKR-Inhibitory Genes, E3L and K3L, in Determining Vaccinia Virus Host Range. Virology (2002).
  • Y He, H Nakao, S Tan, S Polyak, P Neddermann, S Vijaysri, Bertram Jacobs, M Katze. Subversion of cell signaling pathways by hepatitis C virus nonstructural 5A protein via interaction with Grb2 and P85 phosphatidylinositol 3-kinase. J Virol (2002).
  • Y Xiang, R Condit, S Vijaysri, Bertram Jacobs, B Williams, R Silverman. Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus. J Virol (2002).
  • T Brandt, Bertram Jacobs. Both carboxy- and amino-terminal domains of the vaccinia virus interferon resistance gene, E3L, are required for pathogenesis in a mouse model. J Virol (2001).
  • Y He, S Tan, S Tareen, Bertram Jacobs, S Vijaysri, J Langland, M Katze. Regulation of mRNA translation and cellular signaling by hepatitis C virus nonstructural protein NS5A. J Virol (2001).
Research Activity
Fall 2017
Course NumberCourse Title
BIO 492Honors Directed Study
BIO 495Undergraduate Research
MIC 495Undergraduate Research
MBB 495Undergraduate Research
MCB 500Research Methods
MIC 591Seminar
MCB 591Seminar
MIC 791Seminar
MCB 791Seminar
BDE 792Research
BDE 799Dissertation
Summer 2017
Course NumberCourse Title
MIC 484Internship
BIO 484Internship
BIO 495Undergraduate Research
BDE 792Research
Spring 2017
Course NumberCourse Title
MIC 493Honors Thesis
BIO 493Honors Thesis
BIO 495Undergraduate Research
MIC 498Pro-Seminar
BIO 498Pro-Seminar
MIC 591Seminar
MCB 591Seminar
MCB 791Seminar
MIC 791Seminar
BDE 792Research
BDE 799Dissertation
Fall 2016
Course NumberCourse Title
BIO 189Life Sciences Career Paths
BIO 492Honors Directed Study
MIC 495Undergraduate Research
BIO 495Undergraduate Research
MBB 495Undergraduate Research
MCB 500Research Methods
MIC 591Seminar
MCB 591Seminar
MIC 791Seminar
MCB 791Seminar
BDE 792Research
BDE 799Dissertation
Summer 2016
Course NumberCourse Title
SSH 403Cross-Culturl Stds Global Hlth
BIO 484Internship
MIC 484Internship
BIO 495Undergraduate Research
BDE 792Research
Spring 2016
Course NumberCourse Title
MIC 493Honors Thesis
BIO 495Undergraduate Research
MIC 498Pro-Seminar
BIO 498Pro-Seminar
MIC 591Seminar
MCB 591Seminar
MCB 791Seminar
MIC 791Seminar
BDE 792Research
BDE 799Dissertation
Fall 2015
Course NumberCourse Title
BIO 189Life Sciences Career Paths
BIO 492Honors Directed Study
MIC 495Undergraduate Research
BIO 495Undergraduate Research
MBB 495Undergraduate Research
MCB 500Research Methods
MIC 591Seminar
MCB 591Seminar
MIC 791Seminar
MCB 791Seminar
BDE 792Research
BDE 799Dissertation
Summer 2015
Course NumberCourse Title
BIO 495Undergraduate Research
BDE 792Research
Spring 2015
Course NumberCourse Title
MIC 498Pro-Seminar
BIO 498Pro-Seminar
MIC 591Seminar
MCB 591Seminar
MCB 791Seminar
MIC 791Seminar
BDE 792Research
BDE 799Dissertation
Fall 2014
Course NumberCourse Title
BIO 492Honors Directed Study
MIC 495Undergraduate Research
MBB 495Undergraduate Research
MCB 500Research Methods
MIC 591Seminar
MCB 591Seminar
MIC 791Seminar
MCB 791Seminar
BDE 792Research
BDE 799Dissertation
Summer 2014
Course NumberCourse Title
BIO 495Undergraduate Research
BDE 792Research
Spring 2014
Course NumberCourse Title
MIC 314HIV/AIDS: Sci/Behavior/Society
BIO 340General Genetics
MIC 493Honors Thesis
MIC 495Undergraduate Research
MBB 495Undergraduate Research
BIO 498Pro-Seminar
MIC 498Pro-Seminar
MCB 591Seminar
MIC 591Seminar
MIC 791Seminar
MCB 791Seminar
BDE 792Research
BDE 799Dissertation
Fall 2013
Course NumberCourse Title
BIO 340General Genetics
MCB 500Research Methods
MIC 591Seminar
MCB 591Seminar
MIC 791Seminar
MCB 791Seminar
BDE 792Research
BDE 799Dissertation
Summer 2013
Course NumberCourse Title
MIC 492Honors Directed Study
BIO 495Undergraduate Research
BIO 499Individualized Instruction
Spring 2013
Course NumberCourse Title
MIC 314HIV/AIDS: Sci/Behavior/Society
MIC 493Honors Thesis
BIO 494Special Topics
MIC 498Pro-Seminar
BIO 498Pro-Seminar
MIC 499Individualized Instruction
MIC 591Seminar
MCB 591Seminar
MIC 791Seminar
MCB 791Seminar
Presentations
  • Karen Kibler, Shuk-Mei Lantzer, Garilyn Jentarra, Jeffrey Langland and Bert Jacobs. Replication-competent attenuated strains of vaccinia virus as potential HIV vaccine vectors. AIDS Vaccine 2009 (Oct 2009).
  • William Arndt and Bert Jacobs. Interferon resistance of monkeypox virus. American Society for Virology Annual Meeting (Jun 2009).
  • Susan Holechek. Post-exposure prophylaxis of poxvirus infections. American Society for Virology Annual meeting (Jun 2009).
  • Jacobs, Bertram, Kibler, Karen. Replication competent, attenuated vaccine vectors. AIDS Vaccine Meetings (Oct 2008).
  • Jancovich, James, Jacobs, Bertram. Ambystoma tigrinum virus. International Poxvirus Symposium (Jun 2008).
  • Jacobs, Bertram. Replication competent, attenuated vaccine vectors. Keystone HIV vaccine meetings (Apr 2008).
  • Jacobs, Bertram. Vaccines for Biodefense. Annual ASM Biodefense Meetings (Feb 2008).
  • Jacobs, Bertram. Annual Meeting Arizona/Nevada Branch ASM (Feb 2003).
  • Jacobs, Bertram. NIH Orthopoxvirus Research Group Meeting (May 2002).
  • Jacobs, Bertram. Annual SIC Fundraiser - Keynote Speaker
  • Jacobs, Bertram. Biophysics Chalk Talk
  • Jacobs, Bertram. Body Positive
  • Jacobs, Bertram. HIV in Service Training
  • Jacobs, Bertram. Poxvirus Research Meeting
  • Jacobs, Bertram. PVDC Site Visit
  • Jacobs, Bertram. Science Cafe
  • Jacobs, Bertram. SoLS Studio
  • Jacobs, Bertram. University of California, Santa Barbara
Service
  • NIH VirB Study Section, Ad hoc member (2014 - Present)
  • Aunt Rita's Foundation, Board of Directors (2010 - Present)
  • Aunt Rita's Foundation, Board of Directors (2010 - Present)
  • Aunt Rita's Foundation, Board of Directors (2010 - Present)
  • Journal of Virology, Editorial Board (2005 - Present)
  • Journal of Virology, Editorial Board (2005 - Present)
  • Board of Advisors, Support for International Change, Member (2005 - Present)
  • Board of Advisors, Support for International Change, Member (2005 - Present)
  • Board of Advisors, Support for International Change, Member (2005 - Present)
  • Intellectual Property Committee, Member (2005 - Present)
  • Intellectual Property Committee, Member (2005 - Present)
  • Intellectual Property Committee, Member (2005 - Present)
  • Intellectual Property Committee, Member (2005 - Present)
  • Students for International Change, Faculty Advisor (2005 - Present)
  • University Biosafety Committee, Chair (2005 - Present)
  • University Biosafety Committee, Chair (2005 - Present)
  • University Biosafety Committee, Chair (2005 - Present)
  • University Biosafety Committee, Acting Chair (2005 - Present)
  • SoLS, Interim Director (2014 - 2015)
  • Journal of Virology, Editorial Board (2005 - 2011)
  • Journal of Biological Chemistry, Editorial Board (2006 - 2011)
  • Center for Infectious Diseases and Vaccinology, Biodesign Institute, Member (2006 - 2010)
  • International Poxvirus Symposium, Organizer (2006 - 2010)
  • SoLS, Biomedicine and Biotechnology Faculty Leader (2007 - 2010)
  • HEAL, International, Member, Board of Directors (2008 - 2010)
  • Intellectual Property Committee, Member (2005 - 2008)
  • Students for International Change, Faculty Advisor (2005 - 2008)
  • Students for International Change, Member, Board of Advisors (2005 - 2008)
  • University Biosafety Committee, Mmeber (2005 - 2008)
  • SoLS Facilities Committee, Member (2006 - 2007)
  • NIH, Member, Virology A Study Section (2004 - 2007)
  • Civilian Research Development Foundation, Consultant (2005 - 2005)
  • Journal of Biological Chemistry, Ad hoc reviewer (2005 - 2005)
  • Virology, Ad hoc reviewer (2005 - 2005)
  • VATID Review Panel, NIH, Member (2004 - 2004)
  • Poxvirus Proteomics Review Panel, NIH, Chair (2003 - 2003)
  • ASU President's Community Enrichment Program, Journeys of the Mind, Speaker (2003)
  • ASU Sigma Xi, Keynote Speaker (2003)
  • AzBioDesign, Member (2003)
  • Biochemistry, Ad hoc reviewer (2003)
  • Civilian Research Development Foundation, Consultant (2003)
  • Department of Microbiology, St. Louis University Medical School, Guest speaker (2003)
  • Department of Microbiology, University of Mississippi Medical School, Guest speaker (2003)
  • Intellectual Property Committee, Member (2003)
  • Journal of Virology, Ad hoc reviewer (2003)
  • NIH, Study Section member (2003)
  • Radiation Protection Committee, Member (2003)
  • University Biosafety Committee, Mmeber (2003)
  • Virology, Ad hoc reviewer (2003)
  • NIH Poxvirus Proteomics Review Panel, Member (2002 - 2002)
  • NIH Experimental Virology Study Section, Ad hoc Member (2002 - 2002)
  • NIH Rapid Response to Bioterrorism Study Section, Member (2002 - 2002)